{"id":"https://openalex.org/W7203661990","doi":"https://doi.org/10.3389/fmicb.2026.1927904","title":"Gut microbiome\u2013immune\u2013metabolic mechanisms in cerebrovascular disease: evidence-graded insights from cerebral small vessel disease, ischemic stroke, and intracerebral hemorrhage","display_name":"Gut microbiome\u2013immune\u2013metabolic mechanisms in cerebrovascular disease: evidence-graded insights from cerebral small vessel disease, ischemic stroke, and intracerebral hemorrhage","publication_year":2026,"publication_date":"2026-08-18","ids":{"openalex":"https://openalex.org/W7203661990","doi":"https://doi.org/10.3389/fmicb.2026.1927904","pmid":"https://pubmed.ncbi.nlm.nih.gov/42682509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13529723"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1927904","doi":"https://doi.org/10.3389/fmicb.2026.1927904","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1927904","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1927904/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7203661990"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1927904/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057415257","display_name":"Chunna Ren","orcid":"https://orcid.org/0000-0003-3117-7004","observed_orcids":["https://orcid.org/0000-0003-3117-7004"]},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunna Ren","raw_affiliation_strings":["Second Affiliated Hospital of Mudanjiang Medical University","Second Clinical Medical School, Mudanjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Affiliated Hospital of Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]},{"raw_affiliation_string":"Second Clinical Medical School, Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060810530","display_name":"Yunxia Xiu","orcid":"https://orcid.org/0000-0002-4187-5191","observed_orcids":["https://orcid.org/0000-0002-4187-5191"]},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunxia Xiu","raw_affiliation_strings":["Second Affiliated Hospital of Mudanjiang Medical University","Second Clinical Medical School, Mudanjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Affiliated Hospital of Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]},{"raw_affiliation_string":"Second Clinical Medical School, Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354687","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0002-4520-2293","observed_orcids":["https://orcid.org/0000-0002-4520-2293"]},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Second Affiliated Hospital of Mudanjiang Medical University","Second Clinical Medical School, Mudanjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Affiliated Hospital of Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]},{"raw_affiliation_string":"Second Clinical Medical School, Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130630446","display_name":"Xiaoyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Wang","raw_affiliation_strings":["First Clinical Medical School, Mudanjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinical Medical School, Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147382502","display_name":"Hezhen Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hezhen Zhao","raw_affiliation_strings":["School of Basic Medical Sciences, Mudanjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130669184","display_name":"Jiahui Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahui Tang","raw_affiliation_strings":["First Clinical Medical School, Mudanjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinical Medical School, Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147442963","display_name":"Qingjun Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087423","display_name":"Daqing City People's Hospital","ror":"https://ror.org/010z8j306","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingjun Li","raw_affiliation_strings":["Daqing People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daqing People\u2019s Hospital","institution_ids":["https://openalex.org/I4210087423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136562252","display_name":"Shiwei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087423","display_name":"Daqing City People's Hospital","ror":"https://ror.org/010z8j306","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiwei Zhang","raw_affiliation_strings":["Daqing People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Daqing People\u2019s Hospital","institution_ids":["https://openalex.org/I4210087423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5130653884","display_name":"Feipeng Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093324","display_name":"Mudanjiang Medical University","ror":"https://ror.org/00mc5wj35","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093324"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feipeng Zhao","raw_affiliation_strings":["School of Basic Medical Sciences, Mudanjiang Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Mudanjiang Medical University","institution_ids":["https://openalex.org/I4210093324"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5130653884"],"corresponding_institution_ids":["https://openalex.org/I4210093324"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1927904","last_page":"1927904"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.996999979019165},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9559999704360962},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":1.0},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.925000011920929},{"id":"https://openalex.org/keywords/microbial-translocation","display_name":"microbial translocation","score":0.984000027179718},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.996999979019165},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tryptophan-metabolites","display_name":"tryptophan metabolites","score":0.9670000076293945},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/gut-virome","display_name":"gut virome","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mycobiome","display_name":"fungal communities","score":0.9649999737739563},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.8130000233650208},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/microbiota-targeted-interventions","display_name":"microbiota-targeted interventions","score":0.5690000057220459},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.5590000152587891},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.7630000114440918},{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.6654999852180481},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.5654000043869019},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5634999871253967},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5223000049591064},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49050000309944153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4763000011444092},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.45080000162124634},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.40959998965263367},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.3767000138759613},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.3598000109195709},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3490000069141388},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3465000092983246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3422999978065491},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.3296999931335449},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30979999899864197},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2903999984264374},{"id":"https://openalex.org/C2778593929","wikidata":"https://www.wikidata.org/wiki/Q133320","display_name":"Balaenoptera","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26179999113082886},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.2517000138759613},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmicb.2026.1927904","doi":"https://doi.org/10.3389/fmicb.2026.1927904","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1927904","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1927904/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13529723","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13529723/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13529723/pdf/fmicb-17-1927904.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Microbiol","raw_type":"Text"},{"id":"pmid:42682509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42682509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cd598cd442914e3d939be20b0525609a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cd598cd442914e3d939be20b0525609a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Microbiology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1927904","doi":"https://doi.org/10.3389/fmicb.2026.1927904","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1927904","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1927904/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203661990.pdf","grobid_xml":"https://content.openalex.org/works/W7203661990.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1515023627","https://openalex.org/W2051572323","https://openalex.org/W2105388729","https://openalex.org/W2109113634","https://openalex.org/W2152200355","https://openalex.org/W2158742097","https://openalex.org/W2166569595","https://openalex.org/W2332044667","https://openalex.org/W2460079419","https://openalex.org/W2587564932","https://openalex.org/W2612729422","https://openalex.org/W2765279273","https://openalex.org/W2803457956","https://openalex.org/W2938053041","https://openalex.org/W2941176735","https://openalex.org/W2964347729","https://openalex.org/W3031084800","https://openalex.org/W3044949983","https://openalex.org/W3120727757","https://openalex.org/W3126277686","https://openalex.org/W3162008994","https://openalex.org/W3171404117","https://openalex.org/W3182426688","https://openalex.org/W3183275405","https://openalex.org/W3211795092","https://openalex.org/W4205510598","https://openalex.org/W4210836456","https://openalex.org/W4220745026","https://openalex.org/W4221036935","https://openalex.org/W4229074162","https://openalex.org/W4282940157","https://openalex.org/W4288436705","https://openalex.org/W4312114634","https://openalex.org/W4377695790","https://openalex.org/W4379229924","https://openalex.org/W4383912782","https://openalex.org/W4386026343","https://openalex.org/W4390917684","https://openalex.org/W4391139446","https://openalex.org/W4391383920","https://openalex.org/W4393987377","https://openalex.org/W4394575461","https://openalex.org/W4394702428","https://openalex.org/W4394958690","https://openalex.org/W4395466394","https://openalex.org/W4399304110","https://openalex.org/W4401433994","https://openalex.org/W4402419297","https://openalex.org/W4402723140","https://openalex.org/W4402768749","https://openalex.org/W4404424603","https://openalex.org/W4406199605","https://openalex.org/W4406690028","https://openalex.org/W4409370338","https://openalex.org/W4411190671","https://openalex.org/W4411195827","https://openalex.org/W4411371600","https://openalex.org/W4412725901","https://openalex.org/W7124488609"],"related_works":["https://openalex.org/W4380873583","https://openalex.org/W4367601649","https://openalex.org/W4307869704","https://openalex.org/W7126243897","https://openalex.org/W3017155238","https://openalex.org/W4413399580","https://openalex.org/W4404029211","https://openalex.org/W3172241383","https://openalex.org/W4383000737","https://openalex.org/W7147329606"],"abstract_inverted_index":{"Cerebrovascular":[0],"disease":[1,20,158],"is":[2,25,52,127,163,169],"increasingly":[3],"being":[4],"examined":[5],"in":[6,67,130],"relation":[7],"to":[8,26],"the":[9,13,120],"gut":[10,81,121,271],"microbiome,":[11],"but":[12,172],"field":[14],"has":[15],"not":[16],"advanced":[17],"evenly":[18],"across":[19,84],"phenotypes.":[21],"A":[22],"central":[23],"challenge":[24],"distinguish":[27],"broad":[28],"dysbiosis-based":[29],"associations":[30],"from":[31],"microbial":[32,92,97,145,203,225],"functions,":[33],"host-facing":[34,205],"metabolites,":[35,110,146,206],"epithelial":[36],"barrier":[37,95],"injury,":[38],"and":[39,63,74,115,123,138,149,162,177,182,186,210,228,237,245,254,263,278],"immune":[40,147],"pathways":[41,273],"that":[42,192],"may":[43],"plausibly":[44],"influence":[45],"neurovascular":[46],"vulnerability":[47],"or":[48],"recovery.":[49],"This":[50,78,189],"distinction":[51],"particularly":[53],"important":[54],"because":[55],"cerebral":[56,155],"small":[57,156],"vessel":[58,157],"disease,":[59],"acute":[60,131],"ischemic":[61,132],"stroke,":[62,133],"intracerebral":[64,167],"hemorrhage":[65,168],"differ":[66],"time":[68],"scale,":[69],"vascular":[70,260],"pathology,":[71],"clinical":[72],"exposure,":[73],"available":[75],"microbiome":[76,143,194],"evidence.":[77],"review":[79,190],"evaluates":[80],"microbiome-immune-metabolic":[82],"mechanisms":[83,179],"these":[85],"cerebrovascular":[86,193],"contexts":[87],"with":[88],"a":[89],"focus":[90],"on":[91],"ecology,":[93],"intestinal":[94],"dysfunction,":[96],"translocation,":[98],"short-chain":[99],"fatty":[100],"acids":[101],"(SCFAs),":[102],"trimethylamine":[103],"N-oxide":[104],"(TMAO),":[105],"bile":[106],"acid":[107],"derivatives,":[108],"tryptophan-linked":[109],"lipopolysaccharide":[111],"(LPS)-related":[112],"inflammatory":[113],"signaling,":[114],"emerging":[116,171],"multi-kingdom":[117],"signals,":[118],"including":[119],"virome":[122],"mycobiome.":[124],"Current":[125],"evidence":[126],"most":[128],"convincing":[129],"where":[134],"human":[135],"cohort":[136],"studies":[137],"experimental":[139],"perturbation":[140],"models":[141],"link":[142],"disruption,":[144],"programming,":[148],"functional":[150],"outcome.":[151],"Evidence":[152],"for":[153,268],"imaging-defined":[154],"remains":[159],"more":[160],"limited":[161],"largely":[164],"cross-sectional,":[165],"whereas":[166],"an":[170],"mechanistically":[173],"distinct":[174],"domain.":[175],"Virome-":[176],"mycobiome-related":[178],"remain":[180],"exploratory":[181],"require":[183,235],"longitudinal,":[184],"multi-omics,":[185],"perturbation-based":[187],"validation.":[188],"argues":[191],"research":[195],"should":[196],"move":[197],"beyond":[198],"taxonomic":[199],"association":[200],"toward":[201],"time-resolved":[202],"function,":[204],"disease-specific":[207,252],"host-microbe":[208],"interfaces,":[209],"experimentally":[211],"testable":[212],"mechanisms.":[213],"Candidate":[214],"microbiome-directed":[215],"interventions-including":[216],"dietary,":[217],"prebiotic,":[218],"probiotic,":[219],"postbiotic,":[220],"fecal":[221],"microbiota":[222],"transplantation,":[223],"defined":[224],"consortia,":[226],"metabolite-targeted,":[227],"phage-based":[229],"approaches-remain":[230],"investigational.":[231],"Their":[232],"translation":[233],"will":[234,265],"disease-":[236],"time-window-specific":[238],"evaluation":[239],"of":[240,257],"biological":[241],"target":[242],"engagement,":[243],"safety,":[244],"clinically":[246],"meaningful":[247],"outcomes.":[248],"Longitudinal":[249],"multi-omics":[250],"cohorts,":[251],"models,":[253],"careful":[255],"control":[256],"diet,":[258],"antibiotics,":[259],"medications,":[261],"hospitalization,":[262],"frailty":[264],"be":[266],"essential":[267],"determining":[269],"which":[270],"microbiome-related":[272],"are":[274],"causal,":[275],"context-specific,":[276],"modifiable,":[277],"therapeutically":[279],"actionable.":[280]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-19T00:00:00"}