{"id":"https://openalex.org/W7203674620","doi":"https://doi.org/10.1016/j.scr.2026.104078","title":"Generation and characterization of human induced pluripotent stem cell line AUSCIi001-A from spinal muscular atrophy patient","display_name":"Generation and characterization of human induced pluripotent stem cell line AUSCIi001-A from spinal muscular atrophy patient","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7203674620","doi":"https://doi.org/10.1016/j.scr.2026.104078","pmid":"https://pubmed.ncbi.nlm.nih.gov/42632224"},"language":"en","primary_location":{"id":"doi:10.1016/j.scr.2026.104078","doi":"https://doi.org/10.1016/j.scr.2026.104078","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scr.2026.104078","pdf_url":null,"source":{"id":"https://openalex.org/S81007815","display_name":"Stem Cell Research","issn_l":"1873-5061","issn":["1873-5061","1876-7753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.scr.2026.104078","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000977873","display_name":"Ekin DO\u011eAN","orcid":"https://orcid.org/0009-0002-1743-0835","observed_orcids":["https://orcid.org/0009-0002-1743-0835","https://orcid.org/0000-0002-1501-4945"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ekin Do\u011fan","raw_affiliation_strings":["Ankara University Institute of Health Sciences, Turkey; Stem Cell Institute, Ankara University, Ankara, Turkey"],"raw_orcid":"https://orcid.org/0009-0002-1743-0835","affiliations":[{"raw_affiliation_string":"Ankara University Institute of Health Sciences, Turkey; Stem Cell Institute, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035576778","display_name":"Zeynep B\u00fc\u015fra Aksoy","orcid":"https://orcid.org/0000-0002-8288-0974","observed_orcids":["https://orcid.org/0000-0002-8288-0974"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zeynep B\u00fc\u015fra Aksoy","raw_affiliation_strings":["Ankara University Institute of Health Sciences, Turkey; Stem Cell Institute, Ankara University, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University Institute of Health Sciences, Turkey; Stem Cell Institute, Ankara University, Ankara, Turkey","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045128603","display_name":"Bora Ergin","orcid":"https://orcid.org/0000-0002-8854-9713","observed_orcids":["https://orcid.org/0000-0002-8854-9713"]},"institutions":[{"id":"https://openalex.org/I4210161153","display_name":"Intergen (Turkey)","ror":"https://ror.org/04fpsr797","country_code":"TR","type":"company","lineage":["https://openalex.org/I4210161153"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bora Ergin","raw_affiliation_strings":["Intergen, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intergen, Ankara, Turkey","institution_ids":["https://openalex.org/I4210161153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113279193","display_name":"Serdar Ceylaner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161153","display_name":"Intergen (Turkey)","ror":"https://ror.org/04fpsr797","country_code":"TR","type":"company","lineage":["https://openalex.org/I4210161153"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serdar Ceylaner","raw_affiliation_strings":["Intergen, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intergen, Ankara, Turkey","institution_ids":["https://openalex.org/I4210161153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031862428","display_name":"Kamil Can Ak\u00e7al\u0131","orcid":"https://orcid.org/0000-0002-7816-6938","observed_orcids":["https://orcid.org/0000-0002-7816-6938"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kamil Can Ak\u00e7al\u0131","raw_affiliation_strings":["Ankara University Institute of Health Sciences, Turkey; Stem Cell Institute, Ankara University, Ankara, Turkey; Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Turkey. Electronic address: akcali@ankara.edu.tr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University Institute of Health Sciences, Turkey; Stem Cell Institute, Ankara University, Ankara, Turkey; Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Turkey. Electronic address: akcali@ankara.edu.tr","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2360,"currency":"USD","value_usd":2360},"apc_paid":{"value":2360,"currency":"USD","value_usd":2360},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"95","issue":null,"first_page":"104078","last_page":"104078"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-muscular-atrophy","display_name":"spinal muscular atrophy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sendai-virus-reprogramming","display_name":"Sendai virus reprogramming","score":0.8799999952316284},{"id":"https://openalex.org/keywords/integration-free-reprogramming","display_name":"integration-free reprogramming","score":0.953000009059906},{"id":"https://openalex.org/keywords/survival-motor-neuron-protein","display_name":"survival motor neuron protein","score":0.8149999976158142},{"id":"https://openalex.org/keywords/erythroid-progenitors","display_name":"erythroid progenitor cells","score":0.8960000276565552},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ipsc-differentiation","display_name":"iPSC differentiation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cellular-disease-model","display_name":"cellular disease model","score":0.6729999780654907},{"id":"https://openalex.org/keywords/motor-neuron-degeneration","display_name":"motor neuron degeneration","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8774999976158142},{"id":"https://openalex.org/C2778558090","wikidata":"https://www.wikidata.org/wiki/Q580290","display_name":"Spinal muscular atrophy","level":3,"score":0.7646999955177307},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6057999730110168},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5522000193595886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41429999470710754},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3903999924659729},{"id":"https://openalex.org/C198352243","wikidata":"https://www.wikidata.org/wiki/Q37105","display_name":"Line (geometry)","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.34310001134872437},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3407999873161316},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3181000053882599},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3050999939441681},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.2928999960422516},{"id":"https://openalex.org/C2910924664","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Human Induced Pluripotent Stem Cells","level":5,"score":0.2759999930858612},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2734000086784363}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.scr.2026.104078","doi":"https://doi.org/10.1016/j.scr.2026.104078","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scr.2026.104078","pdf_url":null,"source":{"id":"https://openalex.org/S81007815","display_name":"Stem Cell Research","issn_l":"1873-5061","issn":["1873-5061","1876-7753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research","raw_type":"journal-article"},{"id":"pmid:42632224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42632224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3128f50c4ee242edb71a0205b7f567b0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3128f50c4ee242edb71a0205b7f567b0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research, Vol 95, Iss , Pp 104078- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.scr.2026.104078","doi":"https://doi.org/10.1016/j.scr.2026.104078","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.scr.2026.104078","pdf_url":null,"source":{"id":"https://openalex.org/S81007815","display_name":"Stem Cell Research","issn_l":"1873-5061","issn":["1873-5061","1876-7753"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W4401375751"],"related_works":["https://openalex.org/W2909371554","https://openalex.org/W4366124607","https://openalex.org/W3046335377","https://openalex.org/W2077016023","https://openalex.org/W3207171662","https://openalex.org/W3162881926","https://openalex.org/W1996531448","https://openalex.org/W2145492799","https://openalex.org/W2965307666","https://openalex.org/W2316206888"],"abstract_inverted_index":{"Spinal":[0],"muscular":[1],"atrophy":[2,21],"(SMA)":[3],"is":[4],"a":[5,55,79,100],"genetic":[6],"disorder":[7],"characterized":[8],"by":[9],"the":[10,24,27,62,69,90],"degeneration":[11],"of":[12,26,54,73],"motor":[13,29],"neurons,":[14],"leading":[15],"to":[16,23,103,108],"progressive":[17],"muscle":[18],"weakness":[19],"and":[20,87],"due":[22],"deficiency":[25],"survival":[28],"neuron":[30],"(SMN)":[31],"protein.":[32],"Here,":[33],"we":[34],"established":[35],"an":[36],"induced":[37],"pluripotent":[38],"stem":[39],"cell":[40],"(iPSC)":[41],"line":[42,96],"AUSCIi001-A":[43],"from":[44,49],"erythroid":[45],"progenitor":[46],"cells":[47,53],"enriched":[48],"peripheral":[50],"blood":[51],"mononuclear":[52],"2-year-old":[56],"male":[57,81],"individual":[58],"with":[59],"SMA":[60],"using":[61],"integration-free":[63],"Sendai":[64,75],"reprogramming":[65,76],"method.We":[66],"demonstrated":[67],"that":[68],"iPSCs":[70],"are":[71],"free":[72],"exogenous":[74],"vectors,":[77],"have":[78],"normal":[80],"karyotype,":[82],"express":[83],"undifferentiated":[84],"hPSCs'":[85],"markers,":[86],"differentiate":[88],"into":[89],"three":[91],"germ":[92],"layers.":[93],"The":[94],"iPSC":[95],"can":[97],"serve":[98],"as":[99],"valuable":[101],"resource":[102],"generate":[104],"cellular":[105],"model":[106],"systems":[107],"investigate":[109],"molecular":[110],"mechanisms":[111],"underlying":[112],"SMA.":[113]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-19T00:00:00"}