{"id":"https://openalex.org/W7203865879","doi":"https://doi.org/10.3389/fcell.2026.1931336","title":"Induced pluripotent stem cell reprogramming: methodological evolution and challenges in clinical translation","display_name":"Induced pluripotent stem cell reprogramming: methodological evolution and challenges in clinical translation","publication_year":2026,"publication_date":"2026-08-21","ids":{"openalex":"https://openalex.org/W7203865879","doi":"https://doi.org/10.3389/fcell.2026.1931336","pmid":"https://pubmed.ncbi.nlm.nih.gov/42698869","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13542370"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1931336","doi":"https://doi.org/10.3389/fcell.2026.1931336","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1931336","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1931336/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1931336/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147730408","display_name":"Mengmeng Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengmeng Chen","raw_affiliation_strings":["Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053156381","display_name":"Ning Zuo","orcid":"https://orcid.org/0009-0006-7100-297X","observed_orcids":["https://orcid.org/0009-0006-7100-297X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ning Zuo","raw_affiliation_strings":["Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147805454","display_name":"Qi Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147807122","display_name":"Hongyang Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongyang Zhao","raw_affiliation_strings":["Life Valley (Qingdao) Health Technology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Valley (Qingdao) Health Technology Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147757898","display_name":"Pengdan Dai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pengdan Dai","raw_affiliation_strings":["Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112045629","display_name":"Shaoshuai Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaoshuai Liang","raw_affiliation_strings":["Life Valley (Qingdao) Health Technology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Valley (Qingdao) Health Technology Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147731756","display_name":"Wei Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhu","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Qingdao University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Qingdao University","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147778187","display_name":"Haoyun Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haoyun Zhang","raw_affiliation_strings":["Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Shandong Second Medical University","School of Basic Medical Science, Shandong Second Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurologic Disorders and Regenerative Repair Lab of Shandong Higher Education, Shandong Second Medical University","institution_ids":[]},{"raw_affiliation_string":"School of Basic Medical Science, Shandong Second Medical University","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068839210","display_name":"Muhammad Omer Iqbal","orcid":"https://orcid.org/0000-0002-7122-9422","observed_orcids":["https://orcid.org/0000-0002-7122-9422"]},"institutions":[{"id":"https://openalex.org/I143413998","display_name":"Qingdao University of Science and Technology","ror":"https://ror.org/041j8js14","country_code":"CN","type":"education","lineage":["https://openalex.org/I143413998"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muhammad Omer Iqbal","raw_affiliation_strings":["College of Biological Engineering, Qingdao University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biological Engineering, Qingdao University of Science and Technology","institution_ids":["https://openalex.org/I143413998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113255307","display_name":"Dingcai Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143413998","display_name":"Qingdao University of Science and Technology","ror":"https://ror.org/041j8js14","country_code":"CN","type":"education","lineage":["https://openalex.org/I143413998"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dingcai Dong","raw_affiliation_strings":["College of Biological Engineering, Qingdao University of Science and Technology","Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biological Engineering, Qingdao University of Science and Technology","institution_ids":["https://openalex.org/I143413998"]},{"raw_affiliation_string":"Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031642999","display_name":"Bingqiang Zhang","orcid":"https://orcid.org/0009-0002-7160-4322","observed_orcids":["https://orcid.org/0009-0002-7160-4322"]},"institutions":[{"id":"https://openalex.org/I143413998","display_name":"Qingdao University of Science and Technology","ror":"https://ror.org/041j8js14","country_code":"CN","type":"education","lineage":["https://openalex.org/I143413998"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bingqiang Zhang","raw_affiliation_strings":["College of Biological Engineering, Qingdao University of Science and Technology","Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biological Engineering, Qingdao University of Science and Technology","institution_ids":["https://openalex.org/I143413998"]},{"raw_affiliation_string":"Qingdao Engineering Research Center for Cellular Immunity and Early Cancer Screening,Qingdao Restore Biotechnology Co., Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031642999","https://openalex.org/A5113255307"],"corresponding_institution_ids":["https://openalex.org/I143413998"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29476334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":"1931336","last_page":"1931336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.8690000176429749},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.6970000267028809},{"id":"https://openalex.org/keywords/episomal-vectors","display_name":"episomal vectors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/chemical-reprogramming","display_name":"chemical reprogramming","score":0.9860000014305115},{"id":"https://openalex.org/keywords/crispr-gene-editing","display_name":"CRISPR gene editing","score":0.8289999961853027},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9940000176429749},{"id":"https://openalex.org/keywords/good-manufacturing-practices","display_name":"good manufacturing practices","score":0.8519999980926514},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.9129999876022339},{"id":"https://openalex.org/keywords/smart-biomaterials","display_name":"smart biomaterials","score":0.9779999852180481},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.753000020980835},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.6650000214576721},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.9412999749183655},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.7857000231742859},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6230000257492065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.580299973487854},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5559999942779541},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4934000074863434},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.4131999909877777},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.4077000021934509},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.38429999351501465},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.37630000710487366},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.37369999289512634},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3564999997615814},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C2910924664","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Human Induced Pluripotent Stem Cells","level":5,"score":0.33399999141693115},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33230000734329224},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3312000036239624},{"id":"https://openalex.org/C2775893736","wikidata":"https://www.wikidata.org/wiki/Q25324110","display_name":"Biomanufacturing","level":2,"score":0.32339999079704285},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.3192000091075897},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.3174999952316284},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C145290725","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome engineering","level":5,"score":0.2773999869823456},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.27309998869895935},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C2779709869","wikidata":"https://www.wikidata.org/wiki/Q1292017","display_name":"Good manufacturing practice","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.25679999589920044},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.25589999556541443},{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2026.1931336","doi":"https://doi.org/10.3389/fcell.2026.1931336","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1931336","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1931336/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13542370","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42698869/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13542370/pdf/fcell-14-1931336.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:42698869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42698869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:48fd1778790c4968afc4c7e9e90ead53","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/48fd1778790c4968afc4c7e9e90ead53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1931336","doi":"https://doi.org/10.3389/fcell.2026.1931336","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1931336","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1931336/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203865879.pdf","grobid_xml":"https://content.openalex.org/works/W7203865879.grobid-xml"},"referenced_works_count":149,"referenced_works":["https://openalex.org/W2061046795","https://openalex.org/W2068918586","https://openalex.org/W2079716120","https://openalex.org/W2081331532","https://openalex.org/W2086943348","https://openalex.org/W2101569447","https://openalex.org/W2103573028","https://openalex.org/W2109981676","https://openalex.org/W2113056139","https://openalex.org/W2125987139","https://openalex.org/W2131341398","https://openalex.org/W2138977668","https://openalex.org/W2163173465","https://openalex.org/W2601350462","https://openalex.org/W2711913851","https://openalex.org/W2738441173","https://openalex.org/W2744405843","https://openalex.org/W2793361921","https://openalex.org/W2800570754","https://openalex.org/W2805198390","https://openalex.org/W2886812134","https://openalex.org/W2894849432","https://openalex.org/W2899991374","https://openalex.org/W2900659284","https://openalex.org/W2911279170","https://openalex.org/W2928210341","https://openalex.org/W2937721230","https://openalex.org/W2963331801","https://openalex.org/W2966615604","https://openalex.org/W2983894052","https://openalex.org/W2985399327","https://openalex.org/W2991495895","https://openalex.org/W3023981527","https://openalex.org/W3036566204","https://openalex.org/W3037427742","https://openalex.org/W3094155397","https://openalex.org/W3103959996","https://openalex.org/W3111406602","https://openalex.org/W3126867806","https://openalex.org/W3142898847","https://openalex.org/W3157611622","https://openalex.org/W3158086023","https://openalex.org/W3160438588","https://openalex.org/W3160973552","https://openalex.org/W3161426911","https://openalex.org/W3162030608","https://openalex.org/W3166417300","https://openalex.org/W3183169348","https://openalex.org/W3189828545","https://openalex.org/W3192340087","https://openalex.org/W3193612958","https://openalex.org/W3196356748","https://openalex.org/W3197054512","https://openalex.org/W3198668746","https://openalex.org/W3215794551","https://openalex.org/W4200229606","https://openalex.org/W4205312303","https://openalex.org/W4210666526","https://openalex.org/W4213219615","https://openalex.org/W4220692813","https://openalex.org/W4224046406","https://openalex.org/W4282972521","https://openalex.org/W4283655825","https://openalex.org/W4285086646","https://openalex.org/W4286561792","https://openalex.org/W4295084598","https://openalex.org/W4296916826","https://openalex.org/W4307714882","https://openalex.org/W4309621741","https://openalex.org/W4310256165","https://openalex.org/W4310544046","https://openalex.org/W4312194558","https://openalex.org/W4313226850","https://openalex.org/W4313907780","https://openalex.org/W4316363277","https://openalex.org/W4317566710","https://openalex.org/W4321748839","https://openalex.org/W4321791415","https://openalex.org/W4323044282","https://openalex.org/W4327940033","https://openalex.org/W4361284096","https://openalex.org/W4361302966","https://openalex.org/W4364379440","https://openalex.org/W4375864165","https://openalex.org/W4376872415","https://openalex.org/W4377011071","https://openalex.org/W4377042520","https://openalex.org/W4377839647","https://openalex.org/W4380203351","https://openalex.org/W4382199938","https://openalex.org/W4382460808","https://openalex.org/W4386053638","https://openalex.org/W4386734532","https://openalex.org/W4388126562","https://openalex.org/W4388300440","https://openalex.org/W4389137472","https://openalex.org/W4389304646","https://openalex.org/W4391643568","https://openalex.org/W4391721960","https://openalex.org/W4391843347","https://openalex.org/W4392091410","https://openalex.org/W4392755948","https://openalex.org/W4393905874","https://openalex.org/W4395005421","https://openalex.org/W4395114572","https://openalex.org/W4396772901","https://openalex.org/W4399056821","https://openalex.org/W4399363058","https://openalex.org/W4399592508","https://openalex.org/W4400799542","https://openalex.org/W4400916720","https://openalex.org/W4401883582","https://openalex.org/W4402843606","https://openalex.org/W4402967573","https://openalex.org/W4403404638","https://openalex.org/W4404026370","https://openalex.org/W4404209374","https://openalex.org/W4404887103","https://openalex.org/W4405801155","https://openalex.org/W4406034662","https://openalex.org/W4406320178","https://openalex.org/W4406471274","https://openalex.org/W4406813774","https://openalex.org/W4407593317","https://openalex.org/W4407908354","https://openalex.org/W4408244108","https://openalex.org/W4408405901","https://openalex.org/W4408854081","https://openalex.org/W4408913566","https://openalex.org/W4409501791","https://openalex.org/W4409986374","https://openalex.org/W4410185822","https://openalex.org/W4410487404","https://openalex.org/W4410845150","https://openalex.org/W4410919338","https://openalex.org/W4411220171","https://openalex.org/W4411249497","https://openalex.org/W4411405564","https://openalex.org/W4412750600","https://openalex.org/W4413916367","https://openalex.org/W4414465566","https://openalex.org/W4414660317","https://openalex.org/W4414777601","https://openalex.org/W4414972496","https://openalex.org/W4415295928","https://openalex.org/W4415728510","https://openalex.org/W4416599783","https://openalex.org/W4416696246","https://openalex.org/W4416919586"],"related_works":["https://openalex.org/W2046182420","https://openalex.org/W2211210774","https://openalex.org/W7204481005","https://openalex.org/W2075136524","https://openalex.org/W4409856137","https://openalex.org/W2083540113","https://openalex.org/W1997924072","https://openalex.org/W2479215566","https://openalex.org/W2185483850","https://openalex.org/W4312142394"],"abstract_inverted_index":{"Cell":[0],"reprogramming":[1,51,75,116],"can":[2],"transform":[3],"somatic":[4],"cells":[5,10],"into":[6],"induced":[7],"pluripotent":[8],"stem":[9],"providing":[11],"a":[12,172,194,201,205],"platform":[13],"for":[14,106,196],"patient-specific":[15],"disease":[16],"modeling,":[17],"drug":[18],"screening":[19],"and":[20,52,63,71,97,131,142,150,168,170,186],"regenerative":[21],"medicine":[22],"research.":[23],"Since":[24],"the":[25,30,69,74,98,112,122,157,162],"advent":[26],"of":[27,32,73,100,114,125],"OKSM-mediated":[28],"reprogramming,":[29,136],"system":[31],"technical":[33],"approaches":[34],"has":[35],"evolved":[36],"continuously":[37],"-":[38],"from":[39,200],"integrated":[40],"viral":[41,130],"vectors":[42],"to":[43,175,192,204],"non-integrated":[44],"episomal":[45],"systems":[46],"and,":[47],"more":[48],"recently,":[49],"chemical":[50,135],"CRISPR":[53],"approaches.":[54],"The":[55],"simultaneous":[56],"advances":[57],"in":[58,94],"single-cell":[59],"multi-omics,":[60],"biomaterials":[61],"engineering,":[62],"artificial":[64],"intelligence":[65],"have":[66],"further":[67,155],"refined":[68],"controllability":[70],"precision":[72],"process.":[76],"Despite":[77],"these":[78,177],"innovations,":[79],"problems":[80],"persist":[81],"that":[82,138],"hinder":[83],"clinical":[84],"translation:":[85],"incomplete":[86],"epigenetic":[87],"resetting,":[88],"ongoing":[89],"clonal":[90],"heterogeneity,":[91],"genomic":[92],"instability":[93],"long-term":[95],"culture,":[96],"lack":[99],"standardized":[101],"Good":[102],"Manufacturing":[103],"Practice":[104],"protocols":[105],"large-scale":[107],"manufacturing.":[108],"This":[109],"review":[110,190],"summarizes":[111],"trajectory":[113],"iPSC":[115,198],"technologies,":[117],"with":[118,184],"special":[119],"emphasis":[120],"on":[121],"translational":[123],"applicability":[124],"each":[126],"modality.":[127],"We":[128,154],"evaluated":[129],"nonviral":[132],"delivery":[133],"systems,":[134],"strategies":[137],"aid":[139],"gene":[140],"editing,":[141],"emerging":[143],"engineering":[144],"platforms,":[145],"including":[146],"microfluidics,":[147],"smart":[148],"biomaterials,":[149],"artificial-intelligence-driven":[151],"process":[152],"optimization.":[153],"identify":[156],"core":[158],"\"translational":[159],"triltrilas\",":[160],"namely,":[161],"inherent":[163],"tradeoffs":[164],"between":[165],"security,":[166],"homogeneity,":[167],"scalability,":[169],"propose":[171],"comprehensive":[173],"strategy":[174],"overcome":[176],"bottlenecks.":[178],"By":[179],"linking":[180],"basic":[181],"mechanistic":[182],"understandings":[183],"industrial":[185],"regulatory":[187],"considerations,":[188],"this":[189],"aims":[191],"provide":[193],"route":[195],"transitioning":[197],"technology":[199],"laboratory":[202],"tool":[203],"clinically":[206],"viable":[207],"manufacturing":[208],"platform.":[209]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-22T00:00:00"}
