{"id":"https://openalex.org/W7203695469","doi":"https://doi.org/10.1097/cce.0000000000001468","title":"Genetic Regulation of Protein Biomarkers in Pediatric Acute Respiratory Distress Syndrome","display_name":"Genetic Regulation of Protein Biomarkers in Pediatric Acute Respiratory Distress Syndrome","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7203695469","doi":"https://doi.org/10.1097/cce.0000000000001468","pmid":"https://pubmed.ncbi.nlm.nih.gov/42610802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13485844"},"language":"en","primary_location":{"id":"doi:10.1097/cce.0000000000001468","doi":"https://doi.org/10.1097/cce.0000000000001468","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cce.0000000000001468","pdf_url":null,"source":{"id":"https://openalex.org/S4210210302","display_name":"Critical Care Explorations","issn_l":"2639-8028","issn":["2639-8028"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Explorations","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/cce.0000000000001468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070430658","display_name":"Guy Helman","orcid":"https://orcid.org/0000-0002-4784-7423","observed_orcids":["https://orcid.org/0000-0002-4784-7423"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guy Helman","raw_affiliation_strings":["Department of Anesthesiology and Critical Care, Children\u2019s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care, Children\u2019s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136378497","display_name":"Rui Feng","orcid":"https://orcid.org/0000-0003-4151-7228","observed_orcids":["https://orcid.org/0000-0003-4151-7228"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Feng","raw_affiliation_strings":["Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Epidemiology, and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010510018","display_name":"Joshua E. Motelow","orcid":"https://orcid.org/0000-0002-4367-4182","observed_orcids":["https://orcid.org/0000-0002-4367-4182"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua E. Motelow","raw_affiliation_strings":["Division of Critical Care and Hospital Medicine, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care and Hospital Medicine, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031613696","display_name":"Nadir Yehya","orcid":"https://orcid.org/0000-0002-2996-217X","observed_orcids":["https://orcid.org/0000-0002-2996-217X"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I4405271814","display_name":"Leonard Davis Institute of Health Economics","ror":"https://ror.org/033gy9j95","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271814"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nadir Yehya","raw_affiliation_strings":["Department of Anesthesiology and Critical Care, Children\u2019s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA","Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA"],"raw_orcid":"https://orcid.org/0000-0002-2996-217X","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Critical Care, Children\u2019s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I4405271814","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5031613696"],"corresponding_institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I4405271814","https://openalex.org/I79576946"],"apc_list":{"value":1600,"currency":"USD","value_usd":1600},"apc_paid":{"value":1600,"currency":"USD","value_usd":1600},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60965084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"8","first_page":"e1468","last_page":"e1468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-acute-respiratory-distress-syndrome","display_name":"pediatric acute respiratory distress syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-biomarkers","display_name":"protein biomarkers","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-quantitative-trait-loci","display_name":"protein quantitative trait loci","score":0.8130000233650208},{"id":"https://openalex.org/keywords/surfactant-protein-d","display_name":"surfactant protein D","score":0.9070000052452087},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ards-subphenotypes","display_name":"ARDS subphenotypes","score":0.7770000100135803},{"id":"https://openalex.org/keywords/28-day-survival","display_name":"28-day survival","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/pneumonia","display_name":"pneumonia","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.79830002784729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.751800000667572},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7010999917984009},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5932000279426575},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5392000079154968},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5268999934196472},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5080000162124634},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4262000024318695},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4043000042438507},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.38769999146461487},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3776000142097473},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3483000099658966},{"id":"https://openalex.org/C2909621147","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"Acute respiratory distress","level":3,"score":0.3465000092983246},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3400999903678894},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.29670000076293945},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.29159998893737793},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2705000042915344},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2581999897956848},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.2551000118255615},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2526000142097473}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015278","descriptor_name":"Intensive Care Units, Pediatric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040641","descriptor_name":"Quantitative Trait Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/cce.0000000000001468","doi":"https://doi.org/10.1097/cce.0000000000001468","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cce.0000000000001468","pdf_url":null,"source":{"id":"https://openalex.org/S4210210302","display_name":"Critical Care Explorations","issn_l":"2639-8028","issn":["2639-8028"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Explorations","raw_type":"journal-article"},{"id":"pmid:42610802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42610802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical care explorations","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13485844","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13485844/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crit Care Explor","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1097/cce.0000000000001468","doi":"https://doi.org/10.1097/cce.0000000000001468","is_oa":true,"landing_page_url":"https://doi.org/10.1097/cce.0000000000001468","pdf_url":null,"source":{"id":"https://openalex.org/S4210210302","display_name":"Critical Care Explorations","issn_l":"2639-8028","issn":["2639-8028"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Care Explorations","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G8148993102","display_name":"Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome","funder_award_id":"R01HL148054","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1951724000","https://openalex.org/W2124519382","https://openalex.org/W2140749892","https://openalex.org/W2161633633","https://openalex.org/W2510773831","https://openalex.org/W2515625652","https://openalex.org/W2790360707","https://openalex.org/W2885500852","https://openalex.org/W3003044105","https://openalex.org/W3015666641","https://openalex.org/W3135169158","https://openalex.org/W3201934315","https://openalex.org/W4200535019","https://openalex.org/W4387450723","https://openalex.org/W4393950764"],"related_works":["https://openalex.org/W4410274122","https://openalex.org/W7124584779","https://openalex.org/W4205928443","https://openalex.org/W2409578263","https://openalex.org/W2942363620","https://openalex.org/W2037887491","https://openalex.org/W2124943596","https://openalex.org/W4393950764","https://openalex.org/W7163580893","https://openalex.org/W2805881196"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Acute":[1],"respiratory":[2],"distress":[3],"syndrome":[4],"(ARDS)":[5],"is":[6,247],"a":[7,58,101,232],"significant":[8,224],"contributor":[9],"to":[10,21,31,36,44,159,249,264],"ICU":[11],"admissions,":[12],"morbidity,":[13],"and":[14,24,122,124,132,162,179],"mortality.":[15],"Biomarkers":[16],"have":[17],"increasingly":[18],"been":[19],"used":[20,43,263],"dissect":[22],"heterogeneity":[23],"mechanisms":[25],"underlying":[26],"pediatric":[27,46,68,243,254],"ARDS.":[28,244],"We":[29,108,230],"sought":[30],"assess":[32],"the":[33,37,111,153,201,204,260],"genetic":[34,112,257],"contribution":[35],"levels":[38,117,208,241,262],"of":[39,62,92,177,203,217,259],"protein":[40,78,150],"biomarkers":[41,87],"currently":[42],"subphenotype":[45],"ARDS":[47,69,157,165,218],"patients.":[48],"DESIGN,":[49],"SETTING,":[50],"AND":[51,74],"PARTICIPANTS:":[52],"Retrospective,":[53],"single-center":[54,102],"cohort":[55,103],"study":[56],"at":[57],"tertiary":[59],"care":[60],"PICU":[61],"children":[63,140],"(<":[64],"18":[65],"yr)":[66],"with":[67,98,114,125,141,193],"diagnosis.":[70],"INTERVENTIONS:":[71],"None.":[72],"MEASUREMENTS":[73],"MAIN":[75],"RESULTS:":[76],"Genome-wide":[77],"quantitative":[79],"trait":[80],"loci":[81],"(pQTL)":[82],"analysis":[83,146,221],"was":[84,173,182,189],"performed":[85],"on":[86,89,206,214,226],"measured":[88],"day":[90,215],"0":[91,216],"ARDS,":[93,142,255],"which":[94],"were":[95],"previously":[96],"associated":[97],"outcomes":[99],"from":[100,167],"using":[104,128],"linear":[105,129],"regression":[106],"models.":[107],"then":[109],"assessed":[110],"association":[113],"longitudinal":[115],"biomarker":[116,207,240,261],"(on":[118],"days":[119],"0,":[120],"3,":[121],"7)":[123],"28-day":[126],"survival":[127],"mixed-effects":[130],"models":[131],"Cox":[133],"proportional":[134],"hazard":[135],"models,":[136],"respectively.":[137],"From":[138],"333":[139],"267":[143],"underwent":[144],"pQTL":[145],"against":[147],"6":[148],"preselected":[149],"biomarkers.":[151],"Among":[152],"patients,":[154,178],"49.4%":[155],"had":[156,164],"attributed":[158],"infectious":[160],"pneumonia,":[161],"21.7%":[163],"resulting":[166],"nonpulmonary":[168],"sepsis.":[169],"The":[170],"hypoinflammatory":[171],"phenotype":[172],"identified":[174,190,231],"in":[175,191,209,235,242,253],"74.2%":[176],"overall":[180],"mortality":[181,227],"14.6%.":[183],"One":[184],"single":[185],"nucleotide":[186],"polymorphism":[187],"(SNP)":[188],"SFTPD":[192,236],"presumed":[194],"cis-regulatory":[195],"effect.":[196],"Linear":[197],"mixed-effect":[198],"modeling":[199],"confirmed":[200],"effect":[202],"SNP":[205,234],"heterozygous":[210],"or":[211],"homozygous":[212],"carriers":[213],"course.":[219],"Survival":[220],"demonstrated":[222],"no":[223],"impact":[225],"risk.":[228],"CONCLUSIONS:":[229],"gene-associated":[233],"that":[237],"impacts":[238],"relevant":[239],"Further":[245],"characterization":[246],"needed":[248],"better":[250],"understand":[251],"subphenotypes":[252],"including":[256],"determinants":[258],"define":[265],"them.":[266]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-19T00:00:00"}
