{"id":"https://openalex.org/W7203824280","doi":"https://doi.org/10.21203/rs.3.rs-10744735/v1","title":"Evaluation of Parasite Clearance Rates and Associated Baseline Risk Factors Among Malaria-Positive Patients Receiving Treatment at Nchanga North General Hospital, Chingola, Zambia","display_name":"Evaluation of Parasite Clearance Rates and Associated Baseline Risk Factors Among Malaria-Positive Patients Receiving Treatment at Nchanga North General Hospital, Chingola, Zambia","publication_year":2026,"publication_date":"2026-08-20","ids":{"openalex":"https://openalex.org/W7203824280","doi":"https://doi.org/10.21203/rs.3.rs-10744735/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10744735/v1","doi":"https://doi.org/10.21203/rs.3.rs-10744735/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10744735/v1","pdf_url":"https://www.researchsquare.com/article/rs-10744735/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10744735/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042294792","display_name":"Patrick Loti","orcid":"https://orcid.org/0000-0001-8942-8908","observed_orcids":["https://orcid.org/0000-0001-8942-8908"]},"institutions":[{"id":"https://openalex.org/I3130391927","display_name":"Northrise University","ror":"https://ror.org/03vgyhc77","country_code":"ZM","type":"education","lineage":["https://openalex.org/I3130391927"]}],"countries":["ZM"],"is_corresponding":true,"raw_author_name":"Patrick Loti","raw_affiliation_strings":["Ndola College of Biomedical Sciences"],"raw_orcid":"https://orcid.org/0000-0001-8942-8908","affiliations":[{"raw_affiliation_string":"Ndola College of Biomedical Sciences","institution_ids":["https://openalex.org/I3130391927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147651621","display_name":"Frank K. Chisulo","orcid":"https://orcid.org/0009-0002-8656-7552","observed_orcids":["https://orcid.org/0009-0002-8656-7552"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank K. Chisulo","raw_affiliation_strings":["Chilonga Mission Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chilonga Mission Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140071877","display_name":"Agness Chama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agness Chama","raw_affiliation_strings":["Chitoshi Medical Centre"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chitoshi Medical Centre","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120848754","display_name":"Joaquim Musamba","orcid":"https://orcid.org/0009-0000-9366-2027","observed_orcids":["https://orcid.org/0009-0000-9366-2027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joaquim Musamba","raw_affiliation_strings":["Nchanga North General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nchanga North General Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004555138","display_name":"Charles Chishimba","orcid":"https://orcid.org/0000-0003-0740-7551","observed_orcids":["https://orcid.org/0000-0003-0740-7551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Chishimba","raw_affiliation_strings":["Nchanga North General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nchanga North General Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147601542","display_name":"Aaron Sichilima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Sichilima","raw_affiliation_strings":["Nchanga North General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nchanga North General Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042294792"],"corresponding_institution_ids":["https://openalex.org/I3130391927"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.9120000004768372},{"id":"https://openalex.org/keywords/parasite-clearance-time","display_name":"parasite clearance time","score":0.9449999928474426},{"id":"https://openalex.org/keywords/delayed-parasite-clearance","display_name":"delayed parasite clearance","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hyperparasitemia","display_name":"hyperparasitemia","score":0.7889999747276306},{"id":"https://openalex.org/keywords/antimalarial-treatment-efficacy","display_name":"antimalarial treatment efficacy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.5580000281333923},{"id":"https://openalex.org/keywords/pediatric-malaria","display_name":"pediatric malaria","score":0.9169999957084656},{"id":"https://openalex.org/keywords/antimicrobial-resistance-surveillance","display_name":"antimicrobial resistance surveillance","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.8428999781608582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7728999853134155},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.703499972820282},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.49140000343322754},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.4819999933242798},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4781999886035919},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4546999931335449},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.34549999237060547},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.3422999978065491},{"id":"https://openalex.org/C2775993617","wikidata":"https://www.wikidata.org/wiki/Q7135939","display_name":"Parasite load","level":3,"score":0.3402999937534332},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33219999074935913},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3303000032901764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31839999556541443},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.3082999885082245},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.27309998869895935}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10744735/v1","doi":"https://doi.org/10.21203/rs.3.rs-10744735/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10744735/v1","pdf_url":"https://www.researchsquare.com/article/rs-10744735/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10744735/v1","doi":"https://doi.org/10.21203/rs.3.rs-10744735/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10744735/v1","pdf_url":"https://www.researchsquare.com/article/rs-10744735/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203824280.pdf","grobid_xml":"https://content.openalex.org/works/W7203824280.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2163006457","https://openalex.org/W3038794020","https://openalex.org/W4399899918"],"related_works":["https://openalex.org/W7164147754","https://openalex.org/W2157754375","https://openalex.org/W3206109151","https://openalex.org/W4304098904","https://openalex.org/W7008886123","https://openalex.org/W2136730020","https://openalex.org/W2408897541","https://openalex.org/W4406465224","https://openalex.org/W7045613767","https://openalex.org/W2950805750"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Delayed":[2,127],"parasite":[3,42,128,159,177,233,296,317,330],"clearance":[4,25,43,57,119,129,178,258,288,318],"following":[5],"antimalarial":[6,86,362],"treatment":[7,62,125,237],"threatens":[8],"global":[9],"malaria":[10,308],"control":[11],"efforts":[12],"and":[13,36,45,50,155,166,247,269,356],"serves":[14],"as":[15,139,337],"an":[16],"early":[17],"warning":[18],"indicator":[19],"for":[20,347],"emerging":[21],"drug":[22],"resistance.":[23],"Monitoring":[24],"dynamics":[26],"is":[27,324],"critical":[28,279],"in":[29,68,285,364],"high-burden":[30],"regions":[31],"to":[32,109,133,196,213,299,360],"track":[33],"disease":[34],"burden":[35,276],"therapeutic":[37,282],"efficacy.":[38],"Objective":[39],"To":[40],"evaluate":[41],"rates":[44],"identify":[46],"baseline":[47,242,274,295,329],"demographic,":[48],"clinical,":[49],"parasitological":[51,156,275],"risk":[52],"factors":[53,152,157],"associated":[54],"with":[55,260,291,354],"delayed":[56,232,257,287,316],"among":[58,78],"malaria-positive":[59,83],"patients":[60,84,190,284,309,352],"undergoing":[61],"at":[63,207,310,319],"Nchanga":[64,311],"North":[65,312],"General":[66,313],"Hospital":[67,314],"Chingola,":[69],"Zambia.":[70],"Methods":[71],"A":[72,303],"prospective":[73],"clinical":[74,349],"analysis":[75],"was":[76,130,205,277],"conducted":[77],"(N":[79],"=":[80,97,225],"121)":[81],"confirmed":[82],"receiving":[85],"therapy.":[87],"The":[88,175],"cohort":[89,230,289],"primarily":[90],"consisted":[91],"of":[92,142,189,216,227,281,307,351],"a":[93,181,214,278],"pediatric":[94],"population":[95],"(n":[96,224],"120),":[98],"mean":[99,203],"age:":[100],"(5.61":[101],"\u00b1":[102,209],"3.9)":[103],"years,":[104,111],"ranging":[105],"from":[106],"3":[107,146,221,262],"months":[108],"15":[110],"alongside":[112],"one":[113],"adult":[114],"outlier":[115],"(57":[116],"years).":[117],"Parasite":[118],"times":[120],"(PCTs)":[121],"were":[122,161],"calculated":[123],"after":[124],"initiation.":[126],"defined":[131],"according":[132],"World":[134],"Health":[135],"Organization":[136],"(WHO)":[137],"criteria":[138],"the":[140,186,202,228,286,344,365],"persistence":[141],"parasitemia":[143,193],"on":[144],"Day":[145,220,261,320],"(>":[147],"72":[148],"hours).":[149],"Baseline":[150],"demographic":[151,243,334],"(age,":[153],"gender)":[154],"(baseline":[158],"density)":[160],"analyzed":[162],"using":[163],"Chi-square":[164],"tests":[165],"independent":[167],"sample":[168],"metrics":[169],"within":[170,194],"IBM":[171],"SPSS":[172],"Statistics.":[173],"Results":[174],"overall":[176],"profile":[179],"exhibited":[180],"pronounced":[182],"right-hand":[183],"skew.":[184],"While":[185],"vast":[187],"majority":[188],"successfully":[191],"eliminated":[192],"24":[195,200],"48":[197],"hours":[198],"(median:":[199],"hours),":[201],"PCT":[204],"prolonged":[206],"(36.4":[208],"16.8)":[210],"hours,":[211],"extending":[212],"maximum":[215],"144":[217],"hours.":[218],"On":[219],"post-treatment,":[222],"9.1%":[223],"11)":[226],"patient":[229],"demonstrated":[231],"clearance,":[234],"signaling":[235],"potential":[236],"vulnerabilities.":[238],"Cross-tabulation":[239],"revealed":[240],"that":[241],"factors,":[244],"including":[245],"gender":[246],"age":[248,338],"distribution":[249],"(p":[250],">":[251],"0.05),":[252],"did":[253],"not":[254],"statistically":[255],"influence":[256],"trajectories,":[259],"delays":[263],"distributed":[264],"across":[265],"infants,":[266],"young":[267],"children,":[268],"adolescent":[270],"brackets":[271],"alike.":[272],"Conversely,":[273],"determinant":[280],"velocity;":[283],"presented":[290],"profoundly":[292],"elevated":[293],"initial":[294],"densities":[297],"compared":[298],"normal":[300],"responders.":[301],"Conclusion":[302],"notable":[304],"proportion":[305],"(9.1%)":[306],"experience":[315],"3.":[321],"This":[322],"delay":[323],"strictly":[325],"driven":[326],"by":[327],"high":[328],"density":[331],"rather":[332],"than":[333],"vulnerabilities":[335],"such":[336],"or":[339],"gender.":[340],"These":[341],"findings":[342],"underscore":[343],"urgent":[345],"need":[346],"targeted":[348],"monitoring":[350],"presenting":[353],"hyper-parasitemia":[355],"continuous,":[357],"high-vigilance":[358],"surveillance":[359],"safeguard":[361],"efficacy":[363],"region.":[366]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-21T00:00:00"}