{"id":"https://openalex.org/W7203570669","doi":"https://doi.org/10.1016/j.jff.2026.107459","title":"Moringa oleifera leaf polysaccharide alleviates ulcerative colitis by inhibiting glycolysis mediated M1 macrophages polarization","display_name":"Moringa oleifera leaf polysaccharide alleviates ulcerative colitis by inhibiting glycolysis mediated M1 macrophages polarization","publication_year":2026,"publication_date":"2026-08-16","ids":{"openalex":"https://openalex.org/W7203570669","doi":"https://doi.org/10.1016/j.jff.2026.107459"},"language":"en","primary_location":{"id":"doi:10.1016/j.jff.2026.107459","doi":"https://doi.org/10.1016/j.jff.2026.107459","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jff.2026.107459","pdf_url":null,"source":{"id":"https://openalex.org/S8548135","display_name":"Journal of Functional Foods","issn_l":"1756-4646","issn":["1756-4646","2214-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Foods","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jff.2026.107459","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147312417","display_name":"Xiaoguang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoguang Wang","raw_affiliation_strings":["Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006535352","display_name":"Weilong Peng","orcid":"https://orcid.org/0009-0000-3498-5870","observed_orcids":["https://orcid.org/0009-0000-3498-5870"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weilong Peng","raw_affiliation_strings":["Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068191462","display_name":"Man Ni","orcid":"https://orcid.org/0000-0002-7796-3900","observed_orcids":["https://orcid.org/0000-0002-7796-3900"]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man Ni","raw_affiliation_strings":["Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China","institution_ids":["https://openalex.org/I78978612"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121588703","display_name":"Jingui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78978612","display_name":"Yangzhou University","ror":"https://ror.org/03tqb8s11","country_code":"CN","type":"education","lineage":["https://openalex.org/I78978612"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingui Li","raw_affiliation_strings":["Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, Jiangsu, China","institution_ids":["https://openalex.org/I78978612"]},{"raw_affiliation_string":"School of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, PR China","institution_ids":["https://openalex.org/I78978612"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5121588703"],"corresponding_institution_ids":["https://openalex.org/I78978612"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"145","issue":null,"first_page":"107459","last_page":"107459"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12721","display_name":"Moringa oleifera research and applications","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.9200000166893005},{"id":"https://openalex.org/keywords/macrophage-glycolysis","display_name":"macrophage glycolysis","score":0.878000020980835},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.47600001096725464},{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2776836740","wikidata":"https://www.wikidata.org/wiki/Q310468","display_name":"Moringa","level":2,"score":0.7732999920845032},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7580999732017517},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7567999958992004},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.7084000110626221},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.6686000227928162},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4864000082015991},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.45399999618530273},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4074000120162964},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.38029998540878296},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.33719998598098755},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.29499998688697815},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.26249998807907104}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jff.2026.107459","doi":"https://doi.org/10.1016/j.jff.2026.107459","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jff.2026.107459","pdf_url":null,"source":{"id":"https://openalex.org/S8548135","display_name":"Journal of Functional Foods","issn_l":"1756-4646","issn":["1756-4646","2214-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Foods","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jff.2026.107459","doi":"https://doi.org/10.1016/j.jff.2026.107459","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jff.2026.107459","pdf_url":null,"source":{"id":"https://openalex.org/S8548135","display_name":"Journal of Functional Foods","issn_l":"1756-4646","issn":["1756-4646","2214-9414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-2","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Functional Foods","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W987012741","https://openalex.org/W1522804491","https://openalex.org/W1892620062","https://openalex.org/W2021754448","https://openalex.org/W2024279863","https://openalex.org/W2096021562","https://openalex.org/W2112400160","https://openalex.org/W2148266291","https://openalex.org/W2167971335","https://openalex.org/W2168938595","https://openalex.org/W2760815328","https://openalex.org/W2796499199","https://openalex.org/W2899913971","https://openalex.org/W2921966151","https://openalex.org/W2947898121","https://openalex.org/W2991646855","https://openalex.org/W3012314530","https://openalex.org/W3080354041","https://openalex.org/W3146673194","https://openalex.org/W3149053163","https://openalex.org/W3158423255","https://openalex.org/W3182659576","https://openalex.org/W3187406392","https://openalex.org/W4210456813","https://openalex.org/W4213137658","https://openalex.org/W4220950541","https://openalex.org/W4306661746","https://openalex.org/W4306910605","https://openalex.org/W4308874743","https://openalex.org/W4313581372","https://openalex.org/W4365146902","https://openalex.org/W4380360799","https://openalex.org/W4380792003","https://openalex.org/W4383710020","https://openalex.org/W4384926142","https://openalex.org/W4385441840","https://openalex.org/W4385728359","https://openalex.org/W4387451723","https://openalex.org/W4388638825","https://openalex.org/W4391309981","https://openalex.org/W4391480091","https://openalex.org/W4394931595","https://openalex.org/W4397044882","https://openalex.org/W4400132078","https://openalex.org/W4402412196","https://openalex.org/W4402512650","https://openalex.org/W4402689834","https://openalex.org/W4403258911","https://openalex.org/W4404443126","https://openalex.org/W4404754783","https://openalex.org/W4405375990","https://openalex.org/W4405951689","https://openalex.org/W4406101657","https://openalex.org/W4407061545","https://openalex.org/W4408304417","https://openalex.org/W4411075435","https://openalex.org/W4412356008","https://openalex.org/W4414510417"],"related_works":["https://openalex.org/W4308874743","https://openalex.org/W3187406392","https://openalex.org/W4296125806","https://openalex.org/W4408466683","https://openalex.org/W4220927326","https://openalex.org/W3091352383","https://openalex.org/W7163142761","https://openalex.org/W4414480464","https://openalex.org/W4405375990","https://openalex.org/W7134203704"],"abstract_inverted_index":{"Objective":[0],"We":[1],"aimed":[2],"to":[3],"investigate":[4],"the":[5,19,99,137,143,180,187,204,217],"therapeutic":[6],"effects":[7,206],"of":[8,52,101,112,126,139,146,207],"Moringa":[9],"oleifera":[10],"leaf":[11],"polysaccharide":[12],"(MOLP)":[13],"in":[14,68],"ulcerative":[15],"colitis":[16,30,110],"(UC)":[17],"and":[18,38,65,82,98,122,129,142,152,158,164,169,197,216],"underlying":[20],"mechanism":[21],"involving":[22],"macrophages":[23,42,141,157,176,228,237],"polarization.":[24,229],"Methods":[25],"Dextran":[26],"sodium":[27],"sulfate":[28],"(DSS)-induced":[29],"mouse":[31],"model,":[32],"as":[33,35,73,116],"well":[34],"lipopolysaccharide":[36],"(LPS)":[37],"interferon-\u03b3":[39],"(IFN-\u03b3)":[40],"stimulated":[41],"(PMA-differentiated":[43],"THP-1":[44],"cells)":[45],"were":[46,77],"used":[47],"for":[48],"investigations.":[49],"Therapeutic":[50],"effect":[51],"MOLP":[53,107,135,172,208,231],"was":[54,87,184,193],"evaluated":[55],"by":[56,79,89,118,178,186,195,222,235],"measuring":[57,90],"disease":[58],"activity":[59,64,86],"index":[60],"(DAI),":[61],"myeloperoxidase":[62],"(MPO)":[63],"histological":[66],"morphology":[67],"mice,":[69,115],"with":[70,214],"5-aminosalicylic":[71],"acid":[72,92],"positive":[74],"control.":[75],"Macrophages":[76],"determined":[78,88],"flow":[80],"cytometry":[81],"immunofluorescence":[83],"staining.":[84],"Glycolysis":[85],"lactic":[91],"content,":[93],"extracellular":[94],"acidification":[95],"rate":[96],"(ECAR)":[97],"uptake":[100],"fluorescent":[102],"deoxyglucose":[103],"analog":[104],"2-NBDG.":[105],"Results":[106],"effectively":[108],"alleviated":[109],"symptoms":[111],"DSS-induced":[113],"UC":[114,234],"demonstrated":[117],"reduced":[119],"DAI":[120],"score":[121],"MPO":[123],"activity,":[124,182],"alleviation":[125],"colon":[127],"shortening,":[128],"mitigated":[130],"colonic":[131],"histopathological":[132],"damage.":[133],"Besides,":[134],"decreased":[136],"proportion":[138],"M1":[140,175,227,238],"mRNA":[144],"expression":[145],"their":[147,159],"specific":[148,160],"factors":[149,161],"(TNF-\u03b1,":[150],"IL-1\u03b2":[151],"iNOS),":[153],"while":[154],"increasing":[155],"M2":[156],"(CD206,":[162],"Arg1":[163],"Chil3).":[165],"Based":[166],"on":[167,209],"LPS":[168],"IFN\u03b3-stimulated":[170],"macrophages,":[171],"treatment":[173,201],"suppressed":[174],"polarization":[177,239],"inhibiting":[179],"glycolysis":[181,188,221],"which":[183],"confirmed":[185],"inhibitor":[189],"2-DG.":[190],"Mechanistically,":[191],"HMGB1":[192,199,212],"down-regulated":[194],"MOLP,":[196],"recombinant":[198],"protein":[200],"could":[202,232],"offset":[203],"curative":[205],"UC.":[210],"Furthermore,":[211],"interacted":[213],"HAVCR2,":[215],"latter":[218],"mediated":[219,242],"macrophage":[220],"PI3K/Akt/HIF-1\u03b1":[223],"pathway,":[224],"thereby":[225],"regulating":[226,236],"Conclusion":[230],"alleviate":[233],"through":[240],"HMGB1/HAVCR2":[241],"glycolysis.":[243]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-08-17T00:00:00"}