{"id":"https://openalex.org/W7203785976","doi":"https://doi.org/10.1038/s41375-026-03093-z","title":"mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia","display_name":"mTORC1 inhibition upregulates CD20 and enhances anti-CD20 antibody efficacy in B-cell precursor acute lymphoblastic leukemia","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203785976","doi":"https://doi.org/10.1038/s41375-026-03093-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42618701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713584"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-026-03093-z","doi":"https://doi.org/10.1038/s41375-026-03093-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-026-03093-z","pdf_url":"https://www.nature.com/articles/s41375-026-03093-z.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41375-026-03093-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007824110","display_name":"Agnieszka D\u0105bkowska","orcid":"https://orcid.org/0000-0001-8641-5677","observed_orcids":["https://orcid.org/0000-0001-8641-5677"]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agnieszka D\u0105bkowska","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0001-8641-5677","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064499791","display_name":"Martyna Poprzeczko","orcid":"https://orcid.org/0000-0002-8703-5614","observed_orcids":["https://orcid.org/0000-0002-8703-5614"]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Martyna Janowska","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-8703-5614","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001980965","display_name":"Agata Karolina Pastorczak","orcid":"https://orcid.org/0000-0003-3089-6947","observed_orcids":["https://orcid.org/0000-0003-3089-6947"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Agata Pastorczak","raw_affiliation_strings":["Department of Genetic Predisposition to Cancer, Medical University of Lodz, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Predisposition to Cancer, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027945148","display_name":"Krzysztof Domka","orcid":"https://orcid.org/0000-0002-2856-6968","observed_orcids":["https://orcid.org/0000-0002-2856-6968"]},"institutions":[{"id":"https://openalex.org/I268303160","display_name":"Medical University of Warsaw","ror":"https://ror.org/04p2y4s44","country_code":"PL","type":"education","lineage":["https://openalex.org/I268303160"]},{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof Domka","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","Department of Pathology, Medical University of Warsaw, Warsaw, Poland","Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0002-2856-6968","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"raw_affiliation_string":"Department of Pathology, Medical University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I268303160"]},{"raw_affiliation_string":"Doctoral School of Translational Medicine, Centre of Postgraduate Medical Education, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049799223","display_name":"Zuzanna Nowicka","orcid":"https://orcid.org/0000-0001-7814-5830","observed_orcids":["https://orcid.org/0000-0001-7814-5830"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Zuzanna Nowicka","raw_affiliation_strings":["Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0001-7814-5830","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038475392","display_name":"Zuzanna Urba\u0144ska","orcid":"https://orcid.org/0000-0002-4810-6627","observed_orcids":["https://orcid.org/0000-0002-4810-6627"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Zuzanna Urbanska","raw_affiliation_strings":["Department of Genetic Predisposition to Cancer, Medical University of Lodz, Lodz, Poland"],"raw_orcid":"https://orcid.org/0000-0002-4810-6627","affiliations":[{"raw_affiliation_string":"Department of Genetic Predisposition to Cancer, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147540283","display_name":"Weronika Zaj\u0105c","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Weronika Zaj\u0105c","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116880091","display_name":"Miko\u0142aj Bugajewski","orcid":"https://orcid.org/0009-0009-8043-0716","observed_orcids":["https://orcid.org/0009-0009-8043-0716"]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Miko\u0142aj Bugajewski","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0009-0009-8043-0716","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106277316","display_name":"Julia Grzybowska-Adamowicz","orcid":"https://orcid.org/0009-0009-8779-3907","observed_orcids":["https://orcid.org/0009-0009-8779-3907","https://orcid.org/0009-0006-4600-5909"]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Julia Grzybowska","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0009-0006-4600-5909","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032005981","display_name":"Pola Pruchniak","orcid":"https://orcid.org/0009-0004-8199-2263","observed_orcids":["https://orcid.org/0009-0004-8199-2263"]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Pola Pruchniak","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0009-0004-8199-2263","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070387820","display_name":"Klaudyna Fidyt","orcid":"https://orcid.org/0000-0003-0568-4950","observed_orcids":["https://orcid.org/0000-0003-0568-4950"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210089592","display_name":"Josep Carreras Leukaemia Research Institute","ror":"https://ror.org/00btzwk36","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089592","https://openalex.org/I4210144824","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Klaudyna Fidyt","raw_affiliation_strings":["Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain","Red Espa\u00f1ola de Terapias Avanzadas (TERAV), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain","institution_ids":["https://openalex.org/I4210089592"]},{"raw_affiliation_string":"Red Espa\u00f1ola de Terapias Avanzadas (TERAV), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136167795","display_name":"Wojciech Fendler","orcid":"https://orcid.org/0000-0002-5083-9168","observed_orcids":["https://orcid.org/0000-0002-5083-9168"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wojciech Fendler","raw_affiliation_strings":["Department of Genetic Predisposition to Cancer, Medical University of Lodz, Lodz, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetic Predisposition to Cancer, Medical University of Lodz, Lodz, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008284589","display_name":"Jason Taslim","orcid":"https://orcid.org/0000-0002-2290-4209","observed_orcids":["https://orcid.org/0000-0002-2290-4209"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason Taslim","raw_affiliation_strings":["Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064908084","display_name":"Nicholas T. Crump","orcid":"https://orcid.org/0000-0001-9610-6763","observed_orcids":["https://orcid.org/0000-0001-9610-6763"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas T. Crump","raw_affiliation_strings":["Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-9610-6763","affiliations":[{"raw_affiliation_string":"Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046770892","display_name":"Alexey Ushmorov","orcid":"https://orcid.org/0000-0003-3724-7253","observed_orcids":["https://orcid.org/0000-0003-3724-7253"]},"institutions":[{"id":"https://openalex.org/I196349391","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02","country_code":"DE","type":"education","lineage":["https://openalex.org/I196349391"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexey Ushmorov","raw_affiliation_strings":["Institute of Physiological Chemistry, University of Ulm, Ulm, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3724-7253","affiliations":[{"raw_affiliation_string":"Institute of Physiological Chemistry, University of Ulm, Ulm, Germany","institution_ids":["https://openalex.org/I196349391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062641058","display_name":"El\u017cbieta Patkowska","orcid":"https://orcid.org/0000-0001-8691-4310","observed_orcids":["https://orcid.org/0000-0001-8691-4310"]},"institutions":[{"id":"https://openalex.org/I4210090876","display_name":"Instytut Hematologii i Transfuzjologi","ror":"https://ror.org/00csw7971","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210090876"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Elzbieta Patkowska","raw_affiliation_strings":["Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland","institution_ids":["https://openalex.org/I4210090876"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077307369","display_name":"Ma\u0142gorzata Firczuk","orcid":"https://orcid.org/0000-0002-1719-5233","observed_orcids":["https://orcid.org/0000-0002-1719-5233"]},"institutions":[{"id":"https://openalex.org/I4210157213","display_name":"Mossakowski Medical Research Institute,  Polish Academy of Sciences","ror":"https://ror.org/05d3ntb42","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Malgorzata Firczuk","raw_affiliation_strings":["Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland. mfirczuk@imdik.pan.pl"],"raw_orcid":"https://orcid.org/0000-0002-1719-5233","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland. mfirczuk@imdik.pan.pl","institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5077307369"],"corresponding_institution_ids":["https://openalex.org/I4210157213","https://openalex.org/I99542240"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59113315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"11","first_page":"2466","last_page":"2480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-precursor-acute-lymphoblastic-leukemia","display_name":"B-cell precursor acute lymphoblastic leukemia","score":0.972000002861023},{"id":"https://openalex.org/keywords/mtorc1-inhibition","display_name":"mTORC1 inhibition","score":0.8880000114440918},{"id":"https://openalex.org/keywords/anti-cd20-monoclonal-antibody","display_name":"anti-CD20 monoclonal antibody","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/b-cell-maturation","display_name":"B cell maturation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/akt-foxo1-signaling","display_name":"AKT/FOXO1 signaling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/relapsed-refractory-leukemia","display_name":"relapsed/refractory leukemia","score":0.7839999794960022},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6309999823570251},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.6154000163078308},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.6062999963760376},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5600000023841858},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.48919999599456787},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4765999913215637},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43050000071525574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3937000036239624},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3912999927997589},{"id":"https://openalex.org/C2776596971","wikidata":"https://www.wikidata.org/wiki/Q1279013","display_name":"CD43","level":4,"score":0.3797000050544739},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.3732999861240387},{"id":"https://openalex.org/C2779469565","wikidata":"https://www.wikidata.org/wiki/Q6708277","display_name":"Lymphoid leukemia","level":3,"score":0.37310001254081726},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.37130001187324524},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.37040001153945923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3659999966621399},{"id":"https://openalex.org/C98175054","wikidata":"https://www.wikidata.org/wiki/Q18030550","display_name":"PIM1","level":4,"score":0.3653999865055084},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.350600004196167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3337000012397766},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3140000104904175},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.2757999897003174},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.27399998903274536},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.2565999925136566},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015452","descriptor_name":"Precursor B-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015452","descriptor_name":"Precursor B-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015452","descriptor_name":"Precursor B-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015452","descriptor_name":"Precursor B-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018951","descriptor_name":"Antigens, CD20","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018951","descriptor_name":"Antigens, CD20","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018951","descriptor_name":"Antigens, CD20","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051740","descriptor_name":"Ikaros Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051740","descriptor_name":"Ikaros Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41375-026-03093-z","doi":"https://doi.org/10.1038/s41375-026-03093-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-026-03093-z","pdf_url":"https://www.nature.com/articles/s41375-026-03093-z.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713584","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713584/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13713584/pdf/41375_2026_Article_3093.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Text"},{"id":"pmid:42618701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42618701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/s41375-026-03093-z","doi":"https://doi.org/10.1038/s41375-026-03093-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41375-026-03093-z","pdf_url":"https://www.nature.com/articles/s41375-026-03093-z.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6493485904","display_name":null,"funder_award_id":"2023/50/O/NZ7/00422","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"},{"id":"https://openalex.org/G8915241855","display_name":null,"funder_award_id":"2019/35/B/NZ5/01428","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"}],"funders":[{"id":"https://openalex.org/F4320321042","display_name":"Fundacja na rzecz Nauki Polskiej","ror":"https://ror.org/048zd9m77"},{"id":"https://openalex.org/F4320322511","display_name":"Narodowe Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320325530","display_name":"Universit\u00e4t Ulm","ror":"https://ror.org/032000t02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203785976.pdf","grobid_xml":"https://content.openalex.org/works/W7203785976.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1712566393","https://openalex.org/W1964061368","https://openalex.org/W1970550717","https://openalex.org/W1975317091","https://openalex.org/W1983698019","https://openalex.org/W1987959125","https://openalex.org/W1996849272","https://openalex.org/W2067019627","https://openalex.org/W2101650407","https://openalex.org/W2102365540","https://openalex.org/W2121604817","https://openalex.org/W2126783165","https://openalex.org/W2130746744","https://openalex.org/W2134831571","https://openalex.org/W2136858141","https://openalex.org/W2138466297","https://openalex.org/W2164857073","https://openalex.org/W2414395973","https://openalex.org/W2482579995","https://openalex.org/W2520695016","https://openalex.org/W2587505100","https://openalex.org/W2587612009","https://openalex.org/W2759061414","https://openalex.org/W2765507458","https://openalex.org/W2783767400","https://openalex.org/W2794646865","https://openalex.org/W2796129562","https://openalex.org/W2808704302","https://openalex.org/W2892758519","https://openalex.org/W2903563962","https://openalex.org/W2922166085","https://openalex.org/W2951117603","https://openalex.org/W3005512912","https://openalex.org/W3012963517","https://openalex.org/W3024718562","https://openalex.org/W3029779858","https://openalex.org/W3136337004","https://openalex.org/W3174860311","https://openalex.org/W4200075391","https://openalex.org/W4386121575","https://openalex.org/W4387523400","https://openalex.org/W4391379781","https://openalex.org/W4399447348","https://openalex.org/W4401450637","https://openalex.org/W4403629186","https://openalex.org/W4403638019","https://openalex.org/W4407353774","https://openalex.org/W4409703555"],"related_works":["https://openalex.org/W4283375319","https://openalex.org/W2005395372","https://openalex.org/W7223294038","https://openalex.org/W2970632109","https://openalex.org/W2727252409","https://openalex.org/W4386024112","https://openalex.org/W2028744406","https://openalex.org/W2210631642","https://openalex.org/W2587870213","https://openalex.org/W3177832559"],"abstract_inverted_index":{"B-cell":[0,10,85],"precursor":[1],"acute":[2],"lymphoblastic":[3],"leukemia":[4],"(BCP-ALL)":[5],"is":[6,27],"characterized":[7],"by":[8,29],"impaired":[9],"maturation":[11,86],"and":[12,31,58,87,95,108,167],"poor":[13],"prognosis":[14],"in":[15,53,93,96,140,181],"relapsed/refractory":[16],"(R/R)":[17],"cases.":[18],"While":[19],"CD20-targeted":[20],"immunotherapies":[21,166],"offer":[22],"clinical":[23,174],"benefit,":[24],"their":[25,173],"efficacy":[26,103],"limited":[28],"low":[30],"heterogeneous":[32],"CD20":[33,57,90,118],"expression":[34,91],"on":[35,84],"BCP-ALL":[36,141,162],"cells.":[37],"In":[38],"this":[39,132,135],"study,":[40],"we":[41,69],"demonstrate":[42],"that":[43],"overexpression":[44],"of":[45,89,104,157],"wild-type":[46],"IKZF1,":[47],"a":[48,65,169],"tumor":[49],"suppressor":[50],"frequently":[51],"mutated":[52],"high-risk":[54,150],"BCP-ALL,":[55],"upregulates":[56],"promotes":[59],"leukemic":[60],"B":[61],"cell":[62],"maturation.":[63],"Using":[64],"transcriptional":[66,80],"mimicry":[67],"approach,":[68],"identified":[70],"mTORC1":[71,98,158],"inhibitors":[72,159],"as":[73,176],"compounds":[74],"showing":[75],"similarity":[76],"to":[77,149,160,164,178],"selected":[78],"IKZF1-induced":[79],"signatures,":[81],"including":[82],"convergence":[83],"induction":[88],"both":[92],"vitro":[94],"vivo.":[97],"inhibition":[99],"enhanced":[100],"the":[101,123,147,155],"antitumor":[102],"anti-CD20":[105,179],"monoclonal":[106],"antibodies":[107],"promoted":[109],"B-lineage":[110],"antigen":[111],"expression,":[112],"while":[113],"downregulating":[114],"immature":[115],"markers.":[116],"Mechanistically,":[117],"upregulation":[119],"was":[120,138],"mediated":[121],"via":[122],"AKT-FOXO1":[124],"axis,":[125],"with":[126,143],"AKT":[127],"phosphorylation":[128],"being":[129],"essential":[130],"for":[131,172],"effect.":[133],"Importantly,":[134],"phenotypic":[136],"shift":[137],"observed":[139],"models":[142],"IKZF1":[144],"deletions,":[145],"highlighting":[146],"relevance":[148],"disease.":[151],"Our":[152],"findings":[153],"support":[154],"use":[156],"sensitize":[161],"cells":[163],"CD20-directed":[165],"provide":[168],"strong":[170],"rationale":[171],"evaluation":[175],"adjuncts":[177],"immunotherapy":[180],"BCP-ALL.":[182]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-20T00:00:00"}
