{"id":"https://openalex.org/W7203867409","doi":"https://doi.org/10.64898/2026.08.17.745220","title":"A conserved molecular marker for connections between two evolutionarily distinct visual centers","display_name":"A conserved molecular marker for connections between two evolutionarily distinct visual centers","publication_year":2026,"publication_date":"2026-08-20","ids":{"openalex":"https://openalex.org/W7203867409","doi":"https://doi.org/10.64898/2026.08.17.745220"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.17.745220","doi":"https://doi.org/10.64898/2026.08.17.745220","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.17.745220","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.17.745220.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.17.745220.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110019954","display_name":"Nicholas M. Oliver","orcid":"https://orcid.org/0009-0003-3089-9950","observed_orcids":["https://orcid.org/0009-0003-3089-9950"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas M. Oliver","raw_affiliation_strings":["Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137722403","display_name":"Maia Jin Classe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maia Jin Classe","raw_affiliation_strings":["Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, 48109, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, 48109, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042049313","display_name":"Sebastian Werneburg","orcid":"https://orcid.org/0000-0002-2173-8392","observed_orcids":["https://orcid.org/0000-0002-2173-8392"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Werneburg","raw_affiliation_strings":["Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA","Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, 48109, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, 48109, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071611836","display_name":"Elise Laura Savier","orcid":"https://orcid.org/0000-0001-7512-1630","observed_orcids":["https://orcid.org/0000-0001-7512-1630"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elise L. Savier","raw_affiliation_strings":["Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA","Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, 48109, MI, USA"],"raw_orcid":"https://orcid.org/0000-0001-7512-1630","affiliations":[{"raw_affiliation_string":"Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, 48109, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Ophthalmology & Visual Sciences, University of Michigan, Ann Arbor, 48109, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071611836"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.06650000065565109,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.051899999380111694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/superior-colliculus","display_name":"superior colliculus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dorsal-lateral-geniculate-nucleus","display_name":"dorsal lateral geniculate nucleus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thalamus","display_name":"thalamus","score":0.7580000162124634},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/conserved-gene-expression","display_name":"conserved gene expression","score":0.4970000088214874},{"id":"https://openalex.org/keywords/tree-shrew","display_name":"tree shrew","score":0.7200000286102295},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.9890000224113464},{"id":"https://openalex.org/keywords/human","display_name":"human","score":0.6290000081062317},{"id":"https://openalex.org/keywords/parallel-visual-processing","display_name":"parallel visual processing","score":0.7379999756813049},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.4860000014305115},{"id":"https://openalex.org/keywords/single-nucleus-rna-sequencing","display_name":"single-nucleus RNA sequencing","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C2781416072","wikidata":"https://www.wikidata.org/wiki/Q1109417","display_name":"Superior colliculus","level":2,"score":0.7524999976158142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7515000104904175},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.519599974155426},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4487000107765198},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.4142000079154968},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.40790000557899475},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.3752000033855438},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.37059998512268066},{"id":"https://openalex.org/C119088629","wikidata":"https://www.wikidata.org/wiki/Q558363","display_name":"Visual system","level":3,"score":0.3398999869823456},{"id":"https://openalex.org/C124388736","wikidata":"https://www.wikidata.org/wiki/Q3247497","display_name":"Tree of life (biology)","level":4,"score":0.32600000500679016},{"id":"https://openalex.org/C2993410155","wikidata":"https://www.wikidata.org/wiki/Q5508841","display_name":"Functional organization","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C2777160741","wikidata":"https://www.wikidata.org/wiki/Q2311855","display_name":"Molecular marker","level":3,"score":0.3255000114440918},{"id":"https://openalex.org/C175779824","wikidata":"https://www.wikidata.org/wiki/Q7574078","display_name":"Spatial organization","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3095000088214874},{"id":"https://openalex.org/C107968991","wikidata":"https://www.wikidata.org/wiki/Q1868509","display_name":"Functional specialization","level":2,"score":0.3043000102043152},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28279998898506165},{"id":"https://openalex.org/C2778251979","wikidata":"https://www.wikidata.org/wiki/Q7936617","display_name":"Visual processing","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C124980797","wikidata":"https://www.wikidata.org/wiki/Q333018","display_name":"Common descent","level":4,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.17.745220","doi":"https://doi.org/10.64898/2026.08.17.745220","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.17.745220","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.17.745220.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.17.745220","doi":"https://doi.org/10.64898/2026.08.17.745220","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.17.745220","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.17.745220.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","score":0.6767094135284424,"display_name":"Life on land"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203867409.pdf","grobid_xml":"https://content.openalex.org/works/W7203867409.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7223231493","https://openalex.org/W6963503393","https://openalex.org/W7172029189","https://openalex.org/W1981803540","https://openalex.org/W2211904686","https://openalex.org/W3198546360","https://openalex.org/W2883604488","https://openalex.org/W7111497118","https://openalex.org/W2140064558","https://openalex.org/W4415191367"],"abstract_inverted_index":{"Abstract":[0],"Sensory":[1],"systems":[2],"share":[3,44],"common":[4],"circuit":[5],"organization":[6,325],"motifs":[7],"across":[8,122,231,339],"mammalian":[9,232],"species,":[10,123,233],"however,":[11],"anatomical":[12,322],"subdivisions":[13,111],"show":[14],"varying":[15],"degrees":[16],"of":[17,48,84,114,120,129,162,183,216,220,263,314,329],"complexity":[18],"depending":[19,240],"on":[20,241],"ecological":[21],"niche":[22],"and":[23,67,78,91,112,138,157,171,197,209,270,277,324],"species-specific":[24],"sensory":[25,242],"requirements.":[26],"While":[27,225],"coarse":[28,226],"neuroanatomical":[29,227],"connections":[30,68,163,205,228,250],"seem":[31],"preserved":[32],"within":[33],"the":[34,62,74,79,85,89,92,115,126,155,160,165,169,172,181,188,207,217,261,267,271,275,278,327],"visual":[35,72,221,272,284,302],"system,":[36],"it":[37,245],"remains":[38,246],"unknown":[39,247],"if":[40,248],"molecularly":[41,255],"defined":[42,256],"cell-types":[43],"a":[45,95,146,194,264,289,315],"similar":[46],"degree":[47],"conservation,":[49],"regarding":[50],"not":[51],"only":[52],"their":[53,234],"functional":[54],"properties":[55],"but":[56],"also":[57,287],"connectivity.":[58],"Here":[59],"we":[60],"analyze":[61],"organization,":[63],"molecular":[64,108,148,185,195,316],"marker":[65,149,186,317],"expression,":[66],"between":[69,266],"two":[70,300],"prominent":[71],"centers,":[73,303],"superior":[75,268],"colliculus":[76,269],"(SC)":[77],"dorsal":[80],"lateral":[81],"geniculate":[82],"nucleus":[83],"thalamus":[86,273],"(dLGN),":[87],"in":[88,133,154,167,187,206,274],"mouse":[90,170,208,276],"tree":[93,173,210,279],"shrew,":[94,211,280],"highly":[96],"visual,":[97],"diurnal":[98],"species":[99],"closely":[100],"related":[101],"to":[102,106,110,203,296,333],"primates.":[103],"Previous":[104],"attempts":[105],"link":[107],"markers":[109],"connectivity":[113,335],"dLGN":[116,156,204],"have":[117,282],"shown":[118],"lack":[119],"conservation":[121,262,313],"thus":[124],"preventing":[125],"systematic":[127],"investigation":[128],"brain-wide":[130,334],"interactions":[131],"involved":[132],"vision.":[134],"Leveraging":[135],"recent":[136],"single-cell":[137],"single-nucleus":[139],"RNA":[140],"sequencing":[141],"studies,":[142],"our":[143,177],"results":[144,192],"unravel":[145],"conserved":[147,230,338],"that":[150,319],"shows":[151],"spatial":[152],"restriction":[153],"correlates":[158],"with":[159,308],"location":[161],"from":[164],"SC":[166,202],"both":[168],"shrew.":[174],"We":[175,286],"extend":[176],"findings":[178],"by":[179,253],"confirming":[180],"presence":[182],"this":[184],"human":[189],"dLGN.":[190],"These":[191],"provide":[193],"definition":[196],"genetic":[198,290],"access":[199,291],"point":[200],"for":[201],"enabling":[212],"cell-type":[213],"specific":[214],"studies":[215],"parallel":[218],"processing":[219],"information.":[222],"Significance":[223],"Statement":[224],"are":[229,251],"local":[235],"projection":[236,265],"pattern":[237],"can":[238,336],"vary":[239],"specialization.":[243],"Furthermore,":[244],"these":[249,299],"made":[252],"homologous":[254],"cell-types.":[257],"Our":[258],"work":[259],"confirms":[260],"which":[281],"distinct":[283],"capabilities.":[285],"uncover":[288],"point,":[292],"unraveling":[293],"new":[294],"avenues":[295],"understand":[297],"how":[298],"major":[301],"often":[304],"studied":[305],"separately,":[306],"interact":[307],"each":[309],"other.":[310],"The":[311],"remarkable":[312],"suggests":[318],"despite":[320],"core":[321],"variations":[323],"principles,":[326],"expression":[328],"certain":[330],"genes":[331],"linked":[332],"be":[337],"species.":[340]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-22T00:00:00"}