{"id":"https://openalex.org/W7203689720","doi":"https://doi.org/10.1016/j.ejphar.2026.179253","title":"Neuropharmacological and behavioral characterization of 3F-phenetrazine, a novel amphetamine-like substance, in male mice and rats","display_name":"Neuropharmacological and behavioral characterization of 3F-phenetrazine, a novel amphetamine-like substance, in male mice and rats","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7203689720","doi":"https://doi.org/10.1016/j.ejphar.2026.179253","pmid":"https://pubmed.ncbi.nlm.nih.gov/42612772"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejphar.2026.179253","doi":"https://doi.org/10.1016/j.ejphar.2026.179253","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2026.179253","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.ejphar.2026.179253","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147389998","display_name":"Sumin Ban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]},{"id":"https://openalex.org/I4210100168","display_name":"Korea Institute of Toxicology","ror":"https://ror.org/0159w2913","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210100168"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sumin Ban","raw_affiliation_strings":["Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea; Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea","institution_ids":["https://openalex.org/I196345858","https://openalex.org/I4210100168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017680538","display_name":"Kyung Oh Jeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100168","display_name":"Korea Institute of Toxicology","ror":"https://ror.org/0159w2913","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210100168"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung Oh Jeon","raw_affiliation_strings":["Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea","institution_ids":["https://openalex.org/I4210100168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101726175","display_name":"Su Yeon Seo","orcid":"https://orcid.org/0000-0003-1218-9835","observed_orcids":["https://orcid.org/0000-0003-1218-9835"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su Yeon Seo","raw_affiliation_strings":["Korean Medicine (KM) Science Research Division, Korea Institute of Oriental Medicine and Department of Korea Convergence Medical Science, University of Science and Technology (UST), Daejeon, 34054, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korean Medicine (KM) Science Research Division, Korea Institute of Oriental Medicine and Department of Korea Convergence Medical Science, University of Science and Technology (UST), Daejeon, 34054, Republic of Korea","institution_ids":["https://openalex.org/I4210087584","https://openalex.org/I88761825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133321403","display_name":"Young Ju Do","orcid":"https://orcid.org/0009-0009-8388-1934","observed_orcids":["https://orcid.org/0009-0009-8388-1934"]},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Young Ju Do","raw_affiliation_strings":["Korean Medicine (KM) Science Research Division, Korea Institute of Oriental Medicine and Department of Korea Convergence Medical Science, University of Science and Technology (UST), Daejeon, 34054, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0009-8388-1934","affiliations":[{"raw_affiliation_string":"Korean Medicine (KM) Science Research Division, Korea Institute of Oriental Medicine and Department of Korea Convergence Medical Science, University of Science and Technology (UST), Daejeon, 34054, Republic of Korea","institution_ids":["https://openalex.org/I4210087584","https://openalex.org/I88761825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083625738","display_name":"Choon\u2010Gon Jang","orcid":"https://orcid.org/0000-0003-0854-5008","observed_orcids":["https://orcid.org/0000-0003-0854-5008"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Choon-Gon Jang","raw_affiliation_strings":["Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045567340","display_name":"Han Young Eom","orcid":"https://orcid.org/0000-0002-7250-1926","observed_orcids":["https://orcid.org/0000-0002-7250-1926"]},"institutions":[{"id":"https://openalex.org/I4210100168","display_name":"Korea Institute of Toxicology","ror":"https://ror.org/0159w2913","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210100168"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han Young Eom","raw_affiliation_strings":["Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea","institution_ids":["https://openalex.org/I4210100168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147428888","display_name":"Kee Kwang Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kee Kwang Kim","raw_affiliation_strings":["Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100864048","display_name":"Hye Jin","orcid":"https://orcid.org/0009-0002-9523-0759","observed_orcids":["https://orcid.org/0009-0002-9523-0759"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye Jin Cha","raw_affiliation_strings":["College of Veterinary Medicine, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Veterinary Medicine, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009369823","display_name":"Eun Young Jang","orcid":"https://orcid.org/0000-0002-6628-0127","observed_orcids":["https://orcid.org/0000-0002-6628-0127"]},"institutions":[{"id":"https://openalex.org/I4210100168","display_name":"Korea Institute of Toxicology","ror":"https://ror.org/0159w2913","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210100168"]},{"id":"https://openalex.org/I88761825","display_name":"Korea University of Science and Technology","ror":"https://ror.org/000qzf213","country_code":"KR","type":"education","lineage":["https://openalex.org/I88761825"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Eun Young Jang","raw_affiliation_strings":["Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea; School of Korea Institute of Toxicology, University of Science and Technology, Daejeon, 34113, Republic of Korea. Electronic address: eunyoung.jang@kitox.re.kr"],"raw_orcid":"https://orcid.org/0000-0002-6628-0127","affiliations":[{"raw_affiliation_string":"Center for Convergence Toxicology Research, Division of Next-Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea; School of Korea Institute of Toxicology, University of Science and Technology, Daejeon, 34113, Republic of Korea. Electronic address: eunyoung.jang@kitox.re.kr","institution_ids":["https://openalex.org/I4210100168","https://openalex.org/I88761825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5009369823","https://openalex.org/A5083625738"],"corresponding_institution_ids":["https://openalex.org/I4210100168","https://openalex.org/I848706","https://openalex.org/I88761825"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":{"value":3230,"currency":"USD","value_usd":3230},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56477711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1033","issue":null,"first_page":"179253","last_page":"179253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenethylamines","display_name":"phenethylamines","score":0.5429999828338623},{"id":"https://openalex.org/keywords/psychostimulant-effects","display_name":"psychostimulant effects","score":0.8650000095367432},{"id":"https://openalex.org/keywords/drug-self-administration","display_name":"self-administration","score":0.8420000076293945},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.9649999737739563},{"id":"https://openalex.org/keywords/behavioral-sensitization","display_name":"behavioral sensitization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.5809999704360962},{"id":"https://openalex.org/keywords/c-fos","display_name":"c-fos","score":0.925000011920929},{"id":"https://openalex.org/keywords/arc","display_name":"Arc","score":0.7760000228881836},{"id":"https://openalex.org/keywords/dendritic-spine-density","display_name":"dendritic spine density","score":0.9139999747276306},{"id":"https://openalex.org/keywords/dorsal-striatum","display_name":"dorsal striatum","score":0.9449999928474426},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":1.0},{"id":"https://openalex.org/keywords/abuse-potential","display_name":"abuse liability","score":0.8560000061988831},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.7379999756813049},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6575999855995178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5637000203132629},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4352000057697296},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C128188215","wikidata":"https://www.wikidata.org/wiki/Q3026765","display_name":"Neuropharmacology","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.27160000801086426},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.26840001344680786},{"id":"https://openalex.org/C2776190711","wikidata":"https://www.wikidata.org/wiki/Q7398663","display_name":"Safety pharmacology","level":3,"score":0.24770000576972961},{"id":"https://openalex.org/C2993436365","wikidata":"https://www.wikidata.org/wiki/Q925958","display_name":"Locomotor activity","level":2,"score":0.2418999969959259}],"mesh":[{"descriptor_ui":"D000661","descriptor_name":"Amphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016760","descriptor_name":"Proto-Oncogene Proteins c-fos","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejphar.2026.179253","doi":"https://doi.org/10.1016/j.ejphar.2026.179253","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2026.179253","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:42612772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42612772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ejphar.2026.179253","doi":"https://doi.org/10.1016/j.ejphar.2026.179253","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejphar.2026.179253","pdf_url":null,"source":{"id":"https://openalex.org/S187816532","display_name":"European Journal of Pharmacology","issn_l":"0014-2999","issn":["0014-2999","1879-0712"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2749468203","display_name":null,"funder_award_id":"RS-2025-00520266","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G7339734531","display_name":null,"funder_award_id":"22241MFDS251","funder_id":"https://openalex.org/F4320322014","funder_display_name":"Ministry of Food and Drug Safety"},{"id":"https://openalex.org/G8662384816","display_name":null,"funder_award_id":"CAP21025-000","funder_id":"https://openalex.org/F4320325370","funder_display_name":"National Research Council of Science and Technology"},{"id":"https://openalex.org/G995672405","display_name":null,"funder_award_id":"KS-2603-02","funder_id":"https://openalex.org/F4320322102","funder_display_name":"Korea Institute of Toxicology"}],"funders":[{"id":"https://openalex.org/F4320322014","display_name":"Ministry of Food and Drug Safety","ror":"https://ror.org/01f7dp456"},{"id":"https://openalex.org/F4320322102","display_name":"Korea Institute of Toxicology","ror":"https://ror.org/0159w2913"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320325370","display_name":"National Research Council of Science and Technology","ror":"https://ror.org/058rymf81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1900980019","https://openalex.org/W1913760354","https://openalex.org/W1983048332","https://openalex.org/W1986761358","https://openalex.org/W1993087404","https://openalex.org/W1997303573","https://openalex.org/W2013940388","https://openalex.org/W2014051479","https://openalex.org/W2019908904","https://openalex.org/W2021875056","https://openalex.org/W2022110991","https://openalex.org/W2022402243","https://openalex.org/W2037560797","https://openalex.org/W2054504410","https://openalex.org/W2055658875","https://openalex.org/W2061690520","https://openalex.org/W2066848874","https://openalex.org/W2072493041","https://openalex.org/W2080471968","https://openalex.org/W2085073153","https://openalex.org/W2097645509","https://openalex.org/W2102754843","https://openalex.org/W2149463687","https://openalex.org/W2151633169","https://openalex.org/W2167200470","https://openalex.org/W2314633627","https://openalex.org/W2315801434","https://openalex.org/W2514084603","https://openalex.org/W2587072764","https://openalex.org/W2603139834","https://openalex.org/W2611299108","https://openalex.org/W2738278670","https://openalex.org/W2761529652","https://openalex.org/W2783275500","https://openalex.org/W2905127777","https://openalex.org/W2908649987","https://openalex.org/W2913629713","https://openalex.org/W2952777439","https://openalex.org/W2992996143","https://openalex.org/W3003153055","https://openalex.org/W3083269006","https://openalex.org/W3131081585","https://openalex.org/W3134261119","https://openalex.org/W3178063978","https://openalex.org/W3215710974","https://openalex.org/W4280550362","https://openalex.org/W4293796219","https://openalex.org/W4298148700","https://openalex.org/W4306857395","https://openalex.org/W4367672295","https://openalex.org/W4385690984","https://openalex.org/W4391043117","https://openalex.org/W4392385051","https://openalex.org/W4393949472","https://openalex.org/W4396509341","https://openalex.org/W4396968142","https://openalex.org/W4398162097","https://openalex.org/W4399258139","https://openalex.org/W4400743180","https://openalex.org/W4401728476","https://openalex.org/W4403443048","https://openalex.org/W4403828767","https://openalex.org/W4406309688","https://openalex.org/W4407023658","https://openalex.org/W4407991141","https://openalex.org/W4411846418","https://openalex.org/W4412002257","https://openalex.org/W4412626160","https://openalex.org/W7124569741"],"related_works":["https://openalex.org/W2992996143","https://openalex.org/W4412114867","https://openalex.org/W7124569741","https://openalex.org/W1956683302","https://openalex.org/W4387564097","https://openalex.org/W2072493041","https://openalex.org/W2042336844","https://openalex.org/W2915773853","https://openalex.org/W2070024507","https://openalex.org/W7145068847"],"abstract_inverted_index":{"3-Fluorophenetrazine":[0],"(3F-phenetrazine)":[1],"is":[2,8,35],"a":[3,137],"novel":[4],"amphetamine-like":[5],"substance":[6],"that":[7,159,181,204],"structurally":[9],"similar":[10],"to":[11,38,62],"phenmetrazine":[12],"and":[13,27,43,57,71,77,85,102,132,144,153,166,169,185,210,216],"3F-phenmetrazine.":[14],"Despite":[15],"the":[16,36,40,63,82,128,174,221,234,241],"emergence":[17],"of":[18,46,238,246],"3F-phenetrazine":[19,47,92,100,112,120,135,160,193,205],"in":[20,48,81,94,108,125,142,147,173,220],"recreational":[21],"drug":[22],"markets,":[23],"its":[24,150,247],"neuropharmacological":[25],"profile":[26],"abuse":[28,236],"liability":[29,237],"remain":[30],"poorly":[31],"characterized.":[32],"This":[33,227],"study":[34,228],"first":[37],"investigate":[39],"psychostimulant,":[41,208],"rewarding,":[42,209],"reinforcing":[44,154,211],"properties":[45],"male":[49],"rodents":[50],"using":[51],"open-field":[52],"test,":[53],"conditioned":[54,129],"place":[55,130,140],"preference,":[56],"self-administration":[58,133,146],"tests.":[59],"In":[60,127],"addition":[61],"behavioral":[64,123],"assessments,":[65],"we":[66],"analyzed":[67],"serotonin":[68,163],"levels,":[69,164],"c-Fos":[70,165],"activity-regulated":[72],"cytoskeleton-associated":[73],"protein":[74],"(Arc)":[75],"expression,":[76,168],"dendritic":[78,170],"spine":[79,171],"density":[80,172],"dorsal":[83,175,222],"striatum":[84,176,223],"nucleus":[86,178,225],"accumbens":[87],"following":[88],"acute":[89,182],"or":[90],"repeated":[91,119,190],"administration":[93,113,121,161],"mice.":[95,110,126],"Body":[96],"weight":[97],"changes":[98,219],"during":[99],"treatment":[101,194],"withdrawal":[103],"periods":[104],"were":[105],"also":[106],"evaluated":[107],"normal":[109],"Acute":[111],"significantly":[114],"increased":[115,162],"locomotor":[116],"activity,":[117],"whereas":[118],"induced":[122],"sensitization":[124],"preference":[131,141],"studies,":[134],"produced":[136],"significant":[138,207],"drug-paired":[139],"mice":[143],"supported":[145],"rats,":[148],"confirming":[149],"potent":[151],"rewarding":[152],"properties.":[155],"Neurochemical":[156],"analysis":[157],"revealed":[158],"Arc":[167],"and/or":[177,224],"accumbens,":[179],"indicating":[180],"neurochemical":[183],"alteration":[184],"addiction-related":[186,217],"neuroplasticity":[187],"occurred":[188],"after":[189],"administration.":[191],"Finally,":[192],"did":[195],"not":[196],"affect":[197],"body":[198],"weight.":[199],"Collectively,":[200],"these":[201],"findings":[202],"demonstrate":[203],"exerts":[206],"effects":[212],"via":[213],"serotonergic":[214],"neurotransmission":[215],"neuroplastic":[218],"accumbens.":[226],"provides":[229],"critical":[230],"scientific":[231],"evidence":[232],"for":[233,243],"high":[235],"3F-phenetrazine,":[239],"underscoring":[240],"need":[242],"legal":[244],"regulation":[245],"nonmedical":[248],"use.":[249]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2026-08-19T00:00:00"}