{"id":"https://openalex.org/W7203830354","doi":"https://doi.org/10.1183/23120541.cc-2026.tp231","title":"Assessing the effect of flurbiprofen on cough reflex sensitivity in subjects with upper respiratory tract infection.","display_name":"Assessing the effect of flurbiprofen on cough reflex sensitivity in subjects with upper respiratory tract infection.","publication_year":2026,"publication_date":"2026-07-17","ids":{"openalex":"https://openalex.org/W7203830354","doi":"https://doi.org/10.1183/23120541.cc-2026.tp231"},"language":"en","primary_location":{"id":"doi:10.1183/23120541.cc-2026.tp231","doi":"https://doi.org/10.1183/23120541.cc-2026.tp231","is_oa":false,"landing_page_url":"https://doi.org/10.1183/23120541.cc-2026.tp231","pdf_url":null,"source":{"id":"https://openalex.org/S192921980","display_name":"Cough","issn_l":"1745-9974","issn":["1745-9974"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cough","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032045176","display_name":"Stuart B. Mazzone","orcid":"https://orcid.org/0000-0001-5270-1333","observed_orcids":["https://orcid.org/0000-0001-5270-1333"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stuart B. Mazzone","raw_affiliation_strings":["1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136942762","display_name":"Tara G. Bautista","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Tara G. Bautista","raw_affiliation_strings":["1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083454977","display_name":"Willian S. Korim","orcid":"https://orcid.org/0000-0002-8104-7163","observed_orcids":["https://orcid.org/0000-0002-8104-7163"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Willian S. Korim","raw_affiliation_strings":["1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069799518","display_name":"Matthew W. Trewella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew W. Trewella","raw_affiliation_strings":["1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080486324","display_name":"Nathalie A. J. Verzele","orcid":"https://orcid.org/0000-0001-8048-5578","observed_orcids":["https://orcid.org/0000-0001-8048-5578"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nathalie A.J. Verzele","raw_affiliation_strings":["1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Anatomy and Physiology, The University of Melbourne AUSTRALIA, Melbourne, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147592144","display_name":"Junfeng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junfeng Zhang","raw_affiliation_strings":["2The Nicolas School of the Environment & Duke Global Health Institute, Duke University, USA, Durham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Nicolas School of the Environment & Duke Global Health Institute, Duke University, USA, Durham, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147576807","display_name":"Yan Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Lin","raw_affiliation_strings":["2The Nicolas School of the Environment & Duke Global Health Institute, Duke University, USA, Durham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Nicolas School of the Environment & Duke Global Health Institute, Duke University, USA, Durham, United States","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036414874","display_name":"Kian Fan Chung","orcid":"https://orcid.org/0000-0001-7101-1426","observed_orcids":["https://orcid.org/0000-0001-7101-1426"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kian Fan Chung","raw_affiliation_strings":["3National Heart & Lung Institute, Imperial College London, London, UK, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3National Heart & Lung Institute, Imperial College London, London, UK, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071376675","display_name":"Thomas Hallett","orcid":"https://orcid.org/0009-0004-5258-3022","observed_orcids":["https://orcid.org/0009-0004-5258-3022"]},"institutions":[{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Hallett","raw_affiliation_strings":["4Global Category Medical Affairs, Reckitt, Hull, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Global Category Medical Affairs, Reckitt, Hull, United Kingdom","institution_ids":["https://openalex.org/I4405268051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147517972","display_name":"Suneet Kaur Sandhu Bharj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Suneet Kaur Sandhu Bharj","raw_affiliation_strings":["5Global Category Medical Affairs, Reckitt, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Global Category Medical Affairs, Reckitt, London, United Kingdom","institution_ids":["https://openalex.org/I4405268051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005882285","display_name":"Anuradha Kulasekaran","orcid":"https://orcid.org/0000-0002-4970-9091","observed_orcids":["https://orcid.org/0000-0002-4970-9091"]},"institutions":[{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anuradha Kulasekaran","raw_affiliation_strings":["5Global Category Medical Affairs, Reckitt, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Global Category Medical Affairs, Reckitt, London, United Kingdom","institution_ids":["https://openalex.org/I4405268051"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"TP231","last_page":"TP231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flurbiprofen","display_name":"flurbiprofen","score":1.0},{"id":"https://openalex.org/keywords/upper-respiratory-tract-infection","display_name":"upper respiratory tract infection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cough-hypersensitivity","display_name":"cough hypersensitivity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cough-reflex-sensitivity","display_name":"cough reflex sensitivity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/prostanoids","display_name":"prostanoids","score":0.8289999961853027},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/urge-to-cough","display_name":"urge-to-cough","score":0.8330000042915344},{"id":"https://openalex.org/keywords/acute-cough","display_name":"acute cough","score":0.550000011920929},{"id":"https://openalex.org/keywords/sore-throat","display_name":"sore throat","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9592000246047974},{"id":"https://openalex.org/C2781000538","wikidata":"https://www.wikidata.org/wiki/Q419890","display_name":"Flurbiprofen","level":2,"score":0.8953999876976013},{"id":"https://openalex.org/C40956017","wikidata":"https://www.wikidata.org/wiki/Q975803","display_name":"Cough reflex","level":3,"score":0.8252000212669373},{"id":"https://openalex.org/C2777870961","wikidata":"https://www.wikidata.org/wiki/Q1292082","display_name":"Sore throat","level":2,"score":0.7642999887466431},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6978999972343445},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.649399995803833},{"id":"https://openalex.org/C158245101","wikidata":"https://www.wikidata.org/wiki/Q13127755","display_name":"Lozenge","level":2,"score":0.5333999991416931},{"id":"https://openalex.org/C2777054765","wikidata":"https://www.wikidata.org/wiki/Q6402731","display_name":"Dysgeusia","level":3,"score":0.52920001745224},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48840001225471497},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.4672999978065491},{"id":"https://openalex.org/C2778136109","wikidata":"https://www.wikidata.org/wiki/Q12125","display_name":"Common cold","level":2,"score":0.4571000039577484},{"id":"https://openalex.org/C2780805593","wikidata":"https://www.wikidata.org/wiki/Q2622199","display_name":"Upper respiratory tract infection","level":2,"score":0.4207000136375427},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.392300009727478},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.3837999999523163},{"id":"https://openalex.org/C2910715184","wikidata":"https://www.wikidata.org/wiki/Q2085267","display_name":"Acute Pharyngitis","level":3,"score":0.3783999979496002},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C2777707825","wikidata":"https://www.wikidata.org/wiki/Q60791486","display_name":"Chronic cough","level":3,"score":0.36149999499320984},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3546999990940094},{"id":"https://openalex.org/C2776752453","wikidata":"https://www.wikidata.org/wiki/Q174778","display_name":"Pharynx","level":2,"score":0.3481999933719635},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.34529998898506165},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.3384000062942505},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.3312000036239624},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2888000011444092}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/23120541.cc-2026.tp231","doi":"https://doi.org/10.1183/23120541.cc-2026.tp231","is_oa":false,"landing_page_url":"https://doi.org/10.1183/23120541.cc-2026.tp231","pdf_url":null,"source":{"id":"https://openalex.org/S192921980","display_name":"Cough","issn_l":"1745-9974","issn":["1745-9974"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cough","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2991451897","https://openalex.org/W2419047331","https://openalex.org/W2128283773","https://openalex.org/W2326984651","https://openalex.org/W2805220654","https://openalex.org/W2733730458","https://openalex.org/W1915773093","https://openalex.org/W1991584655","https://openalex.org/W7096715487","https://openalex.org/W2792749158"],"abstract_inverted_index":{"Acute":[0],"upper":[1],"respiratory":[2],"tract":[3],"infection":[4],"(URTI)":[5],"frequently":[6],"induces":[7],"cough":[8,31,45,49,65,79,105,204,209,250],"hypersensitivity":[9,46],"and":[10,27,47,63,67,78,114,129,184,190,207],"is":[11,35,50],"associated":[12,68],"with":[13,75,167,213,223],"the":[14,54,124,168,173,214,218,239],"release":[15],"of":[16,56,133,242],"inflammatory":[17],"prostanoids":[18],"such":[19],"as":[20,244],"PGE\u2082.":[21],"Prostanoids":[22],"sensitize":[23],"airway":[24],"sensory":[25,232],"nerves":[26],"may":[28],"contribute":[29],"to":[30,84,143],"hypersensitivity.":[32],"Whilst":[33],"flurbiprofen":[34,57,85,243],"effective":[36],"for":[37,248],"URTI":[38,77],"sore":[39],"throat,":[40],"its":[41],"impact":[42],"on":[43,58,181],"acute":[44,64,249],"urge-to":[48],"unknown.":[51],"To":[52],"assess":[53,238],"efficacy":[55,241],"reducing":[59],"URTI-":[60],"induced":[61],"urge\u2011to\u2011cough":[62],"hypersensitivity,":[66],"changes":[69],"in":[70,203,211,251],"oropharyngeal":[71],"prostanoids.":[72,145],"81":[73],"adults":[74],"current":[76],"or":[80,98],"urge-to-cough":[81,164],"were":[82,118,139],"randomised":[83],"lozenge":[86,91],"(8.75":[87,101],"mg;":[88,96,102],"n=20),":[89,97],"placebo":[90,156],"(n=20),":[92],"low\u2011dose":[93,174],"spray":[94,100,161,171,177,180,216],"(2.92":[95],"full\u2011dose":[99,215],"n=21).":[103],"Capsaicin":[104],"sensitivity":[106,206],"(Cu,":[107],"C2,":[108],"C5)":[109],"was":[110],"measured":[111],"at":[112,152],"baseline":[113],"180":[115,153],"min.":[116],"Symptoms":[117],"recorded":[119],"every":[120],"30":[121],"min":[122],"using":[123],"Cold":[125],"Symptom":[126],"Questionnaire":[127],"(CSQ)":[128],"Patient":[130],"Global":[131],"Impression":[132],"Change":[134],"(PGIC).":[135],"Pharyngeal":[136],"lavage":[137],"samples":[138],"analysed":[140],"by":[141],"LC\u2011MS/MS":[142],"quantify":[144],"Flurbiprofen":[146,199],"(all":[147],"formulations)":[148],"significantly":[149],"reduced":[150,191,224,231],"C5":[151],"mins,":[154],"while":[155],"showed":[157],"no":[158],"change.":[159],"Both":[160],"doses":[162],"increased":[163],"threshold":[165],"(Cu),":[166],"8.75":[169],"mg":[170],"outperforming":[172],"spray.":[175],"High-dose":[176],"outperformed":[178],"low-dose":[179],"CSQ":[182],"scores,":[183],"all":[185],"formulations":[186],"improved":[187],"PGIC":[188],"ratings":[189],"PGE\u2082":[192],"levels.":[193],"No":[194],"serious":[195],"adverse":[196],"events":[197],"occurred.":[198],"produced":[200],"significant":[201],"improvements":[202],"reflex":[205],"subjective":[208],"outcomes":[210],"URTI,":[212],"demonstrating":[217],"greatest":[219],"benefit.":[220],"Effects":[221],"aligned":[222],"pharyngeal":[225],"PGE2,":[226],"supporting":[227],"a":[228,245],"mechanism":[229],"involving":[230],"nerve":[233],"sensitisation.":[234],"Future":[235],"studies":[236],"will":[237],"full":[240],"novel":[246],"therapy":[247],"URTI.":[252]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-21T00:00:00"}