{"id":"https://openalex.org/W7203652902","doi":"https://doi.org/10.64898/2026.08.14.744935","title":"Maternal antiviral history synergizes with pregnancy and lactation to transfer intergenerational systemic immunity through IgG in milk","display_name":"Maternal antiviral history synergizes with pregnancy and lactation to transfer intergenerational systemic immunity through IgG in milk","publication_year":2026,"publication_date":"2026-08-17","ids":{"openalex":"https://openalex.org/W7203652902","doi":"https://doi.org/10.64898/2026.08.14.744935"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.14.744935","doi":"https://doi.org/10.64898/2026.08.14.744935","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.744935","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.14.744935","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064867055","display_name":"Ka Neng Cheong","orcid":"https://orcid.org/0000-0001-9786-4750","observed_orcids":["https://orcid.org/0000-0001-9786-4750"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ka Neng Cheong","raw_affiliation_strings":["Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037","Department of Molecular and Cellular Biology, Scripps Research, La Jolla, CA 92037","Skaggs Graduate school of Chemical and Biological Sciences at Scripps Research, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0001-9786-4750","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Skaggs Graduate school of Chemical and Biological Sciences at Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034692734","display_name":"Juan Sebasti\u00e1n Jara","orcid":"https://orcid.org/0000-0003-1469-5221","observed_orcids":["https://orcid.org/0000-0003-1469-5221"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Sebastian Jara","raw_affiliation_strings":["Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0003-1469-5221","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091875762","display_name":"Leigh M. Sewall","orcid":"https://orcid.org/0000-0002-2020-2991","observed_orcids":["https://orcid.org/0000-0002-2020-2991"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leigh M. Sewall","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037","Skaggs Graduate school of Chemical and Biological Sciences at Scripps Research, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Skaggs Graduate school of Chemical and Biological Sciences at Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051137075","display_name":"Stanislav Dikiy","orcid":"https://orcid.org/0000-0002-8287-6561","observed_orcids":["https://orcid.org/0000-0002-8287-6561"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanislav Dikiy","raw_affiliation_strings":["Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0002-8287-6561","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054897465","display_name":"Xuan Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuan Le","raw_affiliation_strings":["Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132691798","display_name":"Nicole Wolman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Wolman","raw_affiliation_strings":["Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067790213","display_name":"Andrew B. Ward","orcid":"https://orcid.org/0000-0001-7153-3769","observed_orcids":["https://orcid.org/0000-0001-7153-3769","https://orcid.org/0000-0001-6711-9864"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew B. Ward","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0001-7153-3769","affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083999892","display_name":"R. Luke Wiseman","orcid":"https://orcid.org/0000-0001-9287-6840","observed_orcids":["https://orcid.org/0000-0001-9287-6840"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Luke Wiseman","raw_affiliation_strings":["Department of Molecular and Cellular Biology, Scripps Research, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0001-9287-6840","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064328407","display_name":"Alejandra Mendoza","orcid":"https://orcid.org/0000-0001-9116-5465","observed_orcids":["https://orcid.org/0000-0001-9116-5465"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alejandra Mendoza","raw_affiliation_strings":["Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037"],"raw_orcid":"https://orcid.org/0000-0001-9116-5465","affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064328407"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.32179999351501465,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-immune-transfer","display_name":"maternal immune transfer","score":0.722000002861023},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/lactation","display_name":"lactation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mammary-gland-remodeling","display_name":"mammary gland remodeling","score":0.746999979019165},{"id":"https://openalex.org/keywords/fcrn","display_name":"neonatal Fc receptor","score":0.765999972820282},{"id":"https://openalex.org/keywords/hemagglutinin-epitope","display_name":"hemagglutinin epitope","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.7828999757766724},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7404000163078308},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7067999839782715},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.661300003528595},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.646399974822998},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.6107000112533569},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6064000129699707},{"id":"https://openalex.org/C2778668663","wikidata":"https://www.wikidata.org/wiki/Q382646","display_name":"Passive immunity","level":4,"score":0.5346999764442444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.508899986743927},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46810001134872437},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.40310001373291016},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4027000069618225},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39989998936653137},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.3662000000476837},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.3452000021934509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31949999928474426},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.31940001249313354},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.31150001287460327},{"id":"https://openalex.org/C3020294031","wikidata":"https://www.wikidata.org/wiki/Q174876","display_name":"Breast feeding","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.29179999232292175},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.2903999984264374},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.2809999883174896},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C2993183539","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory infection","level":3,"score":0.2671999931335449}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.14.744935","doi":"https://doi.org/10.64898/2026.08.14.744935","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.744935","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.14.744935","doi":"https://doi.org/10.64898/2026.08.14.744935","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.744935","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F279999757","display_name":"Conrad Prebys Foundation","ror":"https://ror.org/00x8e3847"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":122,"referenced_works":["https://openalex.org/W49611453","https://openalex.org/W197019882","https://openalex.org/W1686249017","https://openalex.org/W1753112448","https://openalex.org/W1969516167","https://openalex.org/W1973976214","https://openalex.org/W1983541098","https://openalex.org/W1986071019","https://openalex.org/W1991471550","https://openalex.org/W1995272947","https://openalex.org/W2009979118","https://openalex.org/W2012483332","https://openalex.org/W2013103459","https://openalex.org/W2019171053","https://openalex.org/W2028561648","https://openalex.org/W2030601224","https://openalex.org/W2032348735","https://openalex.org/W2032830044","https://openalex.org/W2039200386","https://openalex.org/W2040641721","https://openalex.org/W2047090987","https://openalex.org/W2047151651","https://openalex.org/W2050931908","https://openalex.org/W2062687768","https://openalex.org/W2070216743","https://openalex.org/W2073290778","https://openalex.org/W2081596239","https://openalex.org/W2083419187","https://openalex.org/W2089017798","https://openalex.org/W2093042553","https://openalex.org/W2093544337","https://openalex.org/W2095336525","https://openalex.org/W2095950478","https://openalex.org/W2100620897","https://openalex.org/W2103663550","https://openalex.org/W2106882037","https://openalex.org/W2108125928","https://openalex.org/W2128395962","https://openalex.org/W2129496659","https://openalex.org/W2129551032","https://openalex.org/W2130410032","https://openalex.org/W2130473078","https://openalex.org/W2139108978","https://openalex.org/W2140205268","https://openalex.org/W2141170366","https://openalex.org/W2141485414","https://openalex.org/W2141929896","https://openalex.org/W2142174337","https://openalex.org/W2151154371","https://openalex.org/W2151464048","https://openalex.org/W2157930949","https://openalex.org/W2161291046","https://openalex.org/W2162334426","https://openalex.org/W2169456326","https://openalex.org/W2171136826","https://openalex.org/W2172283179","https://openalex.org/W2267727860","https://openalex.org/W2312318171","https://openalex.org/W2336491233","https://openalex.org/W2346603537","https://openalex.org/W2505710978","https://openalex.org/W2623733076","https://openalex.org/W2773586544","https://openalex.org/W2783237763","https://openalex.org/W2783608467","https://openalex.org/W2788701488","https://openalex.org/W2800593054","https://openalex.org/W2891470462","https://openalex.org/W2902560198","https://openalex.org/W2907514116","https://openalex.org/W2919790473","https://openalex.org/W2928665623","https://openalex.org/W2941697077","https://openalex.org/W2943161765","https://openalex.org/W2949889415","https://openalex.org/W2951299640","https://openalex.org/W2953151710","https://openalex.org/W2968062885","https://openalex.org/W2999223430","https://openalex.org/W3006399024","https://openalex.org/W3008187404","https://openalex.org/W3014744118","https://openalex.org/W3020633324","https://openalex.org/W3021948769","https://openalex.org/W3088554578","https://openalex.org/W3092792914","https://openalex.org/W3096764372","https://openalex.org/W3121376247","https://openalex.org/W3165406246","https://openalex.org/W3172395885","https://openalex.org/W3176035856","https://openalex.org/W3211777249","https://openalex.org/W3212082238","https://openalex.org/W3213779066","https://openalex.org/W4210997720","https://openalex.org/W4225989013","https://openalex.org/W4280498066","https://openalex.org/W4281787778","https://openalex.org/W4285005423","https://openalex.org/W4291001424","https://openalex.org/W4307432965","https://openalex.org/W4308957364","https://openalex.org/W4310786015","https://openalex.org/W4315628808","https://openalex.org/W4328114473","https://openalex.org/W4361228212","https://openalex.org/W4366226611","https://openalex.org/W4381248578","https://openalex.org/W4385372316","https://openalex.org/W4387164156","https://openalex.org/W4388292371","https://openalex.org/W4390043501","https://openalex.org/W4394909675","https://openalex.org/W4402473336","https://openalex.org/W4402826982","https://openalex.org/W4407445224","https://openalex.org/W4409358294","https://openalex.org/W4410974149","https://openalex.org/W4412709677","https://openalex.org/W4413107370","https://openalex.org/W4413140645","https://openalex.org/W7143287727"],"related_works":["https://openalex.org/W4210660835","https://openalex.org/W7221342441","https://openalex.org/W3118953641","https://openalex.org/W2125321565","https://openalex.org/W7095777279","https://openalex.org/W2901466648","https://openalex.org/W7204084778","https://openalex.org/W4280498066","https://openalex.org/W4385686389","https://openalex.org/W6964290081"],"abstract_inverted_index":{"SUMMARY":[0],"Maternal":[1],"immune":[2,11,141],"transfer":[3,78,218],"is":[4,24,57,187,267],"essential":[5],"for":[6,59,93,269,283],"early-life":[7],"health,":[8],"yet":[9],"whether":[10],"experiences":[12],"before":[13,33,242],"pregnancy":[14,34,243],"shape":[15],"maternal":[16,127,140,156,191,230],"physiology":[17],"to":[18,76,112,124,146,276,280],"optimize":[19,147],"immunity":[20,128],"in":[21,46,53,202,226],"subsequent":[22,281],"offspring":[23,108,123],"unclear.":[25],"Here,":[26],"we":[27],"show":[28],"that":[29,129,138,172],"respiratory":[30],"viral":[31],"infection":[32,70,159,171,241],"confers":[35,160],"robust":[36],"protection":[37,114,166,279],"against":[38,167],"lethal":[39,168],"neonatal":[40,104,162,169],"influenza":[41,96,158,170,213],"through":[42,102,110,184],"antibodies":[43,86],"transferred":[44],"postpartum":[45],"milk.":[47,84],"Despite":[48],"the":[49,73,103,203,253],"predominance":[50],"of":[51,79,119,211,219,252,262],"IgA":[52],"milk,":[54],"antiviral":[55,64,81,198],"IgG":[56,82,206,225,264],"indispensable":[58],"protection.":[60,270,285],"Pregnancy":[61,193],"amplifies":[62],"pre-existing":[63],"B":[65,163,199,235],"cell":[66,164,200,236],"responses,":[67],"while":[68],"prior":[69],"durably":[71],"reprograms":[72],"mammary":[74,237,254],"gland":[75,238],"promote":[77],"circulating":[80],"into":[83,176,265],"These":[85],"retain":[87],"their":[88],"epitope":[89],"specificity,":[90],"are":[91],"enriched":[92],"broadly":[94,220],"protective":[95,221],"epitopes,":[97,215],"remain":[98],"functional":[99],"after":[100],"passage":[101],"intestine,":[105],"and":[106,144,186,248],"enter":[107],"circulation":[109,266],"FcRn":[111],"provide":[113],"beyond":[115,174],"weaning.":[116],"Natural":[117],"transmission":[118],"virus":[120,274],"from":[121,229,233],"infected":[122],"mothers":[125],"establishes":[126],"protects":[130],"future":[131],"offspring,":[132],"revealing":[133],"a":[134,208],"coordinated":[135],"adaptive":[136],"program":[137],"links":[139],"history,":[142],"pregnancy,":[143],"lactation":[145],"intergenerational":[148],"immunity.":[149],"Abstract":[150],"Figure":[151],"GRAPHICAL":[152],"ABSTRACT":[153],"HIGHLIGHTS":[154],"Preconceptual":[155],"intranasal":[157],"complete":[161],"mediated":[165,260],"persists":[173],"weaning":[175],"early":[177],"adulthood.":[178],"Protection":[179],"can":[180],"be":[181],"transmitted":[182],"postnatally":[183],"milk":[185,227,263],"fully":[188],"dependent":[189],"on":[190],"IgG.":[192],"enhances":[194],"rather":[195],"than":[196],"suppresses":[197],"programs":[201],"mother.":[204],"Milk":[205],"targets":[207],"restricted":[209],"set":[210],"conserved":[212],"Hemagglutinin":[214],"suggesting":[216],"selective":[217],"antibody":[222],"populations.":[223],"Protective":[224],"derives":[228],"circulation,":[231],"not":[232],"local":[234],"production.":[239],"Respiratory":[240],"induces":[244],"long-lived":[245],"vascular,":[246],"stromal,":[247],"epithelial":[249],"transcriptional":[250],"remodeling":[251],"gland.":[255],"Neonatal":[256],"Fc":[257],"Receptor":[258],"(FcRn)":[259],"transport":[261],"required":[268],"Infected":[271],"neonates":[272],"transmit":[273],"back":[275],"mothers,":[277],"extending":[278],"litters":[282],"multi-generation":[284]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-08-18T00:00:00"}