{"id":"https://openalex.org/W7203670079","doi":"https://doi.org/10.1098/rsob.250369","title":"Structural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaP","display_name":"Structural insights into the polytopic Escherichia coli phosphoglycosyl transferase WbaP","publication_year":2026,"publication_date":"2026-08-19","ids":{"openalex":"https://openalex.org/W7203670079","doi":"https://doi.org/10.1098/rsob.250369","pmid":"https://pubmed.ncbi.nlm.nih.gov/42613053"},"language":"en","primary_location":{"id":"doi:10.1098/rsob.250369","doi":"https://doi.org/10.1098/rsob.250369","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.250369","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1098/rsob.250369","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018022775","display_name":"Miriam Weckener","orcid":"https://orcid.org/0000-0002-1419-9378","observed_orcids":["https://orcid.org/0000-0002-1419-9378"]},"institutions":[{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Miriam Weckener","raw_affiliation_strings":["The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0002-1419-9378","affiliations":[{"raw_affiliation_string":"The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK","institution_ids":["https://openalex.org/I4210103985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068053923","display_name":"Audrey Le Bas","orcid":"https://orcid.org/0000-0002-1100-6833","observed_orcids":["https://orcid.org/0000-0002-1100-6833"]},"institutions":[{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Audrey Le Bas","raw_affiliation_strings":["2 , Oxford, UK","The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0002-1100-6833","affiliations":[{"raw_affiliation_string":"2 , Oxford, UK","institution_ids":[]},{"raw_affiliation_string":"The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK","institution_ids":["https://openalex.org/I4210103985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069167048","display_name":"Philip N. Ward","orcid":"https://orcid.org/0000-0003-2546-3426","observed_orcids":["https://orcid.org/0000-0003-2546-3426"]},"institutions":[{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip N. Ward","raw_affiliation_strings":["The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0003-2546-3426","affiliations":[{"raw_affiliation_string":"The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK","institution_ids":["https://openalex.org/I4210103985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081981573","display_name":"Bradley R. Clarke","orcid":"https://orcid.org/0000-0003-2233-1268","observed_orcids":["https://orcid.org/0000-0003-2233-1268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bradley R. Clarke","raw_affiliation_strings":["6 , Guelph, Canada"],"raw_orcid":"https://orcid.org/0000-0003-2233-1268","affiliations":[{"raw_affiliation_string":"6 , Guelph, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002644042","display_name":"Peter J. Harrison","orcid":"https://orcid.org/0000-0001-5167-0547","observed_orcids":["https://orcid.org/0000-0001-5167-0547"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Harrison","raw_affiliation_strings":["7 , Didcot, UK","8 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0001-5167-0547","affiliations":[{"raw_affiliation_string":"7 , Didcot, UK","institution_ids":[]},{"raw_affiliation_string":"8 , Didcot, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047508911","display_name":"Stephen A. McMahon","orcid":"https://orcid.org/0000-0003-4273-8364","observed_orcids":["https://orcid.org/0000-0003-4273-8364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen A. McMahon","raw_affiliation_strings":["9 , St Andrews, UK"],"raw_orcid":"https://orcid.org/0000-0003-4273-8364","affiliations":[{"raw_affiliation_string":"9 , St Andrews, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060396046","display_name":"Huanting Liu","orcid":"https://orcid.org/0000-0001-5953-9367","observed_orcids":["https://orcid.org/0000-0001-5953-9367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huanting Liu","raw_affiliation_strings":["9 , St Andrews, UK"],"raw_orcid":"https://orcid.org/0000-0001-5953-9367","affiliations":[{"raw_affiliation_string":"9 , St Andrews, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063037688","display_name":"Alice Eddershaw","orcid":"https://orcid.org/0000-0002-8381-4135","observed_orcids":["https://orcid.org/0000-0002-8381-4135"]},"institutions":[{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alice Eddershaw","raw_affiliation_strings":["3 , Oxford, UK","The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0002-8381-4135","affiliations":[{"raw_affiliation_string":"3 , Oxford, UK","institution_ids":[]},{"raw_affiliation_string":"The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK","institution_ids":["https://openalex.org/I4210103985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034140391","display_name":"Andrew M. Giltrap","orcid":"https://orcid.org/0000-0001-8960-553X","observed_orcids":["https://orcid.org/0000-0001-8960-553X"]},"institutions":[{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M. Giltrap","raw_affiliation_strings":["4 , Oxford, UK","5 , Oxford, UK","The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0001-8960-553X","affiliations":[{"raw_affiliation_string":"4 , Oxford, UK","institution_ids":[]},{"raw_affiliation_string":"5 , Oxford, UK","institution_ids":[]},{"raw_affiliation_string":"The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK","institution_ids":["https://openalex.org/I4210103985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002431875","display_name":"Els Pardon","orcid":"https://orcid.org/0000-0002-2466-0172","observed_orcids":["https://orcid.org/0000-0002-2466-0172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Els Pardon","raw_affiliation_strings":["10 , Brussels, Belgium","11 , Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2466-0172","affiliations":[{"raw_affiliation_string":"10 , Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"11 , Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036441165","display_name":"Abirami Lakshminarayanan","orcid":"https://orcid.org/0000-0002-1688-3667","observed_orcids":["https://orcid.org/0000-0002-1688-3667"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abirami Lakshminarayanan","raw_affiliation_strings":["2 , Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-1688-3667","affiliations":[{"raw_affiliation_string":"2 , Oxford, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001394494","display_name":"Jan Steyaert","orcid":"https://orcid.org/0000-0002-3825-874X","observed_orcids":["https://orcid.org/0000-0002-3825-874X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Steyaert","raw_affiliation_strings":["10 , Brussels, Belgium","11 , Brussels, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-3825-874X","affiliations":[{"raw_affiliation_string":"10 , Brussels, Belgium","institution_ids":[]},{"raw_affiliation_string":"11 , Brussels, Belgium","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043732814","display_name":"Benjamin G. Davis","orcid":"https://orcid.org/0000-0002-5056-407X","observed_orcids":["https://orcid.org/0000-0002-5056-407X"]},"institutions":[{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benjamin G. Davis","raw_affiliation_strings":["4 , Oxford, UK","5 , Oxford, UK","The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0002-5056-407X","affiliations":[{"raw_affiliation_string":"4 , Oxford, UK","institution_ids":[]},{"raw_affiliation_string":"5 , Oxford, UK","institution_ids":[]},{"raw_affiliation_string":"The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK","institution_ids":["https://openalex.org/I4210103985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062469858","display_name":"Chris Whitfield","orcid":"https://orcid.org/0000-0002-5267-7027","observed_orcids":["https://orcid.org/0000-0002-5267-7027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Whitfield","raw_affiliation_strings":["6 , Guelph, Canada"],"raw_orcid":"https://orcid.org/0000-0002-5267-7027","affiliations":[{"raw_affiliation_string":"6 , Guelph, Canada","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066756448","display_name":"James H. Naismith","orcid":"https://orcid.org/0000-0001-6744-5061","observed_orcids":["https://orcid.org/0000-0001-6744-5061"]},"institutions":[{"id":"https://openalex.org/I4210103985","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210103985"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James\u00a0H. Naismith","raw_affiliation_strings":["2 , Oxford, UK","The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK"],"raw_orcid":"https://orcid.org/0000-0001-6744-5061","affiliations":[{"raw_affiliation_string":"2 , Oxford, UK","institution_ids":[]},{"raw_affiliation_string":"The Rosalind Franklin Institute, Harwell Campus 1 , Didcot, UK","institution_ids":["https://openalex.org/I4210103985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51701245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.23160000145435333,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.23160000145435333,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.20340000092983246,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.1898999959230423,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9589999914169312},{"id":"https://openalex.org/keywords/udp-galactose","display_name":"UDP-galactose","score":0.828000009059906},{"id":"https://openalex.org/keywords/galactose-1-phosphate","display_name":"galactose-1-phosphate","score":0.8100000023841858},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.47600001096725464},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.6710000038146973},{"id":"https://openalex.org/keywords/beta-hairpin","display_name":"beta-hairpin","score":0.7889999747276306},{"id":"https://openalex.org/keywords/catalytic-residues","display_name":"catalytic residues","score":0.8029999732971191},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.5669999718666077},{"id":"https://openalex.org/keywords/bacterial-surface","display_name":"bacterial cell surface","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2776376580","wikidata":"https://www.wikidata.org/wiki/Q407355","display_name":"Transferase","level":3,"score":0.879800021648407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7644000053405762},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.758899986743927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6575999855995178},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.642300009727478},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.6301000118255615},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5322999954223633},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.4625999927520752},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.4189999997615814},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.36059999465942383},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.359499990940094},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.3474000096321106},{"id":"https://openalex.org/C161019410","wikidata":"https://www.wikidata.org/wiki/Q67201373","display_name":"Glycosyltransferase","level":3,"score":0.3452000021934509},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.329800009727478},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32670000195503235},{"id":"https://openalex.org/C2781259782","wikidata":"https://www.wikidata.org/wiki/Q422573","display_name":"Uridine","level":4,"score":0.32670000195503235},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.3206999897956848},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.31679999828338623},{"id":"https://openalex.org/C2779461342","wikidata":"https://www.wikidata.org/wiki/Q59817493","display_name":"Ribose","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C2778152042","wikidata":"https://www.wikidata.org/wiki/Q412593","display_name":"Uridine diphosphate","level":3,"score":0.30160000920295715},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.29490000009536743},{"id":"https://openalex.org/C2778321597","wikidata":"https://www.wikidata.org/wiki/Q424702","display_name":"Peptidyl transferase","level":5,"score":0.28360000252723694},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.26100000739097595},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.25609999895095825},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.25380000472068787}],"mesh":[{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014531","descriptor_name":"Uridine Diphosphate Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014531","descriptor_name":"Uridine Diphosphate Galactose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016695","descriptor_name":"Glycosyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1098/rsob.250369","doi":"https://doi.org/10.1098/rsob.250369","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.250369","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},{"id":"pmid:42613053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42613053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1098/rsob.250369","doi":"https://doi.org/10.1098/rsob.250369","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsob.250369","pdf_url":null,"source":{"id":"https://openalex.org/S80033963","display_name":"Open Biology","issn_l":"2046-2441","issn":["2046-2441"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G113182007","display_name":"A membrane protein laboratory for integrative structural biology","funder_award_id":"223727/Z/21/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G1807008105","display_name":"Rosalind Franklin Institute - Next Generation Chemistry","funder_award_id":"EP/V011359/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3859189604","display_name":"A laboratory for membrane protein structural biology","funder_award_id":"202892/Z/16/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5770349843","display_name":"Recurrent funding for the RFI 2019 to 2021","funder_award_id":"EP/T012021/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G787615749","display_name":"Electrifying Life Science","funder_award_id":"220526/Z/20/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8374622837","display_name":"RFI Phase 2","funder_award_id":"EP/X527245/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G9000071214","display_name":null,"funder_award_id":"100209/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4030505941","display_name":"Rosalind Franklin Institute","ror":"https://ror.org/01djcs087"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1189912934","https://openalex.org/W1516644194","https://openalex.org/W1549295917","https://openalex.org/W1922098314","https://openalex.org/W1998292458","https://openalex.org/W2013676328","https://openalex.org/W2015205329","https://openalex.org/W2030632688","https://openalex.org/W2036797884","https://openalex.org/W2074473216","https://openalex.org/W2096221995","https://openalex.org/W2097604487","https://openalex.org/W2098167941","https://openalex.org/W2101871915","https://openalex.org/W2103232590","https://openalex.org/W2108921801","https://openalex.org/W2116137883","https://openalex.org/W2117319600","https://openalex.org/W2119738836","https://openalex.org/W2124026197","https://openalex.org/W2131176528","https://openalex.org/W2131891756","https://openalex.org/W2132629607","https://openalex.org/W2139288315","https://openalex.org/W2140599938","https://openalex.org/W2143117974","https://openalex.org/W2143726587","https://openalex.org/W2143815085","https://openalex.org/W2144081223","https://openalex.org/W2146080841","https://openalex.org/W2160898059","https://openalex.org/W2166347610","https://openalex.org/W2168974130","https://openalex.org/W2173600316","https://openalex.org/W2406050178","https://openalex.org/W2440245506","https://openalex.org/W2519097502","https://openalex.org/W2587625522","https://openalex.org/W2593511418","https://openalex.org/W2606915259","https://openalex.org/W2607005831","https://openalex.org/W2620712420","https://openalex.org/W2668542834","https://openalex.org/W2735876928","https://openalex.org/W2795719567","https://openalex.org/W2803725206","https://openalex.org/W2896957283","https://openalex.org/W2899714098","https://openalex.org/W2952729952","https://openalex.org/W2953320394","https://openalex.org/W2973457155","https://openalex.org/W2992696973","https://openalex.org/W3027219640","https://openalex.org/W3043527632","https://openalex.org/W3108495343","https://openalex.org/W3119448550","https://openalex.org/W3120145943","https://openalex.org/W3124206312","https://openalex.org/W3170191428","https://openalex.org/W3182767159","https://openalex.org/W3185661542","https://openalex.org/W3208774826","https://openalex.org/W3217324411","https://openalex.org/W4234317413","https://openalex.org/W4282922306","https://openalex.org/W4310058955","https://openalex.org/W4366985446","https://openalex.org/W4383058370","https://openalex.org/W4386154725","https://openalex.org/W4388971678","https://openalex.org/W4391954636","https://openalex.org/W4394694796","https://openalex.org/W4404791536","https://openalex.org/W4406135884","https://openalex.org/W4408336341","https://openalex.org/W4415497093"],"related_works":["https://openalex.org/W7168048716","https://openalex.org/W7054783643","https://openalex.org/W7168048709","https://openalex.org/W2173600316","https://openalex.org/W2140599938","https://openalex.org/W4388971743","https://openalex.org/W82881434","https://openalex.org/W3016414814","https://openalex.org/W1964846968","https://openalex.org/W2139288315"],"abstract_inverted_index":{"Host-pathogen":[0],"interactions":[1],"frequently":[2],"depend":[3],"on":[4],"key":[5],"components":[6],"of":[7,26,32,55,76,108,116,125,138,145,165],"the":[8,24,30,49,56,92,103,111,117,135,142,146,162],"bacterial":[9],"cell":[10],"surface,":[11],"such":[12],"as":[13,148],"capsules":[14],"and":[15,95,122,127,132],"lipopolysaccharides":[16],"in":[17,23,152],"Gram-negative":[18],"bacteria.":[19],"The":[20,67],"first":[21],"step":[22],"synthesis":[25],"lipid-linked":[27],"polysaccharides":[28],"is":[29,69],"substitution":[31],"a":[33,38,43,63,70,81,86,96],"uridine":[34],"diphosphate":[35],"(UDP)-sugar":[36],"by":[37,42,120,150],"lipid":[39],"monophosphate":[40],"catalysed":[41],"phosphoglycosyl":[44],"transferase":[45],"(PGT).":[46],"We":[47],"report":[48],"3.0":[50],"\u00c5":[51],"cryo-electron":[52],"microscopy":[53],"apo-structure":[54],"PGT":[57,163],"enzyme":[58],"WbaP":[59,109],"from":[60],"Escherichia":[61],"coli,":[62],"UDP-galactose:undecaprenolphosphate":[64],"galactose-1-phosphoryl":[65],"transferase.":[66],"structure":[68],"dimer":[71],"with":[72,85,110,130],"each":[73],"monomer":[74],"formed":[75],"four":[77],"N-terminal":[78],"transmembrane":[79,104],"helices,":[80],"small":[82],"\u03b1/\u03b2":[83],"domain":[84],"distinctive":[87],"\u03b2-hairpin":[88],"that":[89],"inserts":[90],"into":[91,161],"other":[93],"monomer,":[94],"catalytic":[97,143],"domain,":[98],"which":[99],"sits":[100],"perpendicular":[101],"to":[102],"domain.":[105],"A":[106],"complex":[107],"UDP-galactose":[112],"substrate":[113],"shows":[114],"binding":[115],"UDP":[118],"moiety":[119],"R319":[121,126],"R377.":[123],"Mutations":[124],"R377,":[128],"along":[129],"K331":[131],"R401,":[133],"highlighted":[134],"essential":[136],"nature":[137],"these":[139],"residues":[140],"for":[141],"activity":[144],"protein,":[147],"confirmed":[149],"an":[151],"vivo":[153],"functional":[154],"assay.":[155],"Our":[156],"results":[157],"provide":[158],"new":[159],"insights":[160],"family":[164],"enzymes.":[166]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-08-19T00:00:00"}
