{"id":"https://openalex.org/W7203611067","doi":"https://doi.org/10.1111/anae.70347","title":"Impact of propofol\u2010based vs. volatile\u2010based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta\u2010analysis of randomised trials","display_name":"Impact of propofol\u2010based vs. volatile\u2010based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta\u2010analysis of randomised trials","publication_year":2026,"publication_date":"2026-08-17","ids":{"openalex":"https://openalex.org/W7203611067","doi":"https://doi.org/10.1111/anae.70347","pmid":"https://pubmed.ncbi.nlm.nih.gov/42605750","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13743682"},"language":"en","primary_location":{"id":"doi:10.1111/anae.70347","doi":"https://doi.org/10.1111/anae.70347","is_oa":true,"landing_page_url":"https://doi.org/10.1111/anae.70347","pdf_url":null,"source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1111/anae.70347","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034186891","display_name":"A Mustafa","orcid":"https://orcid.org/0009-0000-4922-437X","observed_orcids":["https://orcid.org/0009-0000-4922-437X"]},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Ashmit Daiyan Mustafa","raw_affiliation_strings":["School of Medicine, Deakin University  Waurn Ponds Melbourne VIC Australia"],"raw_orcid":"https://orcid.org/0009-0000-4922-437X","affiliations":[{"raw_affiliation_string":"School of Medicine, Deakin University  Waurn Ponds Melbourne VIC Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023605633","display_name":"Pavan Shet","orcid":"https://orcid.org/0009-0004-8661-3306","observed_orcids":["https://orcid.org/0009-0004-8661-3306"]},"institutions":[{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Pavan Shet","raw_affiliation_strings":["Anaesthetic and Pain Department St. Vincent's Hospital Melbourne  Fitzroy Melbourne VIC Australia"],"raw_orcid":"https://orcid.org/0009-0004-8661-3306","affiliations":[{"raw_affiliation_string":"Anaesthetic and Pain Department St. Vincent's Hospital Melbourne  Fitzroy Melbourne VIC Australia","institution_ids":["https://openalex.org/I4210087110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5095706294","display_name":"Sameen Sawdagar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802443823","display_name":"Lismore Base Hospital","ror":"https://ror.org/004kvma63","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802443823"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sameen Shadman Sawdagar","raw_affiliation_strings":["Anaesthetic Department Lismore Base Hospital  Lismore NSW Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anaesthetic Department Lismore Base Hospital  Lismore NSW Australia","institution_ids":["https://openalex.org/I2802443823"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034186891"],"corresponding_institution_ids":["https://openalex.org/I149704539"],"apc_list":{"value":4970,"currency":"USD","value_usd":4970},"apc_paid":{"value":4970,"currency":"USD","value_usd":4970},"fwci":0.5706,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53238636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"81","issue":"12","first_page":"1742","last_page":"1751"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cancer-surgery","display_name":"cancer surgery","score":0.7730000019073486},{"id":"https://openalex.org/keywords/oncologic-outcomes","display_name":"oncological outcomes","score":0.6959999799728394},{"id":"https://openalex.org/keywords/recurrence-free-survival","display_name":"recurrence-free survival","score":0.7080000042915344},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9860000014305115},{"id":"https://openalex.org/keywords/postoperative-mortality","display_name":"postoperative mortality","score":0.8650000095367432},{"id":"https://openalex.org/keywords/trial-sequential-analysis","display_name":"trial sequential analysis","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9760000109672546},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6299999952316284},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5899999737739563},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5626999735832214},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.531499981880188},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.45809999108314514},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4544000029563904},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4156000018119812},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.3944999873638153},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34630000591278076},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C2776983577","wikidata":"https://www.wikidata.org/wiki/Q166543","display_name":"General anaesthesia","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3328999876976013},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C3020167199","wikidata":"https://www.wikidata.org/wiki/Q5031455","display_name":"Cancer survival","level":3,"score":0.29809999465942383},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2955999970436096},{"id":"https://openalex.org/C2991678472","wikidata":"https://www.wikidata.org/wiki/Q108872574","display_name":"Cancer recurrence","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2703999876976013},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.257099986076355},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.25600001215934753}],"mesh":[{"descriptor_ui":"D000098963","descriptor_name":"Onco-anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000769","descriptor_name":"Anesthesia, Inhalation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/anae.70347","doi":"https://doi.org/10.1111/anae.70347","is_oa":true,"landing_page_url":"https://doi.org/10.1111/anae.70347","pdf_url":null,"source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},{"id":"pmid:42605750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42605750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13743682","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13743682/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"Text"},{"id":"pmh:oai:share.osf.io:e6471d4a-8c01-453f-9001-24c349ab8bf9","doi":null,"is_oa":false,"landing_page_url":"https://osf.io/b54f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"}],"best_oa_location":{"id":"doi:10.1111/anae.70347","doi":"https://doi.org/10.1111/anae.70347","is_oa":true,"landing_page_url":"https://doi.org/10.1111/anae.70347","pdf_url":null,"source":{"id":"https://openalex.org/S7689096","display_name":"Anaesthesia","issn_l":"0003-2409","issn":["0003-2409","1365-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anaesthesia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W35242962","https://openalex.org/W2068912493","https://openalex.org/W2097338479","https://openalex.org/W2110970000","https://openalex.org/W2114477375","https://openalex.org/W2116748042","https://openalex.org/W2138782976","https://openalex.org/W2162659577","https://openalex.org/W2327822695","https://openalex.org/W2597618526","https://openalex.org/W2755551613","https://openalex.org/W2756110761","https://openalex.org/W2884239768","https://openalex.org/W2889581714","https://openalex.org/W2919785859","https://openalex.org/W2954607948","https://openalex.org/W2970684805","https://openalex.org/W2975424845","https://openalex.org/W2981214241","https://openalex.org/W3003076351","https://openalex.org/W3050973329","https://openalex.org/W3087770431","https://openalex.org/W3093771993","https://openalex.org/W3095689420","https://openalex.org/W3104495101","https://openalex.org/W3118615836","https://openalex.org/W3120472597","https://openalex.org/W4213444127","https://openalex.org/W4283581957","https://openalex.org/W4285591442","https://openalex.org/W4295512947","https://openalex.org/W4307195898","https://openalex.org/W4379261047","https://openalex.org/W4380203591","https://openalex.org/W4385829894","https://openalex.org/W4388666815","https://openalex.org/W4390283305","https://openalex.org/W4393935425","https://openalex.org/W4400700011","https://openalex.org/W4406183736","https://openalex.org/W4417161819"],"related_works":["https://openalex.org/W3093771993","https://openalex.org/W7135577473","https://openalex.org/W4309785562","https://openalex.org/W2919785859","https://openalex.org/W7223118184","https://openalex.org/W4379261047","https://openalex.org/W4391097439","https://openalex.org/W7219060683","https://openalex.org/W7161807403","https://openalex.org/W4390283305"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Choice":[1],"of":[2,114],"peri-operative":[3],"anaesthetic":[4],"technique":[5],"may":[6],"influence":[7],"cancer":[8,67],"recurrence,":[9],"survival":[10,40,109,181],"and":[11,31,41,90,121,168,184],"mortality":[12,135,195],"following":[13],"curative":[14,66],"surgery.":[15,48,68],"Conflicting":[16],"evidence":[17,34],"exists":[18],"on":[19,38,105,134],"whether":[20],"propofol-based":[21,59,95],"anaesthesia":[22,62,170],"improves":[23],"outcomes":[24],"over":[25],"volatile":[26],"anaesthesia.":[27],"This":[28],"systematic":[29],"review":[30],"meta-analysis":[32,75],"examined":[33],"from":[35],"randomised":[36,56],"trials":[37,57],"overall":[39,106],"recurrence":[42,149,183,200],"in":[43,63,163,180],"adult":[44],"patients":[45,92],"having":[46],"oncological":[47,174],"METHODS:":[49],"We":[50],"systematically":[51],"searched":[52],"relevant":[53],"databases":[54],"for":[55,148],"comparing":[58],"with":[60,78,110,176],"volatile-based":[61,97,169],"adults":[64],"undergoing":[65],"In":[69],"addition":[70],"to":[71,94],"narrative":[72],"synthesis,":[73],"random-effects":[74],"was":[76,130,159],"performed":[77],"exploratory":[79],"trial":[80],"sequential":[81,192],"analysis.":[82],"RESULTS:":[83],"Eleven":[84],"studies":[85],"were":[86,146],"included,":[87],"comprising":[88],"3904":[89],"3907":[91],"assigned":[93],"or":[96,107,182],"anaesthesia,":[98],"respectively.":[99,128],"Meta-analysis":[100],"found":[101,147],"no":[102,131,177],"significant":[103,132,178],"effect":[104,133],"recurrence-free":[108],"a":[111],"hazard":[112],"ratio":[113],"1.05":[115],"(95%CI":[116,123],"0.94-1.17,":[117],"p":[118,125,141,155],"=":[119,126,142,156],"0.42)":[120],"1.06":[122],"0.95-1.19,":[124],"0.31),":[127],"There":[129,158],"(relative":[136,150],"risk":[137,151],"1.03,":[138],"95%CI":[139,153],"0.94-1.13,":[140],"0.48).":[143],"Similar":[144],"results":[145],"0.92,":[152],"0.76-1.12,":[154],"0.41).":[157],"minimal":[160,185],"detected":[161],"heterogeneity":[162],"all":[164],"analyses.":[165],"DISCUSSION:":[166],"Propofol-based":[167],"yield":[171],"similar":[172],"long-term":[173],"outcomes,":[175],"differences":[179],"heterogeneity,":[186],"supported":[187],"by":[188],"high-certainty":[189],"evidence.":[190],"Trial":[191],"analysis":[193],"confirms":[194],"findings":[196],"are":[197],"robust":[198],"while":[199],"remains":[201],"inconclusive.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-18T00:00:00"}