{"id":"https://openalex.org/W7203632855","doi":"https://doi.org/10.1093/infdis/jiag513","title":"Obesity in Children is Associated With Increased Dengue Virus Binding, but not Neutralizing, Antibody Responses Following Primary Infection","display_name":"Obesity in Children is Associated With Increased Dengue Virus Binding, but not Neutralizing, Antibody Responses Following Primary Infection","publication_year":2026,"publication_date":"2026-10-24","ids":{"openalex":"https://openalex.org/W7203632855","doi":"https://doi.org/10.1093/infdis/jiag513","pmid":"https://pubmed.ncbi.nlm.nih.gov/42949410"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiag513","doi":"https://doi.org/10.1093/infdis/jiag513","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/jiag513","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/17/2026.08.14.26360483.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027093597","display_name":"Reinaldo Mercado-Hernandez","orcid":"https://orcid.org/0000-0002-1098-7334","observed_orcids":["https://orcid.org/0000-0002-1098-7334"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinaldo Mercado-Hernandez","raw_affiliation_strings":["Division of Infectious Diseases and Vaccinology, School of Public Health, University of California , Berkeley, California ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California , Berkeley, California ,","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003315234","display_name":"Sandra Bos","orcid":"https://orcid.org/0000-0001-5036-0336","observed_orcids":["https://orcid.org/0000-0001-5036-0336"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Bos","raw_affiliation_strings":["Division of Infectious Diseases and Vaccinology, School of Public Health, University of California , Berkeley, California ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California , Berkeley, California ,","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014657699","display_name":"\u00c1ngel Balmaseda","orcid":"https://orcid.org/0000-0003-1174-4235","observed_orcids":["https://orcid.org/0000-0003-1174-4235"]},"institutions":[{"id":"https://openalex.org/I4210133564","display_name":"Ministerio de Salud","ror":"https://ror.org/03c09x508","country_code":"NI","type":"government","lineage":["https://openalex.org/I4210133564"]},{"id":"https://openalex.org/I4210137671","display_name":"Sustainable Sciences Institute","ror":"https://ror.org/02y8mb071","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137671"]}],"countries":["NI","US"],"is_corresponding":false,"raw_author_name":"Angel Balmaseda","raw_affiliation_strings":["Laboratorio Nacional de Virolog\u00eda, Centro Nacional de Diagn\u00f3stico y Referencia, Ministerio de Salud , Managua ,","Sustainable Sciences Institute , Managua ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Nacional de Virolog\u00eda, Centro Nacional de Diagn\u00f3stico y Referencia, Ministerio de Salud , Managua ,","institution_ids":["https://openalex.org/I4210133564"]},{"raw_affiliation_string":"Sustainable Sciences Institute , Managua ,","institution_ids":["https://openalex.org/I4210137671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057357477","display_name":"Guillermina M. Kuan","orcid":"https://orcid.org/0000-0002-5251-173X","observed_orcids":["https://orcid.org/0000-0002-5251-173X"]},"institutions":[{"id":"https://openalex.org/I4210133564","display_name":"Ministerio de Salud","ror":"https://ror.org/03c09x508","country_code":"NI","type":"government","lineage":["https://openalex.org/I4210133564"]},{"id":"https://openalex.org/I4210137671","display_name":"Sustainable Sciences Institute","ror":"https://ror.org/02y8mb071","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210137671"]}],"countries":["NI","US"],"is_corresponding":false,"raw_author_name":"Guillermina Kuan","raw_affiliation_strings":["Centro de Salud S\u00f3crates Flores Vivas, Ministerio de Salud , Managua ,","Sustainable Sciences Institute , Managua ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Salud S\u00f3crates Flores Vivas, Ministerio de Salud , Managua ,","institution_ids":["https://openalex.org/I4210133564"]},{"raw_affiliation_string":"Sustainable Sciences Institute , Managua ,","institution_ids":["https://openalex.org/I4210137671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027442064","display_name":"Eva Harris","orcid":"https://orcid.org/0000-0002-7238-4037","observed_orcids":["https://orcid.org/0000-0002-7238-4037"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eva Harris","raw_affiliation_strings":["Division of Infectious Diseases and Vaccinology, School of Public Health, University of California , Berkeley, California ,"],"raw_orcid":"https://orcid.org/0000-0002-7238-4037","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Vaccinology, School of Public Health, University of California , Berkeley, California ,","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.60552226,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14053","display_name":"Dengue and Mosquito Control Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/dengue-virus","display_name":"dengue virus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9300000071525574},{"id":"https://openalex.org/keywords/primary-dengue-infection","display_name":"primary dengue infection","score":0.902999997138977},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9120000004768372},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":1.0},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9399999976158142},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.7250000238418579},{"id":"https://openalex.org/keywords/bmi-z-score","display_name":"BMI z-score","score":0.878000020980835},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5730000138282776},{"id":"https://openalex.org/keywords/pediatric-dengue","display_name":"pediatric dengue","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.7764000296592712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7509999871253967},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.7343999743461609},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6571000218391418},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6373999714851379},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.623199999332428},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6159999966621399},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.5781000256538391},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5368000268936157},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4697999954223633},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.44999998807907104},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.44209998846054077},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.41029998660087585},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3732999861240387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3637000024318695},{"id":"https://openalex.org/C196594336","wikidata":"https://www.wikidata.org/wiki/Q1662341","display_name":"Antibody-dependent enhancement","level":4,"score":0.323199987411499},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.25429999828338623}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/infdis/jiag513","doi":"https://doi.org/10.1093/infdis/jiag513","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/jiag513","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"doi:10.64898/2026.08.14.26360483","doi":"https://doi.org/10.64898/2026.08.14.26360483","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.26360483","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/17/2026.08.14.26360483.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:42949410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42949410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.08.14.26360483","doi":"https://doi.org/10.64898/2026.08.14.26360483","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.14.26360483","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/17/2026.08.14.26360483.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000920660","display_name":"Protective immunity following dengue virus natural infections and vaccination","funder_award_id":"P01AI106695","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203632855.pdf","grobid_xml":"https://content.openalex.org/works/W7203632855.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400639683","https://openalex.org/W4316465139","https://openalex.org/W2883275350","https://openalex.org/W1973654302","https://openalex.org/W7142896227","https://openalex.org/W2786255039","https://openalex.org/W2152180266","https://openalex.org/W7122452956","https://openalex.org/W2959984751","https://openalex.org/W2134847247"],"abstract_inverted_index":{"BACKGROUND:":[0],"Obesity":[1],"has":[2],"been":[3],"associated":[4,44,121,137,150,178],"with":[5,45,87,89,93,122,138,151,163,179,197,214],"higher":[6,96,123,180,186],"risk":[7],"of":[8,39,98,125,210,227,245],"dengue":[9],"virus":[10],"(DENV)":[11],"infection":[12,68,83],"and":[13,42,81,147,231],"disease,":[14],"yet":[15],"its":[16],"influence":[17],"on":[18,31],"antibody":[19,49,181],"responses":[20,50],"to":[21,51,206],"DENV":[22,52,67,82,99,190],"remains":[23],"undefined.":[24],"METHODS:":[25],"We":[26],"evaluated":[27],"whether":[28],"nutritional":[29],"status-based":[30],"body":[32,40,228],"mass":[33],"index":[34],"z-score":[35],"(BMIz)-or":[36],"blood":[37],"markers":[38],"fat-leptin":[41],"adiponectin-are":[43],"binding":[46,100,126],"and/or":[47],"neutralizing":[48,115,152,155],"in":[53,56,69,114,161,237],"85":[54],"children":[55,88,162,196,213],"the":[57,218,221],"Nicaraguan":[58],"Pediatric":[59],"Dengue":[60],"Cohort":[61],"Study":[62],"who":[63],"experienced":[64],"a":[65],"primary":[66],"2019.":[70],"Associations":[71],"were":[72],"estimated":[73],"using":[74,224],"linear":[75],"models":[76,223],"adjusting":[77],"for":[78],"age,":[79],"sex,":[80],"outcome.":[84],"RESULTS:":[85],"Compared":[86],"normal":[90,215],"weight,":[91],"those":[92],"obesity":[94,164,176,198],"had":[95],"quantities":[97,124,140,205],"antibodies":[101,127,193],"(fold-change":[102],"[FC]":[103],"1.89,":[104],"95%":[105,130,143,167],"confidence":[106],"interval":[107],"[CI]":[108],"1.02,":[109],"3.48)":[110],"but":[111,184],"no":[112],"difference":[113],"antibodies.":[116,153],"Likewise,":[117],"leptin":[118],"concentration":[119],"was":[120,136,149,159],"(FC":[128,141,165],"1.22,":[129],"CI":[131,144,168],"1.09,":[132],"1.37),":[133],"while":[134],"adiponectin":[135],"lower":[139,200],"0.79,":[142],".67,":[145],".94),":[146],"neither":[148],"Lower":[154],"efficiency":[156],"(neutralizing/binding":[157],"antibodies)":[158],"observed":[160],"0.67,":[166],".48,":[169],".93).":[170],"CONCLUSIONS:":[171],"Our":[172],"results":[173],"indicate":[174],"that":[175,192,233],"is":[177],"quantity":[182],"(binding)":[183],"not":[185],"quality":[187],"(neutralization)":[188],"postprimary":[189],"infection-implying":[191],"generated":[194],"by":[195],"have":[199],"neutralization":[201,211],"efficiency,":[202],"requiring":[203],"greater":[204],"reach":[207],"similar":[208],"levels":[209],"than":[212],"weight.":[216],"Further,":[217],"agreement":[219],"among":[220],"3":[222],"distinct":[225],"proxies":[226],"fat-BMIz,":[229],"leptin,":[230],"adiponectin-demonstrates":[232],"adipokines":[234],"are":[235],"useful":[236],"supplementing":[238],"BMIz":[239],"analysis":[240],"or":[241],"as":[242],"independent":[243],"predictors":[244],"immune":[246],"responses.":[247]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-18T00:00:00"}
