{"id":"https://openalex.org/W7203885554","doi":"https://doi.org/10.1016/j.omton.2026.201331","title":"Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway","display_name":"Targeting LKB1-inactivated lung cancers with a stapled peptide inhibitor of the CRTC-CREB pathway","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7203885554","doi":"https://doi.org/10.1016/j.omton.2026.201331","pmid":"https://pubmed.ncbi.nlm.nih.gov/42733562","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13571231"},"language":"en","primary_location":{"id":"doi:10.1016/j.omton.2026.201331","doi":"https://doi.org/10.1016/j.omton.2026.201331","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2026.201331","pdf_url":null,"source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omton.2026.201331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014198549","display_name":"Xin Zhou","orcid":"https://orcid.org/0000-0002-9306-0162","observed_orcids":["https://orcid.org/0000-0002-9306-0162"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Zhou","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058880979","display_name":"Gregory H. Bird","orcid":"https://orcid.org/0000-0002-6853-643X","observed_orcids":["https://orcid.org/0000-0002-6853-643X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory H. Bird","raw_affiliation_strings":["Chemical Biology Program, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Program, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112120901","display_name":"Mu Yu","orcid":"https://orcid.org/0009-0002-0844-7686","observed_orcids":["https://orcid.org/0009-0002-0844-7686"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mu Yu","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026548190","display_name":"Jian\u2010Liang Li","orcid":"https://orcid.org/0000-0002-6487-081X","observed_orcids":["https://orcid.org/0000-0002-6487-081X"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jian-Liang Li","raw_affiliation_strings":["Integrative Bioinformatics, National Institute of Environmental Health Sciences, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrative Bioinformatics, National Institute of Environmental Health Sciences, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094223246","display_name":"Xzaviar Kaymar Solone","orcid":"https://orcid.org/0000-0002-9233-9575","observed_orcids":["https://orcid.org/0000-0002-9233-9575"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xzaviar K. Solone","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147722900","display_name":"Michael C. Chung","orcid":"https://orcid.org/0000-0003-3060-3454","observed_orcids":["https://orcid.org/0000-0003-3060-3454"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Chung","raw_affiliation_strings":["College of Pharmacy, University of Texas, Austin, TX 78712, USA"],"raw_orcid":"https://orcid.org/0000-0003-3060-3454","affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Texas, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103173666","display_name":"Juan Guan","orcid":"https://orcid.org/0000-0002-5944-6512","observed_orcids":["https://orcid.org/0000-0002-5944-6512"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Guan","raw_affiliation_strings":["College of Pharmacy, University of Texas, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Texas, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020222350","display_name":"Loren D. Walensky","orcid":"https://orcid.org/0000-0002-0869-2334","observed_orcids":["https://orcid.org/0000-0002-0869-2334"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Loren D. Walensky","raw_affiliation_strings":["Chemical Biology Program, Dana-Farber Cancer Institute, Boston, MA 02215, USA","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA"],"raw_orcid":"https://orcid.org/0000-0002-0869-2334","affiliations":[{"raw_affiliation_string":"Chemical Biology Program, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084674340","display_name":"Lizi Wu","orcid":"https://orcid.org/0000-0002-0076-2617","observed_orcids":["https://orcid.org/0000-0002-0076-2617"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4390039331","display_name":"UF Health Cancer Center","ror":"https://ror.org/044vhe029","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lizi Wu","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA","UF Institute of Genetics, University of Florida, Gainesville, FL 32610, USA"],"raw_orcid":"https://orcid.org/0000-0002-0076-2617","affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Health Cancer Institute, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4390039331"]},{"raw_affiliation_string":"UF Institute of Genetics, University of Florida, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5020222350","https://openalex.org/A5084674340"],"corresponding_institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144","https://openalex.org/I4210117453","https://openalex.org/I4390039331"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51093047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"3","first_page":"201331","last_page":"201331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-kinase-b1","display_name":"LKB1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8450000286102295},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/stapled-peptides","display_name":"stapled peptides","score":0.7179999947547913},{"id":"https://openalex.org/keywords/creb-dependent-transcription","display_name":"CREB-dependent transcription","score":0.8980000019073486},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.7009999752044678},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49470001459121704},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4749000072479248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41760000586509705},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36820000410079956},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3091999888420105},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2996000051498413},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2971999943256378},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2775999903678894},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27709999680519104},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25760000944137573}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.omton.2026.201331","doi":"https://doi.org/10.1016/j.omton.2026.201331","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2026.201331","pdf_url":null,"source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13571231","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13571231/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13571231/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Oncol","raw_type":"Text"},{"id":"pmid:42733562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42733562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.omton.2026.201331","doi":"https://doi.org/10.1016/j.omton.2026.201331","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omton.2026.201331","pdf_url":null,"source":{"id":"https://openalex.org/S5407037028","display_name":"Molecular Therapy Oncology","issn_l":"2950-3299","issn":["2950-3299"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","doyens","jufo-1","ki-jl-1","norway-1","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G165232755","display_name":"Signaling and Targeting of CRTC1-MAML2 Fusion Oncoprotein in Salivary Gland","funder_award_id":"R01DE023641","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000875615","display_name":"Mechanisms of Assembly and Functional Regulation in Non-canonical Biomolecular Condensates","funder_award_id":"R35GM146877","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000907656","display_name":"Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer","funder_award_id":"R35CA197583","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000917913","display_name":"Stapled Peptides for Protein Interaction Research and Therapeutic Targeting in Human Cancer","funder_award_id":"R50CA211399","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309360","display_name":"Florida Department of Health","ror":"https://ror.org/03e1xkn26"},{"id":"https://openalex.org/F4320310773","display_name":"National Cancer Center","ror":"https://ror.org/0065zqt33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332659","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88"},{"id":"https://openalex.org/F4320336416","display_name":"International Centre for Bamboo and Rattan","ror":"https://ror.org/02h5sfg65"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203885554.pdf","grobid_xml":"https://content.openalex.org/works/W7203885554.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1619256199","https://openalex.org/W1978403601","https://openalex.org/W1982488143","https://openalex.org/W1989452309","https://openalex.org/W2008845432","https://openalex.org/W2013997037","https://openalex.org/W2019010829","https://openalex.org/W2033400446","https://openalex.org/W2035984881","https://openalex.org/W2042061022","https://openalex.org/W2044874695","https://openalex.org/W2048598717","https://openalex.org/W2072435450","https://openalex.org/W2085948054","https://openalex.org/W2088359631","https://openalex.org/W2094207365","https://openalex.org/W2107211259","https://openalex.org/W2134964552","https://openalex.org/W2138297714","https://openalex.org/W2153131926","https://openalex.org/W2158213282","https://openalex.org/W2160834915","https://openalex.org/W2163798887","https://openalex.org/W2165956359","https://openalex.org/W2168106545","https://openalex.org/W2171033030","https://openalex.org/W2180481128","https://openalex.org/W2341084019","https://openalex.org/W2345961903","https://openalex.org/W2463855752","https://openalex.org/W2509008602","https://openalex.org/W2619620886","https://openalex.org/W2770828094","https://openalex.org/W2783897381","https://openalex.org/W2784371446","https://openalex.org/W2797675588","https://openalex.org/W2801961870","https://openalex.org/W2804812017","https://openalex.org/W2898789672","https://openalex.org/W2901825376","https://openalex.org/W2914044487","https://openalex.org/W2963425570","https://openalex.org/W2964583576","https://openalex.org/W2966596554","https://openalex.org/W2967078590","https://openalex.org/W2976744492","https://openalex.org/W3049469146","https://openalex.org/W3083360362","https://openalex.org/W3087229737","https://openalex.org/W3167718525","https://openalex.org/W3178510225","https://openalex.org/W3184405846","https://openalex.org/W3215921195","https://openalex.org/W4225150499","https://openalex.org/W4297535461","https://openalex.org/W4306154770","https://openalex.org/W4366982334","https://openalex.org/W4384120632","https://openalex.org/W4390580084","https://openalex.org/W4417279339"],"related_works":["https://openalex.org/W2789389786","https://openalex.org/W2345961903","https://openalex.org/W2004345651","https://openalex.org/W3167718525","https://openalex.org/W7099812862","https://openalex.org/W2900953710","https://openalex.org/W4409821869","https://openalex.org/W1551648980","https://openalex.org/W2133088932","https://openalex.org/W2330920071"],"abstract_inverted_index":{".":[0],"Importantly,":[1],"SAH-CBDs":[2,31],"penetrate":[3],"cells":[4],"without":[5],"causing":[6],"membrane":[7],"disruption,":[8],"inhibit":[9],"CREB-dependent":[10],"transcription,":[11],"and":[12,36],"selectively":[13],"suppress":[14],"the":[15],"growth":[16],"of":[17],"LKB1-null":[18],"lung":[19],"cancer":[20],"cells,":[21],"with":[22],"minimal":[23],"effects":[24],"on":[25],"LKB1-wild-type":[26],"cells.":[27],"These":[28],"findings":[29],"establish":[30],"as":[32],"a":[33,37,42],"mechanistic":[34],"tool":[35],"prototype":[38],"therapeutic":[39],"for":[40],"targeting":[41],"key":[43],"transcriptional":[44],"vulnerability":[45],"in":[46],"LKB1-inactivated":[47],"NSCLC.":[48]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-22T00:00:00"}