{"id":"https://openalex.org/W7203665833","doi":"https://doi.org/10.1039/d6md00502k","title":"Rhodanine and 2,4-dioxothiazolidine-based amides: synthesis and evaluation as dual-action cholinesterase inhibitors and antioxidants","display_name":"Rhodanine and 2,4-dioxothiazolidine-based amides: synthesis and evaluation as dual-action cholinesterase inhibitors and antioxidants","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7203665833","doi":"https://doi.org/10.1039/d6md00502k","pmid":"https://pubmed.ncbi.nlm.nih.gov/42835501","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13635992"},"language":"en","primary_location":{"id":"doi:10.1039/d6md00502k","doi":"https://doi.org/10.1039/d6md00502k","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00502k","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1039/d6md00502k","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123459657","display_name":"Enik\u0151 \u0160ikorov\u00e1","orcid":"https://orcid.org/0000-0002-9146-573X","observed_orcids":["https://orcid.org/0000-0002-9146-573X"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Enik\u0151 \u0160ikorov\u00e1","raw_affiliation_strings":["Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-9146-573X","affiliations":[{"raw_affiliation_string":"Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048250228","display_name":"Ad\u00e9la \u0160imkov\u00e1","orcid":"https://orcid.org/0000-0002-9526-4708","observed_orcids":["https://orcid.org/0000-0002-9526-4708"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ad\u00e9la Kysl\u00edkov\u00e1","raw_affiliation_strings":["Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035964560","display_name":"Mark\u00e9ta \u0160varcov\u00e1","orcid":"https://orcid.org/0000-0001-8602-9805","observed_orcids":["https://orcid.org/0000-0001-8602-9805"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Mark\u00e9ta \u0160varcov\u00e1","raw_affiliation_strings":["Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006313503","display_name":"Ji\u0159\u00ed Palar\u010d\u00edk","orcid":"https://orcid.org/0000-0003-3763-4341","observed_orcids":["https://orcid.org/0000-0003-3763-4341"]},"institutions":[{"id":"https://openalex.org/I140744787","display_name":"University of Pardubice","ror":"https://ror.org/01chzd453","country_code":"CZ","type":"education","lineage":["https://openalex.org/I140744787"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ji\u0159\u00ed Palar\u010d\u00edk","raw_affiliation_strings":["Institute of Environmental and Chemical Engineering, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0003-3763-4341","affiliations":[{"raw_affiliation_string":"Institute of Environmental and Chemical Engineering, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic","institution_ids":["https://openalex.org/I140744787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014892333","display_name":"\u0160\u00e1rka \u0160t\u011bp\u00e1nkov\u00e1","orcid":"https://orcid.org/0000-0002-1969-5258","observed_orcids":["https://orcid.org/0000-0002-1969-5258"]},"institutions":[{"id":"https://openalex.org/I140744787","display_name":"University of Pardubice","ror":"https://ror.org/01chzd453","country_code":"CZ","type":"education","lineage":["https://openalex.org/I140744787"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"\u0160\u00e1rka \u0160t\u011bp\u00e1nkov\u00e1","raw_affiliation_strings":["Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-1969-5258","affiliations":[{"raw_affiliation_string":"Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentsk\u00e1 573, 532 10 Pardubice, Czech Republic","institution_ids":["https://openalex.org/I140744787"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078611040","display_name":"Martin Kr\u00e1tk\u00fd","orcid":"https://orcid.org/0000-0002-4600-8409","observed_orcids":["https://orcid.org/0000-0002-4600-8409"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Martin Kr\u00e1tk\u00fd","raw_affiliation_strings":["Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-4600-8409","affiliations":[{"raw_affiliation_string":"Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 500 03 Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014892333","https://openalex.org/A5078611040"],"corresponding_institution_ids":["https://openalex.org/I140744787","https://openalex.org/I21250087"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54961687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"10","first_page":"5058","last_page":"5068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhodanine","display_name":"rhodanine","score":0.7739999890327454},{"id":"https://openalex.org/keywords/acetanilide","display_name":"acetanilide","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cholinesterase-inhibitors","display_name":"cholinesterase inhibitors","score":0.9369999766349792},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.722000002861023},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9580000042915344},{"id":"https://openalex.org/keywords/multi-target-drug-design","display_name":"multi-target drug design","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6766999959945679},{"id":"https://openalex.org/C2776836360","wikidata":"https://www.wikidata.org/wiki/Q2741084","display_name":"Rhodanine","level":2,"score":0.6276999711990356},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.4975999891757965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49309998750686646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43130001425743103},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3684999942779541},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.34389999508857727},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.31119999289512634},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.2727000117301941},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6md00502k","doi":"https://doi.org/10.1039/d6md00502k","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00502k","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13635992","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13635992/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13635992/pdf/MD-OLF-D6MD00502K.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Med Chem","raw_type":"Text"},{"id":"pmid:42835501","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42835501","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d6md00502k","doi":"https://doi.org/10.1039/d6md00502k","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6md00502k","pdf_url":null,"source":{"id":"https://openalex.org/S4210227295","display_name":"RSC Medicinal Chemistry","issn_l":"2632-8682","issn":["2632-8682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000921948","display_name":null,"funder_award_id":"260 781","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"}],"funders":[{"id":"https://openalex.org/F4320309755","display_name":"Univerzita Karlova v Praze","ror":"https://ror.org/024d6js02"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203665833.pdf","grobid_xml":"https://content.openalex.org/works/W7203665833.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1970791475","https://openalex.org/W1979600197","https://openalex.org/W2000579023","https://openalex.org/W2007576725","https://openalex.org/W2054979333","https://openalex.org/W2062014588","https://openalex.org/W2085181735","https://openalex.org/W2085907924","https://openalex.org/W2094769478","https://openalex.org/W2098437204","https://openalex.org/W2105668062","https://openalex.org/W2114682709","https://openalex.org/W2128581376","https://openalex.org/W2132629607","https://openalex.org/W2133625553","https://openalex.org/W2134967712","https://openalex.org/W2137809729","https://openalex.org/W2143410390","https://openalex.org/W2470967254","https://openalex.org/W2568450381","https://openalex.org/W2585649818","https://openalex.org/W2606010066","https://openalex.org/W2755756968","https://openalex.org/W2761380851","https://openalex.org/W2774623109","https://openalex.org/W2951440100","https://openalex.org/W2952709614","https://openalex.org/W2972830734","https://openalex.org/W3001533296","https://openalex.org/W3187573306","https://openalex.org/W3197166860","https://openalex.org/W4284892821","https://openalex.org/W4310466556","https://openalex.org/W4385719681","https://openalex.org/W4389300563","https://openalex.org/W4400473074","https://openalex.org/W4402243131","https://openalex.org/W4406288025","https://openalex.org/W4406519657","https://openalex.org/W4409120807"],"related_works":["https://openalex.org/W2470967254","https://openalex.org/W7135637410","https://openalex.org/W4411987674","https://openalex.org/W4410723573","https://openalex.org/W2791670541","https://openalex.org/W4389300563","https://openalex.org/W4220899278","https://openalex.org/W3119038364","https://openalex.org/W3160116050","https://openalex.org/W3136713284"],"abstract_inverted_index":{"=":[0],"2.91":[1],"\u03bcM),":[2],"which":[3],"is":[4],"also":[5],"one":[6],"of":[7,25,43,63,72],"the":[8,40,64],"most":[9],"potent":[10],"AChE":[11],"inhibitors":[12,78],"in":[13],"this":[14,48],"series.":[15],"It":[16],"acts":[17],"as":[18,75],"a":[19],"specific,":[20],"reversible,":[21],"and":[22,28,36,66],"competitive":[23],"inhibitor":[24],"both":[26],"BChE":[27],"AChE.":[29],"Polyhalogenated":[30],"analogues":[31],"consistently":[32],"outperformed":[33],"their":[34],"mono-":[35],"di-substituted":[37],"counterparts,":[38],"highlighting":[39],"critical":[41],"role":[42],"lipophilic":[44],"electron-withdrawing":[45],"substituents.":[46],"Within":[47],"series,":[49],"rhodanines":[50],"were":[51],"generally":[52],"preferred":[53],"over":[54],"thiazolidine-2,4-diones.":[55],"Our":[56],"results":[57],"have":[58],"demonstrated":[59],"that":[60],"rational":[61],"modifications":[62],"rhodanine":[65],"thiazolidine-2,4-dione":[67],"cores":[68],"support":[69],"further":[70],"investigation":[71],"selected":[73],"derivatives":[74],"multitarget":[76],"cholinesterase":[77],"with":[79],"complementary":[80],"antioxidant":[81],"properties.":[82]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-19T00:00:00"}
