{"id":"https://openalex.org/W7203603442","doi":"https://doi.org/10.25258/ijddt.16.75s.112","title":"Development and Optimization of an Herbal Polymeric Matrix Transdermal Patch for Potential Anti-diabetic Drug Delivery","display_name":"Development and Optimization of an Herbal Polymeric Matrix Transdermal Patch for Potential Anti-diabetic Drug Delivery","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7203603442","doi":"https://doi.org/10.25258/ijddt.16.75s.112"},"language":"en","primary_location":{"id":"doi:10.25258/ijddt.16.75s.112","doi":"https://doi.org/10.25258/ijddt.16.75s.112","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijddt.16.75s.112","pdf_url":"https://doi.org/10.25258/ijddt.16.75s.112","source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.25258/ijddt.16.75s.112","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147359748","display_name":"Aatif Jameel Ahmed Shaikh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aatif Jameel Ahmed Shaikh","raw_affiliation_strings":["Ph.D. Scholar, Sandip University, Nashik, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ph.D. Scholar, Sandip University, Nashik, Maharashtra, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038938613","display_name":"Sunita S. Deore","orcid":"https://orcid.org/0000-0001-7768-7355","observed_orcids":["https://orcid.org/0000-0001-7768-7355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunita S. Deore","raw_affiliation_strings":["Research Supervisor, Sandip University, Nashik, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Supervisor, Sandip University, Nashik, Maharashtra, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"75s","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transdermal-patch","display_name":"transdermal patch","score":0.9139999747276306},{"id":"https://openalex.org/keywords/herbal-drug-delivery","display_name":"herbal drug delivery","score":0.7160000205039978},{"id":"https://openalex.org/keywords/antidiabetic-therapy","display_name":"antidiabetic therapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/gymnema-sylvestre","display_name":"Gymnema sylvestre","score":0.953000009059906},{"id":"https://openalex.org/keywords/tinospora-cordifolia","display_name":"Tinospora cordifolia","score":1.0},{"id":"https://openalex.org/keywords/polymer-matrix","display_name":"polymer matrix","score":0.7549999952316284},{"id":"https://openalex.org/keywords/polyvinyl-alcohol","display_name":"polyvinyl alcohol","score":0.9639999866485596},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hydroxypropyl-methylcellulose","display_name":"hydroxypropyl methylcellulose","score":0.9679999947547913},{"id":"https://openalex.org/keywords/solvent-casting","display_name":"solvent casting","score":0.609000027179718},{"id":"https://openalex.org/keywords/drug-excipient-compatibility","display_name":"drug-excipient compatibility","score":0.7070000171661377},{"id":"https://openalex.org/keywords/in-vitro-drug-release","display_name":"in vitro drug release","score":0.7900000214576721},{"id":"https://openalex.org/keywords/zero-order-release-kinetics","display_name":"zero-order release kinetics","score":0.7710000276565552},{"id":"https://openalex.org/keywords/patch-stability","display_name":"patch stability","score":0.6949999928474426},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C205679159","wikidata":"https://www.wikidata.org/wiki/Q3375179","display_name":"Transdermal","level":2,"score":0.5764999985694885},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5281000137329102},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4578000009059906},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4512999951839447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38260000944137573},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.35040000081062317},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3495999872684479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33739998936653137},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C2775842315","wikidata":"https://www.wikidata.org/wiki/Q1145270","display_name":"Transdermal patch","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3160000145435333},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2809000015258789},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.2623000144958496}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.25258/ijddt.16.75s.112","doi":"https://doi.org/10.25258/ijddt.16.75s.112","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijddt.16.75s.112","pdf_url":"https://doi.org/10.25258/ijddt.16.75s.112","source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.25258/ijddt.16.75s.112","doi":"https://doi.org/10.25258/ijddt.16.75s.112","is_oa":true,"landing_page_url":"https://doi.org/10.25258/ijddt.16.75s.112","pdf_url":"https://doi.org/10.25258/ijddt.16.75s.112","source":{"id":"https://openalex.org/S4210211336","display_name":"International Journal of Drug Delivery Technology","issn_l":"0975-4415","issn":["0975-4415"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Drug Delivery Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203603442.pdf","grobid_xml":"https://content.openalex.org/works/W7203603442.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2025672323","https://openalex.org/W2764299795","https://openalex.org/W2796056061","https://openalex.org/W2896663247","https://openalex.org/W2902357007","https://openalex.org/W2908704270","https://openalex.org/W2915078030","https://openalex.org/W3048963245","https://openalex.org/W3081933776","https://openalex.org/W3082868956","https://openalex.org/W3199048579","https://openalex.org/W3199071501","https://openalex.org/W4200026682","https://openalex.org/W4220874088","https://openalex.org/W4281857172","https://openalex.org/W4388611301","https://openalex.org/W4403097333","https://openalex.org/W4409336930","https://openalex.org/W4413175556","https://openalex.org/W7106233193"],"related_works":["https://openalex.org/W2625031189","https://openalex.org/W3152277491","https://openalex.org/W4232795695","https://openalex.org/W7166103709","https://openalex.org/W6948997048","https://openalex.org/W4293099425","https://openalex.org/W3006959304","https://openalex.org/W7162863718","https://openalex.org/W3008571543","https://openalex.org/W1886410880"],"abstract_inverted_index":{"Background:":[0],"Diabetes":[1],"mellitus":[2],"has":[3],"a":[4,13,34,73,186,209],"large":[5],"worldwide":[6],"health":[7],"burden,":[8],"rendering":[9],"transdermal":[10,38,245,260],"medication":[11,18],"administration":[12],"compelling":[14],"alternative":[15],"to":[16,20,30,235],"oral":[17],"due":[19],"first-pass":[21],"metabolism":[22],"and":[23,32,43,56,67,77,92,109,113,117,144,154,164,169,202,254],"superior":[24,248],"systemic":[25],"bioavailability.The":[26],"present":[27],"research":[28],"intended":[29],"create":[31],"investigate":[33],"matrix-shaped":[35],"antidiabetic":[36,261],"herbal":[37,244],"patch":[39,224,246],"including":[40],"Gymnema":[41],"sylvestre":[42],"Tinospora":[44],"cordifolia":[45,58],"extracts":[46,52],"from":[47],"Box-Behnken":[48,81],"design":[49,82],"refinement.Methods:":[50],"Hydroalcoholic":[51],"of":[53,188,196,206],"G.":[54],"sylvestre,":[55],"T.":[57],"were":[59,101,124],"medicinally":[60],"evaluated":[61],"by":[62,103],"phytochemical":[63],"screening,":[64],"fluorescence":[65],"analysis,":[66],"TLC.Drugexcipient":[68],"compatibility":[69],"was":[70,83],"assessed":[71],"before":[72],"formulation":[74,175],"employing":[75],"FTIR":[76],"DSC.A":[78],"three-factor,":[79],"three-level":[80],"applied,":[84],"with":[85,231],"PVA":[86,178],"amount":[87],"(%),":[88,91],"ethanol":[89,180],"concentration":[90],"drying":[93,182],"time":[94],"(h)":[95],"as":[96,111,122],"the":[97,236],"independent":[98],"variables.Fifteen":[99],"formulations":[100],"developed":[102],"solvent":[104],"casting":[105],"using":[106],"PVA,":[107],"HPMC,":[108],"chitosan":[110],"polymers":[112],"PEG":[114],"400.Glycerol,":[115],"DMSO,":[116],"Tween":[118],"80":[119],"are":[120],"utilised":[121],"excipients.Patches":[123],"tested":[125],"for":[126,259],"thickness,":[127],"folding":[128,190],"endurance,":[129],"tensile":[130,194],"strength,":[131],"moisture":[132],"uptake,":[133],"water":[134],"vapour":[135],"distribution,":[136],"surface":[137],"pH,":[138],"drug":[139,142,198,204,237,252],"content,":[140],"in-vitro":[141],"release,":[143,253],"release":[145,205,213,240],"kinetics.Stability":[146],"assessments":[147],"lasted":[148],"60":[149],"days":[150],"at":[151,200],"25\u00b0C/60%":[152],"RH":[153],"40\u00b0C/75%":[155],"RH.Phytochemical":[156],"analysis":[157],"showed":[158,247],"alkaloids,":[159],"glycosides,":[160],"flavonoids,":[161],"saponins,":[162],"steroids,":[163],"tannins":[165],"in":[166,227],"both":[167,228],"extracts.FTIR":[168],"DSC":[170],"verified":[171],"drug-excipient":[172],"compatibility.The":[173],"improved":[174],"(Run":[176],"14:":[177],"70%,":[179],"35%,":[181],"36":[183],"h)":[184],"possessed":[185],"thickness":[187],"0.38\u00b10.01mm,":[189],"endurance":[191],"over":[192,208],"140,":[193],"strength":[195],"3.80\u00b10.16kg/cm\u00b2,":[197],"content":[199,238],"99.1\u00b10.7%,":[201],"cumulative":[203],"96.2\u00b11.5%":[207],"24":[210],"hour":[211],"period.Drug":[212],"follows":[214],"zero-order":[215],"kinetics":[216],"(R\u00b2=0.981)with":[217],"Korsmeyer-Peppas":[218],"exponent":[219],"n=0.62,":[220],"indicating":[221,256],"non-Fickian":[222],"transport.The":[223],"remained":[225],"stable":[226],"storage":[229],"conditions,":[230],"no":[232],"noticeable":[233],"changes":[234],"or":[239],"profile.Conclusion:":[241],"The":[242],"tailored":[243],"physicochemical":[249],"qualities,":[250],"long-term":[251],"stability,":[255],"its":[257],"potential":[258],"therapy.....":[262]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-08-18T00:00:00"}