{"id":"https://openalex.org/W7203797019","doi":"https://doi.org/10.3389/fvets.2026.1866908","title":"Comparative analysis of anesthetic protocols in spontaneously hypertensive rats with sepsis-induced hemodynamic instability","display_name":"Comparative analysis of anesthetic protocols in spontaneously hypertensive rats with sepsis-induced hemodynamic instability","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203797019","doi":"https://doi.org/10.3389/fvets.2026.1866908","pmid":"https://pubmed.ncbi.nlm.nih.gov/42687980","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13533722"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2026.1866908","doi":"https://doi.org/10.3389/fvets.2026.1866908","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1866908","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1866908/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7203797019"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1866908/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037109771","display_name":"Maria Alcione Silva Gomes","orcid":"https://orcid.org/0000-0003-0662-2444","observed_orcids":["https://orcid.org/0000-0003-0662-2444"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Alcione Silva Gomes","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003101642","display_name":"Aline Aparecida Macedo Marques","orcid":"https://orcid.org/0000-0002-6665-3747","observed_orcids":["https://orcid.org/0000-0002-6665-3747"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Aline Aparecida Macedo Marques","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147448681","display_name":"Gabriela Pereira da Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriela Pereira da Silva","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118113146","display_name":"Luana Ale Bertoncello Pael","orcid":"https://orcid.org/0009-0002-9133-6249","observed_orcids":["https://orcid.org/0009-0002-9133-6249"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luana Ale Bertoncello Pael","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104332759","display_name":"Maria Medina de Azevedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Medina de Azevedo","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019840800","display_name":"Maria Luiza Fidelis Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Luiza Fidelis da Silva","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127700498","display_name":"Joyner David Anaya Miranda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Joyner David Anaya Miranda","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138743662","display_name":"Bianca Viana Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bianca Viana Silva","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048140805","display_name":"Telma L\u00e9lia Gon\u00e7alves Schultz de Carvalho","orcid":"https://orcid.org/0000-0002-1449-6743","observed_orcids":["https://orcid.org/0000-0002-1449-6743"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Telma L\u00e9lia Gon\u00e7alves Schultz de Carvalho","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147528144","display_name":"Isabela Marafon Souza F\u00e9liz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157527","display_name":"Centro Universit\u00e1rio da Grande Dourados","ror":"https://ror.org/05net6471","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210157527"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabela Marafon Souza F\u00e9liz","raw_affiliation_strings":["University Center of Grande Dourados (UNIGRAN)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Center of Grande Dourados (UNIGRAN)","institution_ids":["https://openalex.org/I4210157527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099339812","display_name":"S\u00edlvia Beatriz B\u00fcrger Tinelli","orcid":"https://orcid.org/0009-0005-7945-1270","observed_orcids":["https://orcid.org/0009-0005-7945-1270"]},"institutions":[{"id":"https://openalex.org/I187576290","display_name":"Universidade Paranaense","ror":"https://ror.org/0084z7g54","country_code":"BR","type":"education","lineage":["https://openalex.org/I187576290"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"S\u00edlvia Beatriz B\u00fcrger Tinelli","raw_affiliation_strings":["Graduate Program in Biotechnology Applied to Agriculture, Paranaense University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Biotechnology Applied to Agriculture, Paranaense University","institution_ids":["https://openalex.org/I187576290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147491094","display_name":"Juliana Cappellari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187576290","display_name":"Universidade Paranaense","ror":"https://ror.org/0084z7g54","country_code":"BR","type":"education","lineage":["https://openalex.org/I187576290"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana Cappellari","raw_affiliation_strings":["Graduate Program in Medicinal Plants and Phytotherapy in Primary Health Care, Paranaense University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Medicinal Plants and Phytotherapy in Primary Health Care, Paranaense University","institution_ids":["https://openalex.org/I187576290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085998717","display_name":"Salviano Tramontin Belettini","orcid":"https://orcid.org/0000-0002-0600-5836","observed_orcids":["https://orcid.org/0000-0002-0600-5836"]},"institutions":[{"id":"https://openalex.org/I187576290","display_name":"Universidade Paranaense","ror":"https://ror.org/0084z7g54","country_code":"BR","type":"education","lineage":["https://openalex.org/I187576290"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Salviano Tramontin Bellettini","raw_affiliation_strings":["Graduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Animal Science with Emphasis on Bioactive Products, Paranaense University","institution_ids":["https://openalex.org/I187576290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085297367","display_name":"Emerson Luiz Botelho Louren\u00e7o","orcid":"https://orcid.org/0000-0002-1798-7871","observed_orcids":["https://orcid.org/0000-0002-1798-7871"]},"institutions":[{"id":"https://openalex.org/I187576290","display_name":"Universidade Paranaense","ror":"https://ror.org/0084z7g54","country_code":"BR","type":"education","lineage":["https://openalex.org/I187576290"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Emerson Luiz Botelho Louren\u00e7o","raw_affiliation_strings":["Graduate Program in Medicinal Plants and Phytotherapy in Primary Health Care, Paranaense University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Medicinal Plants and Phytotherapy in Primary Health Care, Paranaense University","institution_ids":["https://openalex.org/I187576290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070045140","display_name":"Arquimedes Gasparotto","orcid":"https://orcid.org/0000-0003-3433-5098","observed_orcids":["https://orcid.org/0000-0003-3433-5098"]},"institutions":[{"id":"https://openalex.org/I187420256","display_name":"Universidade Federal da Grande Dourados","ror":"https://ror.org/0310smc09","country_code":"BR","type":"education","lineage":["https://openalex.org/I187420256"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Arquimedes Gasparotto Junior","raw_affiliation_strings":["Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados (UFGD)","institution_ids":["https://openalex.org/I187420256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070045140"],"corresponding_institution_ids":["https://openalex.org/I187420256"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":"1866908","last_page":"1866908"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.22269999980926514,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/anesthesia-protocols","display_name":"anesthetic protocols","score":0.8579999804496765},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.921999990940094},{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ketamine-xylazine","display_name":"ketamine-xylazine","score":0.9210000038146973},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hemodynamic-instability","display_name":"hemodynamic instability","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cardiovascular-safety","display_name":"cardiovascular safety","score":0.6570000052452087},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6679999828338623},{"id":"https://openalex.org/keywords/tissue-hypoxia","display_name":"tissue hypoxia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/renal-dysfunction","display_name":"renal dysfunction","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.9071000218391418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8734999895095825},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.8090000152587891},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.7979999780654907},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6930000185966492},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6215000152587891},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5943999886512756},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.3716999888420105},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C2779537118","wikidata":"https://www.wikidata.org/wiki/Q618362","display_name":"Arterial blood","level":2,"score":0.25940001010894775}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fvets.2026.1866908","doi":"https://doi.org/10.3389/fvets.2026.1866908","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1866908","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1866908/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13533722","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13533722/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13533722/pdf/fvets-13-1866908.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Vet Sci","raw_type":"Text"},{"id":"pmid:42687980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42687980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in veterinary science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2a132bec2c5645f182506c683f3e77b0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2a132bec2c5645f182506c683f3e77b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Veterinary Science, Vol 13 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2026.1866908","doi":"https://doi.org/10.3389/fvets.2026.1866908","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1866908","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1866908/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1489220130","display_name":null,"funder_award_id":"407685/2018-9","funder_id":"https://openalex.org/F4320323354","funder_display_name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul"},{"id":"https://openalex.org/G3081603928","display_name":null,"funder_award_id":"407685/2018-9","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4705761248","display_name":null,"funder_award_id":"83/013.186/2023","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6091949605","display_name":null,"funder_award_id":"83/013.186/2023","funder_id":"https://openalex.org/F4320323354","funder_display_name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul"},{"id":"https://openalex.org/G66028018","display_name":null,"funder_award_id":"150258/2023-2","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G7695270541","display_name":null,"funder_award_id":"150258/2023-2","funder_id":"https://openalex.org/F4320323354","funder_display_name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323354","display_name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","ror":"https://ror.org/05jtrt935"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203797019.pdf","grobid_xml":"https://content.openalex.org/works/W7203797019.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1504699597","https://openalex.org/W1574386044","https://openalex.org/W1937879943","https://openalex.org/W1965449620","https://openalex.org/W1970315166","https://openalex.org/W1981568438","https://openalex.org/W1998984491","https://openalex.org/W2003893395","https://openalex.org/W2012582829","https://openalex.org/W2015372371","https://openalex.org/W2029237503","https://openalex.org/W2036607436","https://openalex.org/W2044142012","https://openalex.org/W2058168232","https://openalex.org/W2058254315","https://openalex.org/W2107318205","https://openalex.org/W2145675697","https://openalex.org/W2157557532","https://openalex.org/W2170384621","https://openalex.org/W2325198470","https://openalex.org/W2754115500","https://openalex.org/W2769149806","https://openalex.org/W2788414583","https://openalex.org/W2905678847","https://openalex.org/W2954553190","https://openalex.org/W3036354880","https://openalex.org/W3135808479","https://openalex.org/W3160881780","https://openalex.org/W3165297427","https://openalex.org/W3177354535","https://openalex.org/W3192141250","https://openalex.org/W4206842453","https://openalex.org/W4221149765","https://openalex.org/W4280551292","https://openalex.org/W4282960004","https://openalex.org/W4379054372","https://openalex.org/W4386226848","https://openalex.org/W4392170701","https://openalex.org/W4400260389","https://openalex.org/W4400617469","https://openalex.org/W4401322316","https://openalex.org/W4410250637","https://openalex.org/W4413814998","https://openalex.org/W7138456419"],"related_works":["https://openalex.org/W2092469478","https://openalex.org/W4297811541","https://openalex.org/W2168080051","https://openalex.org/W2204770774","https://openalex.org/W2047093971","https://openalex.org/W2999742422","https://openalex.org/W2019407358","https://openalex.org/W2414743156","https://openalex.org/W2326238934","https://openalex.org/W1979723222"],"abstract_inverted_index":{"Introduction:":[0],"Sepsis":[1],"remains":[2],"a":[3],"significant":[4,96,119],"clinical":[5],"challenge":[6],"characterized":[7],"by":[8],"complex":[9],"inflammatory":[10],"responses":[11],"and":[12,20,55,79,85,93,105,114],"hemodynamic":[13,113],"instability,":[14],"often":[15],"modeled":[16],"via":[17],"cecal":[18],"ligation":[19],"puncture":[21],"(CLP).":[22],"This":[23],"study":[24],"investigated":[25],"the":[26,82,122,145,158],"cardiovascular":[27,130],"impacts":[28],"of":[29,81],"various":[30],"anesthetic":[31,49,147],"protocols":[32],"in":[33,132],"spontaneously":[34],"hypertensive":[35,133],"rats":[36,111,134],"(SHR)":[37],"subjected":[38],"to":[39,157],"abdominal":[40],"sepsis.":[41],"Methods:":[42],"Septic":[43],"SHR":[44],"were":[45],"allocated":[46],"into":[47],"five":[48],"groups:":[50],"ketamine-xylazine,":[51],"fentanyl-diazepam,":[52,91],"fentanyl-dexmedetomidine,":[53,92],"ketamine-dexmedetomidine,":[54],"inhaled":[56],"isoflurane":[57,143],"(2-3%),":[58],"alongside":[59],"an":[60],"unanesthetized":[61],"septic":[62,123],"control.":[63],"Evaluations":[64],"included":[65],"electrocardiography,":[66],"arterial":[67],"blood":[68,71],"pressure":[69],"monitoring,":[70],"gas":[72],"analysis,":[73],"biochemical":[74,115],"profiling,":[75],"mesenteric":[76],"vascular":[77],"reactivity,":[78],"histopathology":[80],"heart,":[83],"kidney,":[84],"aorta.":[86],"Results:":[87],"Injectable":[88],"combinations":[89],"(ketamine-xylazine,":[90],"ketamine-dexmedetomidine)":[94],"induced":[95],"electrocardiographic":[97],"alterations,":[98],"hypotension,":[99],"tissue":[100],"hypoxia,":[101],"increased":[102],"oxidative":[103],"stress,":[104],"elevated":[106],"serum":[107],"creatinine.":[108],"Conversely,":[109],"isoflurane-anesthetized":[110],"maintained":[112],"stability,":[116],"showing":[117],"no":[118],"deviations":[120],"from":[121],"control":[124],"group.":[125],"Conclusion:":[126],"Isoflurane":[127],"demonstrated":[128],"superior":[129],"safety":[131],"during":[135],"sepsis-induced":[136],"instability.":[137],"These":[138],"findings":[139],"suggest":[140],"that":[141],"while":[142],"is":[144],"preferred":[146],"for":[148],"this":[149],"specific":[150],"model,":[151],"protocol":[152],"selection":[153],"must":[154],"be":[155],"tailored":[156],"experimental":[159],"context.":[160]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-08-20T00:00:00"}