{"id":"https://openalex.org/W7203787741","doi":"https://doi.org/10.1097/mpa.0000000000002707","title":"Chemotherapy for Unresectable Pancreatic Cancer Complicated by Disseminated Intravascular Coagulation: A Retrospective Cohort Study","display_name":"Chemotherapy for Unresectable Pancreatic Cancer Complicated by Disseminated Intravascular Coagulation: A Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203787741","doi":"https://doi.org/10.1097/mpa.0000000000002707","pmid":"https://pubmed.ncbi.nlm.nih.gov/42616029"},"language":"en","primary_location":{"id":"doi:10.1097/mpa.0000000000002707","doi":"https://doi.org/10.1097/mpa.0000000000002707","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mpa.0000000000002707","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/mpa.0000000000002707","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065749372","display_name":"Kohei Nagata","orcid":"https://orcid.org/0000-0003-1487-4676","observed_orcids":["https://orcid.org/0000-0003-1487-4676","https://orcid.org/0000-0002-3794-3737"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]},{"id":"https://openalex.org/I4405284950","display_name":"Kansai Medical University Hospital","ror":"https://ror.org/04gpc9445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405284950"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Nagata","raw_affiliation_strings":["Department of Clinical Oncology, Kansai Medical University Hospital, Osaka, Japan","Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1487-4676","affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Kansai Medical University Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4405284950"]},{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076120991","display_name":"Takayuki Ando","orcid":"https://orcid.org/0000-0001-8219-976X","observed_orcids":["https://orcid.org/0000-0001-8219-976X","https://orcid.org/0000-0001-8369-8536"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Ando","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011482442","display_name":"Hiroki Kawanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Kawanaka","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146519896","display_name":"Jun Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Sakamoto","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052409688","display_name":"Banri Ogino","orcid":"https://orcid.org/0000-0002-2422-8961","observed_orcids":["https://orcid.org/0000-0002-2422-8961"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Banri Ogino","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066087157","display_name":"Toshiki Entani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiki Entani","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049473191","display_name":"Iori Motoo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Iori Motoo","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136579021","display_name":"Yuko Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Ueda","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019940544","display_name":"Nobuhiko Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuhiko Hayashi","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086957005","display_name":"Shinya Kajiura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Kajiura","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064709438","display_name":"Kazuto Tajiri","orcid":"https://orcid.org/0000-0002-2373-8601","observed_orcids":["https://orcid.org/0000-0002-2373-8601"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuto Tajiri","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124061649","display_name":"Ichiro Yasuda","orcid":"https://orcid.org/0000-0002-6888-0310","observed_orcids":["https://orcid.org/0000-0002-6888-0310"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Yasuda","raw_affiliation_strings":["Third Department of Internal Medicine, University of Toyama, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Third Department of Internal Medicine, University of Toyama, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.57692892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-pancreatic-cancer","display_name":"advanced pancreatic cancer","score":0.7990000247955322},{"id":"https://openalex.org/keywords/disseminated-intravascular-coagulation","display_name":"disseminated intravascular coagulation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/antifibrinolytic-therapy","display_name":"antifibrinolytic therapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7950000166893005},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.882099986076355},{"id":"https://openalex.org/C2778734968","wikidata":"https://www.wikidata.org/wiki/Q823027","display_name":"Disseminated intravascular coagulation","level":2,"score":0.821399986743927},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6902999877929688},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6506999731063843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6033999919891357},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5781999826431274},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5184000134468079},{"id":"https://openalex.org/C2781436528","wikidata":"https://www.wikidata.org/wiki/Q575222","display_name":"Antifibrinolytic","level":4,"score":0.5013999938964844},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.43299999833106995},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39500001072883606},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3905999958515167},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.38100001215934753},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3668000102043152},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3513000011444092},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.30709999799728394},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.28929999470710754},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.28610000014305115},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.27790001034736633}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/mpa.0000000000002707","doi":"https://doi.org/10.1097/mpa.0000000000002707","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mpa.0000000000002707","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},{"id":"pmid:42616029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42616029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/mpa.0000000000002707","doi":"https://doi.org/10.1097/mpa.0000000000002707","is_oa":true,"landing_page_url":"https://doi.org/10.1097/mpa.0000000000002707","pdf_url":null,"source":{"id":"https://openalex.org/S10058814","display_name":"Pancreas","issn_l":"0885-3177","issn":["0885-3177","1536-4828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pancreas","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2087255946","https://openalex.org/W4410812475","https://openalex.org/W1821639876","https://openalex.org/W4380795633","https://openalex.org/W4304146278","https://openalex.org/W4206889872","https://openalex.org/W2904807149","https://openalex.org/W1971580619","https://openalex.org/W4405050079","https://openalex.org/W2350928866"],"abstract_inverted_index":{"OBJECTIVES:":[0],"This":[1,44],"study":[2,47],"aimed":[3],"to":[4,70,105,199,238],"characterize":[5],"the":[6,35,112,121,132],"clinical":[7],"features":[8,54],"and":[9,30,33,55,62,77,94,103,196,229],"prognosis":[10,56],"of":[11,37,182],"advanced":[12],"pancreatic":[13],"cancer":[14],"(APC)":[15],"complicated":[16],"by":[17],"disseminated":[18],"intravascular":[19],"coagulation":[20],"(DIC),":[21],"with":[22,51,61,91,97,117,154,166,172,204,221,226],"a":[23,207],"particular":[24],"focus":[25],"on":[26],"distinguishing":[27,74],"between":[28,59,75],"tumor-related":[29,76,92,118,167,222],"infection-related":[31,78,98],"DIC":[32,71,93,119,150,168,185,192,205,223,239],"evaluating":[34],"feasibility":[36],"chemotherapy":[38,171],"in":[39,217],"this":[40],"high-risk":[41],"population.":[42],"METHODS:":[43],"single-center":[45],"retrospective":[46],"analyzed":[48],"284":[49,82],"patients":[50,60,165,220],"APC.":[52],"Clinicopathological":[53],"were":[57,66],"compared":[58],"without":[63],"DIC.":[64,79,99,183],"Outcomes":[65],"further":[67],"stratified":[68],"according":[69],"etiology,":[72],"specifically":[73],"RESULTS:":[80],"Of":[81],"patients,":[83],"19":[84],"(6.7%)":[85],"developed":[86],"DIC,":[87],"including":[88],"10":[89],"(52.6%)":[90],"9":[95],"(47.4%)":[96],"Overall":[100],"survival":[101,137],"(OS)":[102],"time":[104],"treatment":[106],"failure":[107],"(TTF)":[108],"differed":[109],"significantly":[110],"among":[111],"three":[113],"groups":[114],"(P<0.001).":[115],"Patients":[116],"had":[120],"shortest":[122],"survival,":[123],"(median":[124,138],"OS:":[125,139],"1.3":[126],"mo;":[127,141],"TTF:":[128],"0.85":[129],"mo,":[130],"whereas":[131],"non-DIC":[133],"group":[134],"showed":[135],"longest":[136],"10.4":[140],"TTF":[142],"5.2":[143],"mo).":[144],"In":[145],"multivariable":[146],"Cox":[147],"regression":[148],"analysis,":[149],"remained":[151],"independently":[152],"associated":[153],"poor":[155],"OS":[156],"(HR":[157],"3.6,":[158],"95%":[159],"CI":[160],"2.2-5.8;":[161],"P<0.001).":[162],"Among":[163],"8":[164],"who":[169],"received":[170],"concomitant":[173],"anticoagulant":[174,230],"or":[175,231],"antifibrinolytic":[176,232],"therapy,":[177],"4":[178],"(50%)":[179],"achieved":[180],"resolution":[181,240],"Notably,":[184],"recurred":[186],"upon":[187],"tumor":[188,200],"progression,":[189],"suggesting":[190],"that":[191],"control":[193],"was":[194],"temporary":[195],"closely":[197],"tied":[198],"response.":[201],"CONCLUSION:":[202],"APC":[203],"carries":[206],"dismal":[208],"prognosis,":[209],"particularly":[210],"when":[211,224],"tumor-related.":[212],"Chemotherapy":[213],"may":[214],"be":[215],"feasible":[216],"carefully":[218],"selected":[219],"administered":[225],"appropriate":[227],"supportive":[228],"therapy;":[233],"however,":[234],"its":[235],"independent":[236],"contribution":[237],"requires":[241],"cautious":[242],"interpretation.":[243]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-08-20T00:00:00"}