{"id":"https://openalex.org/W7203617201","doi":"https://doi.org/10.26434/chemrxiv.15007468/v1","title":"ATR-FTIR Spectroscopy and Chemometric Analysis to Characterize Drug-Responsive and Drug-Resistant Human Non-Small Cell Lung Cancer Cells","display_name":"ATR-FTIR Spectroscopy and Chemometric Analysis to Characterize Drug-Responsive and Drug-Resistant Human Non-Small Cell Lung Cancer Cells","publication_year":2026,"publication_date":"2026-08-16","ids":{"openalex":"https://openalex.org/W7203617201","doi":"https://doi.org/10.26434/chemrxiv.15007468/v1"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.15007468/v1","doi":"https://doi.org/10.26434/chemrxiv.15007468/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15007468/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15007468/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15007468/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056937958","display_name":"Beatrice Campanella","orcid":"https://orcid.org/0000-0002-6389-4035","observed_orcids":["https://orcid.org/0000-0002-6389-4035"]},"institutions":[{"id":"https://openalex.org/I4210115073","display_name":"Institute for the Chemistry of OrganoMetallic Compounds","ror":"https://ror.org/02fkw1114","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115073","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Campanella","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Chimica dei Composti OrganoMetallici (ICCOM-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Chimica dei Composti OrganoMetallici (ICCOM-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210115073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021340539","display_name":"Giorgia Maroni","orcid":"https://orcid.org/0000-0003-1866-5898","observed_orcids":["https://orcid.org/0000-0003-1866-5898"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgia Maroni","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094249685","display_name":"Eva Cabrera San Mill\u00e1n","orcid":"https://orcid.org/0000-0002-3251-1791","observed_orcids":["https://orcid.org/0000-0002-3251-1791"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eva Cabrera Cabrera San Millan","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072223302","display_name":"Raffaella Mercatelli","orcid":"https://orcid.org/0000-0002-3231-0527","observed_orcids":["https://orcid.org/0000-0002-3231-0527"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaella Mercatelli","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090606689","display_name":"Massimo Onor","orcid":"https://orcid.org/0000-0003-3023-1072","observed_orcids":["https://orcid.org/0000-0003-3023-1072"]},"institutions":[{"id":"https://openalex.org/I4210115073","display_name":"Institute for the Chemistry of OrganoMetallic Compounds","ror":"https://ror.org/02fkw1114","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115073","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Onor","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Chimica dei Composti OrganoMetallici (ICCOM-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Chimica dei Composti OrganoMetallici (ICCOM-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210115073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005098662","display_name":"Lorenzo Birindelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115073","display_name":"Institute for the Chemistry of OrganoMetallic Compounds","ror":"https://ror.org/02fkw1114","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210115073","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Birindelli","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Chimica dei Composti OrganoMetallici (ICCOM-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Chimica dei Composti OrganoMetallici (ICCOM-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210115073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067598183","display_name":"E. Benedetti","orcid":"https://orcid.org/0000-0001-5295-2087","observed_orcids":["https://orcid.org/0000-0001-5295-2087"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edoardo Benedetti","raw_affiliation_strings":["UO Hematology","University of Pisa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UO Hematology","institution_ids":[]},{"raw_affiliation_string":"University of Pisa","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028495282","display_name":"Elena Levantini","orcid":"https://orcid.org/0000-0003-4612-3105","observed_orcids":["https://orcid.org/0000-0003-4612-3105"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Levantini","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","Fondazione Pisana per la Scienza ONLUS (FPS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]},{"raw_affiliation_string":"Fondazione Pisana per la Scienza ONLUS (FPS","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047179112","display_name":"Emilia Bramanti","orcid":"https://orcid.org/0000-0001-8478-7370","observed_orcids":["https://orcid.org/0000-0001-8478-7370"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emilia Bramanti","raw_affiliation_strings":["CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8478-7370","affiliations":[{"raw_affiliation_string":"CNR-Consiglio Nazionale delle Ricerche, Istituto di Tecnologie Biomediche (ITB-CNR, SS di Pisa, Area della Ricerca di Pisa, Italy","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10640","display_name":"Spectroscopy and Chemometric Analyses","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osimertinib-resistance","display_name":"osimertinib resistance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.8899999856948853},{"id":"https://openalex.org/keywords/drug-resistance-markers","display_name":"drug resistance markers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/atr-ftir-spectroscopy","display_name":"ATR-FTIR spectroscopy","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mitochondrial-gene-expression","display_name":"mitochondrial gene expression","score":0.9430000185966492},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6309999823570251},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"principal component analysis","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.5568000078201294},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4853000044822693},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4799000024795532},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4618000090122223},{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.43880000710487366},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38269999623298645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3783000111579895},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3781999945640564},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.3269999921321869},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32420000433921814},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3050000071525574},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2987000048160553},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.29789999127388},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.27219998836517334},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C74887250","wikidata":"https://www.wikidata.org/wiki/Q3455892","display_name":"Principal component regression","level":3,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.15007468/v1","doi":"https://doi.org/10.26434/chemrxiv.15007468/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15007468/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15007468/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.15007468/v1","doi":"https://doi.org/10.26434/chemrxiv.15007468/v1","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.15007468/v1","pdf_url":"https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15007468/v1","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203617201.pdf","grobid_xml":"https://content.openalex.org/works/W7203617201.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1149146151","https://openalex.org/W1546552389","https://openalex.org/W1773888480","https://openalex.org/W1965558299","https://openalex.org/W1978803910","https://openalex.org/W2002922559","https://openalex.org/W2016342028","https://openalex.org/W2023934520","https://openalex.org/W2034773856","https://openalex.org/W2041227213","https://openalex.org/W2051436947","https://openalex.org/W2057835414","https://openalex.org/W2070884546","https://openalex.org/W2079049574","https://openalex.org/W2079305309","https://openalex.org/W2084217576","https://openalex.org/W2105817351","https://openalex.org/W2126747233","https://openalex.org/W2131331741","https://openalex.org/W2148296799","https://openalex.org/W2150494760","https://openalex.org/W2188371841","https://openalex.org/W2214934291","https://openalex.org/W2288906906","https://openalex.org/W2333897814","https://openalex.org/W2544246617","https://openalex.org/W2568887607","https://openalex.org/W2612369911","https://openalex.org/W2616316699","https://openalex.org/W2788719551","https://openalex.org/W2810358408","https://openalex.org/W2885289995","https://openalex.org/W2972509428","https://openalex.org/W3006347594","https://openalex.org/W3042704665","https://openalex.org/W3165559248","https://openalex.org/W3209027647","https://openalex.org/W4205373491","https://openalex.org/W4212943013","https://openalex.org/W4220793420","https://openalex.org/W4223622421","https://openalex.org/W4226365489","https://openalex.org/W4250296624","https://openalex.org/W4323565724","https://openalex.org/W4364382189","https://openalex.org/W4365997891","https://openalex.org/W4377221406","https://openalex.org/W4393935425","https://openalex.org/W4411161282","https://openalex.org/W4411332715","https://openalex.org/W4411798782","https://openalex.org/W4412056702","https://openalex.org/W7128967371"],"related_works":["https://openalex.org/W2070884546","https://openalex.org/W2599510817","https://openalex.org/W1555873096","https://openalex.org/W2214934291","https://openalex.org/W2150494760","https://openalex.org/W2979770869","https://openalex.org/W2169615419","https://openalex.org/W2154522506","https://openalex.org/W2067311239","https://openalex.org/W7098723020"],"abstract_inverted_index":{"Osimertinib":[0],"(Osi)":[1],"resistance":[2,49,162],"is":[3],"a":[4,29,81,102,131,147,172],"pressing":[5],"challenge":[6],"in":[7,50,93,106,111,166,171],"the":[8,43,112],"research":[9],"for":[10,14,137],"new":[11],"therapeutic":[12],"strategies":[13],"Epidermal":[15],"Growth":[16],"Factor":[17],"Receptor":[18],"(EGFR)":[19],"mutant":[20],"Non-Small":[21],"Cell":[22],"Lung":[23],"Cancer":[24],"(NSCLC).":[25],"This":[26,144],"study":[27],"proposes":[28],"novel":[30],"analytical":[31],"strategy":[32],"based":[33],"on":[34],"FTIR":[35,128],"spectroscopy":[36,129],"integrated":[37],"with":[38,47,118],"chemometric":[39],"analyses":[40],"to":[41,151],"characterize":[42],"biochemical":[44],"alterations":[45],"associated":[46],"Osi":[48,73],"whole-cells":[51],"and":[52,59,76,96,121,134,156,170],"their":[53,77],"fractions":[54],"after":[55],"lysis":[56],"(cytosolic":[57],"high-":[58],"low-":[60],"MW":[61],"compounds,":[62],"as":[63,65],"well":[64],"pellets).":[66],"To":[67],"better":[68],"visualize":[69],"spectral":[70],"variability":[71],"between":[72],"resistant":[74,113],"cells":[75],"sensitive":[78],"parental":[79],"counterparts,":[80],"linear":[82],"principal":[83],"component":[84],"analysis":[85,89],"was":[86],"conducted.":[87],"Spectroscopic":[88],"identified":[90],"distinct":[91],"markers":[92],"lipid,":[94],"protein,":[95],"nucleic":[97],"acid":[98],"bands,":[99],"specifically":[100],"highlighting":[101],"significant":[103],"intensity":[104],"increase":[105],"ester-related":[107],"vibrations":[108],"(~1736-1720":[109],"cm-1)":[110],"phenotype.":[114],"These":[115],"findings,":[116],"correlated":[117],"transcriptomic":[119],"profiling":[120],"mitochondrial":[122],"gene":[123],"expression":[124],"data,":[125],"demonstrate":[126],"that":[127],"provides":[130],"rapid,":[132],"high-throughput,":[133],"robust":[135],"platform":[136],"identifying":[138],"spectroscopic":[139,154],"biomarkers":[140],"of":[141,161],"drug":[142],"resistance.":[143],"approach":[145],"offers":[146],"fast,":[148],"high-throughput":[149],"method":[150],"detect":[152],"specific":[153],"markers,":[155],"potentially":[157],"enables":[158],"longitudinal":[159],"monitoring":[160],"development":[163],"over":[164],"time":[165],"cell":[167],"culture":[168],"models":[169],"clinical":[173],"setting.":[174]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-18T00:00:00"}