{"id":"https://openalex.org/W7203784715","doi":"https://doi.org/10.1038/s41416-026-03566-z","title":"Kdm2a histone demethylase ablation restores anti-tumor immunogenicity in liver cancer","display_name":"Kdm2a histone demethylase ablation restores anti-tumor immunogenicity in liver cancer","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203784715","doi":"https://doi.org/10.1038/s41416-026-03566-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42618590","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13740323"},"language":"en","primary_location":{"id":"doi:10.1038/s41416-026-03566-z","doi":"https://doi.org/10.1038/s41416-026-03566-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-026-03566-z","pdf_url":"https://www.nature.com/articles/s41416-026-03566-z.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41416-026-03566-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085916135","display_name":"Laura Gragnani","orcid":"https://orcid.org/0000-0001-6800-9149","observed_orcids":["https://orcid.org/0000-0001-6800-9149"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Laura Gragnani","raw_affiliation_strings":["Department of Translational Research and New Medical and Surgical Technologies, University of Pisa, Pisa, Italy. laura.gragnani@unipi.it"],"raw_orcid":"https://orcid.org/0000-0001-6800-9149","affiliations":[{"raw_affiliation_string":"Department of Translational Research and New Medical and Surgical Technologies, University of Pisa, Pisa, Italy. laura.gragnani@unipi.it","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072176931","display_name":"Matteo Lulli","orcid":"https://orcid.org/0000-0002-8528-4094","observed_orcids":["https://orcid.org/0000-0002-8528-4094"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Matteo Lulli","raw_affiliation_strings":["Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy. matteo.lulli@unifi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy. matteo.lulli@unifi.it","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088654382","display_name":"Patrizio Caini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizio Caini","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036453124","display_name":"Pinuccia Faviana","orcid":"https://orcid.org/0000-0003-4283-1083","observed_orcids":["https://orcid.org/0000-0003-4283-1083"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pinuccia Faviana","raw_affiliation_strings":["Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085890771","display_name":"Rossella Del Frate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rossella Del Frate","raw_affiliation_strings":["Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005428894","display_name":"Enrico Desideri","orcid":"https://orcid.org/0000-0002-1884-7491","observed_orcids":["https://orcid.org/0000-0002-1884-7491"]},"institutions":[{"id":"https://openalex.org/I42775652","display_name":"Link Campus University","ror":"https://ror.org/035mh1293","country_code":"IT","type":"education","lineage":["https://openalex.org/I42775652"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Enrico Desideri","raw_affiliation_strings":["Department of Life Sciences, Health and Health Professions Link Campus University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, Health and Health Professions Link Campus University, Rome, Italy","institution_ids":["https://openalex.org/I42775652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060216121","display_name":"Katia De Ieso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210165410","display_name":"Azienda Ospedaliera Universitaria Pisana","ror":"https://ror.org/05xrcj819","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210165410"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Katia De Ieso","raw_affiliation_strings":["Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy","institution_ids":["https://openalex.org/I4210165410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008056846","display_name":"Francesco Bartoli","orcid":"https://orcid.org/0000-0002-2702-3259","observed_orcids":["https://orcid.org/0000-0002-2702-3259"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Bartoli","raw_affiliation_strings":["Department of Translational Research and New Medical and Surgical Technologies, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Translational Research and New Medical and Surgical Technologies, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025318543","display_name":"Andrew Rennie Hall","orcid":"https://orcid.org/0000-0001-5733-9484","observed_orcids":["https://orcid.org/0000-0001-5733-9484"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Hall","raw_affiliation_strings":["Department of Cellular Pathology, Royal Free Hospital, London, UK","The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pathology, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448"]},{"raw_affiliation_string":"The Sheila Sherlock Liver Centre, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068259376","display_name":"Tu Vinh Luong","orcid":"https://orcid.org/0000-0002-7598-7319","observed_orcids":["https://orcid.org/0000-0002-7598-7319"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tu Vinh Luong","raw_affiliation_strings":["Department of Cellular Pathology, Royal Free Hospital, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Pathology, Royal Free Hospital, London, UK","institution_ids":["https://openalex.org/I2801138448"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031401964","display_name":"Krista Rombouts","orcid":"https://orcid.org/0000-0001-9440-0571","observed_orcids":["https://orcid.org/0000-0001-9440-0571"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Krista Rombouts","raw_affiliation_strings":["University College London (UCL), Institute for Liver & Digestive Health, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-9440-0571","affiliations":[{"raw_affiliation_string":"University College London (UCL), Institute for Liver & Digestive Health, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069403713","display_name":"Vinicio Carloni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vinicio Carloni","raw_affiliation_strings":["Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5072176931","https://openalex.org/A5085916135"],"corresponding_institution_ids":["https://openalex.org/I108290504","https://openalex.org/I45084792"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"135","issue":"10","first_page":"1587","last_page":"1602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5889000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.3068999946117401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kdm2a","display_name":"KDM2A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.8790000081062317},{"id":"https://openalex.org/keywords/h3k36me2","display_name":"H3K36me2","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chromatin-modifiers","display_name":"chromatin modifiers","score":0.75},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.878000020980835},{"id":"https://openalex.org/keywords/redox-imbalance","display_name":"redox imbalance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.8790000081062317},{"id":"https://openalex.org/keywords/immune-exclusion","display_name":"immune exclusion","score":0.6899999976158142},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.7609999775886536},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7106000185012817},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6654999852180481},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5443999767303467},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.49309998750686646},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4781000018119812},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.476500004529953},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.45559999346733093},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.45190000534057617},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4262999892234802},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.42179998755455017},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.41190001368522644},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4074999988079071},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.40720000863075256},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.38199999928474426},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3779999911785126},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.34119999408721924},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3391999900341034},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.30640000104904175},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3052000105381012},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3050000071525574},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26669999957084656},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.25870001316070557},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.25769999623298645},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.25189998745918274}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D044783","descriptor_name":"F-Box Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044783","descriptor_name":"F-Box Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056484","descriptor_name":"Jumonji Domain-Containing Histone Demethylases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056484","descriptor_name":"Jumonji Domain-Containing Histone Demethylases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41416-026-03566-z","doi":"https://doi.org/10.1038/s41416-026-03566-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-026-03566-z","pdf_url":"https://www.nature.com/articles/s41416-026-03566-z.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13740323","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740323/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13740323/pdf/41416_2026_Article_3566.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:42618590","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42618590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1492632","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2158/1492632","pdf_url":"https://flore.unifi.it/bitstream/2158/1492632/1/s41416-026-03566-z-1.pdf","source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:arpi.unipi.it:11568/1375111","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11568/1375111","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41416-026-03566-z","doi":"https://doi.org/10.1038/s41416-026-03566-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41416-026-03566-z","pdf_url":"https://www.nature.com/articles/s41416-026-03566-z.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G621535080","display_name":null,"funder_award_id":"#2017A5TXC3002","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320309727","display_name":"Fondazione Pisa","ror":"https://ror.org/05jhnab13"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322648","display_name":"Universit\u00e0 degli Studi di Firenze","ror":"https://ror.org/04jr1s763"},{"id":"https://openalex.org/F4320331528","display_name":"Ministero dell'Universit\u00e0 e della Ricerca","ror":"https://ror.org/0341vw408"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203784715.pdf","grobid_xml":"https://content.openalex.org/works/W7203784715.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1804157788","https://openalex.org/W1971620413","https://openalex.org/W1985515480","https://openalex.org/W2014696364","https://openalex.org/W2017035524","https://openalex.org/W2026134797","https://openalex.org/W2034291831","https://openalex.org/W2036504531","https://openalex.org/W2038923944","https://openalex.org/W2054643318","https://openalex.org/W2081680109","https://openalex.org/W2082854050","https://openalex.org/W2107060225","https://openalex.org/W2115852450","https://openalex.org/W2132716486","https://openalex.org/W2136964874","https://openalex.org/W2138207763","https://openalex.org/W2141269240","https://openalex.org/W2152239989","https://openalex.org/W2153771353","https://openalex.org/W2200780862","https://openalex.org/W2283284501","https://openalex.org/W2343257250","https://openalex.org/W2519435458","https://openalex.org/W2551905860","https://openalex.org/W2600664554","https://openalex.org/W2624275086","https://openalex.org/W2728594144","https://openalex.org/W2738136165","https://openalex.org/W2756745949","https://openalex.org/W2762602728","https://openalex.org/W2768434280","https://openalex.org/W2788548733","https://openalex.org/W2807322325","https://openalex.org/W2883831719","https://openalex.org/W2886206256","https://openalex.org/W2892170438","https://openalex.org/W2902553069","https://openalex.org/W2914311347","https://openalex.org/W2924985269","https://openalex.org/W2947021796","https://openalex.org/W2999755403","https://openalex.org/W3008955004","https://openalex.org/W3049084893","https://openalex.org/W3049241962","https://openalex.org/W3082160571","https://openalex.org/W3087683890","https://openalex.org/W3105655002","https://openalex.org/W3135937103","https://openalex.org/W3136081418","https://openalex.org/W3159455741","https://openalex.org/W4205956726","https://openalex.org/W4210774372","https://openalex.org/W4225614926","https://openalex.org/W4294216483","https://openalex.org/W4294838953","https://openalex.org/W4315498002","https://openalex.org/W4361296267","https://openalex.org/W4399714354","https://openalex.org/W4403141262","https://openalex.org/W4404186019"],"related_works":["https://openalex.org/W4220764583","https://openalex.org/W3177366873","https://openalex.org/W4396859510","https://openalex.org/W7141603464","https://openalex.org/W3200584539","https://openalex.org/W4413757990","https://openalex.org/W7148906662","https://openalex.org/W4298326356","https://openalex.org/W4400272936","https://openalex.org/W2128779436"],"abstract_inverted_index":{"BACKGROUND:":[0],"Liver":[1],"cancer":[2,34,52],"remains":[3],"a":[4,167,196],"major":[5],"global":[6],"challenge,":[7],"with":[8,137,149],"limited":[9],"benefit":[10],"from":[11],"immune":[12,18,77,113,179],"checkpoint":[13],"inhibitors":[14],"due":[15],"to":[16,75,107,193],"strong":[17],"evasion.":[19],"Emerging":[20],"evidence":[21],"indicates":[22],"that":[23],"chromatin":[24],"modifiers":[25],"shape":[26],"tumor":[27,178,188],"immunogenicity,":[28],"but":[29],"their":[30],"roles":[31],"in":[32,50,56,59,87,181],"liver":[33,51,89,131,182],"immunity":[35],"are":[36],"not":[37],"fully":[38],"understood.":[39],"METHODS:":[40],"We":[41,61],"investigated":[42],"the":[43,46,177],"role":[44],"of":[45,109,144,171],"histone":[47],"demethylase":[48],"KDM2A":[49,96,134,156,164,185],"using":[53],"genetic":[54],"silencing":[55,97],"vitro":[57],"and":[58,69,72,80,91,103,111,126,142,176,190],"vivo.":[60],"evaluated":[62],"mitochondrial":[63,99,172],"function,":[64,173],"redox":[65,101],"balance,":[66],"genomic":[67,174],"stability,":[68,175],"performed":[70],"transcriptomic":[71],"epigenomic":[73],"analyses":[74],"assess":[76],"pathway":[78],"changes":[79],"H3K36me2":[81,118],"distribution.":[82],"Immune":[83],"infiltration":[84],"was":[85],"analyzed":[86],"human":[88,130],"tumors":[90],"syngeneic":[92,154],"mouse":[93],"models.":[94],"RESULTS:":[95],"caused":[98],"dysfunction,":[100],"imbalance,":[102],"DNA":[104],"damage,":[105],"leading":[106],"activation":[108],"innate":[110],"adaptive":[112],"pathways.":[114],"It":[115],"also":[116],"reshaped":[117],"deposition":[119],"at":[120],"loci":[121],"regulating":[122],"chemokine":[123],"signaling,":[124],"metabolism,":[125],"T-cell":[127,161],"recruitment.":[128],"In":[129,153],"tumors,":[132],"high":[133],"expression":[135],"correlated":[136],"poor":[138],"differentiation,":[139],"macrophage":[140],"enrichment,":[141],"exclusion":[143],"CD8\u207a":[145,160],"T":[146],"cells,":[147],"consistent":[148],"an":[150],"immune-excluded":[151],"phenotype.":[152],"models,":[155],"loss":[157],"increased":[158],"intratumoral":[159],"infiltration.":[162],"CONCLUSIONS:":[163],"acts":[165],"as":[166],"key":[168],"epigenetic":[169],"regulator":[170],"microenvironment":[180],"cancer.":[183],"Targeting":[184],"may":[186],"enhance":[187],"immunogenicity":[189],"improve":[191],"responses":[192],"immunotherapy,":[194],"representing":[195],"promising":[197],"therapeutic":[198],"strategy.":[199]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-20T00:00:00"}
