{"id":"https://openalex.org/W7203677598","doi":"https://doi.org/10.14412/1996-7012-2026-4-24-33","title":"Pharmacoeconomic study of tocilizumab dosing strategies as an intravenous solution in rheumatoid arthritis","display_name":"Pharmacoeconomic study of tocilizumab dosing strategies as an intravenous solution in rheumatoid arthritis","publication_year":2026,"publication_date":"2026-08-17","ids":{"openalex":"https://openalex.org/W7203677598","doi":"https://doi.org/10.14412/1996-7012-2026-4-24-33"},"language":"en","primary_location":{"id":"doi:10.14412/1996-7012-2026-4-24-33","doi":"https://doi.org/10.14412/1996-7012-2026-4-24-33","is_oa":true,"landing_page_url":"https://doi.org/10.14412/1996-7012-2026-4-24-33","pdf_url":"https://mrj.ima-press.net/mrj/article/download/2026/1745","source":{"id":"https://openalex.org/S2737069371","display_name":"Modern Rheumatology Journal","issn_l":"1996-7012","issn":["1996-7012","2310-158X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://mrj.ima-press.net/mrj/article/download/2026/1745","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004963520","display_name":"Aleksander M. Lila","orcid":"https://orcid.org/0000-0002-6068-3080","observed_orcids":["https://orcid.org/0000-0002-6068-3080"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. M. Lila","raw_affiliation_strings":["Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia","V.A. Nasonova Research Institute of Rheumatology"],"raw_orcid":"https://orcid.org/0000-0002-6068-3080","affiliations":[{"raw_affiliation_string":"Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023431375","display_name":"A. Vasilenko","orcid":"https://orcid.org/0000-0002-5486-2576","observed_orcids":["https://orcid.org/0000-0002-5486-2576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. A. Vasilenko","raw_affiliation_strings":["Novgorod Regional Clinical Hospital"],"raw_orcid":"https://orcid.org/0000-0002-5486-2576","affiliations":[{"raw_affiliation_string":"Novgorod Regional Clinical Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039229305","display_name":"\u0415. \u0412. \u0413\u0435\u0440\u0430\u0441\u0438\u043c\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-5815-561X","observed_orcids":["https://orcid.org/0000-0001-5815-561X"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. V. Gerasimova","raw_affiliation_strings":["V.A. Nasonova Research Institute of Rheumatology"],"raw_orcid":"https://orcid.org/0000-0001-5815-561X","affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064164173","display_name":"\u0410. \u0418. \u0414\u0443\u0431\u0438\u043a\u043e\u0432","orcid":"https://orcid.org/0000-0002-7501-0137","observed_orcids":["https://orcid.org/0000-0002-7501-0137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. I. Dubikov","raw_affiliation_strings":["Professor A.I. Dubikov Rheumatology Clinic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor A.I. Dubikov Rheumatology Clinic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031154213","display_name":"\u0417\u0430\u0433\u0440\u0435\u0431\u043d\u0435\u0432\u0430 \u0410\u043b\u0435\u043d\u0430 \u0418\u0433\u043e\u0440\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-3235-1425","observed_orcids":["https://orcid.org/0000-0002-3235-1425"]},"institutions":[{"id":"https://openalex.org/I4210087337","display_name":"Moscow Clinical Scientific Center","ror":"https://ror.org/000wnz761","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210087337"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. I. Zagrebneva","raw_affiliation_strings":["Moscow Clinical Scientific Center, Hospital \u211652, Moscow Healthcare Department"],"raw_orcid":"https://orcid.org/0000-0002-3235-1425","affiliations":[{"raw_affiliation_string":"Moscow Clinical Scientific Center, Hospital \u211652, Moscow Healthcare Department","institution_ids":["https://openalex.org/I4210087337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035581742","display_name":"\u0417\u043e\u043d\u043e\u0432\u0430 \u0415\u043b\u0435\u043d\u0430 \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-0228-9085","observed_orcids":["https://orcid.org/0000-0002-0228-9085","https://orcid.org/0000-0001-8529-4105"]},"institutions":[{"id":"https://openalex.org/I145597306","display_name":"Novosibirsk State Medical University","ror":"https://ror.org/00d167n54","country_code":"RU","type":"education","lineage":["https://openalex.org/I145597306"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. V. Zonova","raw_affiliation_strings":["Novosibirsk State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0002-0228-9085","affiliations":[{"raw_affiliation_string":"Novosibirsk State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I145597306","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034524656","display_name":"L. V. Ivanova","orcid":"https://orcid.org/0000-0003-0411-6118","observed_orcids":["https://orcid.org/0000-0003-0411-6118"]},"institutions":[{"id":"https://openalex.org/I4210164508","display_name":"The First Republican Clinical Hospital of the Ministry of Health of the Udmurt Republic","ror":"https://ror.org/05rwq6592","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210164508"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. V. Ivanova","raw_affiliation_strings":["Republican Clinical and Diagnostic Center, Ministry of Health of the Udmurt Republic"],"raw_orcid":"https://orcid.org/0000-0003-0411-6118","affiliations":[{"raw_affiliation_string":"Republican Clinical and Diagnostic Center, Ministry of Health of the Udmurt Republic","institution_ids":["https://openalex.org/I4210164508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147377477","display_name":"T. N. Kargaeva","orcid":"https://orcid.org/0009-0000-6943-9407","observed_orcids":["https://orcid.org/0009-0000-6943-9407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. N. Kargaeva","raw_affiliation_strings":["City Clinical Hospital No.1 named after N.I. Pirogov"],"raw_orcid":"https://orcid.org/0009-0000-6943-9407","affiliations":[{"raw_affiliation_string":"City Clinical Hospital No.1 named after N.I. Pirogov","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101879998","display_name":"Maxim A. Korolev","orcid":"https://orcid.org/0000-0002-4890-0847","observed_orcids":["https://orcid.org/0000-0002-4890-0847"]},"institutions":[{"id":"https://openalex.org/I4210116466","display_name":"Institute of Cytology and Genetics","ror":"https://ror.org/0277xgb12","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I188973947","https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210127387","display_name":"Siberian Branch of the Russian Academy of Sciences","ror":"https://ror.org/02frkq021","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210127387"]},{"id":"https://openalex.org/I4210160615","display_name":"Institute of Clinical and Experimental Lymphology","ror":"https://ror.org/056an8658","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210160615"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. A. Korolev","raw_affiliation_strings":["Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0002-4890-0847","affiliations":[{"raw_affiliation_string":"Research Institute of Clinical and Experimental Lymphology, Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences","institution_ids":["https://openalex.org/I4210116466","https://openalex.org/I4210127387","https://openalex.org/I4210160615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123315772","display_name":"A. Yu. Kulikov","orcid":"https://orcid.org/0000-0002-5259-1266","observed_orcids":["https://orcid.org/0000-0002-5259-1266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. I. Kulikov","raw_affiliation_strings":["Regional Clinical Hospital \u21162"],"raw_orcid":"https://orcid.org/0000-0002-5259-1266","affiliations":[{"raw_affiliation_string":"Regional Clinical Hospital \u21162","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047377148","display_name":"Diana Ildarovna Abdulganieva","orcid":"https://orcid.org/0000-0001-7069-2725","observed_orcids":["https://orcid.org/0000-0001-7069-2725"]},"institutions":[{"id":"https://openalex.org/I186356647","display_name":"Kazan State Medical University","ror":"https://ror.org/013pk4y14","country_code":"RU","type":"education","lineage":["https://openalex.org/I186356647"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. I. Abdulganieva","raw_affiliation_strings":["Kazan State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0001-7069-2725","affiliations":[{"raw_affiliation_string":"Kazan State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I186356647","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055501716","display_name":"S. Lapshina","orcid":"https://orcid.org/0000-0001-5474-8565","observed_orcids":["https://orcid.org/0000-0001-5474-8565"]},"institutions":[{"id":"https://openalex.org/I186356647","display_name":"Kazan State Medical University","ror":"https://ror.org/013pk4y14","country_code":"RU","type":"education","lineage":["https://openalex.org/I186356647"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. A. Lapshina","raw_affiliation_strings":["Kazan State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0001-5474-8565","affiliations":[{"raw_affiliation_string":"Kazan State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I186356647","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049547284","display_name":"Galina V Lukina","orcid":"https://orcid.org/0000-0001-7958-5926","observed_orcids":["https://orcid.org/0000-0001-7958-5926"]},"institutions":[{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. V. Lukina","raw_affiliation_strings":["Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia","V.A. Nasonova Research Institute of Rheumatology"],"raw_orcid":"https://orcid.org/0000-0001-7958-5926","affiliations":[{"raw_affiliation_string":"Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092942709","display_name":"D. N. Malakhova","orcid":"https://orcid.org/0009-0007-4478-4723","observed_orcids":["https://orcid.org/0009-0007-4478-4723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. N. Malakhova","raw_affiliation_strings":["Prof. S.V. Ochapovsky Research Institute\u2013Regional Clinical Hospital \u21161, Ministry of Health of Krasnodar Krai"],"raw_orcid":"https://orcid.org/0009-0007-4478-4723","affiliations":[{"raw_affiliation_string":"Prof. S.V. Ochapovsky Research Institute\u2013Regional Clinical Hospital \u21161, Ministry of Health of Krasnodar Krai","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081566155","display_name":"Zinaida Yu. Mutovina","orcid":"https://orcid.org/0000-0001-5809-6015","observed_orcids":["https://orcid.org/0000-0001-5809-6015"]},"institutions":[{"id":"https://openalex.org/I4210087337","display_name":"Moscow Clinical Scientific Center","ror":"https://ror.org/000wnz761","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210087337"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Z. Yu. Mutovina","raw_affiliation_strings":["Moscow Clinical Scientific Center, Hospital \u211652, Moscow Healthcare Department"],"raw_orcid":"https://orcid.org/0000-0001-5809-6015","affiliations":[{"raw_affiliation_string":"Moscow Clinical Scientific Center, Hospital \u211652, Moscow Healthcare Department","institution_ids":["https://openalex.org/I4210087337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009125671","display_name":"Pavel I Novikov","orcid":"https://orcid.org/0000-0003-0148-5655","observed_orcids":["https://orcid.org/0000-0003-0148-5655"]},"institutions":[{"id":"https://openalex.org/I17877952","display_name":"Sechenov University","ror":"https://ror.org/02yqqv993","country_code":"RU","type":"education","lineage":["https://openalex.org/I17877952"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"P. I. Novikov","raw_affiliation_strings":["I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)"],"raw_orcid":"https://orcid.org/0000-0003-0148-5655","affiliations":[{"raw_affiliation_string":"I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)","institution_ids":["https://openalex.org/I17877952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039980536","display_name":"Ruzana Ramilovna Samigullina","orcid":"https://orcid.org/0000-0002-6341-3334","observed_orcids":["https://orcid.org/0000-0002-6341-3334"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]},{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R. R. Samigullina","raw_affiliation_strings":["I.I. Mechnikov North-Western State Medical University","V.A. Nasonova Clinical Rheumatological Hospital \u211625"],"raw_orcid":"https://orcid.org/0000-0002-6341-3334","affiliations":[{"raw_affiliation_string":"I.I. Mechnikov North-Western State Medical University","institution_ids":["https://openalex.org/I4210151936"]},{"raw_affiliation_string":"V.A. Nasonova Clinical Rheumatological Hospital \u211625","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016472949","display_name":"Anna Vasilyevna Torgashina","orcid":"https://orcid.org/0000-0001-8099-2107","observed_orcids":["https://orcid.org/0000-0001-8099-2107"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Torgashina","raw_affiliation_strings":["V.A. Nasonova Research Institute of Rheumatology"],"raw_orcid":"https://orcid.org/0000-0001-8099-2107","affiliations":[{"raw_affiliation_string":"V.A. Nasonova Research Institute of Rheumatology","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096677463","display_name":"G. F. Fatkhullina","orcid":"https://orcid.org/0009-0006-0991-533X","observed_orcids":["https://orcid.org/0009-0006-0991-533X"]},"institutions":[{"id":"https://openalex.org/I4210166446","display_name":"Republican Clinical Hospital named after G.G. Kuvatova","ror":"https://ror.org/05q50g776","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210166446"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. F. Fatkhullina","raw_affiliation_strings":["G.G. Kuvatov Republican Clinical Hospital"],"raw_orcid":"https://orcid.org/0009-0006-0991-533X","affiliations":[{"raw_affiliation_string":"G.G. Kuvatov Republican Clinical Hospital","institution_ids":["https://openalex.org/I4210166446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030382274","display_name":"\u0410. L. Chudinov","orcid":"https://orcid.org/0000-0002-7675-5683","observed_orcids":["https://orcid.org/0000-0002-7675-5683"]},"institutions":[{"id":"https://openalex.org/I4210121474","display_name":"Association of Rheumatologists of Russia","ror":"https://ror.org/02mfjm186","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210121474"]},{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. L. Chudinov","raw_affiliation_strings":["I.I. Mechnikov North-Western State Medical University","V.A. Nasonova Clinical Rheumatological Hospital \u211625"],"raw_orcid":"https://orcid.org/0000-0002-7675-5683","affiliations":[{"raw_affiliation_string":"I.I. Mechnikov North-Western State Medical University","institution_ids":["https://openalex.org/I4210151936"]},{"raw_affiliation_string":"V.A. Nasonova Clinical Rheumatological Hospital \u211625","institution_ids":["https://openalex.org/I4210121474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072419462","display_name":"Pavel A. Shesternya","orcid":"https://orcid.org/0000-0001-8652-1410","observed_orcids":["https://orcid.org/0000-0001-8652-1410"]},"institutions":[{"id":"https://openalex.org/I4210090231","display_name":"Krasnoyarsk State Medical University","ror":"https://ror.org/00b0jb681","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210090231"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"P. A. Shesternya","raw_affiliation_strings":["Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0001-8652-1410","affiliations":[{"raw_affiliation_string":"Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090231","https://openalex.org/I4210117042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038859956","display_name":"Evgeniy A. Trofimov","orcid":"https://orcid.org/0000-0003-3236-4485","observed_orcids":["https://orcid.org/0000-0003-3236-4485"]},"institutions":[{"id":"https://openalex.org/I4210151936","display_name":"North-Western State Medical University named after I.I. Mechnikov","ror":"https://ror.org/04kayk232","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210151936"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. A. Trofimov","raw_affiliation_strings":["I.I. Mechnikov North-Western State Medical University"],"raw_orcid":"https://orcid.org/0000-0003-3236-4485","affiliations":[{"raw_affiliation_string":"I.I. Mechnikov North-Western State Medical University","institution_ids":["https://openalex.org/I4210151936"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"4","first_page":"24","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.6708999872207642,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.305400013923645,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":1.0},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dose-de-escalation","display_name":"dose de-escalation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.7820000052452087},{"id":"https://openalex.org/keywords/budget-impact","display_name":"budget impact","score":0.625},{"id":"https://openalex.org/keywords/cost-reduction","display_name":"cost reduction","score":0.7260000109672546},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.5680000185966492},{"id":"https://openalex.org/keywords/russian-healthcare-system","display_name":"Russian healthcare system","score":0.6570000052452087},{"id":"https://openalex.org/keywords/il-6-receptor-inhibitor","display_name":"IL-6 receptor inhibitor","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.955299973487854},{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.9042999744415283},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8788999915122986},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7731000185012817},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.4025000035762787},{"id":"https://openalex.org/C2776125615","wikidata":"https://www.wikidata.org/wiki/Q18391886","display_name":"Economic evaluation","level":2,"score":0.38600000739097595},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36309999227523804},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3353999853134155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32989999651908875},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.3012999892234802},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3009999990463257},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C6964187","wikidata":"https://www.wikidata.org/wiki/Q659256","display_name":"Indirect costs","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C2988170871","wikidata":"https://www.wikidata.org/wiki/Q11000047","display_name":"Healthcare system","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C2776738588","wikidata":"https://www.wikidata.org/wiki/Q1567856","display_name":"Pharmacoeconomics","level":2,"score":0.26170000433921814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14412/1996-7012-2026-4-24-33","doi":"https://doi.org/10.14412/1996-7012-2026-4-24-33","is_oa":true,"landing_page_url":"https://doi.org/10.14412/1996-7012-2026-4-24-33","pdf_url":"https://mrj.ima-press.net/mrj/article/download/2026/1745","source":{"id":"https://openalex.org/S2737069371","display_name":"Modern Rheumatology Journal","issn_l":"1996-7012","issn":["1996-7012","2310-158X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14412/1996-7012-2026-4-24-33","doi":"https://doi.org/10.14412/1996-7012-2026-4-24-33","is_oa":true,"landing_page_url":"https://doi.org/10.14412/1996-7012-2026-4-24-33","pdf_url":"https://mrj.ima-press.net/mrj/article/download/2026/1745","source":{"id":"https://openalex.org/S2737069371","display_name":"Modern Rheumatology Journal","issn_l":"1996-7012","issn":["1996-7012","2310-158X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312717","host_organization_name":"IMA-PRESS LLC","host_organization_lineage":["https://openalex.org/P4310312717"],"host_organization_lineage_names":["IMA-PRESS LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Modern Rheumatology Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203677598.pdf","grobid_xml":"https://content.openalex.org/works/W7203677598.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1497514376","https://openalex.org/W1987170274","https://openalex.org/W1997568521","https://openalex.org/W2022713850","https://openalex.org/W2113398090","https://openalex.org/W2114308202","https://openalex.org/W2151858167","https://openalex.org/W2159595908","https://openalex.org/W2177530838","https://openalex.org/W2268541553","https://openalex.org/W2314383248","https://openalex.org/W2892263842","https://openalex.org/W3045428734","https://openalex.org/W4405402247","https://openalex.org/W4407895521"],"related_works":["https://openalex.org/W4416181934","https://openalex.org/W1964123850","https://openalex.org/W4399297828","https://openalex.org/W3164023257","https://openalex.org/W1989137555","https://openalex.org/W2980759709","https://openalex.org/W3033780627","https://openalex.org/W2100192839","https://openalex.org/W2112553711","https://openalex.org/W1977347654"],"abstract_inverted_index":{"Tocilizumab":[0],"(TCZ)":[1],"is":[2,51,85,100],"widely":[3],"used":[4],"in":[5,110,241,273],"rheumatoid":[6],"arthritis":[7],"(RA)":[8],"and":[9,25,45,68,87,115,140,147,186,192,270],"may":[10],"be":[11,280],"administered":[12],"using":[13,246,289],"different":[14],"dosing":[15,133],"regimens,":[16],"including":[17],"the":[18,34,43,59,62,66,105,130,197,232,235,263,274,277],"standard":[19],"dose":[20,28,74,89,250,257],"(SD)":[21],"of":[22,42,48,61,71,107,158,171,204,266],"8":[23,79,96,108],"mg/kg":[24,82,97,109],"regimens":[26],"involving":[27,248],"reduction":[29,240,251],"or":[30,252],"escalation":[31,90],"depending":[32],"on":[33],"clinical":[35,44,67],"response.":[36],"Under":[37],"current":[38],"healthcare":[39,64],"conditions,":[40],"assessment":[41,286],"economic":[46,69],"feasibility":[47,70],"drug-dosing":[49],"strategies":[50,247],"particularly":[52],"relevant.":[53],"Objective":[54],":":[55],"to":[56,80,95,128,182,196,206,220,262],"evaluate,":[57],"from":[58,78,93],"perspective":[60],"Russian":[63,275,290],"system,":[65],"a":[72,88,151,176,202,238,255,283],"TCZ":[73,132],"de-escalation":[75],"strategy":[76,91],"(DDS)":[77],"4":[81,94],"after":[83],"remission":[84,99],"achieved":[86],"(DES)":[92],"if":[98],"not":[101],"achieved,":[102],"compared":[103,164],"with":[104,112,121,165],"SD":[106],"patients":[111,205],"RA.":[113],"Material":[114],"methods":[116],".":[117,149,230],"A":[118],"decision-tree":[119],"model":[120,236],"1and":[122],"3-year":[123,177],"time":[124,153,178],"horizons":[125],"was":[126],"developed":[127],"compare":[129],"three":[131],"strategies.":[134],"Costminimization":[135],"analysis,":[136,139,200],"budget":[137,198],"impact":[138,199],"one-way":[141],"sensitivity":[142],"analysis":[143],"were":[144],"performed.":[145],"Results":[146],"discussion":[148],"Over":[150,175],"1-year":[152],"horizon,":[154,179],"DES":[155,191,207],"provided":[156,169],"savings":[157,170,180],"169,850":[159],"rubles":[160,173,184,188,214],"(28.1%)":[161],"per":[162],"patient":[163],"SD,":[166],"whereas":[167,218],"DDS":[168,221],"58,188":[172],"(9.6%).":[174],"amounted":[181],"168,849":[183],"(10.3%)":[185],"95,848":[187],"(5.8%)":[189],"for":[190],"DDS,":[193],"respectively.":[194],"According":[195],"transferring":[201],"proportion":[203],"could":[208,222],"reduce":[209,223],"costs":[210,224,244],"by":[211,225,259],"1.0\u20131.7":[212],"billion":[213,227],"over":[215],"3":[216],"years,":[217],"transition":[219],"0.6\u20131.0":[226],"rubles.":[228],"Conclusion":[229],"Within":[231],"adopted":[233],"assumptions,":[234],"demonstrates":[237],"potential":[239],"direct":[242,267],"drug":[243],"when":[245],"controlled":[249],"initiation":[253],"at":[254],"lower":[256],"followed":[258],"escalation.":[260],"Owing":[261],"limited":[264],"availability":[265],"comparative":[268],"data":[269],"regulatory":[271],"restrictions":[272],"Federation,":[276],"results":[278],"should":[279],"regarded":[281],"as":[282],"scenario-based":[284],"pharmacoeconomic":[285],"requiring":[287],"validation":[288],"data.":[291]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2026-08-19T00:00:00"}