{"id":"https://openalex.org/W7203617786","doi":"https://doi.org/10.1016/j.cjca.2026.08.004","title":"Aldosterone in Hypertension: From Secondary Cause to Central Driver","display_name":"Aldosterone in Hypertension: From Secondary Cause to Central Driver","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7203617786","doi":"https://doi.org/10.1016/j.cjca.2026.08.004","pmid":"https://pubmed.ncbi.nlm.nih.gov/42607926"},"language":"en","primary_location":{"id":"doi:10.1016/j.cjca.2026.08.004","doi":"https://doi.org/10.1016/j.cjca.2026.08.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cjca.2026.08.004","pdf_url":null,"source":{"id":"https://openalex.org/S126162762","display_name":"Canadian Journal of Cardiology","issn_l":"0828-282X","issn":["0828-282X","1916-7075"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046910928","display_name":"Ernesto L. Schiffrin","orcid":"https://orcid.org/0000-0002-4502-2823","observed_orcids":["https://orcid.org/0000-0002-4502-2823"]},"institutions":[{"id":"https://openalex.org/I2801824472","display_name":"Jewish General Hospital","ror":"https://ror.org/056jjra10","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I4405267356","display_name":"Lady Davis Institute for Medical Research","ror":"https://ror.org/02c1np254","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801824472","https://openalex.org/I2801902503","https://openalex.org/I4210139015","https://openalex.org/I4405256057","https://openalex.org/I4405267356","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ernesto L. Schiffrin","raw_affiliation_strings":["Lady Davis Institute and SMBD-Jewish General University Hospital Centre, McGill University, Montreal, Quebec, Canada. Electronic address: ernesto.schiffrin@mcgill.ca"],"raw_orcid":"https://orcid.org/0000-0002-4502-2823","affiliations":[{"raw_affiliation_string":"Lady Davis Institute and SMBD-Jewish General University Hospital Centre, McGill University, Montreal, Quebec, Canada. Electronic address: ernesto.schiffrin@mcgill.ca","institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063670543","display_name":"Gregory L. Hundemer","orcid":"https://orcid.org/0000-0003-3559-3531","observed_orcids":["https://orcid.org/0000-0003-3559-3531"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]},{"id":"https://openalex.org/I4388482656","display_name":"Ottawa Hospital Research Institute","ror":"https://ror.org/05jtef216","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I153718931","https://openalex.org/I2800722420","https://openalex.org/I4388482656"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gregory L. Hundemer","raw_affiliation_strings":["Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931","https://openalex.org/I2800722420","https://openalex.org/I4388482656"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043443663","display_name":"R\u00e9mi Goupil","orcid":"https://orcid.org/0000-0002-0098-3735","observed_orcids":["https://orcid.org/0000-0002-0098-3735"]},"institutions":[{"id":"https://openalex.org/I4210141135","display_name":"H\u00f4pital du Sacr\u00e9-C\u0153ur de Montr\u00e9al","ror":"https://ror.org/03ey0g045","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210141135"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R\u00e9mi Goupil","raw_affiliation_strings":["H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210141135","https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5046910928"],"corresponding_institution_ids":["https://openalex.org/I2801824472","https://openalex.org/I4405267356","https://openalex.org/I5023651"],"apc_list":{"value":3710,"currency":"USD","value_usd":3710},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59503666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.984000027179718},{"id":"https://openalex.org/keywords/secondary-hypertension","display_name":"secondary hypertension","score":0.9300000071525574},{"id":"https://openalex.org/keywords/renin-angiotensin-aldosterone-system","display_name":"renin-angiotensin-aldosterone system","score":0.859000027179718},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9868000149726868},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.771399974822998},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6509000062942505},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4205999970436096},{"id":"https://openalex.org/C2777581072","wikidata":"https://www.wikidata.org/wiki/Q987319","display_name":"Secondary hypertension","level":3,"score":0.4122999906539917},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.33250001072883606},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.23589999973773956},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.20819999277591705},{"id":"https://openalex.org/C2776292634","wikidata":"https://www.wikidata.org/wiki/Q1640860","display_name":"Hyperaldosteronism","level":3,"score":0.20559999346733093}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cjca.2026.08.004","doi":"https://doi.org/10.1016/j.cjca.2026.08.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cjca.2026.08.004","pdf_url":null,"source":{"id":"https://openalex.org/S126162762","display_name":"Canadian Journal of Cardiology","issn_l":"0828-282X","issn":["0828-282X","1916-7075"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Cardiology","raw_type":"journal-article"},{"id":"pmid:42607926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42607926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Canadian journal of cardiology","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1855150284","display_name":null,"funder_award_id":"PJT-175027","funder_id":"https://openalex.org/F4320338063","funder_display_name":"Institute of Circulatory and Respiratory Health"},{"id":"https://openalex.org/G292218016","display_name":null,"funder_award_id":"851937-21KHRG","funder_id":"https://openalex.org/F4320319947","funder_display_name":"Kidney Foundation of Canada"},{"id":"https://openalex.org/G4463552224","display_name":null,"funder_award_id":"PJT-173313","funder_id":"https://openalex.org/F4320338063","funder_display_name":"Institute of Circulatory and Respiratory Health"},{"id":"https://openalex.org/G4472253991","display_name":null,"funder_award_id":"G-20-0028656","funder_id":"https://openalex.org/F4320307845","funder_display_name":"Heart and Stroke Foundation of Canada"},{"id":"https://openalex.org/G6282341304","display_name":null,"funder_award_id":"123465","funder_id":"https://openalex.org/F4320338063","funder_display_name":"Institute of Circulatory and Respiratory Health"},{"id":"https://openalex.org/G6991520564","display_name":null,"funder_award_id":"24KHRG-1251453","funder_id":"https://openalex.org/F4320319947","funder_display_name":"Kidney Foundation of Canada"},{"id":"https://openalex.org/G7721133741","display_name":null,"funder_award_id":"PJT-198110","funder_id":"https://openalex.org/F4320338063","funder_display_name":"Institute of Circulatory and Respiratory Health"}],"funders":[{"id":"https://openalex.org/F4320307845","display_name":"Heart and Stroke Foundation of Canada","ror":"https://ror.org/00qbpyp73"},{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320319880","display_name":"Government of Canada","ror":"https://ror.org/010q4q527"},{"id":"https://openalex.org/F4320319947","display_name":"Kidney Foundation of Canada","ror":"https://ror.org/019a0gk53"},{"id":"https://openalex.org/F4320319952","display_name":"Canada Foundation for Innovation","ror":"https://ror.org/000az4664"},{"id":"https://openalex.org/F4320331178","display_name":"Fondation de l'H\u00f4pital g\u00e9n\u00e9ral juif","ror":"https://ror.org/02dbykh40"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334618","display_name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","ror":"https://ror.org/02eqrsj93"},{"id":"https://openalex.org/F4320338063","display_name":"Institute of Circulatory and Respiratory Health","ror":"https://ror.org/00bhv3b03"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1974077099","https://openalex.org/W2023472113","https://openalex.org/W2141490105","https://openalex.org/W2159422807","https://openalex.org/W2160393148","https://openalex.org/W2258190478","https://openalex.org/W2541674337","https://openalex.org/W2679063623","https://openalex.org/W2767799851","https://openalex.org/W2852717346","https://openalex.org/W2884884048","https://openalex.org/W2895985163","https://openalex.org/W3150595609","https://openalex.org/W3161638097","https://openalex.org/W3171708529","https://openalex.org/W4206077470","https://openalex.org/W4308367821","https://openalex.org/W4389180807","https://openalex.org/W4399830173","https://openalex.org/W4400785301","https://openalex.org/W4402066166","https://openalex.org/W4409720211","https://openalex.org/W4410759362","https://openalex.org/W4411620227","https://openalex.org/W4412110096","https://openalex.org/W4412473622","https://openalex.org/W4412559155","https://openalex.org/W4413138055","https://openalex.org/W4413846475","https://openalex.org/W4413970123","https://openalex.org/W4417535391","https://openalex.org/W7128490749","https://openalex.org/W7128505334","https://openalex.org/W7128848814"],"related_works":["https://openalex.org/W3210295517","https://openalex.org/W2988330834","https://openalex.org/W2413920740","https://openalex.org/W2599636111","https://openalex.org/W2402651461","https://openalex.org/W2395606402","https://openalex.org/W7071379294","https://openalex.org/W4410263367","https://openalex.org/W2079261704","https://openalex.org/W2085004024"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2026-08-18T00:00:00"}