{"id":"https://openalex.org/W7203839825","doi":"https://doi.org/10.1016/j.ejmcr.2026.100368","title":"Therapeutic evaluation of thiadiazole\u2013piperidinone hybrids as selective anticancer agents for advanced melanoma: Role of PI3K/AKT/mTOR inhibition and induction of cell cycle arrest, apoptosis, and autophagy","display_name":"Therapeutic evaluation of thiadiazole\u2013piperidinone hybrids as selective anticancer agents for advanced melanoma: Role of PI3K/AKT/mTOR inhibition and induction of cell cycle arrest, apoptosis, and autophagy","publication_year":2026,"publication_date":"2026-08-20","ids":{"openalex":"https://openalex.org/W7203839825","doi":"https://doi.org/10.1016/j.ejmcr.2026.100368"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmcr.2026.100368","doi":"https://doi.org/10.1016/j.ejmcr.2026.100368","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejmcr.2026.100368","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772417426000476/pdf","source":{"id":"https://openalex.org/S4210220500","display_name":"European Journal of Medicinal Chemistry Reports","issn_l":"2772-4174","issn":["2772-4174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S2772417426000476/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013034000","display_name":"Kodisundaram Paulrasu","orcid":"https://orcid.org/0000-0001-6771-0961","observed_orcids":["https://orcid.org/0000-0001-6771-0961"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"Kodisundaram Paulrasu","raw_affiliation_strings":["Department of Chemistry, Chemistry section, FEAT Annamalai University, Annamalai nagar-608002, Tamilnadu, India","Department of Surgery, University of Miami, Miami, Florida"],"raw_orcid":"https://orcid.org/0000-0001-6771-0961","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Chemistry section, FEAT Annamalai University, Annamalai nagar-608002, Tamilnadu, India","institution_ids":["https://openalex.org/I197081775"]},{"raw_affiliation_string":"Department of Surgery, University of Miami, Miami, Florida","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082921025","display_name":"Hamida Ali","orcid":"https://orcid.org/0000-0001-7142-3375","observed_orcids":["https://orcid.org/0000-0001-7142-3375"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamida Hamida","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0001-7142-3375","affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147649860","display_name":"Amarnath Marudamuthu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amarnath Marudamuthu","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025961838","display_name":"Shruthi Thada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruthi Thada","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114566992","display_name":"urmi Halder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Urmi Halder","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147521271","display_name":"Parris Adam","orcid":"https://orcid.org/0009-0005-0999-9206","observed_orcids":["https://orcid.org/0009-0005-0999-9206"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parris Adam","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA"],"raw_orcid":"https://orcid.org/0009-0005-0999-9206","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053877940","display_name":"Karthik Gourishetti","orcid":"https://orcid.org/0000-0001-5262-0883","observed_orcids":["https://orcid.org/0000-0001-5262-0883"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karthik Gourishetti","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":"https://orcid.org/0000-0001-5262-0883","affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024754560","display_name":"Balasankar Thirunavukkarasu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197081775","display_name":"Annamalai University","ror":"https://ror.org/01x24z140","country_code":"IN","type":"education","lineage":["https://openalex.org/I197081775"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Balasankar Thirunavukkarasu","raw_affiliation_strings":["Department of Chemistry, Chemistry section, FEAT Annamalai University, Annamalai nagar-608002, Tamilnadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Chemistry section, FEAT Annamalai University, Annamalai nagar-608002, Tamilnadu, India","institution_ids":["https://openalex.org/I197081775"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029010126","display_name":"Muralikrishnan Dhanasekaran","orcid":"https://orcid.org/0000-0001-8986-3440","observed_orcids":["https://orcid.org/0000-0001-8986-3440"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muralikrishnan Dhanasekaran","raw_affiliation_strings":["Department of Drug Discovery and Development, Auburn University, Harrison School of Pharmacy, 4306A Walker Building, Auburn, AL 36849"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Discovery and Development, Auburn University, Harrison School of Pharmacy, 4306A Walker Building, Auburn, AL 36849","institution_ids":["https://openalex.org/I82497590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017741352","display_name":"Dmitriy Minond","orcid":"https://orcid.org/0000-0003-2473-5944","observed_orcids":["https://orcid.org/0000-0003-2473-5944"]},"institutions":[{"id":"https://openalex.org/I203088144","display_name":"Nova Southeastern University","ror":"https://ror.org/042bbge36","country_code":"US","type":"education","lineage":["https://openalex.org/I203088144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dmitriy Minond","raw_affiliation_strings":["College of Pharmacy and Rumbaugh-Goodwin Institute for Cancer Research, Nova Southeastern University, Fort Lauderdale, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Rumbaugh-Goodwin Institute for Cancer Research, Nova Southeastern University, Fort Lauderdale, FL, USA","institution_ids":["https://openalex.org/I203088144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082199982","display_name":"Chuanbing Tang","orcid":"https://orcid.org/0000-0002-0242-8241","observed_orcids":["https://orcid.org/0000-0002-0242-8241"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuanbing Tang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046315471","display_name":"Prakash S. Nagarkatti","orcid":"https://orcid.org/0000-0003-2663-0759","observed_orcids":["https://orcid.org/0000-0003-2663-0759"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prakash Nagarkatti","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061239650","display_name":"Mitzi Nagarkatti","orcid":"https://orcid.org/0000-0002-5977-5615","observed_orcids":["https://orcid.org/0000-0002-5977-5615"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitzi Nagarkatti","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047738474","display_name":"Manikandan Palrasu","orcid":"https://orcid.org/0009-0009-4325-7045","observed_orcids":["https://orcid.org/0009-0009-4325-7045"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manikandan Palrasu","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA"],"raw_orcid":"https://orcid.org/0009-0009-4325-7045","affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, South Carolina, USA","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047738474"],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.5036727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":"100368","last_page":"100368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9413999915122986,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.021900000050663948,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.012900000438094139,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.7770000100135803},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9729999899864197},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.828000009059906},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9919999837875366},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.6759999990463257},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/ulk1","display_name":"ULK1","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.7360000014305115},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.7839999794960022},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.743399977684021},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5504999756813049},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48010000586509705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4779999852180481},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.444599986076355},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3817000091075897},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3619000017642975},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.35249999165534973},{"id":"https://openalex.org/C2994037739","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle progression","level":4,"score":0.33180001378059387},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2808000147342682}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.ejmcr.2026.100368","doi":"https://doi.org/10.1016/j.ejmcr.2026.100368","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejmcr.2026.100368","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772417426000476/pdf","source":{"id":"https://openalex.org/S4210220500","display_name":"European Journal of Medicinal Chemistry Reports","issn_l":"2772-4174","issn":["2772-4174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.ejmcr.2026.100368","doi":"https://doi.org/10.1016/j.ejmcr.2026.100368","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejmcr.2026.100368","pdf_url":"https://www.sciencedirect.com/science/article/pii/S2772417426000476/pdf","source":{"id":"https://openalex.org/S4210220500","display_name":"European Journal of Medicinal Chemistry Reports","issn_l":"2772-4174","issn":["2772-4174"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","oarl"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335279","display_name":"Central ElectroChemical Research Institute","ror":"https://ror.org/01qek3q18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203839825.pdf","grobid_xml":"https://content.openalex.org/works/W7203839825.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1487878063","https://openalex.org/W1965532315","https://openalex.org/W1988452823","https://openalex.org/W2002801265","https://openalex.org/W2003402062","https://openalex.org/W2004295816","https://openalex.org/W2036237603","https://openalex.org/W2046547485","https://openalex.org/W2060902443","https://openalex.org/W2065620201","https://openalex.org/W2070878847","https://openalex.org/W2088226047","https://openalex.org/W2108624831","https://openalex.org/W2132284321","https://openalex.org/W2135929809","https://openalex.org/W2140494950","https://openalex.org/W2143458117","https://openalex.org/W2155107722","https://openalex.org/W2160399783","https://openalex.org/W2163188200","https://openalex.org/W2166662937","https://openalex.org/W2315955486","https://openalex.org/W2318969917","https://openalex.org/W2319369331","https://openalex.org/W2326620506","https://openalex.org/W2333671104","https://openalex.org/W2425235023","https://openalex.org/W2428867055","https://openalex.org/W2471414044","https://openalex.org/W2519279652","https://openalex.org/W2587048937","https://openalex.org/W2606553662","https://openalex.org/W2731794420","https://openalex.org/W2738433531","https://openalex.org/W2740618823","https://openalex.org/W2753432434","https://openalex.org/W2789302862","https://openalex.org/W2949393628","https://openalex.org/W2959062040","https://openalex.org/W3119952098","https://openalex.org/W3203420675","https://openalex.org/W4310248833","https://openalex.org/W4378349102","https://openalex.org/W4379012340","https://openalex.org/W4404496374","https://openalex.org/W4412508905","https://openalex.org/W7118296546"],"related_works":["https://openalex.org/W2944634278","https://openalex.org/W7096629754","https://openalex.org/W1839036473","https://openalex.org/W7133675747","https://openalex.org/W2768050133","https://openalex.org/W4388939284","https://openalex.org/W4413527745","https://openalex.org/W2153761309","https://openalex.org/W4410896420","https://openalex.org/W3113355008"],"abstract_inverted_index":{"ABSTRACT":[0],"Melanoma":[1],"remains":[2],"difficult":[3],"to":[4],"treat":[5],"because":[6],"of":[7,20,41,71,147,197,212],"therapy":[8],"resistance,":[9],"highlighting":[10],"the":[11,42,55],"need":[12],"for":[13,227],"new":[14],"targeted":[15],"therapeutic":[16,229],"agents.":[17],"A":[18],"series":[19],"4-methyl-N\u2032-[(2r,6c)-3,3-dimethyl-2,6-diarylpiperidin-4-ylidene]-1,2,3-thiadiazole-5-carbohydrazides":[21],"(5a\u2013g)":[22],"was":[23,45],"synthesized":[24,43],"and":[25,35,50,61,77,104,114,134,138,150,163,167,193,210],"characterized":[26],"by":[27,144,160,190],"IR,":[28],"1":[29,165],"H":[30],"NMR,":[31,34],"13":[32],"C":[33],"CHN":[36],"analysis.":[37],"The":[38],"antiproliferative":[39],"activity":[40,63,100,111],"compounds":[44],"evaluated":[46],"in":[47,74,80,112,119,179],"melanoma,":[48],"non-melanoma,":[49],"normal":[51,88,191],"cell":[52,128,203],"lines.":[53],"Among":[54],"tested":[56],"compounds,":[57],"5a":[58,96,125,155,174,220],"exhibited":[59,109],"potent":[60],"selective":[62,224],"against":[64,101],"melanoma":[65,106,182],"cells,":[66,82],"with":[67],"IC":[68],"50":[69,92],"values":[70],"0.58":[72],"\u03bcM":[73,79],"WM-266-4":[75,120],"cells":[76,90,107,121],"2.88":[78],"M14":[81],"while":[83],"showing":[84],"minimal":[85],"toxicity":[86],"toward":[87],"HEK293":[89],"(IC":[91],">100":[93],"\u03bcM).":[94],"Compound":[95],"also":[97],"showed":[98],"strong":[99],"A375,":[102],"SKMEL-28,":[103],"B16F10":[105,181],"but":[108],"limited":[110],"A549":[113],"BT474":[115],"cells.":[116],"Mechanistic":[117],"studies":[118],"demonstrated":[122],"that":[123],"compound":[124,154,173,219],"induced":[126,156],"G2/M":[127],"cycle":[129,204],"arrest,":[130],"reduced":[131,202],"cyclin":[132],"B1":[133],"phosphorylated":[135],"Cdc2":[136],"expression,":[137,166],"triggered":[139],"caspase-dependent":[140],"apoptosis,":[141,207],"as":[142,158,188,221],"indicated":[143],"increased":[145,161,206],"levels":[146],"cleaved":[148],"caspase-3":[149],"PARP.":[151],"In":[152,171],"addition,":[153],"autophagy,":[157,209],"evidenced":[159],"LC3-II":[162],"Beclin":[164],"suppressed":[168],"PI3K/AKT/mTOR/ULK1":[169],"signaling.":[170,214],"vivo,":[172],"significantly":[175],"inhibited":[176],"tumor":[177,198],"growth":[178],"a":[180,222],"mouse":[183],"model":[184],"without":[185],"observable":[186],"toxicity,":[187],"supported":[189],"liver":[192],"spleen":[194],"histology.":[195],"Analysis":[196],"tissues":[199],"further":[200,228],"confirmed":[201],"progression,":[205],"enhanced":[208],"suppression":[211],"PI3K/AKT/mTOR":[213],"Collectively,":[215],"these":[216],"findings":[217],"identify":[218],"promising":[223],"anti-melanoma":[225],"agent":[226],"development.":[230]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-21T00:00:00"}
