{"id":"https://openalex.org/W7203655488","doi":"https://doi.org/10.1016/j.medmic.2026.100184","title":"Nano-microbiome interactions in human health and disease exploring therapeutic opportunities, toxicological risks and future directions","display_name":"Nano-microbiome interactions in human health and disease exploring therapeutic opportunities, toxicological risks and future directions","publication_year":2026,"publication_date":"2026-08-17","ids":{"openalex":"https://openalex.org/W7203655488","doi":"https://doi.org/10.1016/j.medmic.2026.100184"},"language":"en","primary_location":{"id":"doi:10.1016/j.medmic.2026.100184","doi":"https://doi.org/10.1016/j.medmic.2026.100184","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.medmic.2026.100184","pdf_url":null,"source":{"id":"https://openalex.org/S4210211835","display_name":"Medicine in Microecology","issn_l":"2590-0978","issn":["2590-0978"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine in Microecology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.medmic.2026.100184","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102496308","display_name":"Shibasini Murugan","orcid":"https://orcid.org/0000-0003-2148-1109","observed_orcids":["https://orcid.org/0000-0003-2148-1109"]},"institutions":[{"id":"https://openalex.org/I175548057","display_name":"Vinayaka Missions University","ror":"https://ror.org/03wt62c10","country_code":"IN","type":"education","lineage":["https://openalex.org/I175548057"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shibasini Murugan","raw_affiliation_strings":["Central Research Laboratory for Biomedical Research, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India"],"raw_orcid":"https://orcid.org/0000-0003-2148-1109","affiliations":[{"raw_affiliation_string":"Central Research Laboratory for Biomedical Research, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India","institution_ids":["https://openalex.org/I175548057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023972322","display_name":"Suganya Kannan","orcid":"https://orcid.org/0000-0002-0341-7405","observed_orcids":["https://orcid.org/0000-0002-0341-7405"]},"institutions":[{"id":"https://openalex.org/I175548057","display_name":"Vinayaka Missions University","ror":"https://ror.org/03wt62c10","country_code":"IN","type":"education","lineage":["https://openalex.org/I175548057"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suganya Kannan","raw_affiliation_strings":["Central Research Laboratory for Biomedical Research, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratory for Biomedical Research, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India","institution_ids":["https://openalex.org/I175548057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009111740","display_name":"Jeyakumar Balakrishnan","orcid":"https://orcid.org/0000-0001-7543-8435","observed_orcids":["https://orcid.org/0000-0001-7543-8435"]},"institutions":[{"id":"https://openalex.org/I175548057","display_name":"Vinayaka Missions University","ror":"https://ror.org/03wt62c10","country_code":"IN","type":"education","lineage":["https://openalex.org/I175548057"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jeyakumar Balakrishnan","raw_affiliation_strings":["Central Research Laboratory for Biomedical Research, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratory for Biomedical Research, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India","institution_ids":["https://openalex.org/I175548057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073325183","display_name":"Namrata Krishna Bhosale","orcid":"https://orcid.org/0000-0002-8756-0494","observed_orcids":["https://orcid.org/0000-0002-8756-0494"]},"institutions":[{"id":"https://openalex.org/I175548057","display_name":"Vinayaka Missions University","ror":"https://ror.org/03wt62c10","country_code":"IN","type":"education","lineage":["https://openalex.org/I175548057"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Namrata K. Bhosale","raw_affiliation_strings":["Department of Microbiology, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Karaikal, Puducherry, India","institution_ids":["https://openalex.org/I175548057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102496308"],"corresponding_institution_ids":["https://openalex.org/I175548057"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":1.0379,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.66825266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"30","issue":null,"first_page":"100184","last_page":"100184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.8144999742507935,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14089","display_name":"Nanotechnology research and applications","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/2500","display_name":"General Materials Science"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/engineered-nanomaterials","display_name":"engineered nanomaterials","score":0.9769999980926514},{"id":"https://openalex.org/keywords/human-microbiome","display_name":"human microbiome","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nanotoxicology","display_name":"nanotoxicology","score":0.625},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/immune-dysfunction","display_name":"immune dysfunction","score":0.5410000085830688},{"id":"https://openalex.org/keywords/biofilm-eradication","display_name":"biofilm eradication","score":0.9039999842643738},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.8199999928474426},{"id":"https://openalex.org/keywords/organoid-models","display_name":"organoid models","score":0.7089999914169312},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/personalized-nanomedicine","display_name":"personalized nanomedicine","score":0.8050000071525574},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6668999791145325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6089000105857849},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.5695000290870667},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43230000138282776},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.32350000739097595},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3100000023841858},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.3075999915599823},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.2953999936580658}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.medmic.2026.100184","doi":"https://doi.org/10.1016/j.medmic.2026.100184","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.medmic.2026.100184","pdf_url":null,"source":{"id":"https://openalex.org/S4210211835","display_name":"Medicine in Microecology","issn_l":"2590-0978","issn":["2590-0978"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine in Microecology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.medmic.2026.100184","doi":"https://doi.org/10.1016/j.medmic.2026.100184","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.medmic.2026.100184","pdf_url":null,"source":{"id":"https://openalex.org/S4210211835","display_name":"Medicine in Microecology","issn_l":"2590-0978","issn":["2590-0978"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine in Microecology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W2070032426","https://openalex.org/W2302132407","https://openalex.org/W2474020675","https://openalex.org/W2589067428","https://openalex.org/W2677259235","https://openalex.org/W2758396470","https://openalex.org/W2931585659","https://openalex.org/W2943293743","https://openalex.org/W3088453264","https://openalex.org/W3096469517","https://openalex.org/W3130957717","https://openalex.org/W3151426092","https://openalex.org/W3182000819","https://openalex.org/W3184109078","https://openalex.org/W3194036002","https://openalex.org/W3196627937","https://openalex.org/W3199352650","https://openalex.org/W3201209343","https://openalex.org/W3201375558","https://openalex.org/W3201389278","https://openalex.org/W4214592158","https://openalex.org/W4221119618","https://openalex.org/W4224005161","https://openalex.org/W4288722632","https://openalex.org/W4289078044","https://openalex.org/W4309606342","https://openalex.org/W4309724035","https://openalex.org/W4311310679","https://openalex.org/W4313398891","https://openalex.org/W4317435132","https://openalex.org/W4319596530","https://openalex.org/W4324364145","https://openalex.org/W4366282733","https://openalex.org/W4378222589","https://openalex.org/W4384407057","https://openalex.org/W4386850166","https://openalex.org/W4387459811","https://openalex.org/W4387757450","https://openalex.org/W4388482895","https://openalex.org/W4389392063","https://openalex.org/W4396678097","https://openalex.org/W4402140888","https://openalex.org/W4402807596","https://openalex.org/W4402837655","https://openalex.org/W4403671142","https://openalex.org/W4405101063","https://openalex.org/W4405120599","https://openalex.org/W4405506885","https://openalex.org/W4405693986","https://openalex.org/W4406329908","https://openalex.org/W4406532188","https://openalex.org/W4407157303","https://openalex.org/W4407193798","https://openalex.org/W4407250121","https://openalex.org/W4407675478","https://openalex.org/W4408072160","https://openalex.org/W4408851836","https://openalex.org/W4408939905","https://openalex.org/W4409125245","https://openalex.org/W4409403796","https://openalex.org/W4409593705","https://openalex.org/W4410383988","https://openalex.org/W4410866184","https://openalex.org/W4411465413","https://openalex.org/W4411502334","https://openalex.org/W4411859612","https://openalex.org/W4412170483","https://openalex.org/W4412689412","https://openalex.org/W4413108438","https://openalex.org/W4413563468","https://openalex.org/W4413819850","https://openalex.org/W4413970169","https://openalex.org/W4414486889","https://openalex.org/W4415321051","https://openalex.org/W4415916432","https://openalex.org/W4416296041","https://openalex.org/W4416308218","https://openalex.org/W4416721874","https://openalex.org/W4417000873","https://openalex.org/W4417013889","https://openalex.org/W4417114506","https://openalex.org/W4417182074","https://openalex.org/W4417295393","https://openalex.org/W7125578060","https://openalex.org/W7126433855","https://openalex.org/W7131663479","https://openalex.org/W7137208870","https://openalex.org/W7158726388"],"related_works":["https://openalex.org/W2219933637","https://openalex.org/W4417182074","https://openalex.org/W6949357596","https://openalex.org/W4310908863","https://openalex.org/W4385652557","https://openalex.org/W4413970169","https://openalex.org/W4405101063","https://openalex.org/W7024859054","https://openalex.org/W3043927416","https://openalex.org/W2884282062"],"abstract_inverted_index":{"Nanotechnology":[0],"is":[1],"rapidly":[2],"advancing":[3],"in":[4,26,47,108,139,175,194],"biomedical,":[5],"pharmaceutical,":[6],"environmental":[7],"and":[8,42,53,57,66,87,128,136,165,202,220],"consumer":[9],"applications,":[10,189],"leading":[11],"to":[12,17,37,149,153],"increasing":[13],"exposure":[14,148],"of":[15,76,81,89,119,122,159,172,185],"humans":[16,176],"engineered":[18],"nanomaterials":[19],"(ENMs)":[20],"with":[21,29],"a":[22,44,182],"corresponding":[23],"growing":[24],"interest":[25],"their":[27],"interactions":[28,94],"the":[30,39,123,157,169,207],"human":[31],"microbiome.":[32],"The":[33],"microbiome,":[34,124],"often":[35],"referred":[36],"as":[38,74,98,100,115],"\u201chidden":[40],"organ\u201d":[41],"plays":[43],"critical":[45],"role":[46],"immune":[48,162],"regulation,":[49],"metabolism,":[50],"tissue":[51],"homeostasis,":[52],"disease":[54],"processes.":[55],"Experimental":[56],"preclinical":[58],"studies":[59,110],"suggest":[60],"that":[61,146,224],"nano-sized":[62],"particles":[63],"can":[64],"directly":[65],"indirectly":[67],"affect":[68],"microbial":[69,82,90],"ecosystems":[70],"by":[71,132],"mechanisms":[72],"such":[73,114],"generation":[75],"reactive":[77],"oxygen":[78],"species,":[79],"disruption":[80,118],"membranes,":[83],"quorum":[84],"sensing":[85],"disruption,":[86,167],"modulation":[88,121],"signaling":[91],"pathways.":[92],"These":[93],"have":[95,105],"therapeutic":[96,188,213],"implications":[97],"well":[99],"potential":[101],"toxicological":[102,190],"implications.":[103],"Nanomaterials":[104],"shown":[106],"promise":[107],"pre-clinical":[109],"for":[111,209,228],"multiple":[112],"applications":[113],"antimicrobial":[116,160],"therapy,":[117],"biofilms,":[120],"smart":[125],"wound":[126],"healing,":[127],"precision":[129],"medicine,":[130],"particularly":[131],"combining":[133],"hydrogels,":[134],"probiotics,":[135],"stimuli-responsive":[137],"systems":[138],"microbiome-responsive":[140],"nanoplatforms.":[141],"However,":[142],"emerging":[143],"evidence":[144],"indicates":[145],"long-term":[147],"nanoparticles":[150],"may":[151],"contribute":[152],"dysbiosis,":[154],"chronic":[155],"inflammation,":[156],"emergence":[158],"resistance,":[161],"system":[163],"dysfunction":[164],"ecosystem":[166],"although":[168],"clinical":[170,229],"significance":[171],"these":[173],"effects":[174],"remains":[177],"limited.":[178],"This":[179],"review":[180],"provides":[181],"comprehensive":[183],"overview":[184],"nano-microbiome":[186],"interactions,":[187],"risks,":[191],"novel":[192],"advancements":[193],"organoid":[195],"models,":[196],"multi-omics":[197],"technologies,":[198],"artificial":[199],"intelligence-based":[200],"prediction,":[201],"personalized":[203],"nanomedicine":[204],"based":[205],"on":[206],"microbiome":[208],"future":[210,221],"clinically":[211],"relevant":[212],"strategies,":[214],"while":[215],"highlighting":[216],"existing":[217],"knowledge":[218],"gaps":[219],"research":[222],"areas":[223],"would":[225],"be":[226],"useful":[227],"translation.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-08-18T00:00:00"}