{"id":"https://openalex.org/W7203676860","doi":"https://doi.org/10.1021/cbmi.6c00179","title":"Quantitative Semisolid Magnetization Transfer and Relayed Nuclear Overhauser Effect Imaging in a Multiple Sclerosis Mouse Model Using Deep Magnetic Resonance Fingerprinting","display_name":"Quantitative Semisolid Magnetization Transfer and Relayed Nuclear Overhauser Effect Imaging in a Multiple Sclerosis Mouse Model Using Deep Magnetic Resonance Fingerprinting","publication_year":2026,"publication_date":"2026-11-08","ids":{"openalex":"https://openalex.org/W7203676860","doi":"https://doi.org/10.1021/cbmi.6c00179"},"language":"en","primary_location":{"id":"doi:10.1021/cbmi.6c00179","doi":"https://doi.org/10.1021/cbmi.6c00179","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cbmi.6c00179","pdf_url":"https://pubs.acs.org/cbihbp/article-pdf/doi/10.1021/cbmi.6c00179/69114693/cbmi.6c00179.pdf","source":{"id":"https://openalex.org/S4387287784","display_name":"Chemical & Biomedical Imaging","issn_l":"2832-3637","issn":["2832-3637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical &amp; Biomedical Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pubs.acs.org/cbihbp/article-pdf/doi/10.1021/cbmi.6c00179/69114693/cbmi.6c00179.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147378498","display_name":"Ruth Ben Chaim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ruth Ben Chaim","raw_affiliation_strings":["Tel Aviv University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel Aviv University , , ,","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056251114","display_name":"Michal Rivlin","orcid":"https://orcid.org/0000-0001-8858-102X","observed_orcids":["https://orcid.org/0000-0001-8858-102X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Rivlin","raw_affiliation_strings":["Tel Aviv University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tel Aviv University , , ,","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027178832","display_name":"Or Perlman","orcid":"https://orcid.org/0000-0002-3566-569X","observed_orcids":["https://orcid.org/0000-0002-3566-569X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Or Perlman","raw_affiliation_strings":["Tel Aviv University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-3566-569X","affiliations":[{"raw_affiliation_string":"Tel Aviv University , , ,","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027178832"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/magnetic-resonance-fingerprinting","display_name":"magnetic resonance fingerprinting","score":0.9300000071525574},{"id":"https://openalex.org/keywords/myelin","display_name":"myelin","score":0.453000009059906},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.9240000247955322},{"id":"https://openalex.org/keywords/disease-biomarkers","display_name":"disease biomarkers","score":0.703000009059906},{"id":"https://openalex.org/keywords/7t-mri","display_name":"7T MRI","score":0.6620000004768372},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C27826641","wikidata":"https://www.wikidata.org/wiki/Q6731637","display_name":"Magnetization transfer","level":3,"score":0.8499000072479248},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.7653999924659729},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7554000020027161},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.71670001745224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5996000170707703},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.5472999811172485},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.48179998993873596},{"id":"https://openalex.org/C119851462","wikidata":"https://www.wikidata.org/wiki/Q901095","display_name":"Nuclear Overhauser effect","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.328000009059906},{"id":"https://openalex.org/C29022207","wikidata":"https://www.wikidata.org/wiki/Q7268943","display_name":"Quantitative susceptibility mapping","level":3,"score":0.3165000081062317},{"id":"https://openalex.org/C73286259","wikidata":"https://www.wikidata.org/wiki/Q7310885","display_name":"Relaxometry","level":4,"score":0.31060001254081726},{"id":"https://openalex.org/C32546565","wikidata":"https://www.wikidata.org/wiki/Q856711","display_name":"Magnetization","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C82233179","wikidata":"https://www.wikidata.org/wiki/Q2054500","display_name":"Partial volume","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C2988005100","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton magnetic resonance","level":2,"score":0.29660001397132874},{"id":"https://openalex.org/C2991897378","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Mri scan","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2676999866962433},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.2556999921798706},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.250900000333786}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/cbmi.6c00179","doi":"https://doi.org/10.1021/cbmi.6c00179","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cbmi.6c00179","pdf_url":"https://pubs.acs.org/cbihbp/article-pdf/doi/10.1021/cbmi.6c00179/69114693/cbmi.6c00179.pdf","source":{"id":"https://openalex.org/S4387287784","display_name":"Chemical & Biomedical Imaging","issn_l":"2832-3637","issn":["2832-3637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical &amp; Biomedical Imaging","raw_type":"journal-article"},{"id":"doi:10.64898/2026.08.17.743476","doi":"https://doi.org/10.64898/2026.08.17.743476","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.17.743476","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1021/cbmi.6c00179","doi":"https://doi.org/10.1021/cbmi.6c00179","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cbmi.6c00179","pdf_url":"https://pubs.acs.org/cbihbp/article-pdf/doi/10.1021/cbmi.6c00179/69114693/cbmi.6c00179.pdf","source":{"id":"https://openalex.org/S4387287784","display_name":"Chemical & Biomedical Imaging","issn_l":"2832-3637","issn":["2832-3637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical &amp; Biomedical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6126515479","display_name":null,"funder_award_id":"101115639","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6639976752","display_name":null,"funder_award_id":"1030/25","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320338453","display_name":"HORIZON EUROPE European Research Council","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203676860.pdf","grobid_xml":"https://content.openalex.org/works/W7203676860.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1482675544","https://openalex.org/W1496642521","https://openalex.org/W1784432185","https://openalex.org/W1901815193","https://openalex.org/W1929179128","https://openalex.org/W1969935384","https://openalex.org/W1975914956","https://openalex.org/W1986357760","https://openalex.org/W1994836057","https://openalex.org/W1995544467","https://openalex.org/W1995721991","https://openalex.org/W2003572429","https://openalex.org/W2004447739","https://openalex.org/W2007438030","https://openalex.org/W2023304339","https://openalex.org/W2057656867","https://openalex.org/W2060437747","https://openalex.org/W2100904149","https://openalex.org/W2110065044","https://openalex.org/W2123491442","https://openalex.org/W2129014164","https://openalex.org/W2133249774","https://openalex.org/W2135788803","https://openalex.org/W2144288697","https://openalex.org/W2181523240","https://openalex.org/W2315326168","https://openalex.org/W2398802375","https://openalex.org/W2519425400","https://openalex.org/W2605468160","https://openalex.org/W2744561951","https://openalex.org/W2766629769","https://openalex.org/W2891401014","https://openalex.org/W2915257066","https://openalex.org/W2993825770","https://openalex.org/W3029926248","https://openalex.org/W3139023360","https://openalex.org/W3188966192","https://openalex.org/W3195836932","https://openalex.org/W3209633379","https://openalex.org/W3214662017","https://openalex.org/W4210772434","https://openalex.org/W4226191729","https://openalex.org/W4226212059","https://openalex.org/W4241890711","https://openalex.org/W4281489846","https://openalex.org/W4281608698","https://openalex.org/W4296959164","https://openalex.org/W4310704648","https://openalex.org/W4321458751","https://openalex.org/W4323534435","https://openalex.org/W4327683114","https://openalex.org/W4360953180","https://openalex.org/W4380991378","https://openalex.org/W4385064560","https://openalex.org/W4387729405","https://openalex.org/W4387865573","https://openalex.org/W4388774347","https://openalex.org/W4396523455","https://openalex.org/W4398775671","https://openalex.org/W4403390049","https://openalex.org/W4403394341","https://openalex.org/W4403589246","https://openalex.org/W4406855782","https://openalex.org/W4409038067","https://openalex.org/W4409426276","https://openalex.org/W4409479581","https://openalex.org/W4412640785","https://openalex.org/W4414272694","https://openalex.org/W4414543042","https://openalex.org/W4414945964","https://openalex.org/W7127391898","https://openalex.org/W7128810342","https://openalex.org/W7153489426"],"related_works":["https://openalex.org/W7163519832","https://openalex.org/W2189396106","https://openalex.org/W3043231745","https://openalex.org/W4405000917","https://openalex.org/W1901815193","https://openalex.org/W2476897050","https://openalex.org/W2625861679","https://openalex.org/W4401571505","https://openalex.org/W4403589246","https://openalex.org/W1966371255"],"abstract_inverted_index":{"Abstract":[0],"Magnetic":[1],"resonance":[2,79],"imaging":[3,7,82],"(MRI)":[4],"is":[5],"the":[6,12,22,37,60,91,94,100,129,162,200],"modality":[8],"of":[9,17,32,93,177,202],"choice":[10],"for":[11,39,207],"diagnosis,":[13],"characterization,":[14],"and":[15,57,74,99,110,156],"monitoring":[16],"multiple":[18],"sclerosis":[19],"(MS).":[20],"Nevertheless,":[21],"contrasts":[23],"manifested":[24],"by":[25,183],"MS":[26,120,208],"lesions":[27],"often":[28],"overlap":[29],"with":[30,54,137,193],"those":[31],"other":[33],"pathological":[34],"conditions,":[35],"highlighting":[36],"need":[38],"additional":[40],"disease":[41],"biomarkers.":[42],"In":[43,126,152],"addition,":[44],"while":[45],"saturation":[46],"transfer":[47,97],"(ST)":[48],"MRI":[49],"provides":[50],"molecular":[51],"information":[52],"associated":[53],"myelin,":[55],"proteins,":[56],"lipids,":[58],"quantifying":[59],"underlying":[61],"proton":[62,131,144,158],"exchange":[63],"parameters":[64],"remains":[65],"challenging.":[66],"Here,":[67],"we":[68],"describe":[69],"a":[70,117,166],"strategy":[71],"that":[72],"extends":[73],"modifies":[75],"AI-boosted":[76],"ST":[77],"magnetic":[78],"fingerprinting":[80],"(MRF)":[81],"at":[83,107],"7T.":[84],"This":[85],"approach":[86],"was":[87],"used":[88],"to":[89,114],"quantify":[90],"dynamics":[92],"semisolid":[95,154],"magnetization":[96],"(MT)":[98],"aliphatic":[101],"relayed":[102],"nuclear":[103],"Overhauser":[104],"effect":[105],"(rNOE":[106],"\u22123.5":[108],"ppm":[109,112],"\u22121.6":[111],"relative":[113],"water)":[115],"in":[116,161,191],"longitudinal":[118],"cuprizone":[119,178],"mouse":[121],"model":[122],"(n":[123],"=":[124],"12).":[125],"lipid":[127,139],"phantoms,":[128],"reconstructed":[130],"volume":[132,159],"fractions":[133,160],"were":[134,190],"strongly":[135],"correlated":[136],"known":[138],"concentrations":[140],"across":[141],"all":[142],"three":[143],"pools":[145],"(r":[146],">":[147],"0.96,":[148],"p":[149],"<":[150,170],"0.001).":[151],"vivo,":[153],"MT":[155],"rNOE":[157],"corpus":[163],"callosum":[164],"demonstrated":[165],"significant":[167],"decrease":[168],"(p":[169],"0.01)":[171],"as":[172,174],"early":[173],"week":[175],"4":[176],"feeding,":[179],"preceding":[180],"changes":[181],"detected":[182],"conventional":[184],"water":[185],"relaxometry.":[186],"ST-MRF":[187,205],"based":[188],"biomarkers":[189],"agreement":[192],"histological":[194],"findings.":[195],"Overall,":[196],"our":[197],"results":[198],"demonstrate":[199],"feasibility":[201],"rapid,":[203],"multipool":[204],"quantification":[206],"characterization.":[209]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-08-19T00:00:00"}