{"id":"https://openalex.org/W7203608560","doi":"https://doi.org/10.3390/medsci14040485","title":"A Small Natural Molecule Targeting IL-23/IL-17 Axis Exerts Dual Effects on T-Cell Function and Breast Cancer Cell Migration","display_name":"A Small Natural Molecule Targeting IL-23/IL-17 Axis Exerts Dual Effects on T-Cell Function and Breast Cancer Cell Migration","publication_year":2026,"publication_date":"2026-08-15","ids":{"openalex":"https://openalex.org/W7203608560","doi":"https://doi.org/10.3390/medsci14040485","pmid":"https://pubmed.ncbi.nlm.nih.gov/42646619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13515054"},"language":"en","primary_location":{"id":"doi:10.3390/medsci14040485","doi":"https://doi.org/10.3390/medsci14040485","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medsci14040485","pdf_url":null,"source":{"id":"https://openalex.org/S2739445098","display_name":"Medical Sciences","issn_l":"2076-3271","issn":["2076-3271"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/medsci14040485","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5143738420","display_name":"Sara Bourdoukh","orcid":"https://orcid.org/0009-0000-0934-8925","observed_orcids":["https://orcid.org/0009-0000-0934-8925"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Sara Bourdoukh","raw_affiliation_strings":["Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco"],"raw_orcid":"https://orcid.org/0009-0000-0934-8925","affiliations":[{"raw_affiliation_string":"Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073624958","display_name":"Khadija El Azhary","orcid":"https://orcid.org/0000-0002-7781-2352","observed_orcids":["https://orcid.org/0000-0002-7781-2352","https://orcid.org/0000-0002-1515-9992"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Khadija El Azhary","raw_affiliation_strings":["Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083952821","display_name":"Sanaa Souat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Sanaa Souat","raw_affiliation_strings":["Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067907065","display_name":"Khouloud Ayed","orcid":"https://orcid.org/0000-0001-6033-8597","observed_orcids":["https://orcid.org/0000-0001-6033-8597"]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Khouloud Ayed","raw_affiliation_strings":["Laboratory of Genetics Immunology and Human Pathology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia"],"raw_orcid":"https://orcid.org/0000-0001-6033-8597","affiliations":[{"raw_affiliation_string":"Laboratory of Genetics Immunology and Human Pathology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091967325","display_name":"Hamza Benthami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hamza Benthami","raw_affiliation_strings":["Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036885441","display_name":"Said Byadi","orcid":"https://orcid.org/0000-0003-0913-2897","observed_orcids":["https://orcid.org/0000-0003-0913-2897"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Said Byadi","raw_affiliation_strings":["Organic Synthesis, Extraction and Valorization Laboratory, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20360, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Organic Synthesis, Extraction and Valorization Laboratory, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074456528","display_name":"Aziz Aboulmouhajir","orcid":"https://orcid.org/0000-0002-0459-6935","observed_orcids":["https://orcid.org/0000-0002-0459-6935"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Aziz Aboulmouhajir","raw_affiliation_strings":["Organic Synthesis, Extraction and Valorization Laboratory, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20360, Morocco"],"raw_orcid":"https://orcid.org/0000-0002-0459-6935","affiliations":[{"raw_affiliation_string":"Organic Synthesis, Extraction and Valorization Laboratory, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109451050","display_name":"Mohamed Elkarroumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Mohamed Elkarroumi","raw_affiliation_strings":["Mohamed VI Oncology Center, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mohamed VI Oncology Center, Ibn Rochd University Hospital Center, Casablanca 20000, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015222917","display_name":"Asma Gati","orcid":"https://orcid.org/0000-0001-8507-0451","observed_orcids":["https://orcid.org/0000-0001-8507-0451"]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Asma Gati","raw_affiliation_strings":["Laboratory of Genetics Immunology and Human Pathology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia"],"raw_orcid":"https://orcid.org/0000-0001-8507-0451","affiliations":[{"raw_affiliation_string":"Laboratory of Genetics Immunology and Human Pathology, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 2092, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I63596082"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044470246","display_name":"Abdallah Badou","orcid":"https://orcid.org/0000-0003-4849-9085","observed_orcids":["https://orcid.org/0000-0003-4849-9085"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Abdallah Badou","raw_affiliation_strings":["City of Innovation and Technology Transfer, Hassan II University of Casablanca, Casablanca 20360, Morocco","Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco"],"raw_orcid":"https://orcid.org/0000-0003-4849-9085","affiliations":[{"raw_affiliation_string":"City of Innovation and Technology Transfer, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"Immuno-Genetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I99297268"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044470246"],"corresponding_institution_ids":["https://openalex.org/I99297268"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1689},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1689},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56358838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"4","first_page":"485","last_page":"485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.24160000681877136,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.15860000252723694,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-23-il-17-axis","display_name":"IL-23/IL-17 axis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9079999923706055},{"id":"https://openalex.org/keywords/il23r","display_name":"IL23R","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-cell-migration","display_name":"tumor cell migration","score":0.8790000081062317},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7379999756813049},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.628000020980835},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8191999793052673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8066999912261963},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6590999960899353},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6118000149726868},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49799999594688416},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4909999966621399},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.474700003862381},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4474000036716461},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4431999921798706},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.41339999437332153},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.40860000252723694},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.39750000834465027},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.37299999594688416},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3246999979019165},{"id":"https://openalex.org/C2776598214","wikidata":"https://www.wikidata.org/wiki/Q6606395","display_name":"Withaferin A","level":4,"score":0.2847000062465668},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27869999408721924},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.2572999894618988},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25110000371932983}],"mesh":[{"descriptor_ui":"D000092302","descriptor_name":"MDA-MB-231 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053759","descriptor_name":"Interleukin-23","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/medsci14040485","doi":"https://doi.org/10.3390/medsci14040485","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medsci14040485","pdf_url":null,"source":{"id":"https://openalex.org/S2739445098","display_name":"Medical Sciences","issn_l":"2076-3271","issn":["2076-3271"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Sciences","raw_type":"journal-article"},{"id":"pmid:42646619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42646619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical sciences (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13515054","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13515054/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Med Sci (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f08a290035c64c008df784861dc1e089","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f08a290035c64c008df784861dc1e089","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medical Sciences, Vol 14, Iss 4, p 485 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medsci14040485","doi":"https://doi.org/10.3390/medsci14040485","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medsci14040485","pdf_url":null,"source":{"id":"https://openalex.org/S2739445098","display_name":"Medical Sciences","issn_l":"2076-3271","issn":["2076-3271"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G734502321","display_name":null,"funder_award_id":"624289-PANAF-1-2020\u20131-KEPANAFMOBAF","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1926597952","https://openalex.org/W1964455146","https://openalex.org/W1967856594","https://openalex.org/W1984467626","https://openalex.org/W2041755933","https://openalex.org/W2044748328","https://openalex.org/W2049820772","https://openalex.org/W2058412827","https://openalex.org/W2080527232","https://openalex.org/W2120868389","https://openalex.org/W2140374399","https://openalex.org/W2346125622","https://openalex.org/W2527091027","https://openalex.org/W2560368559","https://openalex.org/W2578528809","https://openalex.org/W2652151562","https://openalex.org/W2780850472","https://openalex.org/W2898706486","https://openalex.org/W3005834099","https://openalex.org/W3013025666","https://openalex.org/W3017082035","https://openalex.org/W3037219705","https://openalex.org/W3040728513","https://openalex.org/W3140415241","https://openalex.org/W3143657138","https://openalex.org/W3159798193","https://openalex.org/W3180882235","https://openalex.org/W4220848674","https://openalex.org/W4321092565","https://openalex.org/W4387427348","https://openalex.org/W4399427685","https://openalex.org/W4399534733","https://openalex.org/W4403700699","https://openalex.org/W4406332643"],"related_works":["https://openalex.org/W2546889922","https://openalex.org/W2782926218","https://openalex.org/W1896923417","https://openalex.org/W4309543254","https://openalex.org/W2140374399","https://openalex.org/W2135934397","https://openalex.org/W4324079184","https://openalex.org/W2268102483","https://openalex.org/W2558116971","https://openalex.org/W4391737268"],"abstract_inverted_index":{"Background/Objectives:":[0],"Chronic":[1],"inflammation":[2],"in":[3,13,30,52,94,123],"the":[4,17,26,59,75,80,104,165,214,227],"tumor":[5,252],"microenvironment":[6],"(TME)":[7],"promotes":[8],"immune":[9,151],"evasion":[10],"and":[11,33,46,58,91,108,128,134,153,175,206,218,235,250],"metastasis":[12],"breast":[14,31,55,110,125,220,244],"cancer,":[15],"where":[16],"IL-23/IL-17":[18,76,228],"axis":[19,229],"is":[20],"a":[21,35,53,135,160,169,176,231,239],"key":[22],"mediator.":[23],"We":[24],"investigated":[25],"expression":[27,45,140],"of":[28,66,106,172,180,216],"IL-23":[29,44,117,139,166],"cancer":[32,56,111,126,221,245],"identified":[34],"small":[36],"natural":[37],"molecule":[38],"therapeutically":[39],"targeting":[40],"this":[41],"axis.":[42,77],"Methods:":[43],"its":[47,87],"clinicopathological":[48,132],"significance":[49],"were":[50],"assessed":[51],"Moroccan":[54],"cohort":[57],"METABRIC":[60],"dataset.":[61],"A":[62],"High-throughput":[63],"virtual":[64],"screening":[65],"Allium":[67],"sativum":[68],"L.":[69],"compounds":[70],"was":[71,84,118,141],"conducted":[72],"to":[73,120],"target":[74,234],"In":[78,156,188],"vitro,":[79,189],"selected":[81],"candidate,":[82],"IL-23RI,":[83],"evaluated":[85],"for":[86,164,243],"effects":[88],"on":[89,103],"IL-17A":[90,193],"IFN\u03b3":[92,201],"production":[93,194],"human":[95],"PBMCs":[96],"using":[97,113],"flow":[98],"cytometry,":[99],"as":[100,102,230,238],"well":[101],"migration":[105,215],"MCF-7":[107,217],"MDA-MB-231":[109,219],"cells":[112,198],"wound-healing":[114],"assays.":[115],"Results:":[116],"found":[119],"be":[121],"overexpressed":[122],"aggressive":[124],"subtypes":[127],"correlated":[129],"with":[130,143,168],"unfavorable":[131],"features":[133],"poor":[136],"prognosis.":[137],"Elevated":[138],"associated":[142],"an":[144],"immunosuppressive":[145,154],"TME,":[146],"characterized":[147],"by":[148,184,195,203],"increased":[149],"inhibitory":[150],"checkpoints":[152],"chemokines.":[155],"silico,":[157],"IL-23RI":[158,190,211,237],"demonstrates":[159],"high":[161],"binding":[162,177],"affinity":[163],"receptor,":[167],"docking":[170],"score":[171],"\u22127.482":[173],"kcal/mol":[174],"free":[178],"energy":[179],"\u221248.80":[181],"kcal/mol,":[182],"stabilized":[183],"five":[185],"hydrogen":[186],"bonds.":[187],"selectively":[191],"suppressed":[192],"CD4+":[196,205],"T":[197,208],"without":[199],"affecting":[200],"secretion":[202],"both":[204],"CD8+":[207],"cells.":[209,222],"Furthermore,":[210],"significantly":[212],"inhibited":[213],"Conclusions:":[223],"These":[224],"findings":[225],"establish":[226],"critical":[232],"therapeutic":[233],"present":[236],"promising":[240],"dual-function":[241],"agent":[242],"treatment,":[246],"concurrently":[247],"modulating":[248],"immunity":[249],"inhibiting":[251],"cell":[253],"migration.":[254]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-18T00:00:00"}