{"id":"https://openalex.org/W7203702444","doi":"https://doi.org/10.1007/s00535-026-02502-5","title":"Cytotoxic immune activity reflects a coordinated immune microenvironment and is associated with response to total neoadjuvant therapy in rectal cancer","display_name":"Cytotoxic immune activity reflects a coordinated immune microenvironment and is associated with response to total neoadjuvant therapy in rectal cancer","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7203702444","doi":"https://doi.org/10.1007/s00535-026-02502-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/42611325"},"language":"en","primary_location":{"id":"doi:10.1007/s00535-026-02502-5","doi":"https://doi.org/10.1007/s00535-026-02502-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00535-026-02502-5","pdf_url":null,"source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077099061","display_name":"Erina Haraguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Erina Haraguchi","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033759027","display_name":"Norio Tanaka","orcid":"https://orcid.org/0000-0003-2724-8009","observed_orcids":["https://orcid.org/0000-0003-2724-8009"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Tanaka","raw_affiliation_strings":["Division of Cancer Genomics, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Genomics, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032516662","display_name":"Kentaro Sato","orcid":"https://orcid.org/0000-0002-1765-7477","observed_orcids":["https://orcid.org/0000-0002-1765-7477"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Sato","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057129682","display_name":"Tatsuki Noguchi","orcid":"https://orcid.org/0000-0003-1297-0699","observed_orcids":["https://orcid.org/0000-0003-1297-0699"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuki Noguchi","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147414093","display_name":"Takashi Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Sakamoto","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037358815","display_name":"Shimpei Matsui","orcid":"https://orcid.org/0000-0001-7509-9365","observed_orcids":["https://orcid.org/0000-0001-7509-9365"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shimpei Matsui","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043305869","display_name":"Toshiki Mukai","orcid":"https://orcid.org/0000-0002-3553-3590","observed_orcids":["https://orcid.org/0000-0002-3553-3590"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiki Mukai","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121949855","display_name":"Tomohiro Yamaguchi","orcid":"https://orcid.org/0000-0002-5023-0985","observed_orcids":["https://orcid.org/0000-0002-5023-0985"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Yamaguchi","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069216523","display_name":"Eiji Shinozaki","orcid":"https://orcid.org/0000-0002-7448-5894","observed_orcids":["https://orcid.org/0000-0002-7448-5894","https://orcid.org/0000-0003-1831-0536"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eiji Shinozaki","raw_affiliation_strings":["Department of Gastroenterological Chemotherapy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Chemotherapy, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044622676","display_name":"Senzo Taguchi","orcid":"https://orcid.org/0000-0002-3932-8084","observed_orcids":["https://orcid.org/0000-0002-3932-8084"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Senzo Taguchi","raw_affiliation_strings":["Department of Radiation Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067837487","display_name":"Akiko Chino","orcid":"https://orcid.org/0000-0001-7412-4397","observed_orcids":["https://orcid.org/0000-0001-7412-4397"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Chino","raw_affiliation_strings":["Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041000766","display_name":"Manabu Takamatsu","orcid":"https://orcid.org/0000-0001-9601-5802","observed_orcids":["https://orcid.org/0000-0001-9601-5802"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Manabu Takamatsu","raw_affiliation_strings":["Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081696693","display_name":"Ippei Fukada","orcid":"https://orcid.org/0000-0001-7272-3708","observed_orcids":["https://orcid.org/0000-0001-7272-3708"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ippei Fukada","raw_affiliation_strings":["Genomic Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomic Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061220478","display_name":"Takayuki Ueno","orcid":"https://orcid.org/0000-0002-9080-9377","observed_orcids":["https://orcid.org/0000-0002-9080-9377"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Ueno","raw_affiliation_strings":["Department of Breast Surgical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104068053","display_name":"Tetsuo Noda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuo Noda","raw_affiliation_strings":["Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","Graduate School of Medicine, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]},{"raw_affiliation_string":"Graduate School of Medicine, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079451508","display_name":"Seiichi Mori","orcid":"https://orcid.org/0000-0001-8569-4504","observed_orcids":["https://orcid.org/0000-0001-8569-4504"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiichi Mori","raw_affiliation_strings":["Division of Cancer Genomics, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Genomics, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012769131","display_name":"Takashi Akiyoshi","orcid":"https://orcid.org/0000-0002-2321-1412","observed_orcids":["https://orcid.org/0000-0002-2321-1412"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takashi Akiyoshi","raw_affiliation_strings":["Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan. takashi.akiyoshi@jfcr.or.jp","Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan. takashi.akiyoshi@jfcr.or.jp"],"raw_orcid":"https://orcid.org/0000-0002-2321-1412","affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan. takashi.akiyoshi@jfcr.or.jp","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"Rectal Cancer Multidisciplinary Treatment Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-Ku, Tokyo, 135-8550, Japan. takashi.akiyoshi@jfcr.or.jp","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012769131"],"corresponding_institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.7993000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.15029999613761902,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.8980000019073486},{"id":"https://openalex.org/keywords/total-neoadjuvant-therapy","display_name":"total neoadjuvant therapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9190000295639038},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.843999981880188},{"id":"https://openalex.org/keywords/immune-cell-subsets","display_name":"immune cell subsets","score":0.5569999814033508},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.6449999809265137},{"id":"https://openalex.org/keywords/locally-advanced-rectal-cancer","display_name":"locally advanced rectal cancer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/immune-deconvolution","display_name":"immune deconvolution","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8806999921798706},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8396999835968018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.501800000667572},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.49149999022483826},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.48890000581741333},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4832000136375427},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4165000021457672},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3560999929904938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3522999882698059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35109999775886536},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.30889999866485596},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27230000495910645},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2605000138282776}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00535-026-02502-5","doi":"https://doi.org/10.1007/s00535-026-02502-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00535-026-02502-5","pdf_url":null,"source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:42611325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42611325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2556426576","display_name":"TNT\u65bd\u884c\u4e2d\u306e\u7d4c\u6642\u7684scDNA\u89e3\u6790\u306b\u3088\u308b\u76f4\u8178\u304c\u3093\u30af\u30ed\u30fc\u30f3\u9032\u5316\u306e\u89e3\u6790\u3068\u6cbb\u7642\u8010\u6027\u6a5f\u5e8f\u306e\u89e3\u660e","funder_award_id":"25K19784","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3429171146","display_name":"\u9032\u884c\u76f4\u8178\u304c\u3093\u306b\u5bfe\u3059\u308bTNT\u5f8c\u306b\u81d3\u5668\u6e29\u5b58\u53ef\u80fd\u75c7\u4f8b\u3092\u6b63\u78ba\u306b\u8a3a\u65ad\u3059\u308b\u30b7\u30b9\u30c6\u30e0\u306e\u69cb\u7bc9","funder_award_id":"25K02721","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7544233317","display_name":null,"funder_award_id":"JP22ck0106872","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G8533870493","display_name":"\u76f4\u8178\u304c\u3093\u306b\u5bfe\u3059\u308bTNT\u65bd\u884c\u4e2d\u306e\u7d4c\u6642\u7684scRNA\u89e3\u6790\u306b\u3088\u308b\u6cbb\u7642\u52b9\u679c\u4e88\u6e2c\u3068\u8010\u6027\u6a5f\u5e8f\u89e3\u660e","funder_award_id":"25K12042","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8756141430","display_name":null,"funder_award_id":"JP21ck0106688","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1934094702","https://openalex.org/W2028433016","https://openalex.org/W2033751993","https://openalex.org/W2035618305","https://openalex.org/W2101006433","https://openalex.org/W2130410032","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2533508881","https://openalex.org/W2770459634","https://openalex.org/W2793017953","https://openalex.org/W2809278331","https://openalex.org/W2952001873","https://openalex.org/W2952391626","https://openalex.org/W3009788614","https://openalex.org/W3111308000","https://openalex.org/W3154995350","https://openalex.org/W3199931616","https://openalex.org/W4210414550","https://openalex.org/W4220980348","https://openalex.org/W4281255512","https://openalex.org/W4283830211","https://openalex.org/W4291903684","https://openalex.org/W4311002400","https://openalex.org/W4317568296","https://openalex.org/W4362724124","https://openalex.org/W4387951183","https://openalex.org/W4400183110","https://openalex.org/W4400697960","https://openalex.org/W4400775465","https://openalex.org/W4412395242","https://openalex.org/W4413042179","https://openalex.org/W4414161834","https://openalex.org/W4414650835","https://openalex.org/W4417420068"],"related_works":["https://openalex.org/W3206834054","https://openalex.org/W7204946400","https://openalex.org/W4387402620","https://openalex.org/W7154584175","https://openalex.org/W7162647387","https://openalex.org/W2792791488","https://openalex.org/W4225329068","https://openalex.org/W7169519283","https://openalex.org/W1192540099","https://openalex.org/W4385563663"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-08-19T00:00:00"}