{"id":"https://openalex.org/W7203761739","doi":"https://doi.org/10.64898/2026.08.14.744963","title":"Mitochondrial stress signaling shapes the nuclear response to loss of the chromatin reader MRG-1","display_name":"Mitochondrial stress signaling shapes the nuclear response to loss of the chromatin reader MRG-1","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203761739","doi":"https://doi.org/10.64898/2026.08.14.744963"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.14.744963","doi":"https://doi.org/10.64898/2026.08.14.744963","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.744963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.14.744963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.14.744963.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106909237","display_name":"Carole Zaratiegui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4405265670","display_name":"Institute of Functional Epigenetics","ror":"https://ror.org/05ekkb842","country_code":"DE","type":"education","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4405265670"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carole Zaratiegui","raw_affiliation_strings":["Institute of Functional Epigenetics, Helmholtz Munich, Oberschlei\u00dfheim, Germany","LMU Faculty of Medicine, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Epigenetics, Helmholtz Munich, Oberschlei\u00dfheim, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405265670"]},{"raw_affiliation_string":"LMU Faculty of Medicine, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006250302","display_name":"Fernanda Rezende Pabst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4405265670","display_name":"Institute of Functional Epigenetics","ror":"https://ror.org/05ekkb842","country_code":"DE","type":"education","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4405265670"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fernanda Rezende Pabst","raw_affiliation_strings":["Institute of Functional Epigenetics, Helmholtz Munich, Oberschlei\u00dfheim, Germany","LMU Faculty of Medicine, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Epigenetics, Helmholtz Munich, Oberschlei\u00dfheim, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405265670"]},{"raw_affiliation_string":"LMU Faculty of Medicine, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159654410","display_name":"Maria-Jesus Rodriguez Palero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210111405","display_name":"Centro Andaluz de Biolog\u00eda del Desarrollo","ror":"https://ror.org/01v5e3436","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I918821925","https://openalex.org/I95013407"]},{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria-Jesus Rodriguez Palero","raw_affiliation_strings":["Andalusian Centre for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andalusian Centre for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Seville, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I95013407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027155102","display_name":"Peter Meister","orcid":"https://orcid.org/0000-0002-6230-4216","observed_orcids":["https://orcid.org/0000-0002-6230-4216"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Meister","raw_affiliation_strings":["Institute of Cell Biology, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biology, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016951873","display_name":"Marta Artal\u2010Sanz","orcid":"https://orcid.org/0000-0003-1126-0492","observed_orcids":["https://orcid.org/0000-0003-1126-0492"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210111405","display_name":"Centro Andaluz de Biolog\u00eda del Desarrollo","ror":"https://ror.org/01v5e3436","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I918821925","https://openalex.org/I95013407"]},{"id":"https://openalex.org/I95013407","display_name":"Universidad Pablo de Olavide","ror":"https://ror.org/02z749649","country_code":"ES","type":"education","lineage":["https://openalex.org/I95013407"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Artal-Sanz","raw_affiliation_strings":["Andalusian Centre for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Seville, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andalusian Centre for Developmental Biology, Consejo Superior de Investigaciones Cient\u00edficas/Junta de Andaluc\u00eda/Universidad Pablo de Olavide, Seville, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210111405","https://openalex.org/I95013407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011033719","display_name":"Daphne S. Cabianca","orcid":"https://orcid.org/0000-0002-1834-7868","observed_orcids":["https://orcid.org/0000-0002-1834-7868"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4405265670","display_name":"Institute of Functional Epigenetics","ror":"https://ror.org/05ekkb842","country_code":"DE","type":"education","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672","https://openalex.org/I4405265670"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Daphne S. Cabianca","raw_affiliation_strings":["Institute of Functional Epigenetics, Helmholtz Munich, Oberschlei\u00dfheim, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1834-7868","affiliations":[{"raw_affiliation_string":"Institute of Functional Epigenetics, Helmholtz Munich, Oberschlei\u00dfheim, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405265670"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5011033719"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4405265670"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.37299999594688416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin-reader","display_name":"chromatin reader","score":0.6539999842643738},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.7279999852180481},{"id":"https://openalex.org/keywords/mitochondrial-stress-response","display_name":"mitochondrial stress response","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.7310000061988831},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.6859999895095825},{"id":"https://openalex.org/keywords/fertility-defects","display_name":"fertility defects","score":0.6460000276565552},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.9909999966621399},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.8808000087738037},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.6876000165939331},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6870999932289124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.675599992275238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6398000121116638},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5597000122070312},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.47609999775886536},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.460099995136261},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.45159998536109924},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.4449000060558319},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.4431999921798706},{"id":"https://openalex.org/C92149661","wikidata":"https://www.wikidata.org/wiki/Q1616164","display_name":"Heterochromatin protein 1","level":5,"score":0.43869999051094055},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.4311000108718872},{"id":"https://openalex.org/C20750100","wikidata":"https://www.wikidata.org/wiki/Q7068120","display_name":"Nuclear gene","level":4,"score":0.4296000003814697},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3921999931335449},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3224000036716461},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3206999897956848},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.3174999952316284},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.2718999981880188},{"id":"https://openalex.org/C49805395","wikidata":"https://www.wikidata.org/wiki/Q910966","display_name":"Nuclear localization sequence","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2517000138759613}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.14.744963","doi":"https://doi.org/10.64898/2026.08.14.744963","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.744963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.14.744963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.14.744963","doi":"https://doi.org/10.64898/2026.08.14.744963","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.744963","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.14.744963.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1105034524","display_name":"Untersuchung der Funktion des epigenetischen Leserproteins MRG1 in der r\u00e4umlichen Organisation des C. elegans Genoms","funder_award_id":"459488476","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4212894969","display_name":null,"funder_award_id":"PID2022","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G8294187182","display_name":"Entschl\u00fcsselung der Funktion der r\u00e4umlichen Organisation des Heterochromatins bei der Reaktion auf Umwelteinfl\u00fcsse in der fr\u00fchen Lebensphase in C. elegans","funder_award_id":"507935196","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8799960063","display_name":null,"funder_award_id":"P40 OD010440","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000896783","display_name":"Center for C elegans Anatomy","funder_award_id":"R24OD010943","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203761739.pdf","grobid_xml":"https://content.openalex.org/works/W7203761739.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W125846565","https://openalex.org/W1834348670","https://openalex.org/W1974508933","https://openalex.org/W1974522038","https://openalex.org/W1978992677","https://openalex.org/W2007389227","https://openalex.org/W2007986629","https://openalex.org/W2019881443","https://openalex.org/W2023186182","https://openalex.org/W2033160626","https://openalex.org/W2038324706","https://openalex.org/W2085110456","https://openalex.org/W2109791816","https://openalex.org/W2112124900","https://openalex.org/W2116971159","https://openalex.org/W2137173138","https://openalex.org/W2137579141","https://openalex.org/W2138207763","https://openalex.org/W2174420796","https://openalex.org/W2179438025","https://openalex.org/W2289805503","https://openalex.org/W2343051572","https://openalex.org/W2411027615","https://openalex.org/W2432815617","https://openalex.org/W2468541103","https://openalex.org/W2509871258","https://openalex.org/W2810003284","https://openalex.org/W2945027978","https://openalex.org/W2979783981","https://openalex.org/W3010196267","https://openalex.org/W3023887154","https://openalex.org/W3088521497","https://openalex.org/W3189871007","https://openalex.org/W3204699892","https://openalex.org/W4212763753","https://openalex.org/W4292245687","https://openalex.org/W4301130615","https://openalex.org/W4367553228","https://openalex.org/W4367839625","https://openalex.org/W4384819932","https://openalex.org/W4393950665","https://openalex.org/W4394997356","https://openalex.org/W4407199584","https://openalex.org/W4412552460","https://openalex.org/W4413309199","https://openalex.org/W6940210958","https://openalex.org/W7131246240"],"related_works":["https://openalex.org/W2945027978","https://openalex.org/W2768074069","https://openalex.org/W6944770972","https://openalex.org/W4295425529","https://openalex.org/W828612247","https://openalex.org/W4400847523","https://openalex.org/W7167351799","https://openalex.org/W2932458550","https://openalex.org/W7165794289","https://openalex.org/W7039470627"],"abstract_inverted_index":{"Abstract":[0],"Perinuclear":[1],"sequestration":[2],"of":[3,10,28,43,52,67,78,88,104,141],"heterochromatin":[4,29,124],"is":[5],"a":[6,46,68,121],"major":[7],"conserved":[8],"feature":[9],"nuclear":[11,73,106,143,167],"architecture.":[12],"In":[13],"Caenorhabditis":[14],"elegans":[15],",":[16],"the":[17,53,72,79,105,142,156],"euchromatic":[18],"reader":[19],"MRG-1":[20,44,110,146],"was":[21],"previously":[22,128],"shown":[23],"to":[24,64,113,115,145,151],"promote":[25],"peripheral":[26],"localization":[27],"through":[30],"an":[31,138],"indirect":[32],"mechanism":[33],"that":[34,41,60,102,158],"remained":[35],"largely":[36],"unknown.":[37],"Here,":[38],"we":[39],"show":[40],"loss":[42,87,111],"activates":[45],"mitochondrial":[47,55,94,116,134],"stress":[48,56,117,135],"response.":[49],"Genetic":[50],"ablation":[51],"PMK-3/MAPK":[54],"regulator":[57],"CBP-3":[58],"reveals":[59],"this":[61],"pathway":[62],"contributes":[63,112],"both":[65],"detachment":[66],"heterochromatic":[69],"reporter":[70],"from":[71],"periphery":[74],"and":[75,98],"approximately":[76],"one-third":[77],"transcriptional":[80],"changes":[81,160],"induced":[82,108],"by":[83,109],"mrg-1":[84],"depletion.":[85],"Strikingly,":[86],"cbp-3":[89],"in":[90,123,161],"MRG-1-deficient":[91],"animals":[92],"exacerbates":[93],"dysfunction,":[95],"fertility":[96],"defects":[97],"embryonic":[99],"lethality,":[100],"indicating":[101],"part":[103],"response":[107,144],"adaptation":[114],"rather":[118],"than":[119],"constituting":[120],"defect":[122],"3D":[125],"organization":[126],"as":[127,137],"thought.":[129],"Together,":[130],"our":[131],"findings":[132],"identify":[133],"signaling":[136],"unexpected":[139],"mediator":[140],"loss,":[147],"demonstrating":[148],"its":[149],"contribution":[150],"gene":[152],"regulation":[153],"while":[154],"supporting":[155],"idea":[157],"stress-induced":[159],"cellular":[162],"physiology":[163],"can":[164],"also":[165],"shape":[166],"organization.":[168]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-20T00:00:00"}