{"id":"https://openalex.org/W7203589107","doi":"https://doi.org/10.1186/s13064-026-00312-2","title":"A review of Limbic-predominant age-related TDP-43 encephalopathy (LATE)","display_name":"A review of Limbic-predominant age-related TDP-43 encephalopathy (LATE)","publication_year":2026,"publication_date":"2026-08-16","ids":{"openalex":"https://openalex.org/W7203589107","doi":"https://doi.org/10.1186/s13064-026-00312-2"},"language":"en","primary_location":{"id":"doi:10.1186/s13064-026-00312-2","doi":"https://doi.org/10.1186/s13064-026-00312-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13064-026-00312-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13064-026-00312-2.pdf","source":{"id":"https://openalex.org/S5407042911","display_name":"Discover Neuroscience","issn_l":"3005-1827","issn":["3005-1827"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1186/s13064-026-00312-2.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013573322","display_name":"Zachary R. Grese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zachary R. Grese","raw_affiliation_strings":["Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014851933","display_name":"Ay\u015fe Ece B\u00fcy\u00fcksandalyac\u0131 Tun\u00e7","orcid":"https://orcid.org/0000-0002-6358-4643","observed_orcids":["https://orcid.org/0000-0002-6358-4643"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ece Buyuksandalyaci Tunc","raw_affiliation_strings":["Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008190526","display_name":"George Thomas Grossberg","orcid":"https://orcid.org/0000-0002-1493-3931","observed_orcids":["https://orcid.org/0000-0002-1493-3931"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George T. Grossberg","raw_affiliation_strings":["Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Psychiatry, Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013573322"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limbic-predominant-age-related-tdp-43-encephalopathy","display_name":"limbic-predominant age-related TDP-43 encephalopathy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tdp-43-proteinopathy","display_name":"TDP-43 proteinopathy","score":0.9419999718666077},{"id":"https://openalex.org/keywords/alzheimer-s-disease-differential-diagnosis","display_name":"Alzheimer's disease differential diagnosis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/amygdala","display_name":"amygdala","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hippocampal-sclerosis","display_name":"hippocampal sclerosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/oldest-old","display_name":"oldest old","score":0.6200000047683716},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7289999723434448},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.718999981880188},{"id":"https://openalex.org/keywords/antisense-therapy","display_name":"antisense therapy","score":0.6909999847412109},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7986999750137329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7071999907493591},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.5878999829292297},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5386000275611877},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.531499981880188},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5166000127792358},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4781000018119812},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.47749999165534973},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4634999930858612},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.45100000500679016},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4449000060558319},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.4309000074863434},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3684000074863434},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.32199999690055847},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.3149000108242035},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3118000030517578},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C2778615406","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Amnesia","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C2778670691","wikidata":"https://www.wikidata.org/wiki/Q419507","display_name":"Tau protein","level":4,"score":0.28369998931884766},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.28189998865127563},{"id":"https://openalex.org/C2777699746","wikidata":"https://www.wikidata.org/wiki/Q282783","display_name":"Limbic encephalitis","level":4,"score":0.2750000059604645},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C2777597344","wikidata":"https://www.wikidata.org/wiki/Q4421929","display_name":"Hippocampal sclerosis","level":4,"score":0.26820001006126404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13064-026-00312-2","doi":"https://doi.org/10.1186/s13064-026-00312-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13064-026-00312-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13064-026-00312-2.pdf","source":{"id":"https://openalex.org/S5407042911","display_name":"Discover Neuroscience","issn_l":"3005-1827","issn":["3005-1827"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Neuroscience","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13064-026-00312-2","doi":"https://doi.org/10.1186/s13064-026-00312-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13064-026-00312-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13064-026-00312-2.pdf","source":{"id":"https://openalex.org/S5407042911","display_name":"Discover Neuroscience","issn_l":"3005-1827","issn":["3005-1827"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discover Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203589107.pdf","grobid_xml":"https://content.openalex.org/works/W7203589107.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W980103879","https://openalex.org/W1525431743","https://openalex.org/W1545437217","https://openalex.org/W1853546723","https://openalex.org/W1965376857","https://openalex.org/W1991081381","https://openalex.org/W1991208268","https://openalex.org/W1999522052","https://openalex.org/W2003618511","https://openalex.org/W2031964319","https://openalex.org/W2044468792","https://openalex.org/W2055013864","https://openalex.org/W2059980851","https://openalex.org/W2066952414","https://openalex.org/W2070086306","https://openalex.org/W2072413533","https://openalex.org/W2075588816","https://openalex.org/W2087634412","https://openalex.org/W2092646825","https://openalex.org/W2101042581","https://openalex.org/W2102622341","https://openalex.org/W2104199101","https://openalex.org/W2115672510","https://openalex.org/W2115887554","https://openalex.org/W2116660354","https://openalex.org/W2118117906","https://openalex.org/W2123085033","https://openalex.org/W2132704668","https://openalex.org/W2134408741","https://openalex.org/W2151521848","https://openalex.org/W2154520196","https://openalex.org/W2156454183","https://openalex.org/W2158073956","https://openalex.org/W2170087857","https://openalex.org/W2300806746","https://openalex.org/W2315554492","https://openalex.org/W2510545519","https://openalex.org/W2512829170","https://openalex.org/W2525541800","https://openalex.org/W2556839390","https://openalex.org/W2574862016","https://openalex.org/W2606848380","https://openalex.org/W2649090908","https://openalex.org/W2755222361","https://openalex.org/W2793407859","https://openalex.org/W2807398417","https://openalex.org/W2887063742","https://openalex.org/W2898429141","https://openalex.org/W2907108807","https://openalex.org/W2908605292","https://openalex.org/W2911343826","https://openalex.org/W2913454426","https://openalex.org/W2917988060","https://openalex.org/W2920477154","https://openalex.org/W2942421167","https://openalex.org/W2943828894","https://openalex.org/W2966220904","https://openalex.org/W2981963645","https://openalex.org/W3027451106","https://openalex.org/W3033707060","https://openalex.org/W3082794621","https://openalex.org/W3086212084","https://openalex.org/W3114567345","https://openalex.org/W3201218752","https://openalex.org/W3212488072","https://openalex.org/W4206610489","https://openalex.org/W4211120401","https://openalex.org/W4224040319","https://openalex.org/W4225136866","https://openalex.org/W4282596629","https://openalex.org/W4291825280","https://openalex.org/W4306898448","https://openalex.org/W4307496583","https://openalex.org/W4311237378","https://openalex.org/W4312094083","https://openalex.org/W4312094627","https://openalex.org/W4323545808","https://openalex.org/W4327550261","https://openalex.org/W4378569287","https://openalex.org/W4385443568","https://openalex.org/W4386968028","https://openalex.org/W4387949815","https://openalex.org/W4390107055","https://openalex.org/W4393993794","https://openalex.org/W4394782461","https://openalex.org/W4399781663","https://openalex.org/W4400130652","https://openalex.org/W4403008779","https://openalex.org/W4404294115","https://openalex.org/W4406371084","https://openalex.org/W4411272828","https://openalex.org/W4411306414","https://openalex.org/W4412653168","https://openalex.org/W4416093513","https://openalex.org/W7116691884","https://openalex.org/W7124792308"],"related_works":["https://openalex.org/W7092365526","https://openalex.org/W4399099565","https://openalex.org/W4385737350","https://openalex.org/W2943828894","https://openalex.org/W3025209304","https://openalex.org/W4300427377","https://openalex.org/W3192401531","https://openalex.org/W4412654465","https://openalex.org/W7164167276","https://openalex.org/W7161299329"],"abstract_inverted_index":{"Limbic-predominant":[0],"age-related":[1],"TDP-43":[2,20,163,172,189],"encephalopathy":[3],"(LATE)":[4],"is":[5,31,43,59,136,176],"a":[6,48,92,131],"recently":[7],"recognized":[8],"neurodegenerative":[9],"dementia":[10,96,123],"in":[11,23,54,130],"the":[12,55,76],"most":[13],"elderly":[14],"individuals,":[15],"characterized":[16],"by":[17,63,85],"accumulation":[18],"of":[19,133,138],"protein":[21],"aggregates":[22],"limbic":[24,81],"and":[25,42,71,79,113,127,165,182],"medial":[26],"temporal":[27],"lobe":[28],"structures.":[29],"This":[30],"clinically":[32],"important":[33],"pathology":[34],"as":[35],"it":[36],"often":[37,83],"mimics":[38],"Alzheimer\u2019s":[39],"disease":[40],"(AD)":[41],"now":[44],"understood":[45],"to":[46,51,99,170,178],"be":[47],"common":[49],"contributor":[50],"cognitive":[52],"decline":[53],"\u201coldest-old\u201d.":[56],"Pathologically,":[57],"LATE":[58,89],"distinguished":[60],"from":[61],"AD":[62,100],"TDP-43-positive":[64],"neuronal":[65],"inclusions":[66],"(rather":[67],"than":[68],"amyloid":[69,126],"plaques":[70],"neurofibrillary":[72],"tangles),":[73],"typically":[74],"affecting":[75],"amygdala,":[77],"hippocampus,":[78],"other":[80],"regions,":[82],"accompanied":[84],"hippocampal":[86],"sclerosis.":[87],"Clinically,":[88],"presents":[90],"with":[91,124],"gradually":[93],"progressive":[94],"amnestic":[95],"syndrome":[97],"similar":[98],"which":[101],"complicates":[102],"diagnosis.":[103],"Currently,":[104],"there":[105],"are":[106,151],"no":[107],"established":[108],"antemortem":[109],"biomarkers":[110,129,181],"for":[111,184],"LATE,":[112],"definitive":[114],"diagnosis":[115],"relies":[116],"on":[117],"postmortem":[118],"confirmation.":[119],"However,":[120],"an":[121],"AD-like":[122],"negative":[125],"tau":[128],"patient":[132],"advanced":[134],"age":[135],"suggestive":[137],"LATE.":[139],"No":[140],"disease-modifying":[141],"treatment":[142],"exists":[143],"at":[144],"this":[145,185],"time,":[146],"however":[147],"multiple":[148],"therapeutic":[149],"strategies":[150],"under":[152],"investigation,":[153],"including":[154],"immunotherapies":[155],"targeting":[156],"pathological":[157],"TDP-43,":[158],"small":[159],"molecules":[160],"that":[161],"enhance":[162],"clearance,":[164],"gene":[166],"or":[167],"antisense":[168],"approaches":[169],"mitigate":[171],"toxicity.":[173],"Continued":[174],"research":[175],"critical":[177],"develop":[179],"effective":[180],"therapies":[183],"prevalent":[186],"but":[187],"under-recognized":[188],"proteinopathy.":[190]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-17T00:00:00"}
