{"id":"https://openalex.org/W7203744810","doi":"https://doi.org/10.51244/ijrsi.2026.1307000341","title":"In Silico Druggability Analysis of Cdc37 in Candidiasis","display_name":"In Silico Druggability Analysis of Cdc37 in Candidiasis","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7203744810","doi":"https://doi.org/10.51244/ijrsi.2026.1307000341"},"language":"en","primary_location":{"id":"doi:10.51244/ijrsi.2026.1307000341","doi":"https://doi.org/10.51244/ijrsi.2026.1307000341","is_oa":true,"landing_page_url":"https://doi.org/10.51244/ijrsi.2026.1307000341","pdf_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg4647-4657-202608_pdf.pdf","source":{"id":"https://openalex.org/S4210172017","display_name":"International journal of research and scientific innovation","issn_l":"2320-5520","issn":["2320-5520","2321-2705"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research and Scientific Innovation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg4647-4657-202608_pdf.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147522526","display_name":"Sneha Dey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256552","display_name":"JIS University","ror":"https://ror.org/049ndh460","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405256552"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sneha Dey","raw_affiliation_strings":["Department of Bioscience, JIS University","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience, JIS University","institution_ids":["https://openalex.org/I4405256552"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054456266","display_name":"Sanjib Das","orcid":"https://orcid.org/0000-0003-1988-8014","observed_orcids":["https://orcid.org/0000-0003-1988-8014"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjib Das","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029538126","display_name":"Amalesh Mondal","orcid":"https://orcid.org/0000-0003-1448-2517","observed_orcids":["https://orcid.org/0000-0003-1448-2517"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Amalesh Mondal","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani, Department of Physiology, Katwa College","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani, Department of Physiology, Katwa College","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117619728","display_name":"Deepanjan Chattopadhyay","orcid":"https://orcid.org/0000-0001-7790-5973","observed_orcids":["https://orcid.org/0000-0001-7790-5973"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepanjan Chattopadhyay","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107964363","display_name":"Paromita Saha Mondal","orcid":"https://orcid.org/0000-0003-0304-9566","observed_orcids":["https://orcid.org/0000-0003-0304-9566"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Paromita Saha Mondal","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159835063","display_name":"Tanushree Mondal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tanushree Mondal","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147463873","display_name":"Madhurima Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Madhurima Roy","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025210369","display_name":"Tanima Saha","orcid":"https://orcid.org/0000-0002-9529-160X","observed_orcids":["https://orcid.org/0000-0002-9529-160X"]},"institutions":[{"id":"https://openalex.org/I77501641","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16","country_code":"IN","type":"education","lineage":["https://openalex.org/I77501641"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tanima Saha","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology, University of Kalyani","India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology, University of Kalyani","institution_ids":["https://openalex.org/I77501641"]},{"raw_affiliation_string":"India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7","first_page":"4647","last_page":"4657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6693999767303467,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.14869999885559082,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.10249999910593033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdc37","display_name":"Cdc37","score":0.9909999966621399},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9269999861717224},{"id":"https://openalex.org/keywords/candidiasis","display_name":"candidiasis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pkc1","display_name":"PKC1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8349999785423279},{"id":"https://openalex.org/keywords/co-chaperones","display_name":"co-chaperones","score":0.7630000114440918},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.5989999771118164},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/druggability","display_name":"druggability","score":0.7210000157356262},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.6230000257492065},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.7781999707221985},{"id":"https://openalex.org/C104615370","wikidata":"https://www.wikidata.org/wiki/Q18036151","display_name":"CDC37","level":5,"score":0.6362000107765198},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5742999911308289},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.5719000101089478},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.5325999855995178},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5044999718666077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5027999877929688},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.47200000286102295},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45179998874664307},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44589999318122864},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.43790000677108765},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.423799991607666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40790000557899475},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.4074999988079071},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.39809998869895935},{"id":"https://openalex.org/C90080823","wikidata":"https://www.wikidata.org/wiki/Q193129","display_name":"Hypha","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.3815000057220459},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.361299991607666},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.36039999127388},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.3528999984264374},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.3402999937534332},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.3352999985218048},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.3345000147819519},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3330000042915344},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.3260999917984009},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.27950000762939453},{"id":"https://openalex.org/C2910135453","wikidata":"https://www.wikidata.org/wiki/Q3122802","display_name":"Fungal protein","level":4,"score":0.2581000030040741},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.51244/ijrsi.2026.1307000341","doi":"https://doi.org/10.51244/ijrsi.2026.1307000341","is_oa":true,"landing_page_url":"https://doi.org/10.51244/ijrsi.2026.1307000341","pdf_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg4647-4657-202608_pdf.pdf","source":{"id":"https://openalex.org/S4210172017","display_name":"International journal of research and scientific innovation","issn_l":"2320-5520","issn":["2320-5520","2321-2705"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research and Scientific Innovation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.51244/ijrsi.2026.1307000341","doi":"https://doi.org/10.51244/ijrsi.2026.1307000341","is_oa":true,"landing_page_url":"https://doi.org/10.51244/ijrsi.2026.1307000341","pdf_url":"https://rsisinternational.org/journals/ijrsi/uploads/vol13-iss7-pg4647-4657-202608_pdf.pdf","source":{"id":"https://openalex.org/S4210172017","display_name":"International journal of research and scientific innovation","issn_l":"2320-5520","issn":["2320-5520","2321-2705"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Research and Scientific Innovation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322759","display_name":"University of Kalyani","ror":"https://ror.org/03v783k16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203744810.pdf","grobid_xml":"https://content.openalex.org/works/W7203744810.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1992192767","https://openalex.org/W1994957997","https://openalex.org/W1997437177","https://openalex.org/W2031431271","https://openalex.org/W2077088073","https://openalex.org/W2134967712","https://openalex.org/W2144035662","https://openalex.org/W2149525061","https://openalex.org/W2170764510","https://openalex.org/W2295676242","https://openalex.org/W2339584249","https://openalex.org/W2541185728","https://openalex.org/W2767891136","https://openalex.org/W2804822363","https://openalex.org/W3033679143","https://openalex.org/W4303984105","https://openalex.org/W4309506674","https://openalex.org/W4382877349","https://openalex.org/W7116741831"],"related_works":["https://openalex.org/W2028574811","https://openalex.org/W4410582060","https://openalex.org/W2980377058","https://openalex.org/W2045507047","https://openalex.org/W7098633950","https://openalex.org/W2521709510","https://openalex.org/W2088938008","https://openalex.org/W3094129677","https://openalex.org/W4296087443","https://openalex.org/W2728338964"],"abstract_inverted_index":{"Candida":[0],"albicans":[1],"is":[2,51,60,115],"an":[3],"opportunistic":[4],"fungal":[5],"pathogen":[6],"that":[7,64,161],"participates":[8,104],"in":[9,56,105],"the":[10,15,19,40,48,52,67,76,87,101,109,117,123,128,137,149,152,156,164,169],"life-threatening":[11],"bloodstream":[12],"infections.":[13],"Although":[14],"virulent":[16],"nature":[17],"of":[18,119,131,136,151,172],"fungus":[20],"has":[21],"been":[22],"well":[23],"studied,":[24],"targeting":[25,143],"its":[26,144],"druggability":[27],"for":[28,90],"therapeutics":[29],"still":[30],"requires":[31],"extensive":[32],"research.":[33],"The":[34,112],"special":[35],"structural":[36],"morphogenesis":[37],"known":[38],"as":[39],"hyphae":[41,57],"leads":[42],"to":[43,66,127],"pathogenic":[44],"biofilm":[45],"formation":[46,150],"by":[47],"organism.":[49],"Pkc1":[50,59,88,124],"kinase":[53,63],"protein":[54,89,103,125,139],"involved":[55],"formation.":[58],"a":[61],"client":[62,102],"binds":[65,126],"co-chaperone":[68],"Cdc37.":[69,132,173],"This":[70],"Cdc37-Pkc1":[71],"complex":[72],"then":[73],"associates":[74],"with":[75,140],"Hsp90":[77,81,96],"chaperone":[78],"machinery.":[79],"Together,":[80],"and":[82,85,121],"Cdc37":[83,120,138],"stabilize":[84],"activate":[86],"proper":[91],"cell":[92],"integrity":[93],"signalling.":[94],"When":[95],"loses":[97],"control":[98],"over":[99],"Pkc1,":[100],"hyphal":[106],"development":[107],"through":[108],"CWI":[110],"pathway.":[111],"main":[113],"focus":[114],"on":[116],"interaction":[118],"Pkc1;":[122],"N-terminal":[129,145],"domain":[130,146],"Molecular":[133],"docking":[134],"studies":[135],"FDA-approved":[141],"ligands":[142],"may":[147],"inhibit":[148],"Cdc37\u2013Pkc1":[153],"complex.":[154],"Among":[155],"approved":[157],"drugs":[158],"we":[159],"found":[160],"Nilotinib":[162],"shows":[163],"best":[165],"binding":[166],"affinity":[167],"towards":[168],"domain-specific":[170],"inhibition":[171]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-20T00:00:00"}
