{"id":"https://openalex.org/W7203549296","doi":"https://doi.org/10.1007/s12223-026-01573-4","title":"Beyond probiotics: Lacticaseibacillus rhamnosus as a multi-target antagonist of Pseudomonas aeruginosa infections","display_name":"Beyond probiotics: Lacticaseibacillus rhamnosus as a multi-target antagonist of Pseudomonas aeruginosa infections","publication_year":2026,"publication_date":"2026-08-15","ids":{"openalex":"https://openalex.org/W7203549296","doi":"https://doi.org/10.1007/s12223-026-01573-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/42603251"},"language":"en","primary_location":{"id":"doi:10.1007/s12223-026-01573-4","doi":"https://doi.org/10.1007/s12223-026-01573-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12223-026-01573-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12223-026-01573-4.pdf","source":{"id":"https://openalex.org/S68090309","display_name":"Folia Microbiologica","issn_l":"0015-5632","issn":["0015-5632","1874-9356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Microbiologica","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12223-026-01573-4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144145444","display_name":"Weldson Ricardo Silva Gomes","orcid":"https://orcid.org/0009-0009-3502-8322","observed_orcids":["https://orcid.org/0009-0009-3502-8322"]},"institutions":[{"id":"https://openalex.org/I4210126848","display_name":"Universidade Ceuma","ror":"https://ror.org/044g0p936","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210126848"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Weldson Ricardo Silva Gomes","raw_affiliation_strings":["Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"],"raw_orcid":"https://orcid.org/0009-0009-3502-8322","affiliations":[{"raw_affiliation_string":"Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210126848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102573091","display_name":"Gessiane dos Santos de Souza","orcid":"https://orcid.org/0009-0008-4134-5394","observed_orcids":["https://orcid.org/0009-0008-4134-5394"]},"institutions":[{"id":"https://openalex.org/I4210126848","display_name":"Universidade Ceuma","ror":"https://ror.org/044g0p936","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210126848"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gessiane dos Santos Souza","raw_affiliation_strings":["Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"],"raw_orcid":"https://orcid.org/0009-0008-4134-5394","affiliations":[{"raw_affiliation_string":"Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210126848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107125249","display_name":"Jo\u00e3o In\u00e1cio Diniz Ferreira","orcid":"https://orcid.org/0009-0003-6059-2693","observed_orcids":["https://orcid.org/0009-0003-6059-2693"]},"institutions":[{"id":"https://openalex.org/I4210126848","display_name":"Universidade Ceuma","ror":"https://ror.org/044g0p936","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210126848"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o In\u00e1cio Diniz Ferreira","raw_affiliation_strings":["Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"],"raw_orcid":"https://orcid.org/0009-0003-6059-2693","affiliations":[{"raw_affiliation_string":"Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210126848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016169359","display_name":"Rafaella Coelho Oliveira","orcid":"https://orcid.org/0009-0003-0508-9243","observed_orcids":["https://orcid.org/0009-0003-0508-9243"]},"institutions":[{"id":"https://openalex.org/I4210126848","display_name":"Universidade Ceuma","ror":"https://ror.org/044g0p936","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210126848"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafaella Coelho Oliveira","raw_affiliation_strings":["Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"],"raw_orcid":"https://orcid.org/0009-0003-0508-9243","affiliations":[{"raw_affiliation_string":"Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210126848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065221735","display_name":"Marliete Carvalho da Costa","orcid":"https://orcid.org/0000-0003-0381-9225","observed_orcids":["https://orcid.org/0000-0003-0381-9225"]},"institutions":[{"id":"https://openalex.org/I4210126848","display_name":"Universidade Ceuma","ror":"https://ror.org/044g0p936","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210126848"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marliete Carvalho da Costa","raw_affiliation_strings":["Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0381-9225","affiliations":[{"raw_affiliation_string":"Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil","institution_ids":["https://openalex.org/I4210126848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020697102","display_name":"Camila Guerra Martinez","orcid":"https://orcid.org/0000-0001-6116-9182","observed_orcids":["https://orcid.org/0000-0001-6116-9182","https://orcid.org/0000-0002-3136-2325"]},"institutions":[{"id":"https://openalex.org/I4210126848","display_name":"Universidade Ceuma","ror":"https://ror.org/044g0p936","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210126848"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Camila Guerra Martinez","raw_affiliation_strings":["Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil. camila005150@ceuma.com.br"],"raw_orcid":"https://orcid.org/0000-0001-6116-9182","affiliations":[{"raw_affiliation_string":"Master's Program in Applied Biosciences for Health, Universidade Ceuma, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil. camila005150@ceuma.com.br","institution_ids":["https://openalex.org/I4210126848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020697102"],"corresponding_institution_ids":["https://openalex.org/I4210126848"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":0.452,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48832446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.23989999294281006,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lacticaseibacillus-rhamnosus","display_name":"Lactobacillus rhamnosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9340000152587891},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8069999814033508},{"id":"https://openalex.org/keywords/postbiotics","display_name":"postbiotics","score":0.949999988079071},{"id":"https://openalex.org/keywords/cell-free-supernatant","display_name":"cell-free supernatant","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antibiofilm-activity","display_name":"antibiofilm activity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/quorum-quenching","display_name":"quorum sensing inhibition","score":0.7139999866485596},{"id":"https://openalex.org/keywords/organic-acid-production","display_name":"organic acid production","score":0.5899999737739563},{"id":"https://openalex.org/keywords/biosurfactants","display_name":"biosurfactants","score":0.7519999742507935},{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.5989999771118164},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.746999979019165},{"id":"https://openalex.org/keywords/ventilator-associated-pneumonia","display_name":"ventilator-associated pneumonia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.4790000021457672},{"id":"https://openalex.org/keywords/chronic-lung-disease","display_name":"chronic lung disease","score":0.6420000195503235},{"id":"https://openalex.org/keywords/strain-heterogeneity","display_name":"strain heterogeneity","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7125999927520752},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6470000147819519},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3901999890804291},{"id":"https://openalex.org/C2781433018","wikidata":"https://www.wikidata.org/wiki/Q133966","display_name":"Pseudomonadales","level":4,"score":0.3894999921321869},{"id":"https://openalex.org/C2776738503","wikidata":"https://www.wikidata.org/wiki/Q138058","display_name":"Pseudomonadaceae","level":4,"score":0.38830000162124634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37130001187324524},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3628000020980835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3497999906539917},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.34450000524520874},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30160000920295715},{"id":"https://openalex.org/C2776651480","wikidata":"https://www.wikidata.org/wiki/Q1607640","display_name":"Lactobacillus rhamnosus","level":4,"score":0.2775999903678894},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.25459998846054077}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s12223-026-01573-4","doi":"https://doi.org/10.1007/s12223-026-01573-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12223-026-01573-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12223-026-01573-4.pdf","source":{"id":"https://openalex.org/S68090309","display_name":"Folia Microbiologica","issn_l":"0015-5632","issn":["0015-5632","1874-9356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Microbiologica","raw_type":"journal-article"},{"id":"pmid:42603251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42603251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia microbiologica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s12223-026-01573-4","doi":"https://doi.org/10.1007/s12223-026-01573-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12223-026-01573-4","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12223-026-01573-4.pdf","source":{"id":"https://openalex.org/S68090309","display_name":"Folia Microbiologica","issn_l":"0015-5632","issn":["0015-5632","1874-9356"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia Microbiologica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322137","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","ror":"https://ror.org/03vqm2n93"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7203549296.pdf","grobid_xml":"https://content.openalex.org/works/W7203549296.grobid-xml"},"referenced_works_count":211,"referenced_works":["https://openalex.org/W1903990541","https://openalex.org/W1926741639","https://openalex.org/W1966552407","https://openalex.org/W1972752890","https://openalex.org/W1978839325","https://openalex.org/W1987258645","https://openalex.org/W1996054458","https://openalex.org/W1996064131","https://openalex.org/W1996762614","https://openalex.org/W1997259399","https://openalex.org/W2007002493","https://openalex.org/W2026838076","https://openalex.org/W2027005563","https://openalex.org/W2027017334","https://openalex.org/W2034852346","https://openalex.org/W2045825103","https://openalex.org/W2067906280","https://openalex.org/W2095324134","https://openalex.org/W2107606668","https://openalex.org/W2109385786","https://openalex.org/W2109891197","https://openalex.org/W2113796404","https://openalex.org/W2115423075","https://openalex.org/W2119236186","https://openalex.org/W2124439712","https://openalex.org/W2127171502","https://openalex.org/W2129781699","https://openalex.org/W2131256712","https://openalex.org/W2152782041","https://openalex.org/W2154063145","https://openalex.org/W2155894000","https://openalex.org/W2156382695","https://openalex.org/W2167239617","https://openalex.org/W2171000901","https://openalex.org/W2335807995","https://openalex.org/W2339070543","https://openalex.org/W2341166238","https://openalex.org/W2346828811","https://openalex.org/W2413982364","https://openalex.org/W2473016454","https://openalex.org/W2475881350","https://openalex.org/W2480010979","https://openalex.org/W2497912002","https://openalex.org/W2510725435","https://openalex.org/W2528396364","https://openalex.org/W2529846237","https://openalex.org/W2534304485","https://openalex.org/W2552396339","https://openalex.org/W2555982904","https://openalex.org/W2569765060","https://openalex.org/W2585268446","https://openalex.org/W2587185925","https://openalex.org/W2592619208","https://openalex.org/W2593571691","https://openalex.org/W2615363070","https://openalex.org/W2625298688","https://openalex.org/W2626207226","https://openalex.org/W2683261339","https://openalex.org/W2748907032","https://openalex.org/W2754928815","https://openalex.org/W2755004181","https://openalex.org/W2755198076","https://openalex.org/W2766208450","https://openalex.org/W2769959541","https://openalex.org/W2777692148","https://openalex.org/W2779019546","https://openalex.org/W2788458738","https://openalex.org/W2790009938","https://openalex.org/W2790761816","https://openalex.org/W2792729562","https://openalex.org/W2793767849","https://openalex.org/W2794834397","https://openalex.org/W2797148322","https://openalex.org/W2799419788","https://openalex.org/W2807161463","https://openalex.org/W2883244120","https://openalex.org/W2888747144","https://openalex.org/W2889696052","https://openalex.org/W2893526039","https://openalex.org/W2898500510","https://openalex.org/W2900282216","https://openalex.org/W2900729906","https://openalex.org/W2901528433","https://openalex.org/W2905407007","https://openalex.org/W2911995196","https://openalex.org/W2912769303","https://openalex.org/W2914973875","https://openalex.org/W2915283904","https://openalex.org/W2917758234","https://openalex.org/W2929755096","https://openalex.org/W2940535422","https://openalex.org/W2942464443","https://openalex.org/W2945001860","https://openalex.org/W2955145678","https://openalex.org/W2957018722","https://openalex.org/W2986310069","https://openalex.org/W2989949845","https://openalex.org/W2990434592","https://openalex.org/W2993440463","https://openalex.org/W3008012392","https://openalex.org/W3018573010","https://openalex.org/W3027310961","https://openalex.org/W3033772179","https://openalex.org/W3038698648","https://openalex.org/W3041768520","https://openalex.org/W3081297646","https://openalex.org/W3089747452","https://openalex.org/W3091034757","https://openalex.org/W3094493940","https://openalex.org/W3096682950","https://openalex.org/W3097171892","https://openalex.org/W3102032040","https://openalex.org/W3106868625","https://openalex.org/W3127470297","https://openalex.org/W3132269320","https://openalex.org/W3136437910","https://openalex.org/W3170129699","https://openalex.org/W3172695015","https://openalex.org/W3174786519","https://openalex.org/W3183090963","https://openalex.org/W3184668148","https://openalex.org/W3187177963","https://openalex.org/W3215574816","https://openalex.org/W4200054830","https://openalex.org/W4200440943","https://openalex.org/W4206677002","https://openalex.org/W4210456098","https://openalex.org/W4210862506","https://openalex.org/W4211136731","https://openalex.org/W4213037564","https://openalex.org/W4213353716","https://openalex.org/W4220868438","https://openalex.org/W4221067374","https://openalex.org/W4224229867","https://openalex.org/W4225331172","https://openalex.org/W4226367995","https://openalex.org/W4229004138","https://openalex.org/W4232203165","https://openalex.org/W4281572412","https://openalex.org/W4283709433","https://openalex.org/W4292939272","https://openalex.org/W4296774304","https://openalex.org/W4297220006","https://openalex.org/W4303579602","https://openalex.org/W4308348722","https://openalex.org/W4308568638","https://openalex.org/W4308957251","https://openalex.org/W4309046032","https://openalex.org/W4309742254","https://openalex.org/W4310592634","https://openalex.org/W4311961295","https://openalex.org/W4315796668","https://openalex.org/W4361293800","https://openalex.org/W4367047930","https://openalex.org/W4377289691","https://openalex.org/W4383553863","https://openalex.org/W4384938549","https://openalex.org/W4385732923","https://openalex.org/W4385897719","https://openalex.org/W4386510257","https://openalex.org/W4387003074","https://openalex.org/W4387011970","https://openalex.org/W4387326978","https://openalex.org/W4387963223","https://openalex.org/W4388137135","https://openalex.org/W4389685524","https://openalex.org/W4391036370","https://openalex.org/W4391720227","https://openalex.org/W4392147198","https://openalex.org/W4392851135","https://openalex.org/W4394688170","https://openalex.org/W4394792907","https://openalex.org/W4394845645","https://openalex.org/W4397002137","https://openalex.org/W4398164896","https://openalex.org/W4399355198","https://openalex.org/W4400942497","https://openalex.org/W4400983220","https://openalex.org/W4401389900","https://openalex.org/W4401806394","https://openalex.org/W4402369994","https://openalex.org/W4402557213","https://openalex.org/W4404614905","https://openalex.org/W4404956453","https://openalex.org/W4405268717","https://openalex.org/W4408224750","https://openalex.org/W4408802498","https://openalex.org/W4409468682","https://openalex.org/W4409558242","https://openalex.org/W4411367798","https://openalex.org/W4411713495","https://openalex.org/W4411782461","https://openalex.org/W4411841967","https://openalex.org/W4411990104","https://openalex.org/W4412075621","https://openalex.org/W4413111761","https://openalex.org/W4413269824","https://openalex.org/W4413877629","https://openalex.org/W4414329900","https://openalex.org/W4414334917","https://openalex.org/W4414518446","https://openalex.org/W4414559908","https://openalex.org/W4416667319","https://openalex.org/W4417330905","https://openalex.org/W4417358009","https://openalex.org/W7128047387","https://openalex.org/W7133123361","https://openalex.org/W7135223826","https://openalex.org/W7161573744","https://openalex.org/W7163540670","https://openalex.org/W7165863739"],"related_works":["https://openalex.org/W7070529670","https://openalex.org/W7170776292","https://openalex.org/W4383553863","https://openalex.org/W7147401880","https://openalex.org/W4391036370","https://openalex.org/W4412998212","https://openalex.org/W4400123090","https://openalex.org/W2267343279","https://openalex.org/W7215887840","https://openalex.org/W4411841967"],"abstract_inverted_index":{"The":[0],"increasing":[1],"failure":[2],"of":[3,46,56,60,65,77,85,113,139,141,147,173,183,224,239,254],"antimicrobial":[4,70],"therapies":[5],"against":[6,203],"Pseudomonas":[7,204],"aeruginosa":[8,67,185],"represents":[9],"a":[10,54,98,119,278],"major":[11],"challenge":[12],"in":[13,17,100,135,155,180,264],"clinical":[14,195,288],"practice,":[15],"particularly":[16],"patients":[18],"with":[19,62,93,231],"chronic":[20],"lung":[21],"disease":[22],"and":[23,28,33,40,82,87,104,116,144,158,194,209,234,242,252,267,287],"critical":[24],"illness.":[25],"Beyond":[26],"intrinsic":[27],"acquired":[29],"resistance,":[30],"biofilm":[31,88,235],"formation":[32],"persister":[34],"cell":[35],"populations":[36],"contribute":[37],"to":[38,122],"persistent":[39],"refractory":[41],"infections,":[42,186],"limiting":[43],"the":[44,170,181,189],"efficacy":[45],"conventional":[47],"antibiotics.":[48],"Lacticaseibacillus":[49,197],"rhamnosus":[50,175,198],"has":[51],"emerged":[52],"as":[53,176,217],"source":[55],"bioactive":[57],"compounds":[58],"capable":[59],"interfering":[61],"multiple":[63],"stages":[64],"P.":[66,184,240],"pathogenesis.":[68],"Its":[69],"activity":[71,202,222],"involves":[72],"organic":[73],"acid":[74],"production,":[75],"secretion":[76],"low-molecular-weight":[78],"metabolites,":[79],"enzymatic":[80],"effects,":[81],"biosurfactant-mediated":[83],"disruption":[84],"adhesion":[86],"formation.":[89],"In":[90],"addition,":[91],"interactions":[92],"host":[94],"epithelial":[95],"cells":[96],"indicate":[97],"role":[99,172],"modulating":[101],"inflammatory":[102],"responses":[103],"enhancing":[105],"mucosal":[106],"defenses.":[107],"Cell-free":[108,212],"supernatant":[109,213],"(CFS)":[110,214],"retain":[111],"many":[112],"these":[114],"properties":[115],"may":[117],"represent":[118],"safer":[120],"alternative":[121],"live":[123,225],"probiotic":[124],"administration.":[125,227],"Despite":[126],"consistent":[127],"experimental":[128],"evidence,":[129],"key":[130,237],"limitations":[131],"remain,":[132],"including":[133],"variability":[134],"strain":[136,250],"selection,":[137],"lack":[138,253],"standardization":[140,193],"cell-free":[142],"preparations,":[143],"incomplete":[145],"characterization":[146],"active":[148],"compounds.":[149],"Clinical":[150,260],"studies":[151,261],"suggest":[152,262],"potential":[153,171,263],"benefits":[154],"reducing":[156,265],"colonization":[157,266],"ventilator-associated":[159,268],"pneumonia,":[160,269],"although":[161],"robust":[162,271],"evidence":[163],"is":[164,247],"still":[165],"limited.":[166],"These":[167],"findings":[168],"support":[169],"L.":[174],"an":[177],"adjunctive":[178],"strategy":[179],"management":[182],"while":[187],"highlighting":[188],"need":[190],"for":[191,280],"mechanistic":[192],"validation.":[196],"exhibits":[199],"multi-target":[200],"inhibitory":[201],"aeruginosa,":[205],"integrating":[206,284],"antimicrobial,":[207],"antibiofilm,":[208],"immunomodulatory":[210],"effects.":[211],"(postbiotics)":[215],"emerge":[216],"promising":[218],"therapeutic":[219],"alternatives,":[220],"retaining":[221],"independent":[223],"bacterial":[226],"Evidence":[228],"supports":[229],"interference":[230],"quorum":[232],"sensing":[233],"dynamics,":[236],"determinants":[238],"aeruginosapersistence":[241],"antibiotic":[243],"tolerance.":[244],"Current":[245],"literature":[246],"limited":[248],"by":[249],"heterogeneity":[251],"methodological":[255],"standardization,":[256],"restricting":[257],"translational":[258,282],"applicability.":[259],"but":[270],"trials":[272],"remain":[273],"scarce.":[274],"This":[275],"review":[276],"proposes":[277],"framework":[279],"future":[281],"research,":[283],"mechanistic,":[285],"experimental,":[286],"perspectives.":[289]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-16T00:00:00"}
