{"id":"https://openalex.org/W7203724155","doi":"https://doi.org/10.6084/m9.figshare.33277626","title":"Supplemental Material for: The impact of histopathological fetal inflammatory response syndrome on acute neonatal outcomes: a multisite cohort study","display_name":"Supplemental Material for: The impact of histopathological fetal inflammatory response syndrome on acute neonatal outcomes: a multisite cohort study","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7203724155","doi":"https://doi.org/10.6084/m9.figshare.33277626"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.33277626","doi":"https://doi.org/10.6084/m9.figshare.33277626","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33277626","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.33277626","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146365916","display_name":"figshare admin karger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162602","display_name":"Karger Publishers (Switzerland)","ror":"https://ror.org/0572q5a45","country_code":"CH","type":"company","lineage":["https://openalex.org/I2802626578","https://openalex.org/I40120149","https://openalex.org/I4210162602"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"figshare admin karger","raw_affiliation_strings":["Karger Publishers (Switzerland)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karger Publishers (Switzerland)","institution_ids":["https://openalex.org/I4210162602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022984000","display_name":"Daniel P. O\u2019Reilly","orcid":"https://orcid.org/0000-0002-8575-2353","observed_orcids":["https://orcid.org/0000-0002-8575-2353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel O\u2019Reilly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002728826","display_name":"Sharon Dempsey","orcid":"https://orcid.org/0009-0004-7073-3119","observed_orcids":["https://orcid.org/0009-0004-7073-3119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharon Dempsey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157431526","display_name":"Lauren Murphy","orcid":"https://orcid.org/0009-0009-7633-8749","observed_orcids":["https://orcid.org/0009-0009-7633-8749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035236108","display_name":"Ciara Terry","orcid":"https://orcid.org/0000-0002-3550-2487","observed_orcids":["https://orcid.org/0000-0002-3550-2487"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ciara Terry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107529086","display_name":"Alex Gaffney","orcid":"https://orcid.org/0009-0002-3100-7603","observed_orcids":["https://orcid.org/0009-0002-3100-7603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Gaffney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101719445","display_name":"Emma Doyle","orcid":"https://orcid.org/0000-0001-8978-2966","observed_orcids":["https://orcid.org/0000-0001-8978-2966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Doyle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017645464","display_name":"Richard John Drew","orcid":"https://orcid.org/0000-0001-9797-3797","observed_orcids":["https://orcid.org/0000-0001-9797-3797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J Drew","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046337365","display_name":"Maeve Eogan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maeve Eogan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015447669","display_name":"Anna Curley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Curley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5142964313","display_name":"Carmel Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmel Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5030412436","display_name":"Naomi McCallion","orcid":"https://orcid.org/0000-0002-0723-1982","observed_orcids":["https://orcid.org/0000-0002-0723-1982"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naomi McCallion","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.47440001368522644,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.47440001368522644,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.2827000021934509,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.18809999525547028,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-inflammatory-response-syndrome","display_name":"fetal inflammatory response","score":0.9950000047683716},{"id":"https://openalex.org/keywords/very-preterm-infants","display_name":"very preterm infants","score":0.8999999761581421},{"id":"https://openalex.org/keywords/placental-pathology","display_name":"placental pathology","score":0.7900000214576721},{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia","display_name":"bronchopulmonary dysplasia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/neonatal-mortality","display_name":"neonatal mortality","score":0.921999990940094},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.8960000276565552},{"id":"https://openalex.org/keywords/surfactant-replacement-therapy","display_name":"surfactant therapy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/intraventricular-hemorrhage","display_name":"intraventricular hemorrhage","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.824999988079071},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9455000162124634},{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.8364999890327454},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.7114999890327454},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.527899980545044},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5115000009536743},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5101000070571899},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.47850000858306885},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.46869999170303345},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4611999988555908},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4586000144481659},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.44830000400543213},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.43650001287460327},{"id":"https://openalex.org/C2776344615","wikidata":"https://www.wikidata.org/wiki/Q625506","display_name":"Premature birth","level":4,"score":0.4178999960422516},{"id":"https://openalex.org/C2777629866","wikidata":"https://www.wikidata.org/wiki/Q473739","display_name":"Chorioamnionitis","level":4,"score":0.4117000102996826},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3955000042915344},{"id":"https://openalex.org/C2779252433","wikidata":"https://www.wikidata.org/wiki/Q6058597","display_name":"Intraventricular hemorrhage","level":4,"score":0.3646000027656555},{"id":"https://openalex.org/C2781056747","wikidata":"https://www.wikidata.org/wiki/Q1144406","display_name":"Oligohydramnios","level":4,"score":0.3637000024318695},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C2780938740","wikidata":"https://www.wikidata.org/wiki/Q1298973","display_name":"Small for gestational age","level":4,"score":0.32120001316070557},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2703000009059906},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25440001487731934},{"id":"https://openalex.org/C2779303187","wikidata":"https://www.wikidata.org/wiki/Q10859678","display_name":"Necrotizing enterocolitis","level":2,"score":0.25200000405311584},{"id":"https://openalex.org/C2777091541","wikidata":"https://www.wikidata.org/wiki/Q9008292","display_name":"Neonatal intensive care unit","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.33277626","doi":"https://doi.org/10.6084/m9.figshare.33277626","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33277626","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.6084/m9.figshare.33277626.v1","doi":"https://doi.org/10.6084/m9.figshare.33277626.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33277626.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.33277626","doi":"https://doi.org/10.6084/m9.figshare.33277626","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33277626","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7204439429","https://openalex.org/W4321378132","https://openalex.org/W1965971895","https://openalex.org/W2995075764","https://openalex.org/W7204270247","https://openalex.org/W2756894975","https://openalex.org/W4399772862","https://openalex.org/W4405191742","https://openalex.org/W4386526411","https://openalex.org/W4414578959"],"abstract_inverted_index":{"Intro:":[0],"Fetal":[1],"Inflammatory":[2],"response":[3],"syndrome":[4,146],"(FIRS)":[5],"has":[6,18],"previously":[7],"been":[8,19],"associated":[9],"with":[10,63],"poor":[11],"acute":[12,38,92,218],"outcomes":[13,40,94,219],"in":[14,41,54,58,174],"preterm":[15,43,127,191],"neonates":[16,62,128,192],"but":[17],"defined":[20,88],"inconsistently.":[21],"In":[22],"this":[23],"large":[24],"retrospective":[25],"cohort":[26,51],"study,":[27],"we":[28],"sought":[29],"to":[30,84,130,151,194],"examine":[31],"the":[32],"impact":[33],"of":[34,109,176,182,187,200],"histopathological":[35,131],"FIRS":[36,89,132,152,195],"on":[37],"clinical":[39],"very":[42,126],"neonates.":[44],"Methods:":[45],"This":[46],"was":[47,171],"a":[48,135],"two":[49],"site":[50],"study":[52],"based":[53],"tertiary":[55],"maternity":[56],"units":[57],"Dublin,":[59],"Ireland.":[60],"Admitted":[61],"placental":[64],"histology":[65],"and":[66,90,98,111,121,143,156,164,206,213],"without":[67],"congenital":[68],"anomalies":[69],"<":[70],"32":[71],"weeks":[72],"corrected":[73],"gestational":[74,119,168],"age":[75,120,169,212],"born":[76,154],"between":[77],"2018-2022":[78],"(n=955)":[79],"were":[80,153,162,220],"assessed":[81],"for":[82,118,167,211],"exposure":[83],"Amsterdam":[85],"consensus":[86],"guideline":[87],"consequent":[91],"neonatal":[93],"by":[95],"both":[96],"univariate":[97,103],"multivariate":[99,115],"methods.":[100],"Results:":[101],"While":[102],"analysis":[104,116],"showed":[105],"an":[106],"increased":[107],"incidence":[108],"death":[110,140,202],"Bronchopulmonary":[112],"Dysplasia":[113],"(BPD),":[114],"adjusting":[117,166,210],"birth":[122,214],"weight":[123],"demonstrated":[124],"that":[125],"exposed":[129,150,193],"are":[133,196],"at":[134,197],"lower":[136,198],"risk":[137,199],"ofBPD,":[138],"composite":[139],"or":[141,185,203],"BPD":[142],"respiratory":[144],"distress":[145],"(RDS)requiring":[147],"surfactant.":[148],"Neonates":[149],"earlier":[155],"smaller":[157],"than":[158],"their":[159],"peers":[160],"who":[161],"not,":[163],"when":[165,209],"there":[170],"no":[172],"increase":[173],"odds":[175],"severe":[177],"Intraventricular":[178],"Haemorrhage":[179],"(IVH),":[180],"days":[181],"mechanical":[183],"ventilation":[184],"diagnosis":[186],"sepsis.":[188],"Conclusions:":[189],"Very":[190],"developing":[201],"bronchopulmonary":[204],"dysplasia":[205],"requiring":[207],"surfactant":[208],"weight.":[215],"No":[216],"other":[217],"statistically":[221],"significantly":[222],"different.":[223]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-19T00:00:00"}