{"id":"https://openalex.org/W7203839889","doi":"https://doi.org/10.64898/2026.08.19.745850","title":"Upregulation of the Unfolded and Mitochondrial Unfolded Protein Responses in Oxidative Stress-Induced Cataract","display_name":"Upregulation of the Unfolded and Mitochondrial Unfolded Protein Responses in Oxidative Stress-Induced Cataract","publication_year":2026,"publication_date":"2026-08-20","ids":{"openalex":"https://openalex.org/W7203839889","doi":"https://doi.org/10.64898/2026.08.19.745850","pmid":"https://pubmed.ncbi.nlm.nih.gov/42966956","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13722104"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.19.745850","doi":"https://doi.org/10.64898/2026.08.19.745850","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.19.745850","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.19.745850.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.19.745850.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080954078","display_name":"Sarah R. Zelle","orcid":"https://orcid.org/0000-0003-4009-5609","observed_orcids":["https://orcid.org/0000-0003-4009-5609"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah R. Zelle","raw_affiliation_strings":["Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee 37212, United States"],"raw_orcid":"https://orcid.org/0000-0003-4009-5609","affiliations":[{"raw_affiliation_string":"Chemical and Physical Biology Program, Vanderbilt University, Nashville, Tennessee 37212, United States","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":null,"display_name":"W. Hayes McDonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Hayes McDonald","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37212, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37212, United States","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059881003","display_name":"Hassane S. Mchaourab","orcid":"https://orcid.org/0000-0002-5673-0980","observed_orcids":["https://orcid.org/0000-0002-5673-0980"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hassane S. Mchaourab","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee 37232, United States","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043823252","display_name":"Kevin L. Schey","orcid":"https://orcid.org/0000-0002-3959-1712","observed_orcids":["https://orcid.org/0000-0002-3959-1712"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin L. Schey","raw_affiliation_strings":["Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37212, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37212, United States","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5043823252"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.5151000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.18119999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.1120000034570694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-cataract","display_name":"senile cataract","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9789999723434448},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitochondrial-unfolded-protein-response","display_name":"mitochondrial unfolded protein response","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.796999990940094},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.7839999794960022},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.625},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.984000027179718},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.718999981880188},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8914999961853027},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7541999816894531},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.6888999938964844},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.6110000014305115},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6037999987602234},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5390999913215637},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5389999747276306},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.5198000073432922},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5141000151634216},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.45890000462532043},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.4226999878883362},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4212000072002411},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.39980000257492065},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.39820000529289246},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.36559998989105225},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3124000132083893},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.29760000109672546},{"id":"https://openalex.org/C2911203004","wikidata":"https://www.wikidata.org/wiki/Q105409450","display_name":"Protein Carbonylation","level":4,"score":0.2964000105857849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2924000024795532},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.27219998836517334},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.2531000077724457}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.19.745850","doi":"https://doi.org/10.64898/2026.08.19.745850","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.19.745850","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.19.745850.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13722104","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722104/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13722104/pdf/nihpp-2026.08.19.745850v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42966956","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42966956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.19.745850","doi":"https://doi.org/10.64898/2026.08.19.745850","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.19.745850","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/20/2026.08.19.745850.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1149166549","display_name":null,"funder_award_id":"DK59637","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G1354330544","display_name":"Chemistry-Biology Interface Training Grant","funder_award_id":"T32GM065086","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1623511844","display_name":"Mechanisms of Protein Aging in Normal and Cataractous Lenses","funder_award_id":"R01EY024258","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3865556588","display_name":null,"funder_award_id":"DK20593","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G4320917349","display_name":null,"funder_award_id":"DK58404","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G5853943267","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G6224567652","display_name":"Molecular Basis for Lens Transparency","funder_award_id":"R01EY012018","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7220527126","display_name":null,"funder_award_id":"EY08126","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G9000002043","display_name":null,"funder_award_id":"DK-59637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000106052","display_name":null,"funder_award_id":"DK 20593","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000168360","display_name":null,"funder_award_id":"CA-68485","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000173976","display_name":null,"funder_award_id":"EY-08126","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000287526","display_name":null,"funder_award_id":"DK58404","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000326625","display_name":null,"funder_award_id":"EY007135","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000886513","display_name":"Training Grant in Vision Research","funder_award_id":"T32EY007135","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000906943","display_name":"Core Grant in Vision Research","funder_award_id":"P30EY008126","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203839889.pdf","grobid_xml":"https://content.openalex.org/works/W7203839889.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2751842977","https://openalex.org/W2156937471","https://openalex.org/W1936380547","https://openalex.org/W2003602439","https://openalex.org/W2033884290","https://openalex.org/W7095283447","https://openalex.org/W2036373599","https://openalex.org/W1977982633","https://openalex.org/W3094018919","https://openalex.org/W2416679375"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Oxidative":[2],"stress":[3,36,59,79,87,118,193],"is":[4],"thought":[5],"to":[6,8,23,77,82,113,131],"contribute":[7],"the":[9,16,24,27,64,102,115,159,178,195,234],"development":[10],"of":[11,26,74,105,180],"age-related":[12],"cataracts":[13],"(ARCs),":[14],"but":[15],"mechanisms":[17],"by":[18,52,97],"which":[19],"oxidative":[20,35,58,78,84,117,192],"damage":[21],"leads":[22],"opacification":[25],"lens":[28,39,65,134],"remain":[29],"unclear.":[30],"Previous":[31],"studies":[32],"suggest":[33],"that":[34,45,61],"can":[37],"disrupt":[38],"proteostasis.":[40,135],"Therefore,":[41],"it":[42],"was":[43,95],"hypothesized":[44],"ARCs":[46],"arise":[47],"from":[48],"proteomic":[49,72,156],"changes":[50,157,203],"driven":[51],"an":[53],"age-":[54],"associated":[55],"decline":[56],"in":[57,89,121,138,158,207],"defenses":[60],"interact":[62],"with":[63],"proteostatic":[66,86],"state.":[67],"To":[68],"test":[69],"this":[70],"hypothesis,":[71],"analyses":[73],"lenses":[75,152,225],"exposed":[76],"were":[80,111,129,153,161,204],"performed":[81],"examine":[83],"and":[85,146,155,190,197,215,217,229,236],"responses":[88,240],"vivo":[90],".":[91],"Methods":[92],"Cataract":[93],"formation":[94,179],"induced":[96,177],"injecting":[98],"hydrogen":[99],"peroxide":[100,175],"into":[101],"aqueous":[103],"humor":[104],"adult":[106],"zebrafish.":[107],"nrf2":[108,143,150],"fh318/fh318":[109,144,151],"zebrafish":[110,128,224],"used":[112,130],"model":[114,132,227],"reduced":[116],"protection":[119],"observed":[120,206],"aged":[122],"human":[123],"lenses,":[124],"while":[125],"cryaba":[126,140,147],"-/-":[127,141,148],"impaired":[133],"Resulting":[136],"opacities":[137],"WT,":[139],",":[142,145],";":[149],"quantified":[154],"cortex":[160],"analyzed":[162],"using":[163],"data":[164],"independent":[165],"acquisition":[166],"Parallel":[167],"Accumulation":[168],"Serial":[169],"Fragmentation":[170],"mass":[171,230],"spectrometry.":[172],"Results":[173],"Hydrogen":[174],"treatment":[176],"cortical":[181],"cataracts.":[182],"Proteomic":[183],"results":[184],"showed":[185],"that,":[186],"dependent":[187],"on":[188],"genotype":[189],"day,":[191],"activates":[194],"unfolded":[196,199,235,238],"mitochondrial":[198,237],"protein":[200,213,239],"responses.":[201],"Additional":[202],"also":[205],"energy":[208],"metabolism,":[209],"Ca":[210],"2+":[211],"homeostasis,":[212],"degradation,":[214],"cytoskeletal":[216],"extracellular":[218],"matrix":[219],"remodeling":[220],"pathways.":[221],"Conclusions":[222],"Treated":[223],"successfully":[226],"ARC":[228],"spectrometry":[231],"proteomics":[232],"identified":[233],"as":[241],"potential":[242],"therapeutic":[243],"targets":[244],"for":[245],"ARC.":[246]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-21T00:00:00"}
