{"id":"https://openalex.org/W7203551540","doi":"https://doi.org/10.64898/2026.08.13.744318","title":"Directing the Chondro-Fibro Axis via Early Microenvironmental Interactions to Enable Precise and Volumetric Cartilage Repair","display_name":"Directing the Chondro-Fibro Axis via Early Microenvironmental Interactions to Enable Precise and Volumetric Cartilage Repair","publication_year":2026,"publication_date":"2026-08-15","ids":{"openalex":"https://openalex.org/W7203551540","doi":"https://doi.org/10.64898/2026.08.13.744318","pmid":"https://pubmed.ncbi.nlm.nih.gov/42845597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13640781"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.13.744318","doi":"https://doi.org/10.64898/2026.08.13.744318","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.13.744318","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/15/2026.08.13.744318.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/15/2026.08.13.744318.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092313360","display_name":"Maddie Hasson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maddie Hasson","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109694661","display_name":"Hanna Solomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanna Solomon","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085799126","display_name":"Samir Chihab","orcid":"https://orcid.org/0009-0005-5312-3084","observed_orcids":["https://orcid.org/0009-0005-5312-3084"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samir Chihab","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109243330","display_name":"Aniya Hartzler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniya Hartzler","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045519111","display_name":"Lorenzo M. Fernandes","orcid":"https://orcid.org/0000-0001-5116-170X","observed_orcids":["https://orcid.org/0000-0001-5116-170X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lorenzo M. Fernandes","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147243791","display_name":"Alan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Zhao","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120101796","display_name":"William X Patton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William X. Patton","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113005110","display_name":"Nyssa Morgan","orcid":"https://orcid.org/0009-0006-4779-0742","observed_orcids":["https://orcid.org/0009-0006-4779-0742"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nyssa M. Morgan","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024985402","display_name":"Alan Y. Liu","orcid":"https://orcid.org/0000-0002-1398-0568","observed_orcids":["https://orcid.org/0000-0002-1398-0568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Y. Liu","raw_affiliation_strings":["Optics 11 Life Inc., Boston MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Optics 11 Life Inc., Boston MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041553127","display_name":"Nazir M. Khan","orcid":"https://orcid.org/0000-0002-1637-7641","observed_orcids":["https://orcid.org/0000-0002-1637-7641"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nazir M. Khan","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083214240","display_name":"Jarred M. Kaiser","orcid":"https://orcid.org/0000-0001-9373-2961","observed_orcids":["https://orcid.org/0000-0001-9373-2961"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarred M. Kaiser","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072858193","display_name":"Jason Tyler Bariteau","orcid":"https://orcid.org/0000-0001-5290-4026","observed_orcids":["https://orcid.org/0000-0001-5290-4026"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason T. Bariteau","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057380357","display_name":"Jay Patel","orcid":"https://orcid.org/0000-0003-4889-0818","observed_orcids":["https://orcid.org/0000-0003-4889-0818"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jay M. Patel","raw_affiliation_strings":["Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA"],"raw_orcid":"https://orcid.org/0000-0003-4889-0818","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Emory University School of Medicine, Atlanta GA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Joseph Maxwell Cleland Atlanta VA Medical Center, Decatur GA","institution_ids":["https://openalex.org/I4210152539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057380357"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4210152539"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage-repair","display_name":"cartilage repair","score":0.968999981880188},{"id":"https://openalex.org/keywords/microfracture","display_name":"microfracture","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/rho-rock-signaling-pathway","display_name":"Rho/ROCK signaling","score":0.8970000147819519},{"id":"https://openalex.org/keywords/fasudil","display_name":"fasudil","score":0.9120000004768372},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.6179999709129333},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.6010000109672546},{"id":"https://openalex.org/keywords/myofibroblast-phenotype","display_name":"myofibroblast phenotype","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.628600001335144},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5960000157356262},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5770999789237976},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.5756999850273132},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5701000094413757},{"id":"https://openalex.org/C2776048814","wikidata":"https://www.wikidata.org/wiki/Q5437132","display_name":"Fasudil","level":4,"score":0.5034000277519226},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.498199999332428},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.4625000059604645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39570000767707825},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3675999939441681},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.36399999260902405},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34450000524520874},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.33009999990463257},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.325300008058548},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2799000144004822},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.2775999903678894},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27160000801086426},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25200000405311584}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.08.13.744318","doi":"https://doi.org/10.64898/2026.08.13.744318","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.13.744318","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/15/2026.08.13.744318.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42845597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42845597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13640781","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13640781/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.08.13.744318","doi":"https://doi.org/10.64898/2026.08.13.744318","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.13.744318","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/15/2026.08.13.744318.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2289923368","display_name":null,"funder_award_id":"UL1 TR002378","funder_id":"https://openalex.org/F4320309381","funder_display_name":"Emory University"},{"id":"https://openalex.org/G541963208","display_name":null,"funder_award_id":"I50\u2010RX004845","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000895734","display_name":"Georgia Clinical & Translational Science Alliance (Georgia CTSA)","funder_award_id":"UL1TR002378","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320310224","display_name":"Georgia Research Alliance","ror":"https://ror.org/030689123"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333424","display_name":"University Research Committee, Emory University","ror":null},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203551540.pdf","grobid_xml":"https://content.openalex.org/works/W7203551540.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1964744563","https://openalex.org/W1974384763","https://openalex.org/W1974897852","https://openalex.org/W1976089856","https://openalex.org/W1984353324","https://openalex.org/W1985785796","https://openalex.org/W1992696273","https://openalex.org/W2006519242","https://openalex.org/W2008893285","https://openalex.org/W2036465216","https://openalex.org/W2057685431","https://openalex.org/W2058419216","https://openalex.org/W2063266241","https://openalex.org/W2070822120","https://openalex.org/W2077603983","https://openalex.org/W2080167098","https://openalex.org/W2081415617","https://openalex.org/W2088952337","https://openalex.org/W2090591357","https://openalex.org/W2097708776","https://openalex.org/W2109974996","https://openalex.org/W2116425152","https://openalex.org/W2120577501","https://openalex.org/W2123220146","https://openalex.org/W2129573593","https://openalex.org/W2139043745","https://openalex.org/W2142120528","https://openalex.org/W2145458002","https://openalex.org/W2154400398","https://openalex.org/W2155116729","https://openalex.org/W2155559866","https://openalex.org/W2157332721","https://openalex.org/W2161106045","https://openalex.org/W2161206581","https://openalex.org/W2163367446","https://openalex.org/W2301928919","https://openalex.org/W2342679639","https://openalex.org/W2343910187","https://openalex.org/W2464858553","https://openalex.org/W2572149156","https://openalex.org/W2579129946","https://openalex.org/W2611533673","https://openalex.org/W2614482363","https://openalex.org/W2621806017","https://openalex.org/W2767608850","https://openalex.org/W2793875518","https://openalex.org/W2891898487","https://openalex.org/W2900984789","https://openalex.org/W2911030495","https://openalex.org/W2914603303","https://openalex.org/W2948013203","https://openalex.org/W2958658998","https://openalex.org/W2968461036","https://openalex.org/W3007757041","https://openalex.org/W3040768428","https://openalex.org/W3047823019","https://openalex.org/W3092071551","https://openalex.org/W3118519825","https://openalex.org/W3126556456","https://openalex.org/W3133542186","https://openalex.org/W3137523727","https://openalex.org/W3157494576","https://openalex.org/W3176251763","https://openalex.org/W3204571737","https://openalex.org/W3216094338","https://openalex.org/W4313381334","https://openalex.org/W4387642486","https://openalex.org/W4387937499","https://openalex.org/W4391650935","https://openalex.org/W4392788095","https://openalex.org/W4394673598","https://openalex.org/W4394747404","https://openalex.org/W4400370071","https://openalex.org/W4406338323","https://openalex.org/W4415126340"],"related_works":["https://openalex.org/W1997589495","https://openalex.org/W2065739031","https://openalex.org/W3127716812","https://openalex.org/W2325023859","https://openalex.org/W2381786606","https://openalex.org/W2965317052","https://openalex.org/W1970738977","https://openalex.org/W2313852988","https://openalex.org/W3131275777","https://openalex.org/W4287094872"],"abstract_inverted_index":{"Summary":[0],"Successful":[1],"cartilage":[2,253],"repair":[3,25,73,85,254],"remains":[4,22,74],"one":[5,95],"of":[6,19,66,131,153,159,164,171],"the":[7,12,23,54,58,64,112,150,165,181,246],"most":[8],"significant":[9],"challenges":[10],"in":[11,87,97,111,209],"musculoskeletal":[13],"field.":[14],"Microfracture":[15],"(MFx),":[16],"a":[17,123,174,190,213],"form":[18],"marrow":[20],"stimulation,":[21],"predominant":[24],"technique,":[26],"but":[27,142],"it":[28],"exhibits":[29],"routine":[30],"failure":[31],"due":[32],"to":[33,56,70,105,115,125,248],"inadequate":[34],"defect":[35],"fill":[36],"and":[37,51,62,82,89,107,119,193,204,223,240,251],"inferior":[38],"fibrotic":[39,124,151],"tissue":[40],"formation.":[41],"Whereas":[42],"current":[43],"strategies":[44],"focus":[45],"on":[46,146],"augmenting":[47],"MFx":[48,59,72,80,113],"with":[49,180],"scaffolds":[50],"bioactive":[52],"factors,":[53],"potential":[55],"target":[57],"clot":[60,114,202],"itself":[61],"use":[63],"capabilities":[65],"this":[67,217,237],"dynamic":[68],"environment":[69],"guide":[71],"largely":[75],"unexplored.":[76],"We":[77],"verified":[78],"that":[79,231],"contraction":[81,141,203],"fibrosis":[83],"hinder":[84],"success":[86],"minipigs":[88],"become":[90],"evident":[91],"as":[92,94],"early":[93],"week":[96],"multiple":[98],"animal":[99],"models.":[100],"Therefore,":[101],"our":[102],"objective":[103],"was":[104],"investigate":[106],"direct":[108],"microenvironmental":[109,160,256],"interactions":[110],"promote":[116],"volumetric":[117,252],"maintenance":[118],"reprogram":[120],"cells":[121,155,187],"from":[122,189],"more":[126],"chondrogenic":[127],"phenotype.":[128],"Extracellular":[129],"control":[130,158,243],"cell-environment":[132],"interactions,":[133,161],"through":[134,162,255],"fibrinogen":[135],"augmentation":[136],"or":[137,147],"anti-fibrinolytic":[138],"treatment,":[139],"limited":[140],"had":[143],"no":[144],"effect":[145],"even":[148],"exacerbated":[149],"susceptibility":[152],"marrow-derived":[154],"(MDCs).":[156],"Intracellular":[157],"modulation":[163],"Rho-ROCK":[166,232],"pathway,":[167],"drove":[168,185],"TGF-\u03b23":[169],"activity":[170],"MDCs":[172],"along":[173,236],"\u201cchondro-fibro":[175],"axis\u201d.":[176],"In":[177,212],"particular,":[178],"treatment":[179,198,219],"ROCK":[182],"inhibitor":[183],"Fasudil":[184,197],"TGF-\u03b23-treated":[186],"away":[188],"myofibroblast":[191],"phenotype":[192],"towards":[194],"chondrogenesis.":[195],"Short-term":[196],"prevented":[199],"TGF-\u03b23-driven":[200],"macroscale":[201],"enhanced":[205],"cartilage-specific":[206],"matrix":[207],"deposition":[208,222],"vitro":[210],".":[211],"pilot":[214],"rat":[215],"study,":[216],"combination":[218],"improved":[220],"GAG":[221],"better":[224],"protected":[225],"surrounding":[226],"cartilage.":[227],"These":[228],"findings":[229],"suggest":[230],"modulates":[233],"TGF-\u03b2":[234],"signaling":[235],"chondro-fibro":[238],"axis":[239],"its":[241],"precise":[242,250],"could":[244],"be":[245],"key":[247],"promoting":[249],"interactions.":[257]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-16T00:00:00"}
