{"id":"https://openalex.org/W7203719833","doi":"https://doi.org/10.1073/pnas.2617943123","title":"Select intratumoral riboflavin-auxotrophic Enterococcus species enhance cell surface MR1 expression and MAIT TCR activation in lung cancer","display_name":"Select intratumoral riboflavin-auxotrophic Enterococcus species enhance cell surface MR1 expression and MAIT TCR activation in lung cancer","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7203719833","doi":"https://doi.org/10.1073/pnas.2617943123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42611994"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2617943123","doi":"https://doi.org/10.1073/pnas.2617943123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2617943123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2617943123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077020701","display_name":"Pakhi Birla","orcid":"https://orcid.org/0000-0002-7252-5717","observed_orcids":["https://orcid.org/0000-0002-7252-5717"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pakhi Birla","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0002-7252-5717","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111021870","display_name":"Lansaol Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lansaol Yang","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001525939","display_name":"W. Shan","orcid":"https://orcid.org/0000-0003-3176-4874","observed_orcids":["https://orcid.org/0000-0003-3176-4874","https://orcid.org/0000-0003-2811-2218","https://orcid.org/0009-0007-9950-8443","https://orcid.org/0000-0002-6355-1075","https://orcid.org/0000-0002-5819-128X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanting Shan","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120527095","display_name":"Sukara Minamisawa","orcid":"https://orcid.org/0009-0002-6204-7413","observed_orcids":["https://orcid.org/0009-0002-6204-7413"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sakura Minamisawa","raw_affiliation_strings":["Department of Pathology and Oncology, Faculty of Medicine, Juntendo University"],"raw_orcid":"https://orcid.org/0009-0002-6204-7413","affiliations":[{"raw_affiliation_string":"Department of Pathology and Oncology, Faculty of Medicine, Juntendo University","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120077142","display_name":"Omkar Dhaygude","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Omkar Dhaygude","raw_affiliation_strings":["Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054314326","display_name":"Haritha Manoj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haritha Manoj","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010017164","display_name":"Alex J. Lee","orcid":"https://orcid.org/0000-0002-1825-2439","observed_orcids":["https://orcid.org/0000-0002-1825-2439"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex J. Lee","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0002-1825-2439","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113318214","display_name":"Jacqueline Ferri","orcid":"https://orcid.org/0009-0009-4340-6936","observed_orcids":["https://orcid.org/0009-0009-4340-6936"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Ferri","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0009-0009-4340-6936","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102010518","display_name":"Ying Zheng","orcid":"https://orcid.org/0000-0002-4107-6752","observed_orcids":["https://orcid.org/0000-0002-4107-6752","https://orcid.org/0000-0002-6548-7804","https://orcid.org/0000-0003-3014-1587"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Zheng","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0002-4107-6752","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003328729","display_name":"Andrew J. Munoz","orcid":"https://orcid.org/0000-0001-5118-1217","observed_orcids":["https://orcid.org/0000-0001-5118-1217"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Northcutt","raw_affiliation_strings":["Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0001-5118-1217","affiliations":[{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103055706","display_name":"Hongni Fan","orcid":"https://orcid.org/0000-0003-0817-6468","observed_orcids":["https://orcid.org/0000-0003-0817-6468"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongni Fan","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113257752","display_name":"Hadley E. Beauregard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hadley Beauregard","raw_affiliation_strings":["Department of Medicine, Division of Infectious Disease, Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Disease, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002937123","display_name":"Zhen Zeng","orcid":"https://orcid.org/0000-0002-3443-0637","observed_orcids":["https://orcid.org/0000-0002-3443-0637"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Zeng","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0002-3443-0637","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082613510","display_name":"Kellie Nicole Smith","orcid":"https://orcid.org/0000-0002-6295-8930","observed_orcids":["https://orcid.org/0000-0002-6295-8930"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kellie N. Smith","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086045945","display_name":"Fyza Y. Shaikh","orcid":"https://orcid.org/0000-0001-7839-8483","observed_orcids":["https://orcid.org/0000-0001-7839-8483"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fyza Y. Shaikh","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0001-7839-8483","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003313258","display_name":"Cynthia L. Sears","orcid":"https://orcid.org/0000-0003-4059-1661","observed_orcids":["https://orcid.org/0000-0003-4059-1661"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia L. Sears","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Department of Medicine, Division of Infectious Disease, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0003-4059-1661","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Division of Infectious Disease, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066707073","display_name":"Drew M. Pardoll","orcid":"https://orcid.org/0000-0001-6215-1013","observed_orcids":["https://orcid.org/0000-0001-6215-1013"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew M. Pardoll","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0001-6215-1013","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054350714","display_name":"Franck Housseau","orcid":"https://orcid.org/0000-0002-7028-3953","observed_orcids":["https://orcid.org/0000-0002-7028-3953"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Franck Housseau","raw_affiliation_strings":["Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0002-7028-3953","affiliations":[{"raw_affiliation_string":"Bloomberg ~ Kimmel Institute for Cancer Immunotherapy, Johns Hopkins School of Medicine","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210164401"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054350714"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210164401"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62201238,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"34","first_page":"e2617943123","last_page":"e2617943123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.391400009393692,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.391400009393692,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2842000126838684,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.28299999237060547,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mucosa-associated-invariant-t-cells","display_name":"mucosal-associated invariant T cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mr1","display_name":"MR1","score":0.7200000286102295},{"id":"https://openalex.org/keywords/enterococcus","display_name":"Enterococcus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/intratumoral-bacteria","display_name":"intratumoral bacteria","score":0.9139999747276306},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9610000252723694},{"id":"https://openalex.org/keywords/5-op-ru","display_name":"5-OP-RU","score":0.7889999747276306},{"id":"https://openalex.org/keywords/tcr-clonotypes","display_name":"TCR clonotypes","score":0.6700000166893005},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-microbiota","display_name":"tumor microbiome","score":0.5680000185966492},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.748199999332428},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6103000044822693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5810999870300293},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5667999982833862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5109000205993652},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5072000026702881},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.5031999945640564},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.49939998984336853},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4510999917984009},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.424699991941452},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.41929998993873596},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41280001401901245},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.3856000006198883},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35359999537467957},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.35030001401901245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3499000072479248},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.34439998865127563},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.34439998865127563},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3402000069618225},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33869999647140503},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.33480000495910645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31610000133514404},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.2939000129699707},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27950000762939453},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.2632000148296356},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2535000145435333},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25290000438690186}],"mesh":[{"descriptor_ui":"D000072336","descriptor_name":"Mucosal-Associated Invariant T Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000072336","descriptor_name":"Mucosal-Associated Invariant T Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000072336","descriptor_name":"Mucosal-Associated Invariant T Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000072336","descriptor_name":"Mucosal-Associated Invariant T Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072336","descriptor_name":"Mucosal-Associated Invariant T Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000072336","descriptor_name":"Mucosal-Associated Invariant T Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012255","descriptor_name":"Ribitol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012255","descriptor_name":"Ribitol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012255","descriptor_name":"Ribitol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D012256","descriptor_name":"Riboflavin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012256","descriptor_name":"Riboflavin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012256","descriptor_name":"Riboflavin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015778","descriptor_name":"Minor Histocompatibility Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016983","descriptor_name":"Enterococcus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.2617943123","doi":"https://doi.org/10.1073/pnas.2617943123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2617943123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:42611994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42611994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13506043","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13506043/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2617943123","doi":"https://doi.org/10.1073/pnas.2617943123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2617943123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315585","display_name":"Commonwealth Foundation for Cancer Research Foundation","ror":null},{"id":"https://openalex.org/F4320337736","display_name":"Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1703384511","https://openalex.org/W2006188503","https://openalex.org/W2030430693","https://openalex.org/W2033478456","https://openalex.org/W2065252029","https://openalex.org/W2066950435","https://openalex.org/W2068487285","https://openalex.org/W2073247934","https://openalex.org/W2139632459","https://openalex.org/W2151505523","https://openalex.org/W2162709457","https://openalex.org/W2190401727","https://openalex.org/W2236872686","https://openalex.org/W2323955433","https://openalex.org/W2513049377","https://openalex.org/W2586227194","https://openalex.org/W2614152856","https://openalex.org/W2770639073","https://openalex.org/W2901059040","https://openalex.org/W2945685946","https://openalex.org/W2957206257","https://openalex.org/W2981494076","https://openalex.org/W2990618091","https://openalex.org/W2998801145","https://openalex.org/W3098928835","https://openalex.org/W3114479866","https://openalex.org/W3183254943","https://openalex.org/W3194929095","https://openalex.org/W3197684602","https://openalex.org/W4224300003","https://openalex.org/W4284958112","https://openalex.org/W4317499877","https://openalex.org/W4385955916","https://openalex.org/W4389993988","https://openalex.org/W4391249070","https://openalex.org/W4396622426","https://openalex.org/W4396815340","https://openalex.org/W4402438340","https://openalex.org/W4403705752","https://openalex.org/W4404468177","https://openalex.org/W4404742165","https://openalex.org/W4405967889","https://openalex.org/W4410962802","https://openalex.org/W4416820244"],"related_works":[],"abstract_inverted_index":{"Mucosal-associated":[0],"invariant":[1],"T":[2,7,43,162],"(MAIT)":[3],"cells":[4,8,31,44,60,100,119],"are":[5],"innate-like":[6,161],"capable":[9],"of":[10,40,109,148],"MR1-dependent":[11,103,160],"immune":[12,179],"surveillance,":[13],"but":[14,101],"how":[15,75],"intratumoral":[16,29,91],"bacteria":[17,157],"modulate":[18],"MR1":[19,80,115,131],"expression":[20,81,116,134],"in":[21,52,106,130,158],"human":[22],"lung":[23,49],"tumors":[24,51],"remains":[25],"unclear.":[26],"We":[27,87],"studied":[28],"MAIT":[30,59,84,99,104],"from":[32,46],"paired":[33],"single-cell":[34],"RNA":[35],"and":[36,82,125,146,165],"TCR":[37,67,85],"sequencing":[38],"datasets":[39],"tumor-infiltrating":[41],"CD3":[42],"isolated":[45],"non-small":[47],"cell":[48,132,163],"cancer":[50],"patients":[53],"receiving":[54],"neoadjuvant":[55],"PD-1":[56],"blockade":[57],"therapy.":[58],"were":[61,70],"subclustered":[62],"to":[63,73,178],"identify":[64],"conventional":[65],"MAIT-associated":[66],"clonotypes,":[68],"which":[69],"then":[71],"used":[72],"examine":[74],"bacterial":[76],"exposure":[77],"impacts":[78],"cell-surface":[79,114],"downstream":[83],"activation.":[86],"found":[88],"that":[89],"select":[90],"Enterococcus":[92],"species":[93],"(spp.)":[94],"did":[95],"not":[96],"directly":[97],"activate":[98],"enhanced":[102],"activation":[105,164],"the":[107],"presence":[108],"exogenous":[110],"5-OP-RU":[111],"by":[112],"increasing":[113],"on":[117],"antigen-presenting":[118],"including":[120],"dendritic":[121],"cells,":[122,124],"B":[123],"mononuclear":[126],"phagocytes.":[127],"This":[128],"increase":[129],"surface":[133],"is":[135],"modulated":[136],"through":[137],"a":[138,153,167],"posttranscriptional":[139],"mechanism":[140],"consistent":[141],"with":[142],"altered":[143],"intracellular":[144],"processing":[145],"trafficking":[147],"MR1.":[149],"These":[150],"findings":[151],"reveal":[152],"role":[154],"for":[155,169],"tumor-associated":[156],"modulating":[159],"provide":[166],"basis":[168],"future":[170],"studies":[171],"examining":[172],"whether":[173],"this":[174],"process":[175],"influences":[176],"response":[177],"checkpoint":[180],"blockade.":[181]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-19T00:00:00"}