{"id":"https://openalex.org/W7203599153","doi":"https://doi.org/10.1016/j.placenta.2026.08.334","title":"Effects of folic acid on the IRS-PI3K-AKT pathway in an in vitro insulin resistance model","display_name":"Effects of folic acid on the IRS-PI3K-AKT pathway in an in vitro insulin resistance model","publication_year":2026,"publication_date":"2026-08-17","ids":{"openalex":"https://openalex.org/W7203599153","doi":"https://doi.org/10.1016/j.placenta.2026.08.334","pmid":"https://pubmed.ncbi.nlm.nih.gov/42636773"},"language":"en","primary_location":{"id":"doi:10.1016/j.placenta.2026.08.334","doi":"https://doi.org/10.1016/j.placenta.2026.08.334","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.placenta.2026.08.334","pdf_url":null,"source":{"id":"https://openalex.org/S171513543","display_name":"Placenta","issn_l":"0143-4004","issn":["0143-4004","1532-3102"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Placenta","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077085720","display_name":"An\u0131l Y\u00dcCEL","orcid":"https://orcid.org/0000-0002-6018-2737","observed_orcids":["https://orcid.org/0000-0002-6018-2737"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Anil Yucel","raw_affiliation_strings":["Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye. Electronic address: anilyucel@mu.edu.tr"],"raw_orcid":"https://orcid.org/0000-0002-6018-2737","affiliations":[{"raw_affiliation_string":"Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye. Electronic address: anilyucel@mu.edu.tr","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081924420","display_name":"G\u00fcrkan Yi\u011fitt\u00fcrk","orcid":"https://orcid.org/0000-0002-5315-253X","observed_orcids":["https://orcid.org/0000-0002-5315-253X"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gurkan Yigitturk","raw_affiliation_strings":["Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012802073","display_name":"Dilan \u00c7etinavc\u0131","orcid":"https://orcid.org/0000-0002-4148-7711","observed_orcids":["https://orcid.org/0000-0002-4148-7711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dilan Cetinavci","raw_affiliation_strings":["Mugla Training and Research Hospital, Histology and Embryology, Mugla, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mugla Training and Research Hospital, Histology and Embryology, Mugla, T\u00fcrkiye","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007777685","display_name":"H\u00fclya Elbe","orcid":"https://orcid.org/0000-0002-1254-0683","observed_orcids":["https://orcid.org/0000-0002-1254-0683"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hulya Elbe","raw_affiliation_strings":["Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye","institution_ids":["https://openalex.org/I79946792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063109071","display_name":"Feral \u00d6zt\u00fcrk","orcid":"https://orcid.org/0000-0003-1207-5213","observed_orcids":["https://orcid.org/0000-0003-1207-5213"]},"institutions":[{"id":"https://openalex.org/I79946792","display_name":"Mu\u011fla University","ror":"https://ror.org/05n2cz176","country_code":"TR","type":"education","lineage":["https://openalex.org/I79946792"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Feral Ozturk","raw_affiliation_strings":["Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mugla Sitki Kocman University, Faculty of Medicine, Department of Histology and Embryology, Mugla, T\u00fcrkiye","institution_ids":["https://openalex.org/I79946792"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077085720"],"corresponding_institution_ids":["https://openalex.org/I79946792"],"apc_list":{"value":3720,"currency":"USD","value_usd":3720},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"183","issue":null,"first_page":"44","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.9919999837875366},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.9419999718666077},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.9390000104904175},{"id":"https://openalex.org/keywords/maternal-diabetes","display_name":"maternal diabetes","score":0.7379999756813049},{"id":"https://openalex.org/keywords/diabetic-vascular-disease","display_name":"diabetic vascular disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/endothelial-cell-viability","display_name":"endothelial cell viability","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6589000225067139},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6531999707221985},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.6040999889373779},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5511999726295471},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4993000030517578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4779999852180481},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4311000108718872},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34470000863075256},{"id":"https://openalex.org/C2909565028","wikidata":"https://www.wikidata.org/wiki/Q2915477","display_name":"Folic acid supplementation","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30959999561309814},{"id":"https://openalex.org/C3019461512","wikidata":"https://www.wikidata.org/wiki/Q183206","display_name":"Vitamin b complex","level":3,"score":0.26660001277923584}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.placenta.2026.08.334","doi":"https://doi.org/10.1016/j.placenta.2026.08.334","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.placenta.2026.08.334","pdf_url":null,"source":{"id":"https://openalex.org/S171513543","display_name":"Placenta","issn_l":"0143-4004","issn":["0143-4004","1532-3102"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Placenta","raw_type":"journal-article"},{"id":"pmid:42636773","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42636773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Placenta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319756","display_name":"T\u00fcrkiye Sa\u011fl\u0131k Enstit\u00fcleri Ba\u015fkanl\u0131\u011f\u0131","ror":"https://ror.org/01d6ka036"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W60077963","https://openalex.org/W1900044360","https://openalex.org/W1966543736","https://openalex.org/W2011793316","https://openalex.org/W2013107237","https://openalex.org/W2067526890","https://openalex.org/W2131714425","https://openalex.org/W2150026213","https://openalex.org/W2285347461","https://openalex.org/W2773858873","https://openalex.org/W2887283993","https://openalex.org/W3006078128","https://openalex.org/W3096767488","https://openalex.org/W3122101197","https://openalex.org/W3156190502","https://openalex.org/W3184395450","https://openalex.org/W3207320992","https://openalex.org/W4280498851","https://openalex.org/W4317360817","https://openalex.org/W4322737909","https://openalex.org/W4387866001","https://openalex.org/W4402306577","https://openalex.org/W4408163102","https://openalex.org/W4408634221","https://openalex.org/W4409997078","https://openalex.org/W4410037331","https://openalex.org/W4412618614"],"related_works":["https://openalex.org/W1977310811","https://openalex.org/W4307725232","https://openalex.org/W4405224958","https://openalex.org/W3199157238","https://openalex.org/W3030082247","https://openalex.org/W4387166666","https://openalex.org/W2765134326","https://openalex.org/W2082205399","https://openalex.org/W4396920593","https://openalex.org/W2017361291"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-18T00:00:00"}