{"id":"https://openalex.org/W7203709744","doi":"https://doi.org/10.1016/j.prro.2026.08.003","title":"When Standard Craniospinal Irradiation Leads to Severe Brainstem Toxicity: A Morbidity and Mortality Case of Pineoblastoma in 22q11.2 Deletion Syndrome","display_name":"When Standard Craniospinal Irradiation Leads to Severe Brainstem Toxicity: A Morbidity and Mortality Case of Pineoblastoma in 22q11.2 Deletion Syndrome","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7203709744","doi":"https://doi.org/10.1016/j.prro.2026.08.003","pmid":"https://pubmed.ncbi.nlm.nih.gov/42612869"},"language":"en","primary_location":{"id":"doi:10.1016/j.prro.2026.08.003","doi":"https://doi.org/10.1016/j.prro.2026.08.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.prro.2026.08.003","pdf_url":null,"source":{"id":"https://openalex.org/S2764989788","display_name":"Practical Radiation Oncology","issn_l":"1879-8500","issn":["1879-8500","1879-8519"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Practical Radiation Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077827560","display_name":"Daniel Huang","orcid":"https://orcid.org/0000-0003-2624-5439","observed_orcids":["https://orcid.org/0000-0003-2624-5439"]},"institutions":[{"id":"https://openalex.org/I4390039251","display_name":"University of Chicago Medicine Comprehensive Cancer Center","ror":"https://ror.org/042wftp98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865","https://openalex.org/I4390039251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Huang","raw_affiliation_strings":["Department of Radiation and Cellular Oncology, University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois"],"raw_orcid":"https://orcid.org/0000-0003-2624-5439","affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology, University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois","institution_ids":["https://openalex.org/I4390039251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032120009","display_name":"Sudarshawn N. Damodharan","orcid":"https://orcid.org/0000-0002-4738-6356","observed_orcids":["https://orcid.org/0000-0002-4738-6356"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210136340","display_name":"Comer Children's Hospital","ror":"https://ror.org/02y96rp12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudarshawn Damodharan","raw_affiliation_strings":["Department of Pediatrics, Section of Hematology/Oncology, University of Chicago Medicine Comer Children's Hospital, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Hematology/Oncology, University of Chicago Medicine Comer Children's Hospital, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210136340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082640105","display_name":"Lorraine E. Canham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210136340","display_name":"Comer Children's Hospital","ror":"https://ror.org/02y96rp12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210136340"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorraine E. Canham","raw_affiliation_strings":["Department of Pediatrics, Section of Hematology/Oncology, University of Chicago Medicine Comer Children's Hospital, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Hematology/Oncology, University of Chicago Medicine Comer Children's Hospital, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210136340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001479339","display_name":"Philip P. Connell","orcid":"https://orcid.org/0000-0002-7447-9865","observed_orcids":["https://orcid.org/0000-0002-7447-9865"]},"institutions":[{"id":"https://openalex.org/I4390039251","display_name":"University of Chicago Medicine Comprehensive Cancer Center","ror":"https://ror.org/042wftp98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865","https://openalex.org/I4390039251"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip P. Connell","raw_affiliation_strings":["Department of Radiation and Cellular Oncology, University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois. Electronic address: PConnell@bsd.uchicago.edu"],"raw_orcid":"https://orcid.org/0000-0002-7447-9865","affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology, University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois. Electronic address: PConnell@bsd.uchicago.edu","institution_ids":["https://openalex.org/I4390039251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016499084","display_name":"Vinai Gondi","orcid":"https://orcid.org/0009-0002-3963-0539","observed_orcids":["https://orcid.org/0009-0002-3963-0539"]},"institutions":[{"id":"https://openalex.org/I4210147348","display_name":"Northwestern Medicine","ror":"https://ror.org/04fzwnh64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vinai Gondi","raw_affiliation_strings":["Department of Radiation Oncology, Northwestern Medicine Cancer Center Warrenville and Northwestern Medicine Proton Center, Warrenville, Illinois. Electronic address: Vinai.Gondi@nm.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Northwestern Medicine Cancer Center Warrenville and Northwestern Medicine Proton Center, Warrenville, Illinois. Electronic address: Vinai.Gondi@nm.org","institution_ids":["https://openalex.org/I4210147348"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001479339","https://openalex.org/A5016499084"],"corresponding_institution_ids":["https://openalex.org/I4210147348","https://openalex.org/I4390039251"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58296816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.12600000202655792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.10119999945163727,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pineoblastoma","display_name":"pineoblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/22q11-2-deletion-syndrome","display_name":"22q11.2 deletion syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/craniospinal-irradiation","display_name":"craniospinal irradiation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/radiosensitivity","display_name":"radiosensitivity","score":0.8230000138282776},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.8169999718666077},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9620000123977661},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.7879999876022339},{"id":"https://openalex.org/keywords/normal-tissue-toxicity","display_name":"normal tissue toxicity","score":0.5450000166893005},{"id":"https://openalex.org/keywords/laser-interstitial-thermal-therapy","display_name":"laser interstitial thermal therapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9546999931335449},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.6344000101089478},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.46860000491142273},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.400299996137619},{"id":"https://openalex.org/C2994499388","wikidata":"https://www.wikidata.org/wiki/Q656732","display_name":"Gene deletion","level":4,"score":0.36570000648498535},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C2992572678","wikidata":"https://www.wikidata.org/wiki/Q16918398","display_name":"Deletion syndrome","level":4,"score":0.328900009393692},{"id":"https://openalex.org/C2992981700","wikidata":"https://www.wikidata.org/wiki/Q727096","display_name":"Congenital disease","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C2993278735","wikidata":"https://www.wikidata.org/wiki/Q275459","display_name":"Radiation injury","level":3,"score":0.303600013256073},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.prro.2026.08.003","doi":"https://doi.org/10.1016/j.prro.2026.08.003","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.prro.2026.08.003","pdf_url":null,"source":{"id":"https://openalex.org/S2764989788","display_name":"Practical Radiation Oncology","issn_l":"1879-8500","issn":["1879-8500","1879-8519"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Practical Radiation Oncology","raw_type":"journal-article"},{"id":"pmid:42612869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42612869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Practical radiation oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.5856059193611145,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2010456654","https://openalex.org/W2037154100","https://openalex.org/W2039846010","https://openalex.org/W2136963436","https://openalex.org/W2139554694","https://openalex.org/W2161289154","https://openalex.org/W2253685848","https://openalex.org/W2301716009","https://openalex.org/W2592686073","https://openalex.org/W2794514924","https://openalex.org/W2891574176","https://openalex.org/W2897454589","https://openalex.org/W3009425576","https://openalex.org/W3040456262","https://openalex.org/W4394799154","https://openalex.org/W4401103260","https://openalex.org/W4411328604","https://openalex.org/W4415220051"],"related_works":["https://openalex.org/W2973010267","https://openalex.org/W3209150655","https://openalex.org/W4387931021","https://openalex.org/W4281682455","https://openalex.org/W1602894256","https://openalex.org/W4386508038","https://openalex.org/W2273986669","https://openalex.org/W1994594812","https://openalex.org/W2896606918","https://openalex.org/W2048945661"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-08-19T00:00:00"}
