{"id":"https://openalex.org/W7203663852","doi":"https://doi.org/10.20517/evcna.2026.24","title":"Dynamic profiles and subpopulation characteristics of extracellular vesicles in patients undergoing transcatheter pulmonary valve replacement","display_name":"Dynamic profiles and subpopulation characteristics of extracellular vesicles in patients undergoing transcatheter pulmonary valve replacement","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7203663852","doi":"https://doi.org/10.20517/evcna.2026.24","pmid":"https://pubmed.ncbi.nlm.nih.gov/42898751","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13678174"},"language":"en","primary_location":{"id":"doi:10.20517/evcna.2026.24","doi":"https://doi.org/10.20517/evcna.2026.24","is_oa":true,"landing_page_url":"https://doi.org/10.20517/evcna.2026.24","pdf_url":null,"source":{"id":"https://openalex.org/S4210237820","display_name":"Extracellular Vesicles and Circulating Nucleic Acids","issn_l":"2767-6641","issn":["2767-6641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular Vesicles and Circulating Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.20517/evcna.2026.24","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010285851","display_name":"Rixin Liang","orcid":"https://orcid.org/0009-0003-0290-2016","observed_orcids":["https://orcid.org/0009-0003-0290-2016"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runzhang Liang","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","These authors contributed equally to this work"],"raw_orcid":"https://orcid.org/0009-0003-0290-2016","affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137670271","display_name":"Jiaxiong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxiong Wu","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114615424","display_name":"Naijimuding Abudurexiti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Naijimuding Abudurexiti","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, Guangdong, China","institution_ids":["https://openalex.org/I4210105984"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103263878","display_name":"Jing Ling","orcid":"https://orcid.org/0000-0001-6880-9664","observed_orcids":["https://orcid.org/0000-0001-6880-9664"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Ling","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147388995","display_name":"Zirui Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zirui Peng","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147446358","display_name":"Canxin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Canxin Wang","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147395431","display_name":"Jinxin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxin Li","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147381876","display_name":"Yong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhang","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147404465","display_name":"Haiyun Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyun Yuan","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113905365","display_name":"Shusheng Wen","orcid":"https://orcid.org/0000-0003-1672-0099","observed_orcids":["https://orcid.org/0000-0003-1672-0099","https://orcid.org/0009-0008-9200-9163"]},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shusheng Wen","raw_affiliation_strings":["Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]},{"raw_affiliation_string":"Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, Guangdong, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou 510080, Guangdong, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5113905365"],"corresponding_institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47086988,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"3","first_page":"1297","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9620000123977661},{"id":"https://openalex.org/keywords/transcatheter-pulmonary-valve-implantation","display_name":"transcatheter pulmonary valve replacement","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pulmonary-regurgitation","display_name":"pulmonary regurgitation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ev-subpopulations","display_name":"EV subpopulations","score":0.9049999713897705},{"id":"https://openalex.org/keywords/activated-leukocyte-cell-adhesion-molecule","display_name":"ALCAM","score":0.9599999785423279},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cd8a","display_name":"CD8A","score":0.9070000052452087},{"id":"https://openalex.org/keywords/right-ventricular-remodeling","display_name":"right ventricular remodeling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/perioperative-biomarkers","display_name":"perioperative biomarkers","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.5842999815940857},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.5511999726295471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4880000054836273},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.4740000069141388},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.43869999051094055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4025000035762787},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.38190001249313354},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3720000088214874},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C2778120352","wikidata":"https://www.wikidata.org/wiki/Q3870163","display_name":"Nanoparticle tracking analysis","level":5,"score":0.35179999470710754},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.34380000829696655},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.33889999985694885},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3375999927520752},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.322299987077713},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31630000472068787},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3151000142097473},{"id":"https://openalex.org/C10116572","wikidata":"https://www.wikidata.org/wiki/Q18033097","display_name":"LGR5","level":4,"score":0.31130000948905945},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.29420000314712524},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.28859999775886536},{"id":"https://openalex.org/C2780026749","wikidata":"https://www.wikidata.org/wiki/Q7912830","display_name":"Valve replacement","level":3,"score":0.2851000130176544},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2768000066280365},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26930001378059387},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2671000063419342},{"id":"https://openalex.org/C2780456743","wikidata":"https://www.wikidata.org/wiki/Q17816630","display_name":"ALCAM","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.250900000333786}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.20517/evcna.2026.24","doi":"https://doi.org/10.20517/evcna.2026.24","is_oa":true,"landing_page_url":"https://doi.org/10.20517/evcna.2026.24","pdf_url":null,"source":{"id":"https://openalex.org/S4210237820","display_name":"Extracellular Vesicles and Circulating Nucleic Acids","issn_l":"2767-6641","issn":["2767-6641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular Vesicles and Circulating Nucleic Acids","raw_type":"journal-article"},{"id":"pmid:42898751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42898751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular vesicles and circulating nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13678174","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13678174/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracell Vesicles Circ Nucl Acids","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.20517/evcna.2026.24","doi":"https://doi.org/10.20517/evcna.2026.24","is_oa":true,"landing_page_url":"https://doi.org/10.20517/evcna.2026.24","pdf_url":null,"source":{"id":"https://openalex.org/S4210237820","display_name":"Extracellular Vesicles and Circulating Nucleic Acids","issn_l":"2767-6641","issn":["2767-6641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular Vesicles and Circulating Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1544253303","https://openalex.org/W1968772146","https://openalex.org/W1993835819","https://openalex.org/W2006617902","https://openalex.org/W2135436658","https://openalex.org/W2301570128","https://openalex.org/W2314836909","https://openalex.org/W2593111137","https://openalex.org/W2743087301","https://openalex.org/W2885880900","https://openalex.org/W2969837995","https://openalex.org/W2970686861","https://openalex.org/W2990621560","https://openalex.org/W2991378871","https://openalex.org/W3039495480","https://openalex.org/W3159820652","https://openalex.org/W3181803629","https://openalex.org/W4289932077","https://openalex.org/W4311441793","https://openalex.org/W4312084005","https://openalex.org/W4316036614","https://openalex.org/W4319825886","https://openalex.org/W4323921185","https://openalex.org/W4395466383","https://openalex.org/W4396214311","https://openalex.org/W4400409458","https://openalex.org/W4405698390","https://openalex.org/W4406269048","https://openalex.org/W4409169501","https://openalex.org/W4412475199","https://openalex.org/W7117787346"],"related_works":["https://openalex.org/W2921276725","https://openalex.org/W4399070192","https://openalex.org/W2589409860","https://openalex.org/W4379600321","https://openalex.org/W3096968976","https://openalex.org/W3137670430","https://openalex.org/W4297997789","https://openalex.org/W4389952807","https://openalex.org/W3108531314","https://openalex.org/W4413671532"],"abstract_inverted_index":{"Aim:":[0],"Transcatheter":[1],"pulmonary":[2,12],"valve":[3],"replacement":[4],"(TPVR)":[5],"is":[6,227],"a":[7,26,260],"crucial":[8],"intervention":[9],"for":[10],"severe":[11],"regurgitation":[13],"(PR).":[14],"Extracellular":[15],"vesicle":[16],"(EV)":[17],"surface":[18],"proteins":[19,89],"reflect":[20],"cardiovascular":[21],"pathology.":[22],"This":[23,242],"study":[24,243],"employed":[25],"proximity":[27],"barcoding":[28],"assay":[29],"(PBA)":[30],"to":[31,169],"dynamically":[32],"monitor":[33],"EV":[34,98],"protein":[35,175],"profiles":[36,248],"during":[37],"TPVR.":[38],"Methods:":[39],"In":[40],"this":[41],"study,":[42],"40":[43],"biological":[44],"plasma":[45,253],"samples":[46],"were":[47,100,130],"analyzed":[48],"in":[49,111,153,188,213,221,230,236,255],"triplicate,":[50],"including":[51],"10":[52],"from":[53,60],"healthy":[54],"controls":[55],"(N":[56],"group)":[57],"and":[58,75,84,93,102,122,128,143,174,182,239,249],"30":[59],"TPVR":[61],"patients":[62,110,256],"across":[63,90],"three":[64],"time":[65],"points:":[66],"preoperative":[67],"(T1":[68],"group),":[69,74],"1":[70,76,203],"day":[71],"postoperative":[72,78],"(T2":[73],"week":[77],"(T3":[79],"group).":[80],"We":[81],"performed":[82],"combinatorial":[83],"functional":[85],"analyses":[86],"of":[87,119,141,172,180,252,263],"membrane":[88],"different":[91],"groups":[92],"evaluated":[94],"their":[95],"predictive":[96],"performance.":[97],"subpopulations":[99],"clustered":[101],"characterized.":[103],"Results:":[104],"Compared":[105],"with":[106,167],"the":[107,112,139,154,189,214,222,245],"N":[108],"group,":[109,156],"T1":[113],"group":[114],"exhibited":[115],"significantly":[116,131,151,205],"downregulated":[117],"expression":[118,140],"DSCAML1,":[120],"ALCAM,":[121],"LAG3":[123,144],"proteins,":[124],"while":[125,233],"CD8A,":[126],"NECTIN1,":[127],"LGR5":[129],"upregulated":[132],"(P":[133],"<":[134],"0.001;":[135],"AUC:":[136],"0.94-1.00).":[137],"Postoperatively,":[138],"ALCAM":[142],"rapidly":[145],"rebounded.":[146],"The":[147],"ALCAM&CD36&DSCAML1&PECAM1":[148],"combination":[149],"was":[150,159,204,210],"elevated":[152],"control":[155],"whereas":[157,207],"CD36&CD8A&DSCAML1&TACSTD2":[158],"reduced.":[160],"Gene":[161],"Ontology":[162],"(GO)":[163],"analysis":[164,185,199],"indicated":[165],"associations":[166],"response":[168],"stress,":[170],"side":[171],"membrane,":[173],"binding":[176],"pathways.":[177],"Kyoto":[178],"Encyclopedia":[179],"Genes":[181],"Genomes":[183],"(KEGG)":[184],"revealed":[186,200],"enrichment":[187],"phosphatidylinositol":[190],"3-kinase":[191],"(PI3K)/protein":[192],"kinase":[193],"B":[194],"(PKB/AKT)":[195],"signaling":[196],"pathway.":[197],"Subpopulation":[198],"that":[201],"Cluster":[202,208,218,231],"elevated,":[206],"2":[209,238],"markedly":[211],"decreased":[212],"disease":[215],"group.":[216,224],"Additionally,":[217],"4":[219],"dominated":[220],"T3":[223],"Furthermore,":[225],"CD8A":[226],"most":[228],"abundant":[229],"1,":[232],"DSCAML1":[234],"dominates":[235],"Clusters":[237],"4.":[240],"Conclusion:":[241],"provides":[244],"first":[246],"dynamic":[247],"subpopulation":[250],"characteristics":[251],"EVs":[254],"undergoing":[257],"TPVR,":[258],"establishing":[259],"molecular":[261],"atlas":[262],"perioperative":[264],"right":[265],"ventricular":[266],"remodeling":[267]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-19T00:00:00"}
