{"id":"https://openalex.org/W7203735024","doi":"https://doi.org/10.1093/genetics/iyag218","title":"A lipocalin and a Hedgehog-related protein are partners in the Caenorhabditis elegans precuticle apical extracellular matrix","display_name":"A lipocalin and a Hedgehog-related protein are partners in the Caenorhabditis elegans precuticle apical extracellular matrix","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203735024","doi":"https://doi.org/10.1093/genetics/iyag218","pmid":"https://pubmed.ncbi.nlm.nih.gov/42538933","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13419461"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/iyag218","doi":"https://doi.org/10.1093/genetics/iyag218","is_oa":true,"landing_page_url":"https://doi.org/10.1093/genetics/iyag218","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/genetics/iyag218","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020305588","display_name":"Nicholas D Serra","orcid":"https://orcid.org/0000-0002-3556-3861","observed_orcids":["https://orcid.org/0000-0002-3556-3861"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas D Serra","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147544069","display_name":"Jason Chen","orcid":"https://orcid.org/0009-0008-9367-646X","observed_orcids":["https://orcid.org/0009-0008-9367-646X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Chen","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,"],"raw_orcid":"https://orcid.org/0009-0008-9367-646X","affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054537895","display_name":"Susanna K. Birnbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanna K Birnbaum","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119095728","display_name":"Sage G. Aviles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sage G Aviles","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012114487","display_name":"Meera V. Sundaram","orcid":"https://orcid.org/0000-0002-2940-8750","observed_orcids":["https://orcid.org/0000-0002-2940-8750"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meera V Sundaram","raw_affiliation_strings":["Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,"],"raw_orcid":"https://orcid.org/0000-0002-2940-8750","affiliations":[{"raw_affiliation_string":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012114487"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":{"value":4477,"currency":"USD","value_usd":4477},"fwci":1.4605,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86021213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"234","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.16459999978542328,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0746999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apical-extracellular-matrix","display_name":"apical extracellular matrix","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lipocalin","display_name":"lipocalin","score":0.8349999785423279},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7409999966621399},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8299999833106995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7646999955177307},{"id":"https://openalex.org/C30055919","wikidata":"https://www.wikidata.org/wiki/Q1566548","display_name":"Cuticle (hair)","level":2,"score":0.6678000092506409},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6216999888420105},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.5888000130653381},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5728999972343445},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4645000100135803},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4115000069141388},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.40939998626708984},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39399999380111694},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.36550000309944153},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.36480000615119934},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.36320000886917114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36000001430511475},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3474999964237213},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.2734000086784363},{"id":"https://openalex.org/C2776496032","wikidata":"https://www.wikidata.org/wiki/Q1904768","display_name":"Caenorhabditis","level":4,"score":0.26420000195503235},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.2572000026702881}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1093/genetics/iyag218","doi":"https://doi.org/10.1093/genetics/iyag218","is_oa":true,"landing_page_url":"https://doi.org/10.1093/genetics/iyag218","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},{"id":"doi:10.64898/2026.07.18.739337","doi":"https://doi.org/10.64898/2026.07.18.739337","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.07.18.739337","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/07/20/2026.07.18.739337.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42538933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42538933","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42615082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42615082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13419461","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13419461/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:13732703","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732703/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/genetics/iyag218","doi":"https://doi.org/10.1093/genetics/iyag218","is_oa":true,"landing_page_url":"https://doi.org/10.1093/genetics/iyag218","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GENETICS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1994913649","display_name":null,"funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320337901","funder_display_name":"Office of Research Infrastructure Programs, National Institutes of Health"},{"id":"https://openalex.org/G3770255479","display_name":null,"funder_award_id":"OD010440","funder_id":"https://openalex.org/F4320337901","funder_display_name":"Office of Research Infrastructure Programs, National Institutes of Health"},{"id":"https://openalex.org/G9000865705","display_name":"Caenorhabditis Genetics Center","funder_award_id":"P40OD010440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000881117","display_name":"Building and shaping the apical extracellular matrix","funder_award_id":"R35GM136315","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337901","display_name":"Office of Research Infrastructure Programs, National Institutes of Health","ror":"https://ror.org/01jdyfj45"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203735024.pdf","grobid_xml":"https://content.openalex.org/works/W7203735024.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1944127002","https://openalex.org/W1954081530","https://openalex.org/W1996996140","https://openalex.org/W2021111269","https://openalex.org/W2038438679","https://openalex.org/W2046153876","https://openalex.org/W2050868331","https://openalex.org/W2055714869","https://openalex.org/W2070693699","https://openalex.org/W2081849640","https://openalex.org/W2089140462","https://openalex.org/W2106756126","https://openalex.org/W2124733101","https://openalex.org/W2126385448","https://openalex.org/W2135456971","https://openalex.org/W2167279371","https://openalex.org/W2492994488","https://openalex.org/W2616612296","https://openalex.org/W2750370132","https://openalex.org/W2768425954","https://openalex.org/W2800846715","https://openalex.org/W2891018818","https://openalex.org/W2949140418","https://openalex.org/W2979807438","https://openalex.org/W2990967376","https://openalex.org/W2999044305","https://openalex.org/W3035573079","https://openalex.org/W3083406432","https://openalex.org/W3087920740","https://openalex.org/W3094824097","https://openalex.org/W3154886655","https://openalex.org/W4290852271","https://openalex.org/W4313830485","https://openalex.org/W4386709491","https://openalex.org/W4386825714","https://openalex.org/W4388796502","https://openalex.org/W4388826952","https://openalex.org/W4393950665","https://openalex.org/W4396721167","https://openalex.org/W4396852273","https://openalex.org/W4400040492","https://openalex.org/W4400580344","https://openalex.org/W4403978356","https://openalex.org/W4404168084","https://openalex.org/W4409571452","https://openalex.org/W4416722102","https://openalex.org/W7117994005","https://openalex.org/W7162438549","https://openalex.org/W7168500511","https://openalex.org/W7203449247","https://openalex.org/W7221759832"],"related_works":["https://openalex.org/W7169770989","https://openalex.org/W4396852273","https://openalex.org/W2750370132","https://openalex.org/W3199174684","https://openalex.org/W4400580344","https://openalex.org/W4388796502","https://openalex.org/W2046153876","https://openalex.org/W4290852271","https://openalex.org/W7162438549","https://openalex.org/W3149632548"],"abstract_inverted_index":{"Abstract":[0,205],"Apical":[1],"extracellular":[2,225],"matrices":[3,30],"(aECMs)":[4],"line":[5],"exposed":[6],"body":[7],"surfaces":[8],"to":[9,123,140,180,183,271],"shape":[10],"tissues":[11],"and":[12,25,86,133,162,167,219,237,275],"protect":[13],"them":[14,177],"from":[15],"the":[16,41,48,83,87,104,108,128,134,146,195,202,223,249,253,282],"environment.":[17],"These":[18,157,228],"aECMs":[19],"often":[20],"organize":[21],"into":[22,103,234,281],"complex":[23],"patterns":[24,38,54,246],"structures,":[26],"but":[27,150],"how":[28,191,244],"such":[29,69,245],"assemble":[31],"remains":[32],"poorly":[33],"understood.":[34],"Caenorhabditis":[35],"elegans":[36,197,256],"cuticle":[37,51,144,251],"initiate":[39],"within":[40],"transient":[42],"pre-cuticle,":[43],"which":[44,59],"then":[45,276],"helps":[46],"direct":[47],"placement":[49],"of":[50,96,107,194,216,252],"collagens.":[52],"Pre-cuticle":[53],"arise":[55],"through":[56],"post-secretory":[57],"sorting,":[58],"must":[60],"involve":[61],"specific":[62,143,184],"molecular":[63],"interactions":[64,175],"among":[65],"them.":[66],"Consistent":[67],"with":[68,91,201],"a":[70,74,92,99,142,169,214,263,273,278],"model,":[71],"Alphafold3":[72],"predicts":[73],"high":[75],"confidence":[76],"physical":[77,174],"interaction":[78],"between":[79,176],"two":[80],"pre-cuticle":[81,129],"proteins,":[82,217],"lipocalin":[84],"LPR-3":[85,97,119,135,161,179],"Hedgehog-related":[88],"protein":[89,270,280],"WRT-10,":[90],"conserved":[93],"N-terminal":[94],"region":[95,120,137],"forming":[98],"\u03b2-strand":[100,136],"that":[101,115,160,221,266],"incorporates":[102],"\u03b2-barrel-like":[105],"structure":[106],"WRT-10":[109,116,132,163,182],"WRT":[110],"domain.":[111],"Genetic":[112],"studies":[113],"showed":[114],"requires":[117],"this":[118],"in":[121,127,248],"order":[122],"become":[124],"properly":[125],"patterned":[126,235],"matrix.":[130],"Furthermore,":[131],"are":[138,164],"required":[139],"pattern":[141,274],"substructure,":[145],"lateral":[147],"alae":[148],"ridges,":[149],"not":[151],"for":[152,262],"other":[153,192,238],"LPR-3-dependent":[154],"matrix":[155,226,229,269],"roles.":[156],"data":[158],"indicate":[159],"functional":[165],"partners":[166],"support":[168],"\u201clanding":[170],"pad\u201d":[171],"model":[172],"whereby":[173],"allow":[178],"recruit":[181,277],"aECM":[185],"regions.":[186],"Similar":[187],"mechanisms":[188],"may":[189],"explain":[190],"members":[193],"C.":[196,255],"Hh-r":[198],"family":[199],"associate":[200],"aECM.":[203],"Graphical":[204],"Article":[206],"Summary":[207],"All":[208],"animal":[209],"skin":[210],"is":[211],"covered":[212],"by":[213],"set":[215],"sugars":[218],"lipids":[220],"comprise":[222],"apical":[224],"(aECM).":[227],"components":[230],"can":[231],"be":[232],"organized":[233],"ridges":[236],"distinctive":[239],"structures.":[240],"This":[241],"study":[242,259],"addresses":[243],"form":[247],"developing":[250],"nematode":[254],".":[257],"The":[258],"provides":[260],"evidence":[261],"regulatory":[264],"mechanism":[265],"enables":[267],"one":[268],"establish":[272],"second":[279],"same":[283],"pattern.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-20T00:00:00"}