{"id":"https://openalex.org/W7203586636","doi":"https://doi.org/10.1016/j.exer.2026.111205","title":"Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization","display_name":"Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization","publication_year":2026,"publication_date":"2026-08-16","ids":{"openalex":"https://openalex.org/W7203586636","doi":"https://doi.org/10.1016/j.exer.2026.111205","pmid":"https://pubmed.ncbi.nlm.nih.gov/42604675"},"language":"en","primary_location":{"id":"doi:10.1016/j.exer.2026.111205","doi":"https://doi.org/10.1016/j.exer.2026.111205","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exer.2026.111205","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014483526003611/pdf","source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0014483526003611/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044642520","display_name":"Lays Fernanda Nunes Dourado","orcid":"https://orcid.org/0000-0001-5287-455X","observed_orcids":["https://orcid.org/0000-0001-5287-455X"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lays Fernanda Nunes Dourado","raw_affiliation_strings":["Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-5287-455X","affiliations":[{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024039855","display_name":"Carolina Nunes da Silva","orcid":"https://orcid.org/0000-0003-1382-2487","observed_orcids":["https://orcid.org/0000-0003-1382-2487"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carolina Nunes da Silva","raw_affiliation_strings":["Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1382-2487","affiliations":[{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147305527","display_name":"Carolina Meireles Bastos Rodrigues","orcid":"https://orcid.org/0009-0007-9378-0980","observed_orcids":["https://orcid.org/0009-0007-9378-0980"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carolina Meireles Bastos Rodrigues","raw_affiliation_strings":["Animal Venoms Biochemistry Lab, Research and Development Department, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil"],"raw_orcid":"https://orcid.org/0009-0007-9378-0980","affiliations":[{"raw_affiliation_string":"Animal Venoms Biochemistry Lab, Research and Development Department, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090844035","display_name":"Eladio F. S\u00e1nchez","orcid":"https://orcid.org/0000-0003-1637-9345","observed_orcids":["https://orcid.org/0000-0003-1637-9345","https://orcid.org/0000-0002-2845-0447"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Eladio Flores Sanchez","raw_affiliation_strings":["Animal Venoms Biochemistry Lab, Research and Development Department, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-2845-0447","affiliations":[{"raw_affiliation_string":"Animal Venoms Biochemistry Lab, Research and Development Department, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080913923","display_name":"Luciana Souza de Oliveira","orcid":"https://orcid.org/0000-0002-2784-5658","observed_orcids":["https://orcid.org/0000-0002-2784-5658"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciana Souza de Oliveira","raw_affiliation_strings":["Animal Venoms Biochemistry Lab, Research and Development Department, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-2784-5658","affiliations":[{"raw_affiliation_string":"Animal Venoms Biochemistry Lab, Research and Development Department, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079410768","display_name":"Catarina Pacheco","orcid":"https://orcid.org/0000-0002-9148-8915","observed_orcids":["https://orcid.org/0000-0002-9148-8915"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Pacheco","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; INEB - Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; IUCS - Instituto Universit\u00e1rio de Ci\u00eancias da Sa\u00fade, CESPU, Rua Central de Gandra 1317, Gandra, 4585-116, Portugal"],"raw_orcid":"https://orcid.org/0000-0002-9148-8915","affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; INEB - Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; IUCS - Instituto Universit\u00e1rio de Ci\u00eancias da Sa\u00fade, CESPU, Rua Central de Gandra 1317, Gandra, 4585-116, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210096930","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041458969","display_name":"Bruno Filipe Carmelino Cardoso Sarmento","orcid":"https://orcid.org/0000-0001-5763-7553","observed_orcids":["https://orcid.org/0000-0001-5763-7553"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210096930","display_name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio","ror":"https://ror.org/00w7bj245","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210096930"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Bruno Sarmento","raw_affiliation_strings":["i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; INEB - Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; IUCS - Instituto Universit\u00e1rio de Ci\u00eancias da Sa\u00fade, CESPU, Rua Central de Gandra 1317, Gandra, 4585-116, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5763-7553","affiliations":[{"raw_affiliation_string":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; INEB - Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, Rua Alfredo Allen 208, Porto, 4200-135, Portugal; IUCS - Instituto Universit\u00e1rio de Ci\u00eancias da Sa\u00fade, CESPU, Rua Central de Gandra 1317, Gandra, 4585-116, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210096930","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030845308","display_name":"Marina Fran\u00e7a Dias","orcid":"https://orcid.org/0000-0003-3878-5192","observed_orcids":["https://orcid.org/0000-0003-3878-5192"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marina Fran\u00e7a Dias","raw_affiliation_strings":["Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3878-5192","affiliations":[{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060599674","display_name":"S\u00edlvia Lig\u00f3rio Fialho","orcid":"https://orcid.org/0000-0001-8068-5211","observed_orcids":["https://orcid.org/0000-0001-8068-5211"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Silvia Lig\u00f3rio Fialho","raw_affiliation_strings":["Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil. Electronic address: silvia.fialho@funed.mg.gov.br"],"raw_orcid":"https://orcid.org/0000-0001-8068-5211","affiliations":[{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation (FUNED), Rua Conde Pereira Carneiro, 80, Belo Horizonte, MG, 30510-010, Brazil. Electronic address: silvia.fialho@funed.mg.gov.br","institution_ids":["https://openalex.org/I4210098174"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060599674"],"corresponding_institution_ids":["https://openalex.org/I4210098174"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":{"value":4010,"currency":"USD","value_usd":4010},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"272","issue":null,"first_page":"111205","last_page":"111205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.10999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.07909999787807465,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-type-lectin","display_name":"C-type lectin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bothrops-leucurus","display_name":"Bothrops leucurus","score":0.8790000081062317},{"id":"https://openalex.org/keywords/snake-venom","display_name":"snake venom","score":0.9789999723434448},{"id":"https://openalex.org/keywords/corneal-neovascularization","display_name":"corneal neovascularization","score":0.9959999918937683},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ocular-angiogenesis","display_name":"ocular angiogenesis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/topical-ocular-drug-delivery","display_name":"topical ocular drug delivery","score":0.6769999861717224},{"id":"https://openalex.org/keywords/endothelial-tube-formation","display_name":"endothelial tube formation","score":0.75},{"id":"https://openalex.org/keywords/chorioallantoic-membrane-assay","display_name":"chorioallantoic membrane assay","score":0.8289999961853027},{"id":"https://openalex.org/keywords/eye-safety","display_name":"eye safety","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.6326000094413757},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.5849000215530396},{"id":"https://openalex.org/C2777844972","wikidata":"https://www.wikidata.org/wiki/Q1266519","display_name":"Corneal neovascularization","level":4,"score":0.5552999973297119},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5238000154495239},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.4440999925136566},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.41110000014305115},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3822000026702881},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.35989999771118164},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35420000553131104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3393000066280365},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2615000009536743},{"id":"https://openalex.org/C106257327","wikidata":"https://www.wikidata.org/wiki/Q24788214","display_name":"C-type lectin","level":3,"score":0.2563000023365021}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016510","descriptor_name":"Corneal Neovascularization","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016510","descriptor_name":"Corneal Neovascularization","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017837","descriptor_name":"Bothrops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D049033","descriptor_name":"Chorioallantoic Membrane","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D049033","descriptor_name":"Chorioallantoic Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exer.2026.111205","doi":"https://doi.org/10.1016/j.exer.2026.111205","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exer.2026.111205","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014483526003611/pdf","source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},{"id":"pmid:42604675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42604675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental eye research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.exer.2026.111205","doi":"https://doi.org/10.1016/j.exer.2026.111205","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exer.2026.111205","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0014483526003611/pdf","source":{"id":"https://openalex.org/S129637156","display_name":"Experimental Eye Research","issn_l":"0014-4835","issn":["0014-4835","1096-0007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Eye Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3881417528","display_name":null,"funder_award_id":"465687/2014\u20108","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4552264890","display_name":null,"funder_award_id":"2014/509282","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G6779363750","display_name":null,"funder_award_id":"-04449-22","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G7348466054","display_name":"MEDICAMENTOS BIOL\u00d3GICOS BASEADOS EM TERAPIA G\u00caNICA: DA CONCEP\u00c7\u00c3O CIENT\u00cdFICA \u00c0 OBTEN\u00c7\u00c3O DO PRODUTO FINAL","funder_award_id":"APQ-04449-22","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G8611085910","display_name":null,"funder_award_id":"303547/2023-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G971784506","display_name":"REDE NANOGENE - NANOTECNOLOGIA APLICADA AO DESENVOLVIMENTO DE VACINAS E TERAPIA G\u00caNICAS","funder_award_id":"RED-00053-21","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203586636.pdf","grobid_xml":"https://content.openalex.org/works/W7203586636.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W252715413","https://openalex.org/W1966827627","https://openalex.org/W1968819532","https://openalex.org/W1978249299","https://openalex.org/W1978341139","https://openalex.org/W1985692848","https://openalex.org/W1996802631","https://openalex.org/W2047315747","https://openalex.org/W2066680574","https://openalex.org/W2080884813","https://openalex.org/W2108761986","https://openalex.org/W2146307140","https://openalex.org/W2152072770","https://openalex.org/W2563218616","https://openalex.org/W2604884912","https://openalex.org/W2775455323","https://openalex.org/W2885788911","https://openalex.org/W2919970718","https://openalex.org/W2998994248","https://openalex.org/W3010918112","https://openalex.org/W3124974022","https://openalex.org/W3126704857","https://openalex.org/W3136505420","https://openalex.org/W3185506761","https://openalex.org/W3205975262","https://openalex.org/W4211006688","https://openalex.org/W4362474899","https://openalex.org/W4362663531","https://openalex.org/W4365810819","https://openalex.org/W4391787534","https://openalex.org/W4397007748","https://openalex.org/W4399051432","https://openalex.org/W7163148493"],"related_works":["https://openalex.org/W2563218616","https://openalex.org/W2090093512","https://openalex.org/W1968819532","https://openalex.org/W4413862541","https://openalex.org/W2027359865","https://openalex.org/W2002332754","https://openalex.org/W2060076017","https://openalex.org/W2136006353","https://openalex.org/W2330335186","https://openalex.org/W2042492722"],"abstract_inverted_index":{"Pathological":[0],"corneal":[1,62,201],"neovascularization":[2,63],"remains":[3],"a":[4,49,65,123,156,223],"major":[5],"therapeutic":[6,183],"challenge":[7],"due":[8],"to":[9,32,116,165,237],"the":[10,44,76,84,95,130,148,215],"limited":[11],"efficacy":[12],"and":[13,75,105,138,181,191,203,225,243],"safety":[14,142],"of":[15,47,61,102,200,241],"currently":[16],"available":[17],"antiangiogenic":[18,45,92,127,179],"treatments.":[19],"Although":[20],"C-type":[21,50],"lectins":[22],"from":[23,53],"snake":[24],"venom":[25,56],"possess":[26],"various":[27],"biological":[28],"activities,":[29],"their":[30],"potential":[31,141,246],"modulate":[33],"pathological":[34],"ocular":[35,145,186,230],"angiogenesis":[36],"has":[37,177],"not":[38],"been":[39],"explored.":[40],"This":[41],"study":[42],"investigated":[43],"effects":[46,114],"Leuculectin,":[48],"lectin":[51],"isolated":[52],"Bothrops":[54],"leucurus":[55],"using":[57],"an":[58],"experimental":[59],"model":[60],"(CNV),":[64],"HUVEC":[66,85],"(human":[67],"umbilical":[68],"vein":[69],"endothelial":[70],"cell)":[71],"tube":[72,86],"formation":[73,87],"assay,":[74,88,97],"chick":[77],"embryo":[78],"chorioallantoic":[79],"membrane":[80],"(CAM)":[81],"assay.":[82],"In":[83,94,129,147],"Leuculectin":[89,98,133,153,176,219],"demonstrated":[90],"strong":[91],"activity.":[93],"CAM":[96],"applied":[99],"at":[100,168],"concentrations":[101],"1.5,":[103],"2.5":[104],"3.5":[106],"\u03bcg/mL":[107,121],"significantly":[108],"decreased":[109],"new":[110],"vessel":[111],"formation,":[112],"with":[113,119],"comparable":[115],"those":[117],"achieved":[118],"250":[120],"bevacizumab,":[122],"widely":[124],"used":[125],"clinical":[126,247],"agent.":[128],"HET-CAM":[131],"assay":[132],"was":[134],"classified":[135],"as":[136,222],"non-irritant":[137],"supporting":[139],"its":[140,239,245],"for":[143,185,228],"topical":[144,152],"use.":[146],"suture-induced":[149],"CNV":[150],"model,":[151],"resulted":[154],"in":[155,159,211],"significant":[157,182],"reduction":[158],"neovascularized":[160],"areas,":[161],"achieving":[162],"results":[163,216],"similar":[164],"bevacizumab":[166],"administered":[167],"considerably":[169],"higher":[170],"doses.":[171],"These":[172],"findings":[173],"indicate":[174],"that":[175,218],"potent":[178],"properties":[180],"promise":[184],"angiogenic":[187,231],"disorders.":[188],"Histological":[189],"analyses":[190],"optical":[192],"coherence":[193],"tomography":[194],"(OCT)":[195],"further":[196],"revealed":[197],"improved":[198],"organization":[199],"epithelial":[202],"stromal":[204],"layers,":[205],"accompanied":[206],"by":[207],"fewer":[208],"blood":[209],"vessels":[210],"treated":[212],"regions.":[213],"Overall,":[214],"suggest":[217],"may":[220],"serve":[221],"safe":[224],"effective":[226],"alternative":[227],"managing":[229],"diseases.":[232],"Further":[233],"studies":[234],"are":[235],"required":[236],"elucidate":[238],"mechanisms":[240],"action":[242],"assess":[244],"applications.":[248]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-17T00:00:00"}