{"id":"https://openalex.org/W7203797372","doi":"https://doi.org/10.1186/s12903-026-10134-7","title":"Quantitative in vivo monitoring of early erosion-associated enamel optical changes using swept-source optical coherence tomography (SS-OCT)","display_name":"Quantitative in vivo monitoring of early erosion-associated enamel optical changes using swept-source optical coherence tomography (SS-OCT)","publication_year":2026,"publication_date":"2026-10-28","ids":{"openalex":"https://openalex.org/W7203797372","doi":"https://doi.org/10.1186/s12903-026-10134-7"},"language":"en","primary_location":{"id":"doi:10.1186/s12903-026-10134-7","doi":"https://doi.org/10.1186/s12903-026-10134-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12903-026-10134-7","pdf_url":null,"source":{"id":"https://openalex.org/S60760007","display_name":"BMC Oral Health","issn_l":"1472-6831","issn":["1472-6831"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Oral Health","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12903-026-10134-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079191114","display_name":"Azwatee Abdul Aziz","orcid":"https://orcid.org/0000-0003-4682-2774","observed_orcids":["https://orcid.org/0000-0003-4682-2774"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Azwatee Abdul Aziz","raw_affiliation_strings":["Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia"],"raw_orcid":"https://orcid.org/0000-0003-4682-2774","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137288751","display_name":"Maria Angela Garcia Gonzalez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090490","display_name":"National University","ror":"https://ror.org/000a8qk84","country_code":"PH","type":"education","lineage":["https://openalex.org/I4210090490"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Maria Angela Garcia Gonzalez","raw_affiliation_strings":["Department of Restorative Dentistry, College of Dentistry, National University MOA, Pasay City, Philippines"],"raw_orcid":"https://orcid.org/0000-0002-8389-2774","affiliations":[{"raw_affiliation_string":"Department of Restorative Dentistry, College of Dentistry, National University MOA, Pasay City, Philippines","institution_ids":["https://openalex.org/I4210090490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079191114"],"corresponding_institution_ids":["https://openalex.org/I33849332"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56712803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":0.551800012588501,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":0.551800012588501,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.4424000084400177,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12092","display_name":"Erosion and Abrasive Machining","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2302","display_name":"Ecological Modeling"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dental-erosion","display_name":"dental erosion","score":0.9570000171661377},{"id":"https://openalex.org/keywords/swept-source-oct","display_name":"swept-source optical coherence tomography","score":0.9570000171661377},{"id":"https://openalex.org/keywords/integrated-reflectivity","display_name":"integrated reflectivity","score":0.906000018119812},{"id":"https://openalex.org/keywords/orange-juice","display_name":"orange juice","score":0.5440000295639038},{"id":"https://openalex.org/keywords/salivary-stimulation","display_name":"salivary stimulation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/in-vivo-monitoring","display_name":"in vivo monitoring","score":0.6060000061988831},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.6019999980926514},{"id":"https://openalex.org/keywords/enamel-mineral-loss","display_name":"enamel mineral loss","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C156887251","wikidata":"https://www.wikidata.org/wiki/Q2386424","display_name":"Enamel paint","level":2,"score":0.8342000246047974},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.8210999965667725},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.524399995803833},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.512499988079071},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5098000168800354},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.47040000557899475},{"id":"https://openalex.org/C108597893","wikidata":"https://www.wikidata.org/wiki/Q663650","display_name":"Reflectivity","level":2,"score":0.4684999883174896},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.46709999442100525},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.4320000112056732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3727000057697296},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.335099995136261},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.32179999351501465},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.31470000743865967},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.3057999908924103},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2816999852657318},{"id":"https://openalex.org/C2910355441","wikidata":"https://www.wikidata.org/wiki/Q143942","display_name":"Dental enamel","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.2624000012874603},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.26030001044273376},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C3020486325","wikidata":"https://www.wikidata.org/wiki/Q907315","display_name":"Optical density","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s12903-026-10134-7","doi":"https://doi.org/10.1186/s12903-026-10134-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12903-026-10134-7","pdf_url":null,"source":{"id":"https://openalex.org/S60760007","display_name":"BMC Oral Health","issn_l":"1472-6831","issn":["1472-6831"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Oral Health","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-10375267/v1","doi":"https://doi.org/10.21203/rs.3.rs-10375267/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10375267/v1","pdf_url":"https://www.researchsquare.com/article/rs-10375267/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1186/s12903-026-10134-7","doi":"https://doi.org/10.1186/s12903-026-10134-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12903-026-10134-7","pdf_url":null,"source":{"id":"https://openalex.org/S60760007","display_name":"BMC Oral Health","issn_l":"1472-6831","issn":["1472-6831"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Oral Health","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321709","display_name":"Ministry of Higher Education, Malaysia","ror":"https://ror.org/05mcs2t73"},{"id":"https://openalex.org/F4320322604","display_name":"Universiti Malaya","ror":"https://ror.org/00rzspn62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203797372.pdf","grobid_xml":"https://content.openalex.org/works/W7203797372.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7162682821","https://openalex.org/W2616715089","https://openalex.org/W3215152364","https://openalex.org/W7204166098","https://openalex.org/W3165342896","https://openalex.org/W2575580034","https://openalex.org/W2089329223","https://openalex.org/W2019918861","https://openalex.org/W2965791526","https://openalex.org/W2913808625"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"To":[2],"evaluate":[3],"the":[4,33,208,259],"capability":[5],"of":[6,35,144,262],"swept-source":[7],"optical":[8,17,210,252],"coherence":[9],"tomography":[10],"(SS-OCT)":[11],"to":[12,31,114,288],"detect":[13],"early":[14,270],"erosion-associated":[15,271],"enamel":[16,118,230,251,272],"changes":[18,116,211],"in":[19,48,83,117,139,229,237],"vivo":[20],"following":[21,91,233],"repeated":[22,54,166,216,234],"erosive":[23,57,93,217,235],"challenges":[24,58,236],"under":[25],"clinically":[26],"relevant":[27],"oral":[28],"conditions":[29],"and":[30,42,125,184,282],"assess":[32],"influence":[34],"salivary":[36],"stimulation":[37,79,88],"through":[38],"chewing":[39,77,86,221],"gum.":[40],"Materials":[41],"Methods":[43],"Twenty-two":[44],"healthy":[45],"adults":[46],"participated":[47],"a":[49,69,136,265],"two-phase":[50],"longitudinal":[51,161,247],"study":[52],"involving":[53],"orange":[55],"juice":[56],"over":[59,254],"three":[60],"consecutive":[61],"days.":[62],"Participants":[63],"underwent":[64],"both":[65],"phases":[66],"sequentially":[67],"using":[68],"fixed-order":[70],"design.":[71],"In":[72],"Phase":[73,84,145],"A,":[74],"no":[75,151],"post-exposure":[76],"gum":[78,87,222],"was":[80,89,97,112,204],"performed,":[81],"whereas":[82,150],"B,":[85],"introduced":[90],"each":[92],"challenge.":[94],"SS-OCT":[95,225,263],"imaging":[96],"performed":[98],"at":[99],"six":[100],"daily":[101],"time":[102],"points":[103],"(t1\u2013t6).":[104],"Integrated":[105],"reflectivity":[106,232],"(IR),":[107],"derived":[108],"from":[109],"A-scan":[110],"analysis,":[111],"used":[113],"quantify":[115],"backscattering.":[119],"Statistical":[120],"analyses":[121],"included":[122],"paired":[123,241],"t-tests":[124],"linear":[126],"mixed-effects":[127,162],"modelling":[128,163],"(\u03b1":[129],"=":[130,148,177,182,188],"0.05).":[131],"Results":[132],"Paired":[133],"comparisons":[134,242],"demonstrated":[135,168,243],"significant":[137,152,200],"increase":[138],"IR":[140,171],"on":[141,173],"Day":[142,174,185,197],"3":[143,186],"B":[146],"(p":[147],"0.012),":[149],"differences":[153],"were":[154,212],"observed":[155,209],"for":[156,268],"other":[157],"individual":[158],"comparisons.":[159],"However,":[160],"incorporating":[164,276],"all":[165],"measurements":[167],"significantly":[169],"higher":[170],"values":[172],"2":[175],"(\u03b2":[176,187],"4.52":[178],"\u00d7":[179,190],"10\u2079,":[180,191],"p":[181,192],"0.006)":[183],"5.83":[189],"<":[193],"0.001)":[194],"compared":[195],"with":[196,215],"1.":[198],"No":[199],"overall":[201],"phase":[202],"effect":[203],"identified,":[205],"suggesting":[206],"that":[207],"primarily":[213],"associated":[214],"exposure":[218],"rather":[219],"than":[220],"stimulation.":[223],"Conclusions":[224],"detected":[226],"cumulative":[227],"increases":[228],"integrated":[231],"vivo.":[238],"Although":[239],"direct":[240,277],"limited":[244],"statistical":[245],"significance,":[246],"analysis":[248],"identified":[249],"progressive":[250],"alterations":[253],"time.":[255],"These":[256],"findings":[257],"support":[258],"potential":[260],"utility":[261],"as":[264],"non-invasive":[266],"tool":[267],"monitoring":[269],"changes.":[273],"Further":[274],"studies":[275],"mineral":[278],"validation,":[279],"repeatability":[280],"assessment,":[281],"longer-term":[283],"clinical":[284,291],"evaluation":[285],"are":[286],"warranted":[287],"establish":[289],"its":[290],"applicability.":[292],"Trial":[293],"Registration:":[294],"ClinicalTrials.gov,":[295],"NCT07690644,":[296],"1":[297],"July":[298],"2026":[299],"(first":[300],"submitted).":[301],"Retrospectively":[302],"registered.":[303]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-08-20T00:00:00"}