{"id":"https://openalex.org/W7203783251","doi":"https://doi.org/10.1016/j.ajpath.2026.07.010","title":"Mitochondrial Reactive Oxygen Species\u2013Induced Metabolic Alterations Differentially Regulate Ferroptosis Vulnerability of Hepatocytes","display_name":"Mitochondrial Reactive Oxygen Species\u2013Induced Metabolic Alterations Differentially Regulate Ferroptosis Vulnerability of Hepatocytes","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203783251","doi":"https://doi.org/10.1016/j.ajpath.2026.07.010","pmid":"https://pubmed.ncbi.nlm.nih.gov/41509413","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12776056"},"language":"en","primary_location":{"id":"doi:10.1016/j.ajpath.2026.07.010","doi":"https://doi.org/10.1016/j.ajpath.2026.07.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2026.07.010","pdf_url":null,"source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ajpath.2026.07.010","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059829833","display_name":"Somesh Banerjee","orcid":"https://orcid.org/0000-0003-1066-6079","observed_orcids":["https://orcid.org/0000-0003-1066-6079"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Somesh Banerjee","raw_affiliation_strings":["Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0003-1066-6079","affiliations":[{"raw_affiliation_string":"Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147459609","display_name":"Jaehyun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaehyun Kim","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065424304","display_name":"Matthew Ryan Smith","orcid":"https://orcid.org/0000-0002-8889-3477","observed_orcids":["https://orcid.org/0000-0002-8889-3477"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210149289","display_name":"Atlanta VA Health Care System","ror":"https://ror.org/041t78y98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Smith","raw_affiliation_strings":["Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, Georgia; Atlanta Veterans Affairs Healthcare System, Decatur, Georgia"],"raw_orcid":"https://orcid.org/0000-0002-8889-3477","affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University, Atlanta, Georgia; Atlanta Veterans Affairs Healthcare System, Decatur, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210149289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121086639","display_name":"Yining Irene Wang","orcid":"https://orcid.org/0009-0003-4190-7952","observed_orcids":["https://orcid.org/0009-0003-4190-7952"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yining I. Wang","raw_affiliation_strings":["Emory College of Arts and Sciences, Emory University, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0009-0003-4190-7952","affiliations":[{"raw_affiliation_string":"Emory College of Arts and Sciences, Emory University, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121102251","display_name":"Michael Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108920","display_name":"Shawnee Mission Northwest High School","ror":"https://ror.org/01v3kn215","country_code":"US","type":"education","lineage":["https://openalex.org/I4210108920"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Wang","raw_affiliation_strings":["North Gwinnett High School, Suwanee, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"North Gwinnett High School, Suwanee, Georgia","institution_ids":["https://openalex.org/I4210108920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099980653","display_name":"Derrik Gratz","orcid":"https://orcid.org/0009-0002-5934-576X","observed_orcids":["https://orcid.org/0009-0002-5934-576X"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derrik Gratz","raw_affiliation_strings":["Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, Washington"],"raw_orcid":"https://orcid.org/0009-0002-5934-576X","affiliations":[{"raw_affiliation_string":"Immunotherapy Integrated Research Center, Fred Hutchinson Cancer Center, Seattle, Washington","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009550935","display_name":"Gregory K. Tharp","orcid":"https://orcid.org/0000-0003-3075-755X","observed_orcids":["https://orcid.org/0000-0003-3075-755X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4392738091","display_name":"Emory National Primate Research Center","ror":"https://ror.org/038kr2d80","country_code":"US","type":"facility","lineage":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory K. Tharp","raw_affiliation_strings":["Emory National Primate Research Center Genomics Core, Emory University, Atlanta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory National Primate Research Center Genomics Core, Emory University, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4392738091"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022690335","display_name":"Sumin Kang","orcid":"https://orcid.org/0000-0001-5111-0232","observed_orcids":["https://orcid.org/0000-0001-5111-0232"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumin Kang","raw_affiliation_strings":["Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia"],"raw_orcid":"https://orcid.org/0000-0001-5111-0232","affiliations":[{"raw_affiliation_string":"Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003993556","display_name":"Peijian He","orcid":"https://orcid.org/0000-0002-9526-8004","observed_orcids":["https://orcid.org/0000-0002-9526-8004"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peijian He","raw_affiliation_strings":["Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia. Electronic address: phe@gsu.edu"],"raw_orcid":"https://orcid.org/0000-0002-9526-8004","affiliations":[{"raw_affiliation_string":"Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia. Electronic address: phe@gsu.edu","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I181565077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5003993556"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I181565077"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6006548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"196","issue":"11","first_page":"2355","last_page":"2372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8740000128746033},{"id":"https://openalex.org/keywords/coenzyme-q10-biosynthesis","display_name":"coenzyme Q10 biosynthesis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.984000027179718},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.9440000057220459},{"id":"https://openalex.org/keywords/farnesoid-x-receptor","display_name":"farnesoid X receptor","score":0.9559999704360962},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"retinoid X receptor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.6970000267028809},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.800599992275238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7041000127792358},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.6538000106811523},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6100999712944031},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6047000288963318},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5598000288009644},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4399999976158142},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.436599999666214},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.3882000148296356},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3878999948501587},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.35519999265670776},{"id":"https://openalex.org/C165135838","wikidata":"https://www.wikidata.org/wiki/Q133895","display_name":"Citric acid cycle","level":3,"score":0.34369999170303345},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.32359999418258667},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30970001220703125},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2797999978065491},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2791000008583069},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.27230000495910645},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.26969999074935913},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ajpath.2026.07.010","doi":"https://doi.org/10.1016/j.ajpath.2026.07.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2026.07.010","pdf_url":null,"source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},{"id":"doi:10.64898/2025.12.21.695848","doi":"https://doi.org/10.64898/2025.12.21.695848","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2025.12.21.695848","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41509413","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41509413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42617800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42617800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12776056","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12776056/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.ajpath.2026.07.010","doi":"https://doi.org/10.1016/j.ajpath.2026.07.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ajpath.2026.07.010","pdf_url":null,"source":{"id":"https://openalex.org/S145577119","display_name":"American Journal Of Pathology","issn_l":"0002-9440","issn":["0002-9440","1525-2191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2749731564","display_name":null,"funder_award_id":"5IK2BX005913","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8058136223","display_name":"Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory University","funder_award_id":"1s10od026799-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000862239","display_name":"Decoding and targeting saccharopine pathway in cancer metastasis","funder_award_id":"R01CA266613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000874029","display_name":"Dissecting and Targeting MAST1 Signaling in chemoresistant Cancers","funder_award_id":"R01CA287782","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904859","display_name":"Role of frataxin in liver injury","funder_award_id":"R01DK140441","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000905479","display_name":"Mechanistic insights into the crosstalk between iron metabolism and diabetes","funder_award_id":"R01DK125647","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000906557","display_name":"Emory National Primate Research Center","funder_award_id":"P51OD011132","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W1503760388","https://openalex.org/W1530092824","https://openalex.org/W1589007430","https://openalex.org/W1944496442","https://openalex.org/W1969296748","https://openalex.org/W1972998779","https://openalex.org/W1973122898","https://openalex.org/W1983053647","https://openalex.org/W1985431145","https://openalex.org/W1992053460","https://openalex.org/W1997183854","https://openalex.org/W2001565942","https://openalex.org/W2005558408","https://openalex.org/W2010802040","https://openalex.org/W2011574523","https://openalex.org/W2017275974","https://openalex.org/W2035327550","https://openalex.org/W2050605495","https://openalex.org/W2052356187","https://openalex.org/W2054687549","https://openalex.org/W2072822958","https://openalex.org/W2088038616","https://openalex.org/W2088417711","https://openalex.org/W2089779289","https://openalex.org/W2115248104","https://openalex.org/W2116011443","https://openalex.org/W2119080788","https://openalex.org/W2123082386","https://openalex.org/W2137506791","https://openalex.org/W2143881989","https://openalex.org/W2146544786","https://openalex.org/W2237575183","https://openalex.org/W2239083587","https://openalex.org/W2273624704","https://openalex.org/W2300320800","https://openalex.org/W2345350059","https://openalex.org/W2503158277","https://openalex.org/W2518959324","https://openalex.org/W2525119183","https://openalex.org/W2543821606","https://openalex.org/W2549188196","https://openalex.org/W2553902009","https://openalex.org/W2618666860","https://openalex.org/W2622164463","https://openalex.org/W2624770669","https://openalex.org/W2754373993","https://openalex.org/W2775842190","https://openalex.org/W2782636372","https://openalex.org/W2792926837","https://openalex.org/W2802176353","https://openalex.org/W2883979293","https://openalex.org/W2884486379","https://openalex.org/W2906319220","https://openalex.org/W2913137771","https://openalex.org/W2922778385","https://openalex.org/W2952112680","https://openalex.org/W2980472864","https://openalex.org/W2981179816","https://openalex.org/W2997191693","https://openalex.org/W2997406734","https://openalex.org/W3005253578","https://openalex.org/W3008188366","https://openalex.org/W3013065729","https://openalex.org/W3027578465","https://openalex.org/W3034112560","https://openalex.org/W3044383543","https://openalex.org/W3131823095","https://openalex.org/W3153494025","https://openalex.org/W3162306949","https://openalex.org/W3179416847","https://openalex.org/W4211242412","https://openalex.org/W4252021281","https://openalex.org/W4282830875","https://openalex.org/W4283738313","https://openalex.org/W4285405623","https://openalex.org/W4285821353","https://openalex.org/W4303645586","https://openalex.org/W4323312905","https://openalex.org/W4360752272","https://openalex.org/W4366085904","https://openalex.org/W4376275349","https://openalex.org/W4383999429","https://openalex.org/W4386099975","https://openalex.org/W4386166450","https://openalex.org/W4386813045","https://openalex.org/W4388033469","https://openalex.org/W4389509461","https://openalex.org/W4396980187","https://openalex.org/W4399871284","https://openalex.org/W4401543386","https://openalex.org/W4403475258","https://openalex.org/W4405982876","https://openalex.org/W4412844748","https://openalex.org/W4414780226","https://openalex.org/W4415655430"],"related_works":["https://openalex.org/W7116946799","https://openalex.org/W7167641586","https://openalex.org/W4385709258","https://openalex.org/W7131799399","https://openalex.org/W4303645586","https://openalex.org/W4402451740","https://openalex.org/W4400453439","https://openalex.org/W4386714875","https://openalex.org/W4206812710","https://openalex.org/W4413107412"],"abstract_inverted_index":{"Ferroptosis":[0],"is":[1,149],"an":[2],"iron-catalyzed":[3],"lipid":[4,79],"peroxidation-dependent":[5],"cell":[6],"death":[7,175],"that":[8,144,163],"mediates":[9],"the":[10,32,37,46,60,113,122,139],"development":[11],"of":[12,25,34,48,59,121,133,138,147,167],"many":[13],"diseases,":[14],"including":[15,68,110],"liver":[16],"injury.":[17],"Compelling":[18],"evidence":[19],"has":[20],"suggested":[21],"a":[22,118],"crucial":[23],"role":[24],"mitochondrial":[26],"reactive":[27],"oxygen":[28],"species":[29],"(mtROS)":[30],"in":[31,75,102,112,176],"induction":[33],"ferroptosis,":[35],"but":[36],"underlying":[38],"mechanism":[39],"remains":[40],"poorly":[41],"defined.":[42],"In":[43,95],"this":[44],"study,":[45],"impact":[47],"mtROS-driven":[49],"signaling":[50,98],"on":[51,151],"cellular":[52],"metabolism,":[53],"oxidation-reduction":[54],"state,":[55],"and":[56,71,78,86,105,116,155,169],"ferroptosis":[57,136],"vulnerability":[58],"hepatocytes":[61,92],"was":[62],"investigated":[63],"by":[64],"using":[65],"mtROS":[66,76,164],"inducers,":[67],"iron":[69],"overload":[70],"pharmacologic":[72],"inducers.":[73],"Elevations":[74],"production":[77],"peroxidation":[80],"suppressed":[81],"glycolysis,":[82],"fatty":[83],"acid":[84,88],"oxidation,":[85],"tricarboxylic":[87],"cycle":[89],"activity,":[90],"protecting":[91],"from":[93],"ferroptosis.":[94],"contrast,":[96],"mtROS-induced":[97],"down-regulated":[99],"genes":[100],"involved":[101],"glutathione":[103,168],"biosynthesis,":[104,109,171],"coenzyme":[106],"Q10":[107],"(CoQ)":[108],"those":[111],"mevalonate":[114],"pathway,":[115],"CoQ8A,":[117],"key":[119],"stabilizer":[120],"CoQ":[123,170],"biosynthetic":[124],"complex.":[125],"Importantly,":[126],"silencing":[127],"CoQ8A":[128,134,148],"expression":[129],"enhanced,":[130],"whereas":[131],"overexpression":[132],"reduced,":[135],"susceptibility":[137],"hepatocytes.":[140,177],"Further":[141],"analysis":[142],"showed":[143],"mtROS-mediated":[145],"down-regulation":[146,166],"dependent":[150],"farnesoid":[152],"X":[153,157],"receptor":[154],"retinoid":[156],"receptor.":[158],"Collectively,":[159],"these":[160],"findings":[161],"suggest":[162],"induces":[165],"thereby":[172],"promoting":[173],"ferroptotic":[174]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-20T00:00:00"}
