{"id":"https://openalex.org/W7203560047","doi":"https://doi.org/10.25122/jml-2026-0025","title":"Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial","display_name":"Efficacy and safety of ashwagandha root extract in children and adolescents with mild attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled trial","publication_year":2026,"publication_date":"2026-06-01","ids":{"openalex":"https://openalex.org/W7203560047","doi":"https://doi.org/10.25122/jml-2026-0025","pmid":"https://pubmed.ncbi.nlm.nih.gov/42602386","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13474374"},"language":"en","primary_location":{"id":"doi:10.25122/jml-2026-0025","doi":"https://doi.org/10.25122/jml-2026-0025","is_oa":true,"landing_page_url":"https://doi.org/10.25122/jml-2026-0025","pdf_url":null,"source":{"id":"https://openalex.org/S2755172410","display_name":"Journal of Medicine and Life","issn_l":"1844-122X","issn":["1844-122X","1844-3117"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320337","host_organization_name":"Carol Davila University of Medicine and Pharmacy Publishing House","host_organization_lineage":["https://openalex.org/P4310320337"],"host_organization_lineage_names":["Carol Davila University of Medicine and Pharmacy Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicine and Life","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.25122/jml-2026-0025","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025927361","display_name":"Mukta Jain","orcid":"https://orcid.org/0000-0001-7643-2115","observed_orcids":["https://orcid.org/0000-0001-7643-2115"]},"institutions":[{"id":"https://openalex.org/I4405285233","display_name":"MGM Medical College, Nerul","ror":"https://ror.org/051dq2v14","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210107677","https://openalex.org/I4405285233"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mukta Jain","raw_affiliation_strings":["Mahatma Gandhi Mission Medical College, Nerul, Navi Mumbai, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mahatma Gandhi Mission Medical College, Nerul, Navi Mumbai, India","institution_ids":["https://openalex.org/I4405285233"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024772892","display_name":"Sunil Naik","orcid":"https://orcid.org/0000-0002-9753-6666","observed_orcids":["https://orcid.org/0000-0002-9753-6666"]},"institutions":[{"id":"https://openalex.org/I2800401362","display_name":"Government of Andhra Pradesh","ror":"https://ror.org/045mrnd19","country_code":"IN","type":"government","lineage":["https://openalex.org/I2800401362"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sunil Naik","raw_affiliation_strings":["Government Medical College and Government General Hospital, Srikakulam, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Medical College and Government General Hospital, Srikakulam, Andhra Pradesh, India","institution_ids":["https://openalex.org/I2800401362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114319429","display_name":"Gudla Muralidhar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800401362","display_name":"Government of Andhra Pradesh","ror":"https://ror.org/045mrnd19","country_code":"IN","type":"government","lineage":["https://openalex.org/I2800401362"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gudla Muralidhar","raw_affiliation_strings":["Government Medical College and Government General Hospital, Srikakulam, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Medical College and Government General Hospital, Srikakulam, Andhra Pradesh, India","institution_ids":["https://openalex.org/I2800401362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113495715","display_name":"B.D. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800401362","display_name":"Government of Andhra Pradesh","ror":"https://ror.org/045mrnd19","country_code":"IN","type":"government","lineage":["https://openalex.org/I2800401362"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bade Srinivas Rao","raw_affiliation_strings":["Government Medical College and Government General Hospital, Srikakulam, Andhra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Government Medical College and Government General Hospital, Srikakulam, Andhra Pradesh, India","institution_ids":["https://openalex.org/I2800401362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147255321","display_name":"Sanjay Agarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153931","display_name":"DY Patil Deemed to be University","ror":"https://ror.org/045qb5273","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210153931"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjay Agarwal","raw_affiliation_strings":["Department of Community Medicine, D.Y Patil University, School of Medicine, Nerul-Navi Mumbai, Maharshtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Medicine, D.Y Patil University, School of Medicine, Nerul-Navi Mumbai, Maharshtra, India","institution_ids":["https://openalex.org/I4210153931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025927361"],"corresponding_institution_ids":["https://openalex.org/I4405285233"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62346856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"6","first_page":"456","last_page":"466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.1607999950647354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ashwagandha-root-extract","display_name":"ashwagandha root extract","score":0.9700000286102295},{"id":"https://openalex.org/keywords/ashwagandha","display_name":"Withania somnifera","score":0.9950000047683716},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.9750000238418579},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.8799999952316284},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.8740000128746033},{"id":"https://openalex.org/keywords/adhd-symptom-severity","display_name":"ADHD symptom severity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.7900000214576721},{"id":"https://openalex.org/keywords/herbal-supplementation","display_name":"herbal supplementation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/safety-profile","display_name":"safety profile","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7843999862670898},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5760999917984009},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.49320000410079956},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3617999851703644},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.30059999227523804},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.27079999446868896},{"id":"https://openalex.org/C171078966","wikidata":"https://www.wikidata.org/wiki/Q111029","display_name":"Root (linguistics)","level":2,"score":0.2443999946117401},{"id":"https://openalex.org/C130963320","wikidata":"https://www.wikidata.org/wiki/Q1401207","display_name":"Root cause analysis","level":2,"score":0.23399999737739563},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.22679999470710754},{"id":"https://openalex.org/C3018875020","wikidata":"https://www.wikidata.org/wiki/Q1441305","display_name":"Signs and symptoms","level":2,"score":0.22669999301433563}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001289","descriptor_name":"Attention Deficit Disorder with Hyperactivity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018517","descriptor_name":"Plant Roots","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D056344","descriptor_name":"Executive Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.25122/jml-2026-0025","doi":"https://doi.org/10.25122/jml-2026-0025","is_oa":true,"landing_page_url":"https://doi.org/10.25122/jml-2026-0025","pdf_url":null,"source":{"id":"https://openalex.org/S2755172410","display_name":"Journal of Medicine and Life","issn_l":"1844-122X","issn":["1844-122X","1844-3117"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320337","host_organization_name":"Carol Davila University of Medicine and Pharmacy Publishing House","host_organization_lineage":["https://openalex.org/P4310320337"],"host_organization_lineage_names":["Carol Davila University of Medicine and Pharmacy Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicine and Life","raw_type":"journal-article"},{"id":"pmid:42602386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42602386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicine and life","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13474374","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13474374/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Life","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.25122/jml-2026-0025","doi":"https://doi.org/10.25122/jml-2026-0025","is_oa":true,"landing_page_url":"https://doi.org/10.25122/jml-2026-0025","pdf_url":null,"source":{"id":"https://openalex.org/S2755172410","display_name":"Journal of Medicine and Life","issn_l":"1844-122X","issn":["1844-122X","1844-3117"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320337","host_organization_name":"Carol Davila University of Medicine and Pharmacy Publishing House","host_organization_lineage":["https://openalex.org/P4310320337"],"host_organization_lineage_names":["Carol Davila University of Medicine and Pharmacy Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicine and Life","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6939647844","https://openalex.org/W4403163846","https://openalex.org/W7135032014","https://openalex.org/W4413989271","https://openalex.org/W75295550","https://openalex.org/W2966293623","https://openalex.org/W4417035855","https://openalex.org/W2357323268","https://openalex.org/W2393734509","https://openalex.org/W3029655899"],"abstract_inverted_index":{"<":[0],"0.001).":[1],"No":[2,19],"significant":[3],"between-group":[4],"differences":[5],"or":[6],"clinically":[7],"meaningful":[8],"changes":[9],"were":[10,23],"observed":[11],"in":[12,47],"safety":[13,57],"markers":[14],"across":[15],"the":[16],"intervention":[17],"period.":[18],"serious":[20],"adverse":[21],"events":[22],"reported.":[24],"Supplementation":[25],"with":[26,51,54],"300":[27],"mg/day":[28],"of":[29],"ashwagandha":[30],"root":[31],"extract":[32],"for":[33],"56":[34],"days":[35],"significantly":[36],"improved":[37],"ADHD":[38],"symptom":[39],"severity,":[40],"executive":[41],"functioning,":[42],"and":[43,49],"selected":[44],"patient-reported":[45],"outcomes":[46],"children":[48],"adolescents":[50],"mild":[52],"ADHD,":[53],"a":[55],"favorable":[56],"profile.":[58]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-08-16T00:00:00"}