{"id":"https://openalex.org/W7203748969","doi":"https://doi.org/10.64898/2026.08.18.745407","title":"MiRNA let-7a-5p Ameliorates Pulmonary Fibrosis by Suppressing TGFBR1-Mediated Endothelial-to-Mesenchymal Transition","display_name":"MiRNA let-7a-5p Ameliorates Pulmonary Fibrosis by Suppressing TGFBR1-Mediated Endothelial-to-Mesenchymal Transition","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203748969","doi":"https://doi.org/10.64898/2026.08.18.745407"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.18.745407","doi":"https://doi.org/10.64898/2026.08.18.745407","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745407","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.18.745407.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.18.745407.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073772754","display_name":"Juan Pang","orcid":"https://orcid.org/0000-0001-6272-9890","observed_orcids":["https://orcid.org/0000-0001-6272-9890"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Pang","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159338949","display_name":"Jiarui Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiarui Shen","raw_affiliation_strings":["Department of Cardiology, Affilliated Hospital of Yangzhou University, Yangzhou University, Institute of Cardiovascular Disease, Yangzhou 225001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Affilliated Hospital of Yangzhou University, Yangzhou University, Institute of Cardiovascular Disease, Yangzhou 225001, China","institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159851860","display_name":"Wei Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Yang","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124284314","display_name":"Zhihui Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhihui Wu","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100541384","display_name":"Xing Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Gu","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147637943","display_name":"Yuhang Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhang Xia","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707148","display_name":"Ruixuan Wang","orcid":"https://orcid.org/0000-0002-6238-6987","observed_orcids":["https://orcid.org/0000-0002-6238-6987"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruixuan Wang","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147560357","display_name":"Longzhi Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longzhi Wang","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128853357","display_name":"Yujie Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Cao","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100778635","display_name":"Jianying Li","orcid":"https://orcid.org/0000-0002-9825-672X","observed_orcids":["https://orcid.org/0000-0002-9825-672X"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianying Li","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123760128","display_name":"Hui Shen","orcid":"https://orcid.org/0000-0001-6231-5671","observed_orcids":["https://orcid.org/0000-0001-6231-5671"]},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]},{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Shen","raw_affiliation_strings":["Department of Cardiology, Affilliated Hospital of Yangzhou University, Yangzhou University, Institute of Cardiovascular Disease, Yangzhou 225001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Affilliated Hospital of Yangzhou University, Yangzhou University, Institute of Cardiovascular Disease, Yangzhou 225001, China","institution_ids":["https://openalex.org/I4210137355","https://openalex.org/I78978612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002269332","display_name":"Fenqing Shang","orcid":"https://orcid.org/0000-0002-8973-7118","observed_orcids":["https://orcid.org/0000-0002-8973-7118"]},"institutions":[{"id":"https://openalex.org/I37802460","display_name":"Northwest University","ror":"https://ror.org/00z3td547","country_code":"CN","type":"education","lineage":["https://openalex.org/I37802460"]},{"id":"https://openalex.org/I4210162379","display_name":"Xi'an Chest Hospital","ror":"https://ror.org/052f2mx26","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162379"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fenqing Shang","raw_affiliation_strings":["Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China"],"raw_orcid":"https://orcid.org/0000-0002-8973-7118","affiliations":[{"raw_affiliation_string":"Xi\u2019an Chest Hospital, Northwest University Affiliated Thoracic Hospital, Xi\u2019an 710100, China","institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002269332"],"corresponding_institution_ids":["https://openalex.org/I37802460","https://openalex.org/I4210162379"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/let-7a-5p","display_name":"let-7a-5p","score":0.968999981880188},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8069999814033508},{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.652999997138977},{"id":"https://openalex.org/keywords/endothelial-mesenchymal-transition","display_name":"endothelial-to-mesenchymal transition","score":0.9800000190734863},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta-receptor-1","display_name":"TGFBR1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tgf-beta-smad-signaling-pathway","display_name":"TGF-\u03b2/Smad signaling","score":0.9570000171661377},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9150000214576721},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/bleomycin-induced-fibrosis","display_name":"bleomycin-induced fibrosis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.6632000207901001},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6496999859809875},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6463000178337097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6456999778747559},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.590499997138977},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5681999921798706},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5612000226974487},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.519599974155426},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4950999915599823},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.46129998564720154},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42410001158714294},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4156999886035919},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4156999886035919},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4043000042438507},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38449999690055847},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.3749000132083893},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.33980000019073486},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33079999685287476},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3131999969482422},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.18.745407","doi":"https://doi.org/10.64898/2026.08.18.745407","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745407","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.18.745407.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.18.745407","doi":"https://doi.org/10.64898/2026.08.18.745407","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.18.745407","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/19/2026.08.18.745407.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1250325628","display_name":null,"funder_award_id":"82370406","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321392","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86"},{"id":"https://openalex.org/F4320322439","display_name":"Northwest University","ror":"https://ror.org/00z3td547"},{"id":"https://openalex.org/F4320324173","display_name":"Natural Science Foundation of Shaanxi Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203748969.pdf","grobid_xml":"https://content.openalex.org/works/W7203748969.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W2292869933","https://openalex.org/W3041062936","https://openalex.org/W3047507938","https://openalex.org/W3163857320","https://openalex.org/W3174066365","https://openalex.org/W3178196812","https://openalex.org/W3210943973","https://openalex.org/W3217209062","https://openalex.org/W4207046220","https://openalex.org/W4210892134","https://openalex.org/W4220657654","https://openalex.org/W4220800092","https://openalex.org/W4281395591","https://openalex.org/W4282938976","https://openalex.org/W4282971572","https://openalex.org/W4283758424","https://openalex.org/W4296691801","https://openalex.org/W4308330879","https://openalex.org/W4367669697","https://openalex.org/W4376612004","https://openalex.org/W4378515787","https://openalex.org/W4386475798","https://openalex.org/W4387117408","https://openalex.org/W4390127577","https://openalex.org/W4390769107","https://openalex.org/W4392964067","https://openalex.org/W4393973991","https://openalex.org/W4396746787","https://openalex.org/W4399666550","https://openalex.org/W4400513318","https://openalex.org/W4404645831","https://openalex.org/W4406015725","https://openalex.org/W4408190140","https://openalex.org/W4409397948","https://openalex.org/W4409676553","https://openalex.org/W4409866341","https://openalex.org/W4410252753","https://openalex.org/W4410777540","https://openalex.org/W4411952798","https://openalex.org/W4411990257","https://openalex.org/W4412455085","https://openalex.org/W4414073397","https://openalex.org/W4415269571","https://openalex.org/W4417231182","https://openalex.org/W7131813024"],"related_works":["https://openalex.org/W7214194520","https://openalex.org/W2996019954","https://openalex.org/W4399218199","https://openalex.org/W4378640335","https://openalex.org/W2990510643","https://openalex.org/W4415618616","https://openalex.org/W4403560312","https://openalex.org/W7171691795","https://openalex.org/W4391836311","https://openalex.org/W4413341364"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Idiopathic":[2],"Pulmonary":[3],"Fibrosis":[4],"(IPF)":[5],"is":[6,28],"a":[7,31,128],"fatal":[8],"chronic":[9],"lung":[10,117,213],"disease":[11,239],"with":[12,98,116,132,162,238],"limited":[13],"therapeutic":[14],"options.":[15],"While":[16],"alveolar":[17],"epithelial":[18,118],"injury":[19],"and":[20,69,83,111,146,184,190,198,215],"fibroblast":[21],"activation":[22],"are":[23],"well-studied,":[24],"endothelial-mesenchymal":[25],"transition":[26,201],"(EndoMT)":[27],"emerging":[29],"as":[30],"critical":[32],"pathogenic":[33],"mechanism.":[34],"The":[35],"regulatory":[36],"role":[37],"of":[38,60,66,177],"exosomal":[39,50,75,221],"miRNAs":[40,76],"in":[41,54,155,234],"pulmonary":[42,61,92,147,224],"fibrosis":[43,225],"remains":[44],"unclear.":[45],"This":[46],"study":[47],"investigates":[48],"serum":[49,156],"miRNAs,":[51],"particularly":[52],"let-7a-5p,":[53],"modulating":[55],"EndoMT":[56,197],"during":[57],"the":[58,107,169],"onset":[59],"fibrosis.":[62],"Methods":[63],"Clinical":[64],"cohorts":[65],"IPF":[67,159,235],"patients":[68,236],"healthy":[70],"controls":[71],"were":[72,77,114],"enrolled.":[73],"Serum":[74,220],"profiled,":[78],"followed":[79],"by":[80,226],"differential":[81],"expression":[82],"functional":[84],"enrichment":[85],"analyses.":[86],"In":[87,124],"vitro":[88],"experiments":[89],"involved":[90],"human":[91],"artery":[93],"endothelial":[94],"cells":[95,119],"(HPAECs)":[96],"transfected":[97],"let-7a-5p":[99,110,133,166,178,193,222],"mimic":[100,194],"or":[101],"inhibitor.":[102],"Dual-luciferase":[103],"reporter":[104],"assays":[105],"confirmed":[106],"binding":[108],"between":[109],"TGFBR1.":[112],"HPAECs":[113],"co-cultured":[115],"to":[120,172,229],"examine":[121],"paracrine":[122,204],"signaling.":[123,205,218],"vivo":[125],"studies":[126],"used":[127],"bleomycin-induced":[129,196],"mouse":[130],"model":[131],"agomir":[134,208],"administration.":[135],"Assessments":[136],"included":[137],"histopathological":[138],"staining,":[139],"hydroxyproline":[140],"content,":[141],"Western":[142],"blot,":[143],"qPCR,":[144],"micro-CT,":[145],"function":[148],"tests.":[149],"Results":[150],"Let-7a-5p":[151],"was":[152],"significantly":[153],"downregulated":[154],"exosomes":[157],"from":[158],"patients,":[160],"correlating":[161],"clinical":[163],"indicators.":[164],"Mechanistically,":[165],"directly":[167],"bound":[168],"TGFBR1":[170,228],"3\u2032UTR":[171],"inhibit":[173,230],"its":[174,242],"expression.":[175],"Inhibition":[176],"upregulated":[179],"\u03b1-SMA,":[180],"FN1,":[181],"smad2/3":[182],"phosphorylation,":[183],"collagen":[185],"I,":[186],"while":[187],"downregulating":[188],"CD31":[189],"VE-cadherin.":[191],"Therapeutically,":[192],"reversed":[195],"suppressed":[199,216],"epithelial-mesenchymal":[200],"(EMT)":[202],"via":[203],"Mice":[206],"administered":[207],"showed":[209],"reduced":[210],"fibrosis,":[211],"improved":[212],"function,":[214],"TGF-\u03b2/Smad":[217],"Conclusion":[219],"suppresses":[223],"targeting":[227],"EndoMT.":[231],"Its":[232],"downregulation":[233],"correlates":[237],"progression,":[240],"highlighting":[241],"biomarker":[243],"potential.":[244]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-20T00:00:00"}
