{"id":"https://openalex.org/W7203748561","doi":"https://doi.org/10.1016/j.spinee.2026.06.171","title":"152. Efficacy of fibroblast spheroid-derived chondrocyte spheroids in a rabbit model of degenerative disc disease","display_name":"152. Efficacy of fibroblast spheroid-derived chondrocyte spheroids in a rabbit model of degenerative disc disease","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203748561","doi":"https://doi.org/10.1016/j.spinee.2026.06.171"},"language":"en","primary_location":{"id":"doi:10.1016/j.spinee.2026.06.171","doi":"https://doi.org/10.1016/j.spinee.2026.06.171","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.spinee.2026.06.171","pdf_url":null,"source":{"id":"https://openalex.org/S112180307","display_name":"The Spine Journal","issn_l":"1529-9430","issn":["1529-9430","1878-1632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Spine Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030538847","display_name":"Nikolay Bazhanov","orcid":"https://orcid.org/0000-0002-0504-0584","observed_orcids":["https://orcid.org/0000-0002-0504-0584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikolay Bazhanov","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147531688","display_name":"Phillip Baker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip Baker","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147641744","display_name":"Ashley Heard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashley Heard","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016387174","display_name":"Midori Taruishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Midori Taruishi","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064461704","display_name":"Simon Gebremeskel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Gebremeskel","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102801244","display_name":"Chuo Fang","orcid":"https://orcid.org/0000-0002-2473-0951","observed_orcids":["https://orcid.org/0000-0002-2473-0951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chuo Fang","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020741434","display_name":"Christen J. Boyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christen Boyer","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119023652","display_name":"Inah Bianca Embile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Inah Bianca Embile","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026685645","display_name":"Jinsam Chang","orcid":"https://orcid.org/0000-0002-6827-3756","observed_orcids":["https://orcid.org/0000-0002-6827-3756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinsam Chang","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147625633","display_name":"Bianca Lopez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bianca Lopez","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147508380","display_name":"Kiersten Dery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kiersten Dery","raw_affiliation_strings":["UC San Diego Health, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC San Diego Health, CA, USA","institution_ids":["https://openalex.org/I2800935791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147450407","display_name":"Angelina Kwan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelina Kwan","raw_affiliation_strings":["University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024382372","display_name":"\u9ec4\u60e0\u82f1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huiying Huang","raw_affiliation_strings":["University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088717375","display_name":"Shanelle N. Dorn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shanelle Dorn","raw_affiliation_strings":["UC San Diego Health, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC San Diego Health, CA, USA","institution_ids":["https://openalex.org/I2800935791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073176709","display_name":"Jiyo Athertya","orcid":"https://orcid.org/0000-0002-0866-1052","observed_orcids":["https://orcid.org/0000-0002-0866-1052"]},"institutions":[{"id":"https://openalex.org/I2800935791","display_name":"UC San Diego Health System","ror":"https://ror.org/01kbfgm16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiyo Athertya","raw_affiliation_strings":["UC San Diego Health, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UC San Diego Health, CA, USA","institution_ids":["https://openalex.org/I2800935791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147620444","display_name":"Justin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin Wang","raw_affiliation_strings":["University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147559007","display_name":"Yajun Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yajun Ma","raw_affiliation_strings":["University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000662848","display_name":"Koichi Masuda","orcid":"https://orcid.org/0000-0002-5361-4415","observed_orcids":["https://orcid.org/0000-0002-5361-4415"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koichi Masuda","raw_affiliation_strings":["University of California, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072360996","display_name":"Pete O\u2019Heeron","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pete O\u2019Heeron","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039170011","display_name":"Hamid Khoja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hamid Khoja","raw_affiliation_strings":["FibroBiologics Inc., TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FibroBiologics Inc., TX, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60800692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"10","first_page":"S66","last_page":"S67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11518","display_name":"Cervical and Thoracic Myelopathy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9319999814033508},{"id":"https://openalex.org/keywords/intervertebral-disc-regeneration","display_name":"intervertebral disc regeneration","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.597000002861023},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8555999994277954},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.8165000081062317},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.7515000104904175},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6751999855041504},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6384000182151794},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.599399983882904},{"id":"https://openalex.org/C2778051963","wikidata":"https://www.wikidata.org/wiki/Q11773731","display_name":"Degenerative disc disease","level":3,"score":0.5503000020980835},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.33629998564720154},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.30480000376701355},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C2779133491","wikidata":"https://www.wikidata.org/wiki/Q25401","display_name":"Lagomorpha","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26460000872612},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2524000108242035}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.spinee.2026.06.171","doi":"https://doi.org/10.1016/j.spinee.2026.06.171","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.spinee.2026.06.171","pdf_url":null,"source":{"id":"https://openalex.org/S112180307","display_name":"The Spine Journal","issn_l":"1529-9430","issn":["1529-9430","1878-1632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Spine Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403975916","https://openalex.org/W2888298044","https://openalex.org/W2337480542","https://openalex.org/W2077009549","https://openalex.org/W4386041608","https://openalex.org/W3159310786","https://openalex.org/W1970044252","https://openalex.org/W4320723611","https://openalex.org/W2109567270","https://openalex.org/W2517697233"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-20T00:00:00"}