{"id":"https://openalex.org/W7203580361","doi":"https://doi.org/10.1002/cnr2.70657","title":"Real\u2010World Outcomes of Acute Myeloid Leukemia Patients Undergoing Treatment With Tyrosine Kinase Inhibitor (TKI) Therapy Targeting FLT3, IDH1, or IDH2","display_name":"Real\u2010World Outcomes of Acute Myeloid Leukemia Patients Undergoing Treatment With Tyrosine Kinase Inhibitor (TKI) Therapy Targeting FLT3, IDH1, or IDH2","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7203580361","doi":"https://doi.org/10.1002/cnr2.70657","pmid":"https://pubmed.ncbi.nlm.nih.gov/42604951","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13478251"},"language":"en","primary_location":{"id":"doi:10.1002/cnr2.70657","doi":"https://doi.org/10.1002/cnr2.70657","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.70657","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.70657","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.70657","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078936217","display_name":"Manuel Ricardo Espinoza-Gutarra","orcid":"https://orcid.org/0000-0002-7906-8782","observed_orcids":["https://orcid.org/0000-0002-7906-8782"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039376","display_name":"O'Neal Comprehensive Cancer Center","ror":"https://ror.org/03j18km61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250","https://openalex.org/I4390039376"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manuel R. Espinoza\u2010Gutarra","raw_affiliation_strings":["The University of Alabama at Birmingham O'Neal Comprehensive Cancer Center  Birmingham Alabama USA"],"raw_orcid":"https://orcid.org/0000-0002-7906-8782","affiliations":[{"raw_affiliation_string":"The University of Alabama at Birmingham O'Neal Comprehensive Cancer Center  Birmingham Alabama USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023632987","display_name":"Brooke A. Jarrett","orcid":"https://orcid.org/0000-0003-2966-3521","observed_orcids":["https://orcid.org/0000-0003-2966-3521"]},"institutions":[{"id":"https://openalex.org/I4210153546","display_name":"Flatiron Health (United States)","ror":"https://ror.org/0508h6p74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153546"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooke Jarret","raw_affiliation_strings":["Flatiron Health  New York New York USA"],"raw_orcid":"https://orcid.org/0000-0003-2966-3521","affiliations":[{"raw_affiliation_string":"Flatiron Health  New York New York USA","institution_ids":["https://openalex.org/I4210153546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100369105","display_name":"Xiaoliang Wang","orcid":"https://orcid.org/0000-0001-5184-2935","observed_orcids":["https://orcid.org/0000-0001-5184-2935"]},"institutions":[{"id":"https://openalex.org/I4210153546","display_name":"Flatiron Health (United States)","ror":"https://ror.org/0508h6p74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153546"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoliang Wang","raw_affiliation_strings":["Flatiron Health  New York New York USA"],"raw_orcid":"https://orcid.org/0000-0001-5184-2935","affiliations":[{"raw_affiliation_string":"Flatiron Health  New York New York USA","institution_ids":["https://openalex.org/I4210153546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087930191","display_name":"Anosheh Afghahi","orcid":"https://orcid.org/0000-0003-1225-406X","observed_orcids":["https://orcid.org/0000-0003-1225-406X"]},"institutions":[{"id":"https://openalex.org/I4210153546","display_name":"Flatiron Health (United States)","ror":"https://ror.org/0508h6p74","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153546"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anosheh Afghahi","raw_affiliation_strings":["Flatiron Health  New York New York USA","University of Colorado School of Medicine  Aurora Colorado USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flatiron Health  New York New York USA","institution_ids":["https://openalex.org/I4210153546"]},{"raw_affiliation_string":"University of Colorado School of Medicine  Aurora Colorado USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100608570","display_name":"Sejong Bae","orcid":"https://orcid.org/0000-0001-9982-3223","observed_orcids":["https://orcid.org/0000-0001-9982-3223"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]},{"id":"https://openalex.org/I4210087454","display_name":"Augusta University Health","ror":"https://ror.org/007rawr89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087454"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sejong Bae","raw_affiliation_strings":["Augusta University Georgia Cancer Center  Augusta Georgia USA","Wellstar MCG Health Medical Center  Augusta Georgia USA"],"raw_orcid":"https://orcid.org/0000-0001-9982-3223","affiliations":[{"raw_affiliation_string":"Augusta University Georgia Cancer Center  Augusta Georgia USA","institution_ids":["https://openalex.org/I25041050","https://openalex.org/I4210087454"]},{"raw_affiliation_string":"Wellstar MCG Health Medical Center  Augusta Georgia USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078936217"],"corresponding_institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039376"],"apc_list":{"value":3280,"currency":"USD","value_usd":3280},"apc_paid":{"value":3280,"currency":"USD","value_usd":3280},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.55395512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"8","first_page":"e70657","last_page":"e70657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/flt3-inhibitors","display_name":"FLT3 inhibitors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/idh1-inhibitor","display_name":"IDH1 inhibitor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/idh2-inhibitors","display_name":"IDH2 inhibitors","score":1.0},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.8489999771118164},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0},{"id":"https://openalex.org/keywords/allogeneic-hematopoietic-stem-cell-transplantation","display_name":"allogeneic hematopoietic stem cell transplantation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.5410000085830688},{"id":"https://openalex.org/keywords/second-line-treatment","display_name":"second-line therapy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/insurance-status","display_name":"insurance status","score":0.503000020980835},{"id":"https://openalex.org/keywords/eln-risk-classification","display_name":"ELN risk classification","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.917900025844574},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.8047000169754028},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.6699000000953674},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.635699987411499},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6280999779701233},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.544700026512146},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5293999910354614},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5266000032424927},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4821000099182129},{"id":"https://openalex.org/C2776059313","wikidata":"https://www.wikidata.org/wiki/Q21116031","display_name":"IDH2","level":5,"score":0.4650000035762787},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.35519999265670776},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3407999873161316},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.33550000190734863},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.31610000133514404},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C2991767035","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Induction therapy","level":3,"score":0.26260000467300415},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.26159998774528503},{"id":"https://openalex.org/C169382597","wikidata":"https://www.wikidata.org/wiki/Q21208025","display_name":"Programmed cell death 1","level":5,"score":0.26010000705718994},{"id":"https://openalex.org/C3018095205","wikidata":"https://www.wikidata.org/wiki/Q55641553","display_name":"Real world evidence","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051941","descriptor_name":"fms-Like Tyrosine Kinase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cnr2.70657","doi":"https://doi.org/10.1002/cnr2.70657","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.70657","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.70657","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},{"id":"pmid:42604951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42604951","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer reports (Hoboken, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13478251","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13478251/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Rep (Hoboken)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:25f1b24270444c8387a5197fb5023668","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/25f1b24270444c8387a5197fb5023668","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Reports, Vol 9, Iss 8, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cnr2.70657","doi":"https://doi.org/10.1002/cnr2.70657","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cnr2.70657","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cnr2.70657","source":{"id":"https://openalex.org/S4210241191","display_name":"Cancer Reports","issn_l":"2573-8348","issn":["2573-8348"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203580361.pdf","grobid_xml":"https://content.openalex.org/works/W7203580361.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W2147083172","https://openalex.org/W2170075800","https://openalex.org/W2559537906","https://openalex.org/W2584163334","https://openalex.org/W2623089849","https://openalex.org/W2654449699","https://openalex.org/W2806682325","https://openalex.org/W2909346948","https://openalex.org/W2982353618","https://openalex.org/W2995123606","https://openalex.org/W3048542015","https://openalex.org/W3095552675","https://openalex.org/W3137252881","https://openalex.org/W3162883085","https://openalex.org/W3164441110","https://openalex.org/W3164477864","https://openalex.org/W3205063602","https://openalex.org/W4200072715","https://openalex.org/W4206578074","https://openalex.org/W4207016957","https://openalex.org/W4224290890","https://openalex.org/W4281558955","https://openalex.org/W4283073514","https://openalex.org/W4289522686","https://openalex.org/W4293473168","https://openalex.org/W4294631309","https://openalex.org/W4307303119","https://openalex.org/W4308744032","https://openalex.org/W4311231074","https://openalex.org/W4375854036","https://openalex.org/W4376871815","https://openalex.org/W4377968995","https://openalex.org/W4378648779","https://openalex.org/W4379281959","https://openalex.org/W4386019076","https://openalex.org/W4389221371","https://openalex.org/W4389246838","https://openalex.org/W4401504326","https://openalex.org/W7118175517"],"related_works":["https://openalex.org/W7135073540","https://openalex.org/W4401876102","https://openalex.org/W3045370386","https://openalex.org/W3116995261","https://openalex.org/W2889500728","https://openalex.org/W3094671707","https://openalex.org/W4409414327","https://openalex.org/W4389248244","https://openalex.org/W2335470228","https://openalex.org/W3009748122"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Acute":[3],"myeloid":[4],"leukemia":[5],"(AML)":[6],"remains":[7],"the":[8,76],"most":[9],"common":[10],"cause":[11],"of":[12,34,140,252,262,264],"death":[13],"in":[14,28,75],"adults":[15],"with":[16,56,59,112,166,201,234],"acute":[17],"leukemia.":[18],"Tyrosine":[19],"kinase":[20],"inhibitors":[21],"(TKIs)":[22],"have":[23,40,240],"shown":[24],"significant":[25,241],"clinical":[26,257],"efficacy":[27],"defined":[29],"patient":[30],"subgroups.":[31],"Real-world":[32],"outcomes":[33,258],"AML":[35,57,253],"patients":[36,55,199,254],"undergoing":[37],"TKI":[38,61,141,202,237,245,265],"therapy":[39,142],"not":[41,239],"been":[42],"widely":[43],"reported.":[44],"METHODS:":[45],"In":[46,247],"this":[47,248],"real-world":[48,93,250],"retrospective":[49],"study,":[50],"we":[51],"included":[52],"482":[53],"adult":[54],"treated":[58,200,233],"a":[60,103,121],"targeting":[62],"FLT3,":[63],"IDH1,":[64,219],"or":[65],"IDH2":[66],"from":[67],"January":[68],"1,":[69],"2015,":[70],"to":[71,90,108,198,244],"December":[72],"31,":[73],"2023,":[74],"countrywide":[77],"Flatiron":[78],"Health":[79],"electronic":[80],"health":[81],"record-derived":[82],"deidentified":[83],"database.":[84],"We":[85,101],"utilized":[86,102],"unadjusted":[87],"Kaplan-Meier":[88],"methods":[89],"calculate":[91],"median":[92],"event-free":[94],"survival":[95,99],"(rwEFS)":[96],"and":[97,132,135,152,185,212,220,222,227,269],"overall":[98],"(rwOS).":[100],"multivariable":[104],"Cox":[105],"regression":[106],"model":[107],"evaluate":[109],"characteristics":[110],"associated":[111,165],"rwOS,":[113],"modeling":[114],"post-TKI":[115],"stem":[116],"cell":[117],"transplant":[118],"(SCT)":[119],"as":[120],"time-varying":[122],"covariate.":[123],"RESULTS:":[124],"Those":[125],"who":[126],"received":[127],"treatment":[128],"at":[129,203],"1L":[130],"(first-line)":[131],"2L+":[133,204],"(second-line":[134],"beyond)":[136],"had":[137],"similar":[138],"length":[139],"(3.7":[143],"vs.":[144,149,155],"3.4":[145],"months),":[146,151,157],"rwEFS":[147,208],"(2.2":[148],"2.5":[150],"rwOS":[153,163,223],"(12.3":[154],"13.1":[156],"respectively.":[158,230],"Among":[159],"all":[160],"patients,":[161],"greater":[162],"was":[164],"receiving":[167,255],"pre-TKI":[168],"SCT":[169],"(p":[170,182],"<":[171],"0.001),":[172],"commercial":[173],"insurance":[174],"(vs.":[175,191],"Medicaid;":[176],"p":[177,193],"=":[178,183,194],"0.035),":[179],"younger":[180],"age":[181],"0.043),":[184],"favorable":[186],"2017":[187],"ELN":[188],"risk":[189],"classification":[190],"adverse;":[192],"0.032).":[195],"When":[196],"restricted":[197],"without":[205],"prior":[206],"SCT,":[207],"were":[209,224],"1.4,":[210],"1.6,":[211],"2.1":[213],"months":[214],"by":[215],"targetable":[216],"mutation":[217],"(IDH2,":[218],"FLT3),":[221],"8.7,":[225],"15.4,":[226],"9.5":[228],"months,":[229],"CONCLUSION:":[231],"Patients":[232],"HMA":[235],"plus":[236],"did":[238],"differences":[242],"compared":[243],"alone.":[246],"substantial,":[249],"cohort":[251],"TKIs,":[256],"remained":[259],"deficient":[260],"irrespective":[261],"timing":[263],"start,":[266],"mutational":[267],"target,":[268],"concurrent":[270],"HMA.":[271]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-17T00:00:00"}