{"id":"https://openalex.org/W7203623892","doi":"https://doi.org/10.22270/jddt.v16i8.7950","title":"Neuroprotective Activity of Medicinal Plants: Comprehensive Review of Phytochemicals, Neuronal Survival Mechanisms, Pharmacological Evidence, Safety Evaluation, Clinical Potential","display_name":"Neuroprotective Activity of Medicinal Plants: Comprehensive Review of Phytochemicals, Neuronal Survival Mechanisms, Pharmacological Evidence, Safety Evaluation, Clinical Potential","publication_year":2026,"publication_date":"2026-08-16","ids":{"openalex":"https://openalex.org/W7203623892","doi":"https://doi.org/10.22270/jddt.v16i8.7950"},"language":"en","primary_location":{"id":"doi:10.22270/jddt.v16i8.7950","doi":"https://doi.org/10.22270/jddt.v16i8.7950","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v16i8.7950","pdf_url":null,"source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.22270/jddt.v16i8.7950","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147321162","display_name":"Kishan Lal Bharti","orcid":"https://orcid.org/0009-0003-0230-389X","observed_orcids":["https://orcid.org/0009-0003-0230-389X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kishan Lal Bharti","raw_affiliation_strings":["Sita Ram Kashyap College of Pharmacy, Rahod, Np-Rahod, Teh - Pamgarh Dist.- Janjgir- Champa, pin code -495556 Chhattisgarh, India"],"raw_orcid":"https://orcid.org/0009-0003-0230-389X","affiliations":[{"raw_affiliation_string":"Sita Ram Kashyap College of Pharmacy, Rahod, Np-Rahod, Teh - Pamgarh Dist.- Janjgir- Champa, pin code -495556 Chhattisgarh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147352384","display_name":"Ashish Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashish Kumar","raw_affiliation_strings":["Sita Ram Kashyap College of Pharmacy, Rahod, Np-Rahod, Teh - Pamgarh Dist.- Janjgir- Champa, pin code -495556 Chhattisgarh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sita Ram Kashyap College of Pharmacy, Rahod, Np-Rahod, Teh - Pamgarh Dist.- Janjgir- Champa, pin code -495556 Chhattisgarh, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076457918","display_name":"Shiv Kumar Bhardwaj","orcid":"https://orcid.org/0009-0005-1454-4791","observed_orcids":["https://orcid.org/0009-0005-1454-4791"]},"institutions":[{"id":"https://openalex.org/I4405287660","display_name":"Columbia Institute of Pharmacy","ror":"https://ror.org/05t525t18","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405287660"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shiv Kumar Bhardwaj","raw_affiliation_strings":["Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Road, Raipur-493111, Chhattisgarh, India"],"raw_orcid":"https://orcid.org/0009-0005-1454-4791","affiliations":[{"raw_affiliation_string":"Columbia Institute of Pharmacy, Tekari, Near Vidhansabha Road, Raipur-493111, Chhattisgarh, India","institution_ids":["https://openalex.org/I4405287660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"8","first_page":"217","last_page":"222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9739999771118164},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":1.0},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.8849999904632568},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.800000011920929},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9860000014305115},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9449999928474426},{"id":"https://openalex.org/keywords/alkaloids","display_name":"alkaloids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.9850000143051147},{"id":"https://openalex.org/keywords/phenolic-acids","display_name":"phenolic acids","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glycosides","display_name":"glycosides","score":0.9789999723434448},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.8019999861717224},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"neurotransmission","score":0.7329999804496765},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.5180000066757202},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9470000267028809},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.6625000238418579},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5934000015258789},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5813000202178955},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5627999901771545},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4846999943256378},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3343999981880188},{"id":"https://openalex.org/C2993744773","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Neuronal damage","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.31450000405311584},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C2992208609","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neuronal degeneration","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26840001344680786},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C128188215","wikidata":"https://www.wikidata.org/wiki/Q3026765","display_name":"Neuropharmacology","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.22270/jddt.v16i8.7950","doi":"https://doi.org/10.22270/jddt.v16i8.7950","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v16i8.7950","pdf_url":null,"source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.jddtonline.info:article/7950","doi":null,"is_oa":true,"landing_page_url":"http://jddtonline.info/index.php/jddt/article/view/7950","pdf_url":"https://jddtonline.info/index.php/jddt/article/download/7950/7661","source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2250-1177","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.22270/jddt.v16i8.7950","doi":"https://doi.org/10.22270/jddt.v16i8.7950","is_oa":true,"landing_page_url":"https://doi.org/10.22270/jddt.v16i8.7950","pdf_url":null,"source":{"id":"https://openalex.org/S2764977280","display_name":"Journal of Drug Delivery and Therapeutics","issn_l":"2250-1177","issn":["2250-1177"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4323972972","host_organization_name":"Society of Pharmaceutical Tecnocrats","host_organization_lineage":["https://openalex.org/P4323972972"],"host_organization_lineage_names":["Society of Pharmaceutical Tecnocrats"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Drug Delivery and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203623892.pdf","grobid_xml":"https://content.openalex.org/works/W7203623892.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W4385988904","https://openalex.org/W4386812559","https://openalex.org/W4388487011","https://openalex.org/W4391276043","https://openalex.org/W4391860093","https://openalex.org/W4396778209","https://openalex.org/W4396926084","https://openalex.org/W4398149967","https://openalex.org/W4399321157","https://openalex.org/W4401056647","https://openalex.org/W4402051290","https://openalex.org/W4402115361","https://openalex.org/W4402479186","https://openalex.org/W4402926857","https://openalex.org/W4403321402","https://openalex.org/W4403639589","https://openalex.org/W4407555164","https://openalex.org/W4407819983","https://openalex.org/W4407836923","https://openalex.org/W4408302494","https://openalex.org/W4410908575","https://openalex.org/W4411133193","https://openalex.org/W4412079601","https://openalex.org/W4412183473","https://openalex.org/W4412452184","https://openalex.org/W4413745088","https://openalex.org/W4414027168","https://openalex.org/W4414127323","https://openalex.org/W4415170001","https://openalex.org/W4415904971","https://openalex.org/W4416393202","https://openalex.org/W4417534693","https://openalex.org/W7115018217","https://openalex.org/W7117985188","https://openalex.org/W7124422261","https://openalex.org/W7124428081","https://openalex.org/W7129044573","https://openalex.org/W7148504551"],"related_works":["https://openalex.org/W7166090830","https://openalex.org/W7214353554","https://openalex.org/W4414548772","https://openalex.org/W4411612741","https://openalex.org/W4407068993","https://openalex.org/W4400499254","https://openalex.org/W7219479824","https://openalex.org/W7216108542","https://openalex.org/W3038522504","https://openalex.org/W6911950746"],"abstract_inverted_index":{"Neurodegenerative":[0],"disorders":[1],"and":[2,11,33,59,68,76,84,94,114],"neuronal":[3,48,82,97],"injuries":[4],"resulting":[5],"from":[6],"oxidative":[7],"stress,":[8],"inflammation,":[9],"excitotoxicity":[10],"mitochondrial":[12],"dysfunction":[13],"represent":[14],"significant":[15],"global":[16],"health":[17],"challenges.":[18],"Medicinal":[19,120],"plants":[20],"possessing":[21],"neuroprotective":[22,105],"properties":[23],"are":[24],"increasingly":[25],"investigated":[26],"as":[27],"potential":[28,110],"therapeutic":[29,109],"agents":[30],"for":[31,44],"prevention":[32],"management":[34],"of":[35,54,57,61,81],"neurological":[36],"diseases.":[37],"This":[38],"systematic":[39],"review":[40],"evaluates":[41],"phytochemicals":[42],"responsible":[43],"neuroprotection,":[45],"mechanisms":[46],"underlying":[47],"survival":[49],"including":[50],"antioxidant":[51],"defense,":[52],"modulation":[53],"neurotransmission,":[55],"inhibition":[56],"apoptosis":[58],"regulation":[60],"neuroinflammatory":[62],"pathways,":[63],"along":[64],"with":[65],"pharmacological":[66],"evidence":[67],"safety":[69],"considerations.":[70],"Flavonoids,":[71],"alkaloids,":[72],"terpenoids,":[73],"phenolic":[74],"acids":[75],"glycosides":[77],"contribute":[78],"to":[79],"preservation":[80],"integrity":[83],"synaptic":[85],"function.":[86],"Experimental":[87],"studies":[88],"demonstrate":[89],"improvement":[90],"in":[91,96],"cognitive":[92],"performance":[93],"reduction":[95],"degeneration.":[98],"Although":[99],"clinical":[100,116],"data":[101],"remain":[102],"limited,":[103],"plant-derived":[104],"compounds":[106],"show":[107],"promising":[108],"requiring":[111],"further":[112],"standardization":[113],"controlled":[115],"evaluation.":[117],"Keywords:":[118],"Neuroprotection;":[119],"plants;":[121],"Neuronal":[122],"survival;":[123],"Oxidative":[124],"stress;":[125],"Phytochemicals.":[126]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-08-18T00:00:00"}