{"id":"https://openalex.org/W7203596050","doi":"https://doi.org/10.37489/2588-0527-0013","title":"Omics biomarkers of antipsychotic efficacy and safety: focus on lurasidone","display_name":"Omics biomarkers of antipsychotic efficacy and safety: focus on lurasidone","publication_year":2026,"publication_date":"2026-08-15","ids":{"openalex":"https://openalex.org/W7203596050","doi":"https://doi.org/10.37489/2588-0527-0013"},"language":"en","primary_location":{"id":"doi:10.37489/2588-0527-0013","doi":"https://doi.org/10.37489/2588-0527-0013","is_oa":true,"landing_page_url":"https://doi.org/10.37489/2588-0527-0013","pdf_url":"https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/download/368/316","source":{"id":"https://openalex.org/S4210170216","display_name":"Pharmacogenetics and Pharmacogenomics","issn_l":"2588-0527","issn":["2588-0527","2686-8849"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Pharmacogenomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/download/368/316","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027314376","display_name":"A.E. Gareeva","orcid":"https://orcid.org/0000-0003-0254-3917","observed_orcids":["https://orcid.org/0000-0003-0254-3917"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210112273","display_name":"Institute of Biochemistry and Genetics of Ufa Scientific Centre","ror":"https://ror.org/02a9vnt59","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210112273","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. E. Gareeva","raw_affiliation_strings":["Bashkir State Medical University","Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0003-0254-3917","affiliations":[{"raw_affiliation_string":"Bashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]},{"raw_affiliation_string":"Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210112273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038531231","display_name":"Liliya Borodina","orcid":"https://orcid.org/0000-0001-5116-0790","observed_orcids":["https://orcid.org/0000-0001-5116-0790"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. S. Borodina","raw_affiliation_strings":["Republican Narcology Dispensary No. 1, Ministry of Health of the Republic of Bashkortostan"],"raw_orcid":"https://orcid.org/0000-0001-5116-0790","affiliations":[{"raw_affiliation_string":"Republican Narcology Dispensary No. 1, Ministry of Health of the Republic of Bashkortostan","institution_ids":["https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111458167","display_name":"E. G. Mikhailova","orcid":"https://orcid.org/0009-0007-2136-2931","observed_orcids":["https://orcid.org/0009-0007-2136-2931"]},"institutions":[{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. G. Mikhailova","raw_affiliation_strings":["Republican Narcology Dispensary No. 1, Ministry of Health of the Republic of Bashkortostan"],"raw_orcid":"https://orcid.org/0009-0007-2136-2931","affiliations":[{"raw_affiliation_string":"Republican Narcology Dispensary No. 1, Ministry of Health of the Republic of Bashkortostan","institution_ids":["https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119478594","display_name":"P.A. Gindullina","orcid":"https://orcid.org/0009-0003-8262-9311","observed_orcids":["https://orcid.org/0009-0003-8262-9311"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"P. A. Gindullina","raw_affiliation_strings":["Bashkir State Medical University"],"raw_orcid":"https://orcid.org/0009-0003-8262-9311","affiliations":[{"raw_affiliation_string":"Bashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059290591","display_name":"Rinat G. Valinurov","orcid":"https://orcid.org/0000-0002-7284-0530","observed_orcids":["https://orcid.org/0000-0002-7284-0530"]},"institutions":[{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"R. G. Valinurov","raw_affiliation_strings":["Bashkir State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-7284-0530","affiliations":[{"raw_affiliation_string":"Bashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033173309","display_name":"\u0418. \u0424. \u0422\u0438\u043c\u0435\u0440\u0431\u0443\u043b\u0430\u0442\u043e\u0432","orcid":"https://orcid.org/0000-0001-5241-6073","observed_orcids":["https://orcid.org/0000-0001-5241-6073"]},"institutions":[{"id":"https://openalex.org/I4210106113","display_name":"Central State Medical Academy","ror":"https://ror.org/00xx5qr89","country_code":"RU","type":"education","lineage":["https://openalex.org/I2800573802","https://openalex.org/I4210106113"]},{"id":"https://openalex.org/I4210108300","display_name":"Russian Medical Academy of Continuous Professional Education","ror":"https://ror.org/01t6bjk79","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210108300","https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4210120901","display_name":"Bashkir State Medical University","ror":"https://ror.org/02w1g0f30","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210120901"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I. F. Timerbulatov","raw_affiliation_strings":["Bashkir State Medical University","Central State Medical Academy","Russian Medical Academy of Continuous Professional Education","Russian University of Medicine"],"raw_orcid":"https://orcid.org/0000-0001-5241-6073","affiliations":[{"raw_affiliation_string":"Bashkir State Medical University","institution_ids":["https://openalex.org/I4210120901"]},{"raw_affiliation_string":"Central State Medical Academy","institution_ids":["https://openalex.org/I4210106113"]},{"raw_affiliation_string":"Russian Medical Academy of Continuous Professional Education","institution_ids":["https://openalex.org/I4210108300"]},{"raw_affiliation_string":"Russian University of Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"2","first_page":"82","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8095999956130981,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.1809999942779541,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lurasidone","display_name":"lurasidone","score":1.0},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.8009999990463257},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":0.7170000076293945},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8949999809265137},{"id":"https://openalex.org/keywords/mir-181b","display_name":"miR-181b","score":0.921999990940094},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mir-122","display_name":"miR-122","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.5120000243186951},{"id":"https://openalex.org/keywords/epigenomics","display_name":"epigenomics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6230000257492065},{"id":"https://openalex.org/keywords/bipolar-ii-depression","display_name":"bipolar II depression","score":0.9639999866485596},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.7369999885559082},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.7620000243186951},{"id":"https://openalex.org/keywords/liver-dysfunction","display_name":"liver dysfunction","score":0.703000009059906},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.3440000116825104},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2776701107","wikidata":"https://www.wikidata.org/wiki/Q416992","display_name":"Lurasidone","level":4,"score":0.9879000186920166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6233999729156494},{"id":"https://openalex.org/C2779626651","wikidata":"https://www.wikidata.org/wiki/Q416545","display_name":"Asenapine","level":4,"score":0.5746999979019165},{"id":"https://openalex.org/C2776921671","wikidata":"https://www.wikidata.org/wiki/Q758295","display_name":"Atypical antipsychotic","level":4,"score":0.517300009727478},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.4959000051021576},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.478300005197525},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4715999960899353},{"id":"https://openalex.org/C2780634440","wikidata":"https://www.wikidata.org/wiki/Q408535","display_name":"Quetiapine","level":3,"score":0.4551999866962433},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.42080000042915344},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.3905999958515167},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3896999955177307},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.3774000108242035},{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.3625999987125397},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.3610000014305115},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.35659998655319214},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.35260000824928284},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.35179999470710754},{"id":"https://openalex.org/C149172746","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Efficacy","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C2780272996","wikidata":"https://www.wikidata.org/wiki/Q1261151","display_name":"Therapeutic drug monitoring","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.29420000314712524},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2687000036239624},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2632000148296356},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.26170000433921814},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.37489/2588-0527-0013","doi":"https://doi.org/10.37489/2588-0527-0013","is_oa":true,"landing_page_url":"https://doi.org/10.37489/2588-0527-0013","pdf_url":"https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/download/368/316","source":{"id":"https://openalex.org/S4210170216","display_name":"Pharmacogenetics and Pharmacogenomics","issn_l":"2588-0527","issn":["2588-0527","2686-8849"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Pharmacogenomics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.37489/2588-0527-0013","doi":"https://doi.org/10.37489/2588-0527-0013","is_oa":true,"landing_page_url":"https://doi.org/10.37489/2588-0527-0013","pdf_url":"https://www.pharmacogenetics-pharmacogenomics.ru/jour/article/download/368/316","source":{"id":"https://openalex.org/S4210170216","display_name":"Pharmacogenetics and Pharmacogenomics","issn_l":"2588-0527","issn":["2588-0527","2686-8849"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenetics and Pharmacogenomics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203596050.pdf","grobid_xml":"https://content.openalex.org/works/W7203596050.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1839220452","https://openalex.org/W1878849870","https://openalex.org/W1907592623","https://openalex.org/W1908776387","https://openalex.org/W1963627631","https://openalex.org/W1968738343","https://openalex.org/W1969594359","https://openalex.org/W1983283139","https://openalex.org/W1986484493","https://openalex.org/W1993718146","https://openalex.org/W1994928579","https://openalex.org/W1999200006","https://openalex.org/W1999521688","https://openalex.org/W2017426710","https://openalex.org/W2029343515","https://openalex.org/W2040134200","https://openalex.org/W2043396015","https://openalex.org/W2045252284","https://openalex.org/W2061084580","https://openalex.org/W2061847417","https://openalex.org/W2062239841","https://openalex.org/W2063120354","https://openalex.org/W2080242218","https://openalex.org/W2095792627","https://openalex.org/W2108992760","https://openalex.org/W2124607109","https://openalex.org/W2126772533","https://openalex.org/W2137044087","https://openalex.org/W2143525518","https://openalex.org/W2162086299","https://openalex.org/W2176893009","https://openalex.org/W2207886204","https://openalex.org/W2278070452","https://openalex.org/W2314412819","https://openalex.org/W2334817225","https://openalex.org/W2415541687","https://openalex.org/W2465215099","https://openalex.org/W2473877914","https://openalex.org/W2507730280","https://openalex.org/W2528927644","https://openalex.org/W2589120675","https://openalex.org/W2724843392","https://openalex.org/W2751846858","https://openalex.org/W2754527362","https://openalex.org/W2755580913","https://openalex.org/W2758762136","https://openalex.org/W2789913340","https://openalex.org/W2792421382","https://openalex.org/W2802377439","https://openalex.org/W2808815533","https://openalex.org/W2886924838","https://openalex.org/W2975909877","https://openalex.org/W2980841732","https://openalex.org/W2986164387","https://openalex.org/W3041672983","https://openalex.org/W3048830308","https://openalex.org/W3080584333","https://openalex.org/W3112838714","https://openalex.org/W3139506249","https://openalex.org/W3161210054","https://openalex.org/W3176413157","https://openalex.org/W3189333299","https://openalex.org/W4200090812","https://openalex.org/W4289443785","https://openalex.org/W4297318874","https://openalex.org/W4302283381","https://openalex.org/W4317538917","https://openalex.org/W4318965916","https://openalex.org/W4385405980","https://openalex.org/W4387142154","https://openalex.org/W4388440280","https://openalex.org/W4389056106","https://openalex.org/W4392201174","https://openalex.org/W4399705375","https://openalex.org/W4404064961","https://openalex.org/W4404217079","https://openalex.org/W4406503284","https://openalex.org/W4407780177","https://openalex.org/W4410089331","https://openalex.org/W4410513306","https://openalex.org/W4411913301","https://openalex.org/W4414616815","https://openalex.org/W4415813758","https://openalex.org/W7117998203","https://openalex.org/W7129150836"],"related_works":["https://openalex.org/W2605379571","https://openalex.org/W4407780177","https://openalex.org/W2802377439","https://openalex.org/W2980841732","https://openalex.org/W2797471065","https://openalex.org/W2528927644","https://openalex.org/W4408937331","https://openalex.org/W1969594359","https://openalex.org/W4389056106","https://openalex.org/W4388440280"],"abstract_inverted_index":{"Introduction.":[0],"Lurasidone":[1,174],"is":[2,18,93,103,140],"an":[3],"atypical":[4],"antipsychotic":[5],"with":[6,47,95],"high":[7],"affinity":[8],"for":[9,32,167],"5-HT\u2082A,":[10],"5-HT\u2087,":[11],"and":[12,24,43,50,61,153,170,196],"DRD2":[13],"receptors;":[14],"however,":[15],"its":[16],"use":[17],"limited":[19],"by":[20],"interindividual":[21],"pharmacokinetic":[22],"variability":[23],"dose-dependent":[25],"adverse":[26],"effects.":[27],"Multi-omics":[28],"approaches":[29],"offer":[30],"opportunities":[31],"personalized":[33],"dosing.":[34],"Objective.":[35],"To":[36],"systematically":[37],"review":[38],"evidence":[39],"on":[40],"genomic,":[41],"transcriptomic,":[42],"epigenomic":[44],"biomarkers":[45,166],"associated":[46,94],"lurasidone":[48,96],"efficacy":[49,97,176],"safety.":[51],"Methods.":[52],"A":[53],"literature":[54],"search":[55],"was":[56],"conducted":[57],"in":[58,98,130,177,212],"PubMed,":[59],"Scopus,":[60],"RSCI":[62],"(2010\u20132026)":[63],"using":[64],"keywords:":[65],"lurasidone,":[66],"pharmacogenomics,":[67],"CYP3A4,":[68],"HTR1A,":[69],"microRNA,":[70],"therapeutic":[71],"drug":[72],"monitoring.":[73,173],"Of":[74],"187":[75],"initially":[76],"identified":[77,144],"publications,":[78],"83":[79],"sources":[80],"were":[81],"selected":[82],"after":[83],"screening.":[84],"Results.":[85],"The":[86,187],"rs6295":[87],"polymorphism":[88],"of":[89,151],"the":[90,104],"HTR1A":[91,197],"gene":[92],"European":[99],"schizophrenia":[100],"patients.":[101],"CYP3A4":[102,193],"main":[105],"metabolizing":[106],"enzyme:":[107],"CYP3A4*1G":[108],"(rs2242480)":[109],"significantly":[110],"affects":[111],"clearance":[112],"(CL/F:":[113],"C/C":[114],"\u2014":[115,119],"330":[116],"L/h,":[117],"T/T":[118],"441":[120],"L/h);":[121],"CYP3A4*15":[122],"requires":[123],"dose":[124,135],"adjustment":[125],"up":[126],"to":[127,137,208],"240":[128],"mg/day":[129,139],"carriers.":[131],"In":[132],"hepatic":[133],"impairment,":[134],"reduction":[136],"20\u201340":[138],"recommended.":[141],"Transcriptomic":[142],"studies":[143,205],"1907":[145],"differentially":[146],"expressed":[147],"genes,":[148],"including":[149],"modulation":[150],"PER1":[152],"BMAL1,":[154],"as":[155,157,200,202],"well":[156,201],"neurotransmitter":[158],"imbalance.":[159],"MicroRNAs":[160],"(miR-181b,":[161],"miR-21,":[162],"miR-122)":[163],"are":[164,192,206],"promising":[165],"response":[168],"prediction":[169],"CYP":[171],"activity":[172],"monotherapy":[175],"bipolar":[178],"II":[179],"depression":[180],"does":[181],"not":[182],"exceed":[183],"41.3":[184],"%.":[185],"Conclusion.":[186],"most":[188],"clinically":[189],"relevant":[190],"markers":[191],"(rs2242480,":[194],"CYP3A4*15)":[195],"(rs6295)":[198],"polymorphisms,":[199],"microRNAs.":[203],"Prospective":[204],"required":[207],"validate":[209],"multi-omics":[210],"panels":[211],"clinical":[213],"practice.":[214]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-08-18T00:00:00"}
