{"id":"https://openalex.org/W7203796839","doi":"https://doi.org/10.3389/fimmu.2026.1932788","title":"Shared Treg dysregulation underlies psoriasis vulgaris and atopic dermatitis through the PHF19-PRC2 epigenetic axis","display_name":"Shared Treg dysregulation underlies psoriasis vulgaris and atopic dermatitis through the PHF19-PRC2 epigenetic axis","publication_year":2026,"publication_date":"2026-08-20","ids":{"openalex":"https://openalex.org/W7203796839","doi":"https://doi.org/10.3389/fimmu.2026.1932788","pmid":"https://pubmed.ncbi.nlm.nih.gov/42694095","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13538097"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1932788","doi":"https://doi.org/10.3389/fimmu.2026.1932788","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932788","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932788/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932788/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072088304","display_name":"Yiting Lin","orcid":"https://orcid.org/0009-0004-5351-5945","observed_orcids":["https://orcid.org/0009-0004-5351-5945"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Lin","raw_affiliation_strings":["Department of Dermatology, Tangdu Hospital, Fourth Military Medical University","Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tangdu Hospital, Fourth Military Medical University","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]},{"raw_affiliation_string":"Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159744037","display_name":"Xiaolei Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolei Su","raw_affiliation_strings":["Department of Dermatology, Xijing Hospital, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Xijing Hospital, Fourth Military Medical University","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125568877","display_name":"Mingzhu Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingzhu Jin","raw_affiliation_strings":["Department of Dermatology, Tangdu Hospital, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tangdu Hospital, Fourth Military Medical University","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451687","display_name":"Yuqi Wang","orcid":"https://orcid.org/0000-0002-9793-6002","observed_orcids":["https://orcid.org/0000-0002-9793-6002","https://orcid.org/0009-0003-9580-6145","https://orcid.org/0009-0004-8224-4689","https://orcid.org/0009-0008-9122-6086","https://orcid.org/0009-0007-7862-2570"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Wang","raw_affiliation_strings":["Department of Dermatology, Xijing Hospital, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Xijing Hospital, Fourth Military Medical University","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5154117167","display_name":"Yaoyao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaoyao Li","raw_affiliation_strings":["School of Basic Medicine, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Fourth Military Medical University","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125588690","display_name":"Bingquan Zong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingquan Zong","raw_affiliation_strings":["School of Basic Medicine, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Fourth Military Medical University","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147618869","display_name":"Haoran Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoran Song","raw_affiliation_strings":["School of Basic Medicine, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Fourth Military Medical University","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072975711","display_name":"Yajie Lv","orcid":"https://orcid.org/0000-0001-9598-920X","observed_orcids":["https://orcid.org/0000-0001-9598-920X"]},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajie Lv","raw_affiliation_strings":["Department of Dermatology, Tangdu Hospital, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Tangdu Hospital, Fourth Military Medical University","institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420221","display_name":"Zhenhua Liu","orcid":"https://orcid.org/0000-0003-4228-2504","observed_orcids":["https://orcid.org/0000-0003-4228-2504"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenhua Liu","raw_affiliation_strings":["Department of Dermatology, Xijing Hospital, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Xijing Hospital, Fourth Military Medical University","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138537412","display_name":"Gang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gang Wang","raw_affiliation_strings":["Department of Dermatology, Xijing Hospital, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Xijing Hospital, Fourth Military Medical University","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147599379","display_name":"Shengxi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shengxi Wu","raw_affiliation_strings":["Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University","institution_ids":["https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100420221","https://openalex.org/A5138537412","https://openalex.org/A5147599379"],"corresponding_institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55957822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1932788","last_page":"1932788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/phf19","display_name":"PHF19","score":0.9419999718666077},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.8379999995231628},{"id":"https://openalex.org/keywords/h3k27me3","display_name":"H3K27me3","score":0.9670000076293945},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.6470000147819519},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.7549999952316284},{"id":"https://openalex.org/keywords/imiquimod-induced-psoriasis-like-dermatitis","display_name":"imiquimod-induced psoriasis-like dermatitis","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6305999755859375},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.5760999917984009},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5619999766349792},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.5099999904632568},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.504800021648407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46059998869895935},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.396699994802475},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.382999986410141},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.35850000381469727},{"id":"https://openalex.org/C12652872","wikidata":"https://www.wikidata.org/wiki/Q18027997","display_name":"IRF4","level":4,"score":0.35010001063346863},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.34119999408721924},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.328900009393692},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C2778015335","wikidata":"https://www.wikidata.org/wiki/Q17051163","display_name":"Mass cytometry","level":4,"score":0.3057999908924103},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.26010000705718994},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D063151","descriptor_name":"Polycomb Repressive Complex 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1932788","doi":"https://doi.org/10.3389/fimmu.2026.1932788","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932788","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932788/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13538097","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13538097/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13538097/pdf/fimmu-17-1932788.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42694095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42694095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1f346e2283cf4561a92d632d9d7a59bb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1f346e2283cf4561a92d632d9d7a59bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1932788","doi":"https://doi.org/10.3389/fimmu.2026.1932788","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1932788","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1932788/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2429106284","display_name":null,"funder_award_id":"82203912","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324530","display_name":"Fourth Military Medical University","ror":"https://ror.org/00ms48f15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203796839.pdf","grobid_xml":"https://content.openalex.org/works/W7203796839.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1971079822","https://openalex.org/W1984883254","https://openalex.org/W1986646780","https://openalex.org/W2029200807","https://openalex.org/W2050345155","https://openalex.org/W2093260830","https://openalex.org/W2136830554","https://openalex.org/W2159675211","https://openalex.org/W2408053871","https://openalex.org/W2775205191","https://openalex.org/W2777101704","https://openalex.org/W2788322159","https://openalex.org/W2805983714","https://openalex.org/W2907514116","https://openalex.org/W3044679662","https://openalex.org/W3104522300","https://openalex.org/W3132661792","https://openalex.org/W3158401813","https://openalex.org/W3175617087","https://openalex.org/W3175752499","https://openalex.org/W4200155910","https://openalex.org/W4210311642","https://openalex.org/W4211103501","https://openalex.org/W4220774890","https://openalex.org/W4223927448","https://openalex.org/W4229453439","https://openalex.org/W4293537589","https://openalex.org/W4294215450","https://openalex.org/W4296794454","https://openalex.org/W4298042816","https://openalex.org/W4301183220","https://openalex.org/W4310645475","https://openalex.org/W4317874806","https://openalex.org/W4320730824","https://openalex.org/W4377294381","https://openalex.org/W4378212544","https://openalex.org/W4385476310","https://openalex.org/W4386023075","https://openalex.org/W4387057770","https://openalex.org/W4390115792","https://openalex.org/W4391677679","https://openalex.org/W4396797233","https://openalex.org/W4400735087","https://openalex.org/W4400767200","https://openalex.org/W4403469038","https://openalex.org/W4405643666","https://openalex.org/W4407029728","https://openalex.org/W4410092406","https://openalex.org/W4411413351","https://openalex.org/W4412470305","https://openalex.org/W4412520467","https://openalex.org/W4413117499","https://openalex.org/W4413330766","https://openalex.org/W4415158474","https://openalex.org/W7124957811","https://openalex.org/W7134941775","https://openalex.org/W7154487486","https://openalex.org/W7161759257","https://openalex.org/W7162559486"],"related_works":["https://openalex.org/W4229449815","https://openalex.org/W4401229063","https://openalex.org/W4388420592","https://openalex.org/W4280618297","https://openalex.org/W2752670171","https://openalex.org/W2027574380","https://openalex.org/W4393274308","https://openalex.org/W2047154603","https://openalex.org/W2164841087","https://openalex.org/W2801995066"],"abstract_inverted_index":{"Background":[0],"Psoriasis":[1],"vulgaris":[2],"(PV)":[3],"and":[4,51,62,75,92,106,113,137,190,218,238],"atopic":[5],"dermatitis":[6,109],"(AD)":[7],"are":[8],"chronic":[9],"inflammatory":[10],"skin":[11,240],"diseases":[12,34,72],"characterized":[13],"by":[14,87,110],"distinct":[15],"dominant":[16],"T":[17,44],"cell":[18],"subsets,":[19],"yet":[20],"emerging":[21],"evidence":[22],"suggests":[23],"overlapping":[24],"immune":[25],"mechanisms.":[26],"Whether":[27],"a":[28,148,171,181,210,250,258],"shared":[29,83,118,172,196,251],"Treg":[30,57,119,127,134,139,159,235,246],"abnormality":[31],"underlies":[32],"both":[33,71,143,243],"remains":[35],"unclear.":[36],"Methods":[37],"Single-cell":[38],"RNA":[39],"sequencing":[40],"data":[41],"from":[42,70,180],"lesional":[43],"cells":[45],"of":[46,103,214],"8":[47],"PV,":[48],"7":[49,52],"AD,":[50],"healthy":[53],"controls":[54],"were":[55,65,73,96],"analyzed.":[56],"subset":[58,236,247],"identification,":[59],"trajectory,":[60],"communication,":[61],"enrichment":[63],"analyses":[64],"conducted.":[66],"Differentially":[67],"expressed":[68],"genes":[69,198],"intersected":[74],"subjected":[76],"to":[77,80,184,229],"Mendelian":[78,192],"randomization":[79,193],"screen":[81],"for":[82],"causal":[84,197],"genes,":[85],"followed":[86],"interaction":[88],"mapping,":[89],"drug":[90],"prediction,":[91],"molecular":[93],"docking.":[94],"Findings":[95],"validated":[97],"in":[98,142,219,242],"Foxp3-tdTomato":[99],"reporter":[100],"mouse":[101],"models":[102],"imiquimod-induced":[104],"psoriasis-like":[105],"MC903-induced":[107],"AD-like":[108],"flow":[111],"cytometry":[112],"quantitative":[114],"PCR.":[115],"Results":[116],"A":[117],"triad":[120],"remodeling":[121,174,248],"pattern":[122],"was":[123,129],"identified:":[124],"central":[125],"memory":[126],"(cmTreg)":[128],"almost":[130],"completely":[131],"depleted,":[132],"cycling":[133],"(Treg-c)":[135],"expanded,":[136],"effector":[138,158],"(eTreg)":[140],"accumulated":[141],"diseases.":[144],"Pseudotemporal":[145],"analysis":[146,165],"revealed":[147],"differentiation":[149],"coordination":[150],"defect,":[151],"with":[152,176,206],"upstream":[153],"Treg-c":[154,189],"shifting":[155,179],"prematurely":[156],"while":[157],"failed":[160],"terminal":[161],"maturation.":[162],"Cell":[163],"communication":[164],"identified":[166,194],"enhanced":[167],"MIF-(CD74+CXCR4/CD44)":[168],"signaling":[169],"as":[170,209,257],"intercellular":[173],"axis,":[175,233],"the":[177,231],"network":[178],"cmTreg-centric":[182],"topology":[183],"one":[185],"jointly":[186],"centered":[187],"on":[188],"eTreg.":[191],"seven":[195],"(PDCD5,":[199],"PHF19,":[200,226],"GNAQ,":[201],"LRR1,":[202],"DHX36,":[203],"TMEM107,":[204],"FAM200B),":[205],"PHF19":[207],"serving":[208],"core":[211],"accessory":[212],"subunit":[213],"PRC2.":[215],"Molecular":[216],"docking":[217],"vivo":[220],"experiments":[221],"demonstrated":[222],"that":[223],"resveratrol":[224],"binds":[225],"is":[227,249],"predicted":[228],"activate":[230],"PHF19-PRC2-H3K27me3":[232],"restores":[234],"homeostasis,":[237],"ameliorates":[239],"lesions":[241],"models.":[244],"Conclusions":[245],"pathogenic":[252],"feature,":[253],"nominating":[254],"PHF19-targeted":[255],"activation":[256],"tolerance-restoring":[259],"therapeutic":[260],"strategy.":[261]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-20T00:00:00"}
